Insecticides Derived from Natural Products: Diversity and Potential Applications

2020 ◽  
pp. 403-437
Author(s):  
Johnson Wahengbam ◽  
Laxman Sonawane Bhushan ◽  
Jyoti B. Patil ◽  
Jayakumar Pathma
Keyword(s):  
Natural Products ◽  
Potential Applications

Nanoscale Delivery Systems: Actual and Potential Applications in the Natural Products Industry

2017 ◽  
Vol 23 (17) ◽  
Author(s):  
Antal Diana Simona ◽  
Ardelean Florina ◽  
Chis Aimee Rodica ◽  
Ollivier Evelyne ◽  
Serban Maria-Corina
Keyword(s):  
Natural Products ◽  
Delivery Systems ◽  
Potential Applications

scholarly journals Bioactive Nitrogenous Secondary Metabolites from the Marine Sponge Genus Haliclona

Marine Drugs ◽  
2019 ◽  
Vol 17 (12) ◽  
pp. 682 ◽  
Author(s):  
Jiaying Zhu ◽  
Yang Liu ◽  
Zijun Liu ◽  
Hao Wang ◽  
Huawei Zhang
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Secondary Metabolites ◽  
Marine Sponge ◽  
Literature Search ◽  
Extensive Literature ◽  
Symbiotic Microorganisms ◽  
Bioactive Properties ◽  
Potential Applications ◽  
Extensive Literature Search

Marine sponge genus Haliclona, one of the most prolific sources of natural products, contains over 600 species but only a small part of them had been classified and chemically investigated. On the basis of extensive literature search, this review firstly summarizes 112 nitrogenous secondary metabolites from classified and unclassified Haliclona sponges as well as from their symbiotic microorganisms. Most of these substances have only been found in Haliclona sponges, and display diverse bioactive properties with potential applications in new drug discovery.

scholarly journals COCONUT online: Collection of Open Natural Products database

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Maria Sorokina ◽  
Peter Merseburger ◽  
Kohulan Rajan ◽  
Mehmet Aziz Yirik ◽  
Christoph Steinbeck
Keyword(s):  
Natural Products ◽  
Small Molecules ◽  
In Silico ◽  
Web Interface ◽  
Computational Screening ◽  
Online Resource ◽  
The World ◽  
Potential Applications ◽  
Living Organisms ◽  
Application Fields

AbstractNatural products (NPs) are small molecules produced by living organisms with potential applications in pharmacology and other industries as many of them are bioactive. This potential raised great interest in NP research around the world and in different application fields, therefore, over the years a multiplication of generalistic and thematic NP databases has been observed. However, there is, at this moment, no online resource regrouping all known NPs in just one place, which would greatly simplify NPs research and allow computational screening and other in silico applications. In this manuscript we present the online version of the COlleCtion of Open Natural prodUcTs (COCONUT): an aggregated dataset of elucidated and predicted NPs collected from open sources and a web interface to browse, search and easily and quickly download NPs. COCONUT web is freely available at https://coconut.naturalproducts.net.

Origins, Structures, and Bioactivities of Secondary Metabolites from Marine-derived Penicillium Fungi

2021 ◽  
Vol 21 ◽  
Author(s):  
Xiliang Yang ◽  
Jinping Liu ◽  
Jiahui Mei ◽  
Rui Jiang ◽  
Shizheng Tu ◽  
...  
Keyword(s):  
Natural Products ◽  
Secondary Metabolites ◽  
Drug Development ◽  
Valuable Source ◽  
Chemical Structures ◽  
New Drug ◽  
Bioactive Properties ◽  
Potential Applications ◽  
New Drug Development ◽  
Anti Inflammatory

: In recent years, marine-derived Penicillium fungi have received remarkable interest as a valuable source of novel natural products encompassing diverse chemical structures and bioactive properties. Mangroves, sediments, algae, and sponges are the four main sources of marine-derived Penicillium fungi. As of 2014, more than 390 novel natural products have been isolated from the marine-derived Penicillium fungi, mainly including polyketides, alkaloids, terpenoids, and macrolides. Biological investigations have shown that these compounds possess antimicrobial, anti-inflammatory, cytotoxic, and other activities with potential applications in new drug development. To provide an updated catalog of this field, our mini-review summarized the origins, structures, and bioactivities of 188 secondary metabolites from marine-derived Penicillium fungi based on bioactivities classification published from 2015 to 2020.

scholarly journals Loseolamycins: A Group of New Bioactive Alkylresorcinols Produced after Heterologous Expression of a Type III PKS from Micromonospora endolithica

Molecules ◽  
2020 ◽  
Vol 25 (20) ◽  
pp. 4594
Author(s):  
Constanze Lasch ◽  
Nils Gummerlich ◽  
Maksym Myronovskyi ◽  
Anja Palusczak ◽  
Josef Zapp ◽  
...  
Keyword(s):  
Natural Products ◽  
Heterologous Expression ◽  
Transcriptional Activation ◽  
Polyketide Synthase ◽  
Biologically Active ◽  
Aliphatic Chain ◽  
Biosynthetic Pathways ◽  
Type Iii Polyketide Synthase ◽  
Type Iii ◽  
Potential Applications

Natural products are a valuable source of biologically active compounds with potential applications in medicine and agriculture. Unprecedented scaffold diversity of natural products and biocatalysts from their biosynthetic pathways are of fundamental importance. Heterologous expression and refactoring of natural product biosynthetic pathways are generally regarded as a promising approach to discover new secondary metabolites of microbial origin. Here, we present the identification of a new group of alkylresorcinols after transcriptional activation and heterologous expression of the type III polyketide synthase of Micromonospora endolithica. The most abundant compounds loseolamycins A1 and A2 have been purified and their structures were elucidated by NMR. Loseolamycins contain an unusual branched hydroxylated aliphatic chain which is provided by the host metabolism and is incorporated as a starter fatty acid unit. The isolated loseolamycins show activity against gram-positive bacteria and inhibit the growth of the monocot weed Agrostis stolonifera in a germination assay. The biosynthetic pathway leading to the production of loseolamycins is proposed in this paper.

scholarly journals Coconut Online: Collection of Open Natural Products Database

2020 ◽  
Author(s):  
Maria Sorokina ◽  
Peter Merseburger ◽  
Kohulan Rajan ◽  
Mehmet Aziz Yirik ◽  
Christoph Steinbeck
Keyword(s):  
Natural Products ◽  
Small Molecules ◽  
In Silico ◽  
Web Interface ◽  
Computational Screening ◽  
Online Resource ◽  
Potential Applications ◽  
Living Organisms

Abstract Natural products (NPs) are small molecules produced by living organisms with potential applications in pharmacology and other industries for their high bioactivities. Over the years a multiplication of thematic NP databases has been observed. However, there is no online resource regrouping all known NPs in just one place, which would greatly simplify NP research and allow computational screening and other in silico applications. Here we present the COlleCtion of Open Natural prodUcTs (COCONUT): an aggregated dataset of NPs available in different open sources and a subsequent web interface to browse, search and easily and quickly download NPs. COCONUT web is freely available at https://coconut.naturalproducts.net.

scholarly journals In Vitro and In Vivo Toxicity Evaluation of Natural Products with Potential Applications as Biopesticides

Toxins ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 805
Author(s):  
Felicia Sangermano ◽  
Marco Masi ◽  
Amrish Kumar ◽  
Ravindra Peravali ◽  
Angela Tuzi ◽  
...  
Keyword(s):  
Natural Products ◽  
Cell Lines ◽  
Mammalian Cell ◽  
Mammalian Cells ◽  
Toxic Effects ◽  
Mammalian Cell Lines ◽  
Dittrichia Viscosa ◽  
Potential Applications

The use of natural products in agriculture as pesticides has been strongly advocated. However, it is necessary to assess their toxicity to ensure their safe use. In the present study, mammalian cell lines and fish models of the zebrafish (Danio rerio) and medaka (Oryzias latipes) have been used to investigate the toxic effects of ten natural products which have potential applications as biopesticides. The fungal metabolites cavoxin, epi-epoformin, papyracillic acid, seiridin and sphaeropsidone, together with the plant compounds inuloxins A and C and ungeremine, showed no toxic effects in mammalian cells and zebrafish embryos. Conversely, cyclopaldic and α-costic acids, produced by Seiridium cupressi and Dittrichia viscosa, respectively, caused significant mortality in zebrafish and medaka embryos as a result of yolk coagulation. However, both compounds showed little effect in zebrafish or mammalian cell lines in culture, thus highlighting the importance of the fish embryotoxicity test in the assessment of environmental impact. Given the embryotoxicity of α-costic acid and cyclopaldic acid, their use as biopesticides is not recommended. Further ecotoxicological studies are needed to evaluate the potential applications of the other compounds.

scholarly journals Azoacetylenes for the Synthesis of Arylazotriazole Photoswitches

2021 ◽  
Author(s):  
Patrick Pfaff ◽  
Felix Anderl ◽  
Moritz Fink ◽  
Moritz Balkenhohl ◽  
Erick Carreira
Keyword(s):  
Natural Products ◽  
Arachidonic Acid ◽  
Modular Approach ◽  
Complex Molecules ◽  
Design And Synthesis ◽  
Wide Range ◽  
Potential Applications ◽  
First Time ◽  
Oriented Approach

We report a modular approach towards novel arylazotriazole photoswitches and their photophysical characterization. Addition of lithiated TIPS-acetylene to aryldiazonium tetrafluoroborate salts gives a wide range of azoacetylenes, constituting an underexplored class of stable intermediates. <i>In situ </i>desilylation transiently leads to terminal arylazoacetylenes that undergo copper-catalyzed cycloadditions (CuAAC) with a diverse collection of organoazides. These include complex molecules derived from natural products or drugs, such as colchicine, taxol, tamiflu, and arachidonic acid. The arylazotriazoles display near-quantitative photoisomerization and long thermal <i>Z</i>-half-lives. Using the method, we introduce for the first time the design and synthesis of a diacetylene platform that permits implementation of a consecutive and diversity-oriented approach linking two different conjugants to independently addressable acetylenes within a common photoswitchable azotriazole. This is showcased in the synthesis of several photoswitchable conjugates, with potential applications as photoPROTACs and photoswitchable biotin conjugates

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