The Role of Microbiome in the Induction, Diagnosis, and Therapy of Skin Cancer

2021 ◽  
pp. 89-100
Author(s):  
Malini Kotak
Keyword(s):  
Skin Cancer ◽  
Diagnosis And Therapy

Role of exosomes in diagnosis and therapy of prostate cancer

2020 ◽  
Vol 28 (3) ◽  
pp. 399-405
Author(s):  
Fabrizio Fontana ◽  
Olga A. Babenko
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Biological Fluids ◽  
Diagnosis And Treatment ◽  
Diagnosis And Therapy ◽  
The Future ◽  
Important Direction ◽  
Potential Biomarkers

Aim of this letter is to attract the attention of journal readers to the study of exosomes as an important direction in the development of Oncology, in particular, in the diagnosis and treatment of prostate cancer. Exosomes are produced by tumor cells and regulate proliferation, metastasis, and the development of chemoresistance. Their extraction from biological fluids allows further use of these vesicles as potential biomarkers of prostate cancer. In the future, exosomes can be successfully used in the delivery of drugs and other anti-tumor substances to cancer cells.

scholarly journals Differential Role of Basal Keratinocytes in UV-Induced Immunosuppression and Skin Cancer

2006 ◽  
Vol 26 (22) ◽  
pp. 8515-8526 ◽  
Author(s):  
Judith Jans ◽  
George A. Garinis ◽  
Wouter Schul ◽  
Adri van Oudenaren ◽  
Michael Moorhouse ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Biological Effects ◽  
Mouse Skin ◽  
Cell Type ◽  
Cell Type Specificity ◽  
Basal Keratinocytes ◽  
Expression Of Genes ◽  
Pyrimidine Dimers ◽  
Response To Stress

ABSTRACT Cyclobutane pyrimidine dimers (CPDs) and 6-4 photoproducts (6-4PPs) comprise major UV-induced photolesions. If left unrepaired, these lesions can induce mutations and skin cancer, which is facilitated by UV-induced immunosuppression. Yet the contribution of lesion and cell type specificity to the harmful biological effects of UV exposure remains currently unclear. Using a series of photolyase-transgenic mice to ubiquitously remove either CPDs or 6-4PPs from all cells in the mouse skin or selectively from basal keratinocytes, we show that the majority of UV-induced acute effects to require the presence of CPDs in basal keratinocytes in the mouse skin. At the fundamental level of gene expression, CPDs induce the expression of genes associated with repair and recombinational processing of DNA damage, as well as apoptosis and a response to stress. At the organismal level, photolyase-mediated removal of CPDs, but not 6-4PPs, from the genome of only basal keratinocytes substantially diminishes the incidence of skin tumors; however, it does not affect the UVB-mediated immunosuppression. Taken together, these findings reveal a differential role of basal keratinocytes in these processes, providing novel insights into the skin's acute and chronic responses to UV in a lesion- and cell-type-specific manner.

The Role of Caveolin-1 in Skin Cancer

2011 ◽  
pp. 65-74
Author(s):  
Alessandra Carè ◽  
Isabella Parolini ◽  
Federica Felicetti ◽  
Massimo Sargiacomo
Keyword(s):  
Skin Cancer ◽  
Caveolin 1

Complications of Percutaneous Transtracheal Procedures

1977 ◽  
Vol 86 (5) ◽  
pp. 633-634 ◽  
Author(s):  
George D. Lyons ◽  
Maynard E. Garrett ◽  
David G. Fourrier
Keyword(s):  
Percutaneous Puncture ◽  
Diagnosis And Therapy ◽  
Air Space ◽  
Therapeutic Procedures ◽  
The Many

The increasing use of transtracheal procedures by various specialties has caused a rash of new complications which have interested the endoscopist. These complications have resulted from the many diagnostic and therapeutic procedures involving the percutaneous puncture of the laryngeal or tracheal air space. The validity of these procedures is not questioned. However, they have spawned a host of diverse and bizarre complications which have led to serious and even fatal problems. The role of the endoscopist as a consultant in both the diagnosis and therapy of these developments must be understood and stressed.

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