Intercellular bridges in ovarian follicle cells of Drosophila melanogaster

1978 ◽  
Vol 186 (3) ◽  
Author(s):  
Franco Giorgi
Keyword(s):  
Drosophila Melanogaster ◽  
Ovarian Follicle ◽  
Follicle Cells ◽  
Intercellular Bridges

scholarly journals Drosophila melanogaster Cad99C, the orthologue of human Usher cadherin PCDH15, regulates the length of microvilli

2005 ◽  
Vol 171 (3) ◽  
pp. 549-558 ◽  
Author(s):  
Cecilia D'Alterio ◽  
Dao D.D. Tran ◽  
Maggie W.Y. Au Yeung ◽  
Michael S.H. Hwang ◽  
Michelle A. Li ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Plasma Membrane ◽  
Epithelial Cells ◽  
Binding Sites ◽  
Actin Filaments ◽  
Transmembrane Protein ◽  
Ovarian Follicle ◽  
Pdz Domain ◽  
Follicle Cells ◽  
Apical Surface

Actin-based protrusions can form prominent structures on the apical surface of epithelial cells, such as microvilli. Several cytoplasmic factors have been identified that control the dynamics of actin filaments in microvilli. However, it remains unclear whether the plasma membrane participates actively in microvillus formation. In this paper, we analyze the function of Drosophila melanogaster cadherin Cad99C in the microvilli of ovarian follicle cells. Cad99C contributes to eggshell formation and female fertility and is expressed in follicle cells, which produce the eggshells. Cad99C specifically localizes to apical microvilli. Loss of Cad99C function results in shortened and disorganized microvilli, whereas overexpression of Cad99C leads to a dramatic increase of microvillus length. Cad99C that lacks most of the cytoplasmic domain, including potential PDZ domain–binding sites, still promotes excessive microvillus outgrowth, suggesting that the amount of the extracellular domain determines microvillus length. This study reveals Cad99C as a critical regulator of microvillus length, the first example of a transmembrane protein that is involved in this process.

scholarly journals Graft-versus-host disease targets ovary and causes female infertility in mice

Blood ◽  
2017 ◽  
Vol 129 (9) ◽  
pp. 1216-1225 ◽  
Author(s):  
Sonoko Shimoji ◽  
Daigo Hashimoto ◽  
Hidetsugu Tsujigiwa ◽  
Kohta Miyawaki ◽  
Koji Kato ◽  
...  
Keyword(s):  
T Cell ◽  
Graft Versus Host Disease ◽  
Ovarian Follicle ◽  
Follicle Cells ◽  
Cell Infiltration ◽  
Ovarian Insufficiency ◽  
Graft Versus Host ◽  
T Cell Infiltration ◽  
Gvhd Prophylaxis ◽  
Key Points

Key Points GVHD mediates donor T-cell infiltration and apoptosis of the ovarian follicle cells, leading to ovarian insufficiency and infertility. Ovarian insufficiency and infertility are independent of conditioning, and pharmacologic GVHD prophylaxis preserves fertility.

Role of ovarian follicle cells in vitellogenesis and oocyte resorption inCapitella sp. I (Polychaeta)

1984 ◽  
Vol 79 (2) ◽  
pp. 133-144 ◽  
Author(s):  
K. J. Eckelbarger ◽  
P. A. Linley ◽  
J. P. Grassle
Keyword(s):  
Ovarian Follicle ◽  
Follicle Cells ◽  
Oocyte Resorption

Studies on the Ovarian Follicle Cells of Drosophila

1963 ◽  
Vol s3-104 (67) ◽  
pp. 297-320
Author(s):  
R. C. KING ◽  
ELIZABETH A. KOCH
Keyword(s):  
Ovarian Follicle ◽  
Protein A ◽  
Follicle Cell ◽  
Follicle Cells ◽  
Vitelline Membrane ◽  
Membrane Material ◽  
Adjacent Layer ◽  
Membrane Formation ◽  
Precursor Material ◽  
Egg Shell

Studies are described of the ultrastructure of the follicle cells which invest the oocyte of Drosophila melanogaster at the time of vitelline membrane formation. Of particular interest are organelles made up of endoplasmic reticulum organized into a husk of concentric lamellae which surround lipidal droplets. These epithelial bodies are seen only at the time the vitelline membrane is being formed, and it is assumed therefore that the lipidal material of the epithelial body may be utilized somehow in the fabrication of the vitelline membrane. Cytochemical studies have shown this membrane to contain at least 5 classes of compounds; a protein, two lipids (which may be distinguished by differences in their resistance to extraction by various solvents), and 2 polysaccharides (1 neutral and 1 acidic). Studies were made of vitelline membrane formation in the ovaries of flies homozygous for either of 2 recessive, female-sterile genes (tiny and female sterile). In the case of the ty mutation vitelline membrane material is sometimes secreted between follicle and nurse cells, while in the mutant fes vitelline membrane is observed in rare instances to be secreted between follicle cells and an adjacent layer of tumour cells. In the latter case the vitelline membrane shows altered cytochemical properties. The fact that vitelline membrane can be secreted by follicle cells not adjacent to an oocyte demonstrates that it is the follicle cell rather than the oocyte that plays the major role in the secretion of the precursor material of the vitelline membrane. Subsequently the follicle cells secrete the egg-shell, or chorion, which is subdivided into a dense, compartmented, inner endochorion, and a pale, outer exochorion. A description is given of the ultrastructure of the follicle cells during the secretion of the endochorion and the exochorion. The endochorion contains a protein, a polysaccharide, and a lipid, all of which may be distinguished cytochemically from the vitelline membrane compounds. The exochorion contains large amounts of acidic mucopolysaccharides. Specialized follicle cells form the micropylar apparatus and the chorionic appendages. The formation of the chorion and chorionic appendages is discussed in the light of information gained from abnormalities of the chorions and chorionic appendages seen in ty and fs 2.1 oocytes. Subsequent to the time the egg leaves the ovariole a layer of waterproofing wax is secreted between the vitelline membrane and the chorion.

Intercellular bridges between follicle cells and oocyte during the differentiation of follicular epithelium in Lacerta sicula Raf

1978 ◽  
Vol 33 (1) ◽  
pp. 341-350
Author(s):  
P. Andreuccetti ◽  
C. Taddei ◽  
S. Filosa
Keyword(s):  
Follicle Cells ◽  
Follicular Epithelium ◽  
Intercellular Bridges ◽  
Cytoplasmic Material ◽  
Function Transfer ◽  
Pyriform Cells

Intercellular bridges first appear during lizard oogenesis when follicles are rather small (150 microgram in diameter); at this stage they form connecting links between the oocyte and follicle cells, which have not yet differentiated into pyriform cells. Later on, when the follicles have become larger (1 mm) and the follicular epithelium appears constituted by 3 types of cells (small, intermediate and pyriform cells) they form connecting links between the oocyte and both intermediate and pyriform cells. The establishment of intercellular bridges between pyriform cells and the oocyte precedes the complete differentiation of the former, which excludes the possibility that the fusion between pyriform cells and oocyte occurs only after these cells are completely differentiated. In still larger follicles (up to 2 mm in diameter), during the degeneration of the pyriform cells, the occurrence, inside the bridges, of mitochondria and other cytoplasmic material suggests that these cells at the end of their function transfer their contents into the oocyte.

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