Prevalence rate of candida in the oral cavity of patients with oral lichen planus

1980 ◽  
Vol 267 (3) ◽  
pp. 317-318 ◽  
Author(s):  
M. Simon ◽  
O. P. Hornstein
Keyword(s):  
Oral Cavity ◽  
Lichen Planus ◽  
Prevalence Rate ◽  
Oral Lichen Planus ◽  
Oral Lichen

scholarly journals Prevalence of desquamative gingivitis in dermatological lesions - A retrospective institution based study

2020 ◽  
Vol 11 (SPL3) ◽  
pp. 1259-1263
Author(s):  
Santosh Bala ◽  
Herald J. Sherlin ◽  
Vivek Narayan
Keyword(s):  
Oral Cavity ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Histopathological Diagnosis ◽  
Oral Manifestations ◽  
Dental Hospital ◽  
Study Population ◽  
The Common ◽  
Oral Lichen ◽  
Oral Involvement

The oral cavity is considered to be the window to your body because oral manifestations accompany many systemic diseases. In many instances, oral involvement precedes the appearance of other symptoms or lesions at other locations. The aim of this study is to find the correlation of these formative gingiva along with dermatological lesions. Details of patients reported with dermatological lesions to the dental hospital with oral manifestations were obtained from a detailed patient record. The data collected is tabulated graphically via SPSS for statistical analysis. 24 patients were reported with various dermatological lesions. 70% of female predilection was observed, and maximum patients carried the lesion for about 12 months. Out of the 24 patients, 70% show the presence of desquamative gingiva clinically. Histopathological diagnosis shows that 75% of the dermatological lesions present in the oral cavity is lichen planus. According to the current study population, dermatological lesions are the common cause of desquamative gingiva. The prevalence of oral lichen planus was higher and commonly seen along with desquamative gingiva.

scholarly journals CONDITION OF PERIODONTAL TISSUES IN PATIENTS WITH DERMATOSES

2018 ◽  
Vol 14 (4) ◽  
pp. 54-57
Author(s):  
Н. Чернышева ◽  
N. Chernyshova ◽  
Сергей Чуйкин ◽  
Sergey Chuykin ◽  
Гузель Акмалова ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Periodontal Disease ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Periodontal Diseases ◽  
Complex Treatment ◽  
Adequate Treatment ◽  
Periodontal Tissues ◽  
Periodontal Index ◽  
Oral Lichen

Background. Periodontal disease is one of the most common and complex pathologies in dentistry. It is known frequently damage to the tissues of the periodontal complex with dermatoses. The most relevant among the dermatoses of the mucous membrane of the mouth and the red border of the lips is oral lichen planus. Among the six clinical forms of red flat oral lichen planus and the red border of the lips, the exudative-hyperemic and erosive-ulcerous forms occur most often. Atypical form is much less common than other forms and is often diagnosed by dentists as an inflammatory periodontal disease. At the same time, the pathogenetic mechanisms of inflammatory processes in the gums, which are different in oral lichen planus, are not taken into account, which, accordingly, complicates adequate treatment. Objectives. The aim of the study was to analyze the periodontal status in patients with exudative-hyperemic, erosive-ulcerative and atypical forms of oral lichen planus. Methods. Under our supervision there were 181 patients with oral lichen planus, in whom a simplified Green-Vermillion hygiene index was determined. To assess the state of periodontal used periodontal index according to Russell. Results. When assessing the hygienic condition of the oral cavity, high values were observed in individuals with severe forms of the disease: erosive-ulcerative, exudative-hyperemic. The highest values of the periodontal index were found in patients with atypical, erosive and ulcerative forms of oral lichen planus. Conclusions. The results of the clinical examination of patients with oral lichen planus dictate, first of all, to include in the scheme of complex treatment of it the sanitization of oral cavity and complex treatment of inflammatory periodontal diseases as well.

scholarly journals Oral lichen planus with linear lichen planus: a rare association

2019 ◽  
Vol 5 (2) ◽  
pp. 429
Author(s):  
N. Padmapriya ◽  
K. Karthikeyan
Keyword(s):  
Oral Cavity ◽  
Lichen Planus ◽  
Rare Variant ◽  
Oral Lichen Planus ◽  
Skin Lesions ◽  
Topical Steroids ◽  
Rare Association ◽  
Oral Lichen

<p class="abstract">Lichen planus (LP) is a papulosquamous disorder with both cutaneous and mucosal manifestation. Linear lichen planus is rare variant of lichen planus which occurs in the extremities. Oral lichen planus is another variant of lichen planus. Coexistence of linear lichen planus with oral lichen planus is rare and only one case has been reported before this case. A 35 year old female presented with hyperpigmented linear lesion in the leg and whitish plaques in the oral cavity. Biopsy of the skin lesions showed features of lichen planus. The patient was started on topical steroids and oral hydroxychloroquine. Patient responded to treatment.</p>

Lichen Planus and Lichenoid Lesions of the Oral Cavity

1994 ◽  
Vol 103 (6) ◽  
pp. 495-497 ◽  
Author(s):  
John G. Batsakis ◽  
Karen R. Cleary ◽  
Kyung-Ja Cho
Keyword(s):  
Oral Cavity ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Clinical Manifestations ◽  
Spontaneous Resolution ◽  
Increased Risk ◽  
History Of ◽  
Cutaneous Form ◽  
Oral Lichen ◽  
Chronic Course

Lichen planus is a mucocutaneous disease of unknown cause that has its principal clinical manifestations in the skin and mucosa of the oral cavity. The natural history of the cutaneous form is one of spontaneous resolution over time, while oral lichen planus pursues a much more chronic course with a low order of resolution. Oral lichen planus must be distinguished from lichenoid lesions, including lichenoid dysplasia. Malignant change in oral lichen planus is rare and is prompted by carcinogenic cofactors. There is no increased risk of development of carcinoma in cutaneous lichen planus.

scholarly journals Expression of HER2/neu in premalignant lesions of oral cavity

2020 ◽  
Author(s):  
Vansh Verma ◽  
Dr. Ashesh Kumar Jha ◽  
Dr. Karsing Patiri ◽  
Dr. Nikhil Arora
Keyword(s):  
Oral Cancer ◽  
Oral Cavity ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Normal Mucosa ◽  
Premalignant Lesions ◽  
Severe Dysplasia ◽  
Positive Contribution ◽  
Cytoplasmic Staining ◽  
Oral Lichen

Context: Molecular alterations in premalignant lesions of oral cavity are not well known, many reports and have found increased HER2 expression to be correlated with poor prognosis in oral cancer. However,literature on expression of HER2 in premalignant lesions is limited and data is conflicting in nature. Overexpression of HER2 in premalignant lesions may denote its positive contribution in malignant transformation of these lesions. Aims: To evaluate the expression of HER2 in premalignant lesions of oral cavity. Settings and Design: In this prospective observational study of 2 months, patients attending OPD at Department of ENT and meeting the inclusion criteria were included. Methods and Material: 23 samples of Leukoplakia and 1 sample of oral lichen planus were stained by routine H&E to confirm clinical diagnosis and assess dysplasia if any, 5 samples of normal mucosa were used as control. Immunohistochemical staining for HER2 was done. ASCO/CAP 2018 guidelines were used for reporting the results. Statistical analysis used: Percentage of lesions expressing cytoplasmic or membranous expression was calculated. Results: 1 sample of Leukoplakia with severe dysplasia expressed focal membranous staining. 20% leukoplakia lesions expressed cytoplasmic staining. Staining was not observed in oral lichen planus and leucoplakia without dysplasia. Conclusions: Membranous expression in Severe dysplasia and higher expression in oral cancer is in concordance with the multistep theory of carcinogenesis. Larger studies are needed if HER2 is to be proposed as a marker for oral premalignant lesions. Significance of cytoplasmic staining in oral premalignant lesions needs to be elucidated.

scholarly journals Genomic study of oral lichen planus and oral microbiome with RNAseq

2020 ◽  
Author(s):  
Evelyn F. Zhong ◽  
Andrea Chang ◽  
Andres Stucky ◽  
Xuelian Chen ◽  
Tarun Mundluru ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Chronic Inflammatory Disease ◽  
Oral Microbiome ◽  
Microbial Composition ◽  
Genomic Study ◽  
Oral Lichen

ABSTRACTOral lichen planus (OLP) is a common chronic inflammatory disease affecting the oral mucosa. The pathogenesis of OLP is incompletely understood but is thought to be related to the immune system. As the oral cavity is a major reservoir and transmission gateway for bacteria, viruses, and fungi, the microbial composition of the oral cavity could play a role in the pathogenesis of OLP. However, due to limitations of analytic technology and incomplete knowledge of the microbial community in the oral cavity, it is not yet clear which pathogens are associated with OLP. Next-generation sequencing (NGS) is a powerful tool that can help to identify pathogens for many infectious diseases. In this study, we compared host cell gene expression profiles and microbial profiles from OLP patients and matched healthy individuals. We identified activation of the hepatocyte nuclear factor alpha (HNF4A) network in OLP patients and potential pathogens, including Corynebacterium matruchotii, Fusobacterium periodonticum, Streptococcus intermedius, Streptococcus oralis, and Prevotella denticola. P. denticola is capable of activating the HNF4A gene network. Our findings shed light on the previously elusive association of OLP with various diseases like hepatitis, and indicate that OLP is a T-helper type 17 (Th17)-mediated mucosal inflammatory process. The molecular pathways and microbes identified here can inform future investigations into OLP pathogenesis and development of novel therapeutics for OLP treatment.

scholarly journals Genomic Analysis of Oral Lichen Planus and Related Oral Microbiome Pathogens

Pathogens ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 952
Author(s):  
Evelyn F. Zhong ◽  
Andrea Chang ◽  
Andres Stucky ◽  
Xuelian Chen ◽  
Tarun Mundluru ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Genomic Analysis ◽  
Chronic Inflammatory Disease ◽  
Oral Microbiome ◽  
Microbial Composition ◽  
Oral Lichen

Oral lichen planus (OLP) is a common chronic inflammatory disease affecting the oral mucosa. The pathogenesis of OLP is incompletely understood but is thought to be related to the immune system. As the oral cavity is a major reservoir and transmission gateway for bacteria, viruses, and fungi, the microbial composition of the oral cavity could play a role in the pathogenesis of OLP. However, limited by analytic technology and knowledge of the microbial community in the oral cavity, it is not yet clear which pathogens are associated with OLP. Next generation sequencing (NGS) is a powerful tool to identify pathogens for many infectious diseases. In this study, we compared the host cell gene expression profiles and the microbial profiles between OLP patients and matched healthy individuals. We identified the activation of the hepatocyte nuclear factor alpha (HNF4A) network in OLP patients and potential pathogens, including Corynebacterium matruchotii, Fusobacterium periodonticum, Streptococcus intermedius, Streptococcus oralis, and Prevotella denticola. Prevotella denticola is capable of activating the HNF4A gene network. Our findings shed light on the previously elusive association of OLP with various diseases like hepatitis, and indicate that OLP is a T-helper type 17 (Th17) mediated mucosal inflammatory process. The identified molecular pathways and microbes could be used to inform future investigations into OLP pathogenesis and to develop novel therapeutics for OLP treatment.

scholarly journals Оцінка специфічного імунітету порожнини рота при комплексному лікуванні пацієнтів із генералізованим пародонтитом на тлі червоного плоского лишаю

2016 ◽  
Author(s):  
O. V. Yelisieyeva
Keyword(s):  
Oral Cavity ◽  
Lichen Planus ◽  
Successful Treatment ◽  
Oral Lichen Planus ◽  
The State ◽  
Treatment Quality ◽  
Objective Criterion ◽  
Specific Immunity ◽  
Oral Lichen ◽  
Siga Level

<p>The state of the oral cavity immunity of the patients with chronicle generalized periodontitis together with oral lichen planus<strong> </strong>has been examined as one of the possible objective criterion of the treatment quality. Successful treatment of the patients according to the worked out scheme (lizomukoid, lisobakt, lysozyme containing gel) is accompanied by restoration of the local specific immunity characteristics of the oral cavity sIgA level normalization just after the end of the course of treatment and in 3 months after the therapy.</p>

scholarly journals THE FREQUENCY OF COMBINATION OF ORAL LICHEN PLANUS WITH SOMATIC PATHOLOGY AND LOCAL UNFAVORABLE FACTORS OF THE ORAL CAVITY

2019 ◽  
Vol 15 (1) ◽  
pp. 16-22 ◽  
Author(s):  
Ирина Анисимова ◽  
Irina Anisimova ◽  
Лаура Симонян ◽  
Laura Simonyan
Keyword(s):  
Blood Pressure ◽  
Oral Cavity ◽  
Emotional Disorders ◽  
Lichen Planus ◽  
Oral Hygiene ◽  
Oral Lichen Planus ◽  
Main Group ◽  
Galvanic Current ◽  
Low Level ◽  
Oral Lichen

Background. In this article, we studied the frequency of combination of oral lichen planus with somatic pathology. The analysis of the survey, testing of individuals with oral lichen planus, laboratory blood counts; personalized advisory opinions of the local therapists. The influence of local adverse factors was studied by analyzing the indicators of galvanic current and the oral hygiene index. Objectives ― to study the frequency of combination of lichen planus with somatic pathology, the level of psycho-emotional status of patients, the role of local adverse factors in the oral cavity. Methods. There were analyzed two groups of patients in the age of 24―65 years. The main group (numbered in 22 people), included patients with oral lichen planus and control group (numbered in 15 people) combined people without pathology of the oral mucosa. The main group was divided into two subgroups I (numbered in 11 people), combined patients with a typical form of oral lichen planus and subgroup II (numbered in 11 people) included patients with an erosive-ulcerative form of oral lichen planus. Clinical and laboratory examinations were conducted by a local therapist to identify somatic pathology. Filled in the “health questionnaire” and tested by the method of Zung. Determined the concentration of glucose in blood; blood pressure indicators; the level of hygiene and galvanic current. Results. Questioning showed that patients with oral lichen planus have somatic pathology. Testing according to Zung's method revealed psycho-emotional disorders. Clinical and laboratory examination by a therapist revealed 100 % somatic pathology, concentration of glucose in blood and blood pressure in most individuals exceeded WHO standards. Analysis of the hygiene index showed a low level of oral hygiene; analysis of galvanometry revealed the presence of galvanic current in the oral cavity. Conclusions. Among all patients with oral lichen planus somatic pathology was detected in 100 % of cases. Lichen planus proceeds against the background of psycho-emotional disorders. Local unfavorable factors of the oral cavity (low level of hygiene and galvanic current) aggravate the course of lichen planus, slow down the regeneration.

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