Programming action of androgens on formation of sexual dimorphism of the corticosteroid-binding globulin level in rats

1991 ◽  
Vol 111 (2) ◽  
pp. 225-228
Author(s):  
R. M. Kurabekova ◽  
G. D. Mataradze ◽  
V. B. Rozen
Keyword(s):  
Sexual Dimorphism ◽  
Globulin Level ◽  
Corticosteroid Binding Globulin

scholarly journals Liver at the nexus of rat postnatal HPA axis maturation and sexual dimorphism

2021 ◽  
Vol 248 (1) ◽  
pp. R1-R17
Author(s):  
Julia N C Toews ◽  
Geoffrey L Hammond ◽  
Victor Viau
Keyword(s):  
Sexual Dimorphism ◽  
Hpa Axis ◽  
Mammalian Species ◽  
Normal Function ◽  
Expression Of Genes ◽  
Corticosteroid Binding Globulin ◽  
Pituitary Thyroid Axis ◽  
Thyroid Axis ◽  
Context Specific

Normal function of the hypothalamic–pituitary–adrenal (HPA) axis is critical for survival, and its development is choreographed for age-, sex- and context-specific actions. The liver influences HPA ontogeny, integrating diverse endocrine signals that inhibit or activate its development. This review examines how developmental changes in the expression of genes in the liver coordinate postnatal changes in multiple endocrine systems that facilitate the maturation and sexual dimorphism of the rat HPA axis. Specifically, it examines how the ontogeny of testicular androgen production, somatostatin-growth hormone activities, and hypothalamic-pituitary-thyroid axis activity intersect to influence the hepatic gene expression of insulin-like growth factor 1, corticosteroid-binding globulin, thyroxine-binding globulin, 11β-hydroxysteroid dehydrogenase type 1 and 5α-reductase type 1. The timing of such molecular changes vary between mammalian species, but they are evolutionarily conserved and are poised to control homeostasis broadly, especially during adversity. Importantly, with the liver as their nexus, these diverse endocrine systems establish the fundamental organization of the HPA axis throughout postnatal development, and thereby ultimately determine the actions of glucocorticoids during adulthood.

scholarly journals Somatostatin Is Essential for the Sexual Dimorphism of GH Secretion, Corticosteroid-Binding Globulin Production, and Corticosterone Levels in Mice

Endocrinology ◽  
2015 ◽  
Vol 156 (3) ◽  
pp. 1052-1065 ◽  
Author(s):  
Jessica M. Adams ◽  
Veronica Otero-Corchon ◽  
Geoffrey L. Hammond ◽  
Johannes D. Veldhuis ◽  
Nathan Qi ◽  
...  
Keyword(s):  
Sexual Dimorphism ◽  
Peak Plasma ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Plasma Corticosterone ◽  
Automated System ◽  
Sexually Dimorphic ◽  
Mrna Levels ◽  
Gh Secretion ◽  
Corticosteroid Binding Globulin

Abstract Distinct male and female patterns of pituitary GH secretion produce sexually differentiated hepatic gene expression profiles, thereby influencing steroid and xenobiotic metabolism. We used a fully automated system to obtain serial nocturnal blood samples every 15 minutes from cannulated wild-type (WT) and somatostatin knockout (Sst-KO) mice to determine the role of SST, the principal inhibitor of GH release, in the generation of sexually dimorphic GH pulsatility. WT males had lower mean and median GH values, less random GH secretory bursts, and longer trough periods between GH pulses than WT females. Each of these parameters was feminized in male Sst-KO mice, whereas female Sst-KO mice had higher GH levels than all other groups, but GH pulsatility was unaffected. We next performed hepatic mRNA profiling with high-density microarrays. Male Sst-KO mice exhibited a globally feminized pattern of GH-dependent mRNA levels, but female Sst-KO mice were largely unaffected. Among the differentially expressed female-predominant genes was Serpina6, which encodes corticosteroid-binding globulin (CBG). Increased CBG was associated with elevated diurnal peak plasma corticosterone in unstressed WT females and both sexes of Sst-KO mice compared with WT males. Sst-KO mice also had exaggerated ACTH and corticosterone responses to acute restraint stress. However, consistent with their lack of phenotypic signs of excess glucocorticoids, cerebrospinal fluid concentrations of free corticosterone in Sst-KO mice were not elevated. In summary, SST is necessary for the prolonged interpulse troughs that define masculinized pituitary GH secretion. SST also contributes to sexual dimorphism of the hypothalamic-pituitary-adrenal axis via GH-dependent regulation of hepatic CBG production.

scholarly journals Corticosteroid-Binding Globulin is expressed in the adrenal gland and its absence impairs corticosterone synthesis and secretion in a sex-dependent manner

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
José Gulfo ◽  
Ricard Castel ◽  
Angelo Ledda ◽  
María del Mar Romero ◽  
Montserrat Esteve ◽  
...  
Keyword(s):  
Sexual Dimorphism ◽  
Adrenal Gland ◽  
Synthetic Activity ◽  
Dependent Manner ◽  
Adrenal Hormones ◽  
Corticosteroid Binding Globulin ◽  
Relevant Role ◽  
Response To Stress ◽  
Hormone Control

Abstract Corticosteroid-binding globulin (CBG) is synthesized by the liver and secreted into the bloodstream where binds to glucocorticoids. Thus CBG has the role of glucocorticoid transport and free hormone control. In addition, CBG has been detected in some extrahepatic tissues without a known role. CBG-deficient mice show decreased total corticosterone levels with missing of classical sexual dimorphism, increased free corticosterone, higher adrenal gland size and altered HPA axis response to stress. Our aim was to ascertain whether CBG deficiency could affect the endocrine synthetic activity of adrenal gland and if the adrenal gland produces CBG. We determined the expression in adrenal gland of proteins involved in the cholesterol uptake and its transport to mitochondria and the main enzymes involved in the corticosterone, aldosterone and catecholamine synthesis. The results showed that CBG is synthesized in the adrenal gland. CBG-deficiency reduced the expression of ACTH receptor, SRB1 and the main genes involved in the adrenal hormones synthesis, stronger in females resulting in the loss of sexual dimorphism in corticosteroid adrenal synthesis, despite corticosterone content in adrenal glands from CBG-deficient females was similar to wildtype ones. In conclusion, these results point to an unexplored and relevant role of CBG in the adrenal gland functionality related to corticosterone production and release.

Central role for corticosteroid-binding globulin in rat HPA axis sexual dimorphism

2019 ◽  
Author(s):  
Julia Toews ◽  
Lesley Hill ◽  
Tristan Philippe ◽  
Juilee Rege ◽  
William Rainey ◽  
...  
Keyword(s):  
Sexual Dimorphism ◽  
Hpa Axis ◽  
Corticosteroid Binding Globulin

RHYNCHOLITES AND THE PROBLEM OF NARROW AND BROAD CONCEPTION OF TAXONS

2018 ◽  
pp. 12-17 ◽  
Author(s):  
I. R. Khuzina ◽  
V. N. Komarov
Keyword(s):  
Sexual Dimorphism ◽  
Morphological Characteristics ◽  
Mass Scale ◽  
Individual Variability ◽  
Point Of View ◽  
The Other ◽  
New Taxon ◽  
Artificial System ◽  
Broad Understanding

The paper considers a point of view, based on the conception of the broad understanding of taxons. According to this point of view, rhyncholites of the subgenus Dentatobeccus and Microbeccus are accepted to be synonymous with the genus Rhynchoteuthis, and subgenus Romanovichella is considered to be synonymous with the genus Palaeoteuthis. The criteria, exercising influence on the different approaches to the classification of rhyncholites, have been analyzed (such as age and individual variability, sexual dimorphism, pathological and teratological features, degree of disintegration of material), underestimation of which can lead to inaccuracy. Divestment of the subgenuses Dentatobeccus, Microbeccus and Romanovichella, possessing very bright morphological characteristics, to have an independent status and denomination to their synonyms, has been noted to be unjustified. An artificial system (any suggested variant) with all its minuses is a single probable system for rhyncholites. The main criteria, minimizing its negative sides and proving the separation of the new taxon, is an available mass-scale material. The narrow understanding of the genus, used in sensible limits, has been underlined to simplify the problem of the passing the view about the genus to the other investigators and recognition of rhyncholites for the practical tasks.

Observation on the breeding biology of Polypedates teraiensis (Dubois, 1987) (Amphibia: Rhacophoridae)

2017 ◽  
Vol 17 (1) ◽  
pp. 25-32
Author(s):  
Jacinta Lalchhanhimi ◽  
Lalremsanga H.T.
Keyword(s):  
Sexual Dimorphism ◽  
Breeding Season ◽  
Sound Production ◽  
Reproductive Function ◽  
Breeding Biology ◽  
Tree Frog ◽  
University Campus ◽  
Morphometric Measurements ◽  
Advertisement Calls ◽  
Males And Females

The breeding biology of tree frog, Polypedates teraiensis was studied during the breeding season at Mizoram University Campus. It was found that sound production by male during the breeding season was primarily a reproductive function and advertisement calls attract females to the breeding areas and announce other males that a given territory is occupied. The aim of this study was to provide the detailed information on the breeding behaviour and the advertisement calls of Polypedates teraiensis. The morphometric measurements of the amplecting pairs (males and females) for sexual dimorphism along with clutch sizes were also studied.

AN IMPROVED METHOD FOR THE ASSAY OF PROGESTERONE BY COMPETITIVE PROTEIN BINDING

1970 ◽  
Vol 63 (2) ◽  
pp. 225-241 ◽  
Author(s):  
B. D. Reeves ◽  
M. L. A. de Souza ◽  
I. E. Thompson ◽  
E. Diczfalusy
Keyword(s):  
Protein Binding ◽  
Binding Sites ◽  
Entire Range ◽  
Improved Method ◽  
Plasma Progesterone ◽  
Extraction And Purification ◽  
Corticosteroid Binding Globulin ◽  
Competitive Protein Binding ◽  
The Individual ◽  
Range Of Values

ABSTRACT An improved method for the assay of plasma progesterone by competitive protein binding is described. The improvement is based upon rigorous control of the variables, the compensation for and standardisation of interfering factors inherent in the method and the use of a human corticosteroid binding globulin, that meets the requirements for sensitivity at levels of 1.0 ng of progesterone and below. The assessment of the reliability of the individual steps in the method as well as that of the complete method is presented. The sensitivity of the method is around 0.2 ng progesterone per ml plasma. Accuracy was measured by adding progesterone in amounts ranging from 0.0 to 1.0 ng to 1.0 ml plasma. There was a linear relationship between the progesterone added and recovered throughout the entire range of values, with a coefficient of correlation (r) of 0.94. Of 52 related steroids tested, none was found which would remain associated with progesterone following extraction and purification and which would also compete with progesterone for binding sites.

Spatial expression profiling reveals tissue-specific sexual dimorphism of the natriuretic peptide system in mice

2014 ◽  
Author(s):  
Samantha Mirczuk ◽  
Camille Robson ◽  
Benjamin Robinson ◽  
Andrew Lessey ◽  
Victoria Lipscomb ◽  
...  
Keyword(s):  
Sexual Dimorphism ◽  
Natriuretic Peptide ◽  
Expression Profiling ◽  
Tissue Specific ◽  
Spatial Expression ◽  
Peptide System ◽  
Natriuretic Peptide System
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