Influence of imprinting with A and B chains of insulin on binding and functional changes in tetrahymena

1990 ◽  
Vol 10 (5) ◽  
pp. 431-436 ◽  
Author(s):  
G. Csaba ◽  
P. Kovács

Insulin and its A and B chain increased the quantity of intracellular PAS-positive material (glycogen) in tetrahymena, whereas the combined A+B chains decreased it. Imprinting—previous interaction—with insulin, its A and B chains in themselves and with the A+B chain increased the hormone binding capacity of tetrahymena, but the functional effect of imprinting (storage or breakdown of glycogen) showed a different tendency with insulin and A+B chain on the one hand, and A chain and B chain on the other. Since the imprinting potential of a molecule promotes the induction of receptor formation, the fact remains that both component chains of insulin were able to act as potential imprinters, although the A chain was superior to the B chain in this respect throughout, and combined treatment with the A+B chain ultimately induced the formation of a similar binding site as insulin itself.

1878 ◽  
Vol 28 (2) ◽  
pp. 633-671 ◽  
Author(s):  
Alexander Macfarlane

The experiments to which I shall refer were carried out in the physical laboratory of the University during the late summer session. I was ably assisted in conducting the experiments by three students of the laboratory,—Messrs H. A. Salvesen, G. M. Connor, and D. E. Stewart. The method which was used of measuring the difference of potential required to produce a disruptive discharge of electricity under given conditions, is that described in a paper communicated to the Royal Society of Edinburgh in 1876 in the names of Mr J. A. Paton, M. A., and myself, and was suggested to me by Professor Tait as a means of attacking the experimental problems mentioned below.The above sketch which I took of the apparatus in situ may facilitate tha description of the method. The receiver of an air-pump, having a rod capable of being moved air-tight up and down through the neck, was attached to one of the conductors of a Holtz machine in such a manner that the conductor of the machine and the rod formed one conducting system. Projecting from the bottom of the receiver was a short metallic rod, forming one conductor with the metallic parts of the air-pump, and by means of a chain with the uninsulated conductor of the Holtz machine. Brass balls and discs of various sizes were made to order, capable of being screwed on to the ends of the rods. On the table, and at a distance of about six feet from the receiver, was a stand supporting two insulated brass balls, the one fixed, the other having one degree of freedom, viz., of moving in a straight line in the plane of the table. The fixed insulated ball A was made one conductor with the insulated conductor of the Holtz and the rod of the receiver, by means of a copper wire insulated with gutta percha, having one end stuck firmly into a hole in the collar of the receiver, and having the other fitted in between the glass stem and the hollow in the ball, by which it fitted on to the stem tightly. A thin wire similarly fitted in between the ball B and its insulating stem connected the ball with the insulated half ring of a divided ring reflecting electrometer.


1997 ◽  
Vol 7 (4) ◽  
pp. 359-397 ◽  
Author(s):  
JOSÉ MESEGUER ◽  
UGO MONTANARI ◽  
VLADIMIRO SASSONE

Place/transition (PT) Petri nets are one of the most widely used models of concurrency. However, they still lack, in our view, a satisfactory semantics: on the one hand the ‘token game’ is too intensional, even in its more abstract interpretations in terms of nonsequential processes and monoidal categories; on the other hand, Winskel's basic unfolding construction, which provides a coreflection between nets and finitary prime algebraic domains, works only for safe nets. In this paper we extend Winskel's result to PT nets. We start with a rather general category PTNets of PT nets, we introduce a category DecOcc of decorated (nondeterministic) occurrence nets and we define adjunctions between PTNets and DecOcc and between DecOcc and Occ, the category of occurrence nets. The role of DecOcc is to provide natural unfoldings for PT nets, i.e., acyclic safe nets where a notion of family is used to relate multiple instances of the same place. The unfolding functor from PTNets to Occ reduces to Winskel's when restricted to safe nets. Moreover, the standard coreflection between Occ and Dom, the category of finitary prime algebraic domains, when composed with the unfolding functor above, determines a chain of adjunctions between PTNets and Dom.


2021 ◽  
Vol 3 (1) ◽  
pp. 112-133
Author(s):  
Maria R. Nenarokova

The article focuses on the reception of Russian classical literature translations in the English-speaking culture. The research was carried out on the material of three existing translations of ‘Forest and Steppe’ by both Russian and English translators published in 1895, 1955 and 1967. The main objective of the research is to determine the difficulties translators of Russian literature of the 19th century could face in the case of Turgenev's epigraph to ‘Forest and Steppe’. The tasks of the study were to define and describe the peculiarities of conveying the epigraph’s vocabulary, to outline the group of the most important keywords of the text, to recognize and describe discrepancies in their translation, to indicate why the chosen option is possible or impossible in the translation of Turgenev’s text. The study showed that Turgenev's worldview was formed under the influence of the culture of ‘rhetorical word’, and the epigraph to ‘Forest and Steppe’ proves it. The epigraph consists of a chain of symbolic images that add up to a single picture. The writer's worldview determined the style of the epigraph, the choice of vocabulary, and the composition of the text. For translators, the main difficulty at the lexical level lies in the fact that they often choose words that carry a greater emotional load than Turgenev’s vocabulary, and also introduce tropes, absent in the original, into translations. On the one hand, the translations create a realistic picture, in contrast to Turgenev’s symbolic landscape, on the other hand, the atmosphere of the text, reflecting the personality of the writer, is destroyed. The translations mirror profound changes that took place in the 19th–20th centuries in the European worldview.


2021 ◽  
pp. 174-186
Author(s):  
Senka Belić

Since ancient times, the concept of ethos has been a distinguished part of cultural heritage, living in various spheres of social, cultural, intellectual and religious life. During the Renaissance, the encounter of rhetorical categories and Christian doctrine opened the space for the manifestation of ethos in sacred music. Ethos is important as a rhetorical category, therefore, as a way to achieve persuasiveness, in which the theory of ethos of the Greek rhetorician Hermogenes of Tarsus will be consulted. Following this theory, which was also known in the Renaissance, a series of counterpoint methods will take form, which may indicate the manifestation of certain subcategories of ethos in music. Having in mind Hermogenes' concept of ethos on the one hand, and the significance of ethos in the Christian figure of Mary on the other, this paper examines a chain of manifestations and, given Hermogenes' subcategories, offers an in-depth reading of the text and music in the motet from the end of the 16th century. It is an early work of Claudio Monteverdi on the words of the Ave Maria prayer, which, according to its religious function and meaning, represents not only a concise appeal to the ethos of believers, but also the ethical foundation of Marian devotions.


Author(s):  
Daria V. Krotova

The paper examines the influence of acmeistic patterns on V. Shalamov-poet’s artistic consciousness. The study involves Shalamov’s epistolary and memoirs heritage (letters to N. Mandelstam, N. Stolyarova, essay “Akhmatova,” etc.), where the author reflected on the significance of acmeistic literary tradition, as well as put forward his own understanding of acmeism — not only as an artistic direction, but also as a kind of “life teaching,” a worldview system. One may trace the inheritance of acmeistic principles in Shalamov’s work at different levels. The paper seeks to identify and systematize acmeistic influences in poet’s consciousness. First of all, we are talking about the installation on the “fight for this world” (according to S. Gorodetsky): the multifaceted representation of the phenomena of environmental reality in its colors, forms and subject details. Shalamov inherits this principle, so that the objects of reality play a paramount role in his poetry system and receive no less distinct and large embodiment than in the work of acmeists. Such an arrangement is carried out by Shalamov in contrasting aspects: on the one hand, the imprinting of terrible world in which man barely survives and to which he seeks to resist; оn the other hand, even in the most adverse circumstances of imprisonment, the poet saw and felt the harmony and greatness of nature. The connection with the acmeistic thinking in Shalamov’s works is also expressed in the fact that his images are almost always substantive and tangible (this feature manifested itself as early as in the first poem of “Kolyma notebooks”). As in the lyrics of acmeists, he often refracted the inner world through external, spiritual experiences — through the prism of the subject plan (the principle that was realized brightly in the lyrics of A. Akhmatova). It is not often that the reader finds “pure” lyrical monologues, much more typical for Shalamov`s creative tactics — to characterize the internal state through a chain of real images. Acmeistic logic could be traced in the interpretation of a number of important topics, among which the theme of creativity (characteristic features of its interpretation are shown in the article on the example of poems “Ode to Loaf,” “May it be clumsily uneven…,” “By ungainly prisoner step...”). The paper addresses such a significant aspect (also linking the poet to the acmeistic tradition) as a bodily nature of the figurative world. Finally, important feature of acmeistic thinking, which is inherited by Shalamov, is the obvious appeal of his creativity to the interlocutor, the focus on the reader (this feature is immanent, certainly, not only in the consciousness of akmeists, but it has fundamental significance in their creativity). The study concludes that among the traditions influenced Shalamov-poet, the acmeist becomes one of the most important, most significant artistic and worldview guidelines.


Crepidula fornicata is a streptoneurous Gastropod belonging to the Calyptræidæ, a family of the Tænioglossa. It was first introduced into England from America about 1880 (1), when it was imported with American oysters. In America it is found on the east coast from Labrador to Florida, but in England so far as is known, it is confined to the Essex and Lincolnshire coasts, occurring, however, in abundance in shallow water in the neighbourhood of the mouths of the Crouch and Blackwater rivers. The conditions on the Essex coast seem to be highly favourable for its growth and propagation; indeed, so favourable, that within five or six years it has over-run the oyster beds at West Mersea. By attaching themselves very strongly to oyster-shells they cause the oyster fisherman much trouble, and it may be remarked, by competing for food and oxygen with the oysters may become a cause of much more serious trouble in the future. To obtain food the animals raise the anterior part of their shell and extending the head to the front edge of the shell, move it slowly from side to side: at times the whole shell may be similarly turned slowly round to the one side or the other. Crepidula fornicata is sedentary for the greater part of its life. It forms "chains," as Prof. Conklin calls them, by the curious habit the individuals have of fixing themselves in linear series one on the top of another as in fig. 1. Chains of as many as 12 individuals have been found. Viewed as a whole, a chain is seen to form a spiral of about half a trun, bending over to the right.


2019 ◽  
Vol 135 (3) ◽  
pp. 625-642
Author(s):  
Paloma Gracia

Abstract  The topic of this paper revolves around the links that unite the motif of the Waste Land with the wound of the Fisher King in the Conte du Graal. These links are based, on the one hand, on ancestral beliefs that connect the land’s fecundity with the goodness of the king, while his faults are punished with its sterility, and on the other, with Augustinism. The ills of the Grail’s family constitute a deserved castigation derived from a chain of sins, originating in the previous generation with the commission of a sin of origin. The punishment embraces all the members of the family, and, in the very same way that Original sin is the cause of both mortality and the earth’s aridity, its punishment presupposes the king’s impotence and the kingdom’s barrenness, Perceval’s matricide, and his silence in front of the Grail. The awaited irruption of Perceval in the Fisher King’s domain signified for the Grail’s family the same as that of redemption for mankind. Perceval thus redeems his lineage, and with it, the earth, in the line of the old belief that linked the king’s sins with the earth’s sterility, in conformity with the pattern of the Fall, Punishment and Redemption.


1983 ◽  
Vol 15 (2) ◽  
pp. 157-183 ◽  
Author(s):  
Moojan Momen

In the middle of the nineteenth century, Iran was shaken by a series of serious upheavals caused by the Bābī movement. Although of short duration, these upheavals engulfed the entire country and had far-reaching effects in that they formed the first of a chain of events that led on the one hand, to the constitional movement in Iran, and on the other, to the establishment of the now world-wide Bahā'ī Faith.


2017 ◽  
Vol 8 (1) ◽  
pp. 157-176
Author(s):  
Helga Lutz
Keyword(s):  
A Chain ◽  

"Der Text vergleicht zwei fetischistische Puppenexperimente des 20. Jahrhunderts. Auf der einen Seite steht der vielbeachtete Versuch Oskar Kokoschkas, die verlorene Alma Mahler durch eine lebensechte Puppe zu ersetzen. Auf der anderen Seite geht es um die verborgen gehaltenen Bücher des Schweizer Einsiedlers Armand Schulthess, bevölkert von Hunderten von erotischen Collage-Frauen, die kunstvoll zusammengeklebt, vernäht und ineinander gefaltet sind. So unterschiedlich das zugrundeliegende fetischistische Ritual auch ausfällt, so zeigt sich in beiden Anordnungen doch eine grundlegende Übereinstimmung: In beiden Fällen nimmt das Inkarnieren die Form einer Operationskette an, die das Bild ins Register einer mimetischen Transformationsontologie überstellt. The paper compares two fetishistic experiments with puppets of the 20th century. On the one hand, there is Oskar Kokoschka’s much discussed attempt to replace the lost Alma Mahler with a life-size doll. On the other hand, the paper treats the secret books of Swiss hermit Armand Schulthess, populated by hundreds of erotic women, which are artfully glued, sewn and folded together. However different the underlying fetishistic ritual may be, the two groups show a fundamental agreement: In both cases, the process of incarnating becomes a chain of operations, translating the image into the register of a mimetic ontology of transformation. "


2020 ◽  
Vol V (III) ◽  
pp. 191-199
Author(s):  
Asma Mustafa

This is a hermeneutic study of the spiritual Odyssey, Hippie, a bildungsroman novel that focuses on quest and mysteries to analyze the Truth or Reality, which leads to enlightenment. The concept of Bildungsroman is studied in the context of the Theory of Hermeneutics enunciated by Hans-Georg Gadamer and Anthony Giddens (Double Hermeneutics). This study shows how Paulo uses the essentials of romances, the Grail as a common object, Buddha's journey, long-cherished dreams, examples of epics, listening to one's heart, the signs, ventures, exploration, self-discovery to search a Hidden Treasure, and wisdom on legendary roads and places. For Gadamer, everyone has its particular viewpoint or perspective known as its horizon that helps to understand the world and the literary work. This study shows, along with the other elements, how one's journey for selfidentification always initiates with a successful new understanding of unity that everything in this world is interlinked and connected like a chain. This new realization of the unity which connects ones with The One is known as the soul of the world.


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