Effects of chronically administered fluoxetine and fenfluramine on food intake, body weight and the behavioural satiety sequence

1992 ◽  
Vol 106 (3) ◽  
pp. 401-407 ◽  
Author(s):  
Joan McGuirk ◽  
Richard Muscat ◽  
Paul Willner
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Behavioural Satiety Sequence ◽  
Satiety Sequence

Dose–response effects of orexin-A on food intake and the behavioural satiety sequence in rats

2000 ◽  
Vol 96 (1-2) ◽  
pp. 71-84 ◽  
Author(s):  
R.J Rodgers ◽  
J.C.G Halford ◽  
R.L Nunes de Souza ◽  
A.L Canto de Souza ◽  
D.C Piper ◽  
...  
Keyword(s):  
Food Intake ◽  
Dose Response ◽  
Orexin A ◽  
Behavioural Satiety Sequence ◽  
Satiety Sequence

The 5-HT1B receptor agonist CP-94,253 reduces food intake and preserves the behavioural satiety sequence

1996 ◽  
Vol 60 (3) ◽  
pp. 933-939 ◽  
Author(s):  
J.C.G. Halford ◽  
J.E. Blundell
Keyword(s):  
Food Intake ◽  
Receptor Agonist ◽  
Behavioural Satiety Sequence ◽  
Satiety Sequence

Palatability, food intake and the behavioural satiety sequence in male rats

2003 ◽  
Vol 80 (1) ◽  
pp. 37-47 ◽  
Author(s):  
Y Ishii ◽  
J.E Blundell ◽  
J.C.G Halford ◽  
R.J Rodgers
Keyword(s):  
Food Intake ◽  
Male Rats ◽  
Behavioural Satiety Sequence ◽  
Satiety Sequence

Effects of Cyproterone Acetate on Body Weight and Food Intake

1973 ◽  
Author(s):  
William W. Beatty ◽  
Thomas R. Vilberg ◽  
Paul B. Revland
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Cyproterone Acetate

FoxO1 ablation in hypothalamic pomc neurons reduces food intake and body weight

2007 ◽  
Vol 2 (S 1) ◽  
Author(s):  
L Plum ◽  
M Matsumoto ◽  
D Accili
Keyword(s):  
Body Weight ◽  
Food Intake

Central Histamine, the H3-Receptor and Obesity Therapy

2019 ◽  
Vol 18 (7) ◽  
pp. 516-522
Author(s):  
Néstor F. Díaz ◽  
Héctor Flores-Herrera ◽  
Guadalupe García-López ◽  
Anayansi Molina-Hernández
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Animal Studies ◽  
Energy Homeostasis ◽  
Receptor Activation ◽  
Receptor Ligands ◽  
Histaminergic System ◽  
H3 Receptor ◽  
Weight One ◽  
The Central Nervous System

The brain histaminergic system plays a pivotal role in energy homeostasis, through H1- receptor activation, it increases the hypothalamic release of histamine that decreases food intake and reduces body weight. One way to increase the release of hypothalamic histamine is through the use of antagonist/inverse agonist for the H3-receptor. Histamine H3-receptors are auto-receptors and heteroreceptors located on the presynaptic membranes and cell soma of neurons, where they negatively regulate the synthesis and release of histamine and other neurotransmitters in the central nervous system. Although several compounds acting as H3-receptor antagonist/inverse agonists have been developed, conflicting results have been reported and only one has been tested as anti-obesity in humans. Animal studies revealed the opposite effect in food intake, energy expeditor, and body weight, depending on the drug, spice, and route of administration, among others. The present review will explore the state of art on the effects of H3-receptor ligands on appetite and body-weight, going through the following: a brief overview of the circuit involved in the control of food intake and energy homeostasis, the participation of the histaminergic system in food intake and body weight, and the H3-receptor as a potential therapeutic target for obesity.

Roux-en-Y Gastrointestinal Bypass Promotes Activation of TGR5 and Peptide YY

2020 ◽  
Vol 20 (8) ◽  
pp. 1262-1267
Author(s):  
Haojun Yang ◽  
Hanyang Liu ◽  
YuWen Jiao ◽  
Jun Qian
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Metabolic Diseases ◽  
Peptide Yy ◽  
The Body ◽  
Wild Type ◽  
L Cells ◽  
Body Weights ◽  
Gastrointestinal Bypass ◽  
G Protein Coupled

Background: G protein-coupled bile acid receptor (TGR5) is involved in a number of metabolic diseases. The aim of this study was to identify the role of TGR5 after Roux-en-Y gastric bypass (GBP). Methods: Wild type and TGR5 knockout mice (tgr5-/-) were fed a high-fat diet (HFD) to establish the obesity model. GBP was performed. The changes in body weight and food intake were measured. The levels of TGR5 and peptide YY (PYY) were evaluated by RT-PCR, Western blot, and ELISA. Moreover, the L-cells were separated from wild type and tgr5-/- mice. The levels of PYY in L-cells were evaluated by ELISA. Results: The body weights were significantly decreased after GBP in wild type mice (p<0.05), but not tgr5-/- mice (p>0.05). Food intake was reduced after GBP in wild type mice, but also not significantly affected in tgr5-/- mice (p>0.05). The levels of PYY were significantly increased after GBP compared with the sham group (p<0.05); however, in tgr5-/- mice the expression of PYY was not significantly affected (p>0.05). After INT-777 stimulation in L-cells obtained from murine intestines, the levels of PYY were significantly increased in L-cells tgr5+/+ (p<0.05). Conclusion: Our study suggests that GBP up-regulated the expression of TGR5 in murine intestines, and increased the levels of PYY, which further reduced food intake and decreased the body weight.

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