Lipid peroxidation and antioxidative defense systems in early leaf growth

1991 ◽  
Vol 10 (1-4) ◽  
pp. 187-189
Author(s):  
Rongliang Zheng ◽  
Zhentu Yang
Keyword(s):  
Lipid Peroxidation ◽  
Leaf Growth ◽  
Antioxidative Defense ◽  
Defense Systems

Lipid peroxidation and antioxidant defense systems in rat liver after chronic ethanol feeding

Hepatology ◽  
1989 ◽  
Vol 10 (5) ◽  
pp. 815-821 ◽  
Author(s):  
Tateo Kawase ◽  
Shinzo Kato ◽  
Charles S. Lieber
Keyword(s):  
Lipid Peroxidation ◽  
Rat Liver ◽  
Antioxidant Defense ◽  
Chronic Ethanol ◽  
Defense Systems ◽  
Ethanol Feeding ◽  
Antioxidant Defense Systems

Interrelationship of antioxidative status, lipid peroxidation, and lipid profile in insulin-dependent and non-insulin-dependent diabetic patients

2007 ◽  
Vol 85 (10) ◽  
pp. 997-1003 ◽  
Author(s):  
Branko Cimbaljević ◽  
Ana Vasilijević ◽  
Slavica Cimbaljević ◽  
Biljana Buzadžić ◽  
Aleksandra Korać ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Plasma Levels ◽  
Lipid Peroxide ◽  
Diabetic Patients ◽  
Antioxidative Defense ◽  
Erythrocyte Morphology ◽  
Insulin Dependent ◽  
Niddm Patients

This study aimed to investigate the interrelationship of plasma lipid profile, lipid peroxidation, and erythrocyte antioxidative defense in patients with insulin-dependent (IDDM) and non-insulin-dependent (NIDDM) diabetes mellitus. Plasma levels of total cholesterol, triglycerides, and lipid peroxides and the activities of copper, zinc superoxide dismutase (CuZnSOD), catalase, glutathione peroxidase (GSH-Px), as well as the amount of glutathione in erythrocytes, were determined in IDDM, NIDDM, and nondiabetic control subjects. Additionally, morphology of erythrocytes in all subjects was examined. Plasma levels of total cholesterol and triglycerides were significantly increased in NIDDM compared with controls. Also, the lipid peroxide level was higher in NIDDM than in either control or IDDM subjects. CuZnSOD activity in erythrocytes was elevated in NIDDM patients compared with the control. In NIDDM patients, more extensive erythrocyte spherocytosis and echinocytosis compared with both control and IDDM subjects were observed. In contrast with the IDDM group, the observed abnormality in lipid metabolism in NIDDM patients is closely associated with increased lipid peroxidation, changes in antioxidative defense, and erythrocyte morphology.

Anti-adipogenesis and antioxidative defense status of a crude extract of ‘Kalasin 2’ peanut sprouts in 3T3-L1 mouse adipocytes

2019 ◽  
Vol 97 (6) ◽  
pp. 740-749
Author(s):  
Tantip Boonsong ◽  
Siriporn Pakwan ◽  
Wanida Chawnawa
Keyword(s):  
Oxidative Stress ◽  
Protein Expression ◽  
Oxidative Status ◽  
Peroxisome Proliferator ◽  
Antioxidative Defense ◽  
Peroxisome Proliferator Activated Receptor ◽  
Defense Systems ◽  
Treatment Of Obesity ◽  
Mouse Adipocytes ◽  
And Oxidative Stress

The aim of this study was to investigate the effects of extracts from germinated (GPE) and non-germinated peanuts (NGPE) on adipogenesis and oxidative status in normal and oxidative-stress-induced 3T3-L1 mouse adipocytes. The treated cells were analysed for cell growth, lipid accumulation, levels of intracellular reactive oxygen species (ROS), and the expression levels of mRNAs and proteins related to adipogenesis and antioxidative defense systems. The results indicated that an extract from peanuts made 9 days after germination (9GPE) reduced lipid contents and mRNA expression of adipogenesis-related genes to a greater extent than an extract from peanuts made 1-day after germination (1GPE) or from NGPE, respectively. In oxidative-stress-induced adipocytes, 9GPE decreased ROS levels, lipid content, and the protein expression of peroxisome-proliferator-activated receptor gamma, and also increased the protein expression of antioxidants. These results illustrate the anti-adipogenic capacity and oxidative status improvement achievable with GPE, and that it could be used as a putative therapeutic agent in the prevention of and (or) treatment of obesity and diseases associated with oxidative stress.

scholarly journals Asiatic Acid Derivatives Protect Primary Cultures of Rat Hepatocytes against Carbon Tetrachloride-Induced Injury via the Cellular Antioxidant System

2009 ◽  
Vol 4 (6) ◽  
pp. 1934578X0900400
Author(s):  
Mi Kyeong Lee ◽  
Seung Hyun Kim ◽  
Hyekyung Yang ◽  
Doo-Yeon Lim ◽  
Je-Ho Ryu ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Antioxidant Enzymes ◽  
Carbon Tetrachloride ◽  
Primary Cultures ◽  
Rat Hepatocytes ◽  
Asiatic Acid ◽  
Antioxidative Defense ◽  
Protective Activity ◽  
Defense System

We attempted to elucidate the hepatoprotective mechanism of two asiatic acid (AS) derivatives, 3β,23-dihydroxyurs-2-oxo-12-ene-28-oic acid (AS-10) and 3β,23-dihydroxyurs-12-ene-28-oic acid (AS-14), which exhibited significant protective activity against carbon tetrachloride (CCl4)-induced hepatotoxicity in primary cultures of rat hepatocytes. Our findings showed that AS-10 and AS-14 preserved the level of glutathione and the activities of antioxidant enzymes such as glutathione reductase, glutathione peroxidase, superoxide dismutase and catalase. In addition, these compounds ameliorated lipid peroxidation, as demonstrated by a reduction in the production of malondialdehyde. Furthermore, AS-10 and AS-14 did not restore the reduced total GSH level by BSO, indicating that the hepatoprotective activities of these compounds may be involved, in part, by regulating GSH synthesis. From these results, we suggest that both AS-10 and AS-14 exerted their hepatoprotective activities against CCl4-induced injury by preserving the cellular antioxidative defense system.

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