The relationship of biochemical and morphological information in the central nervous system: The problem of sampling

1967 ◽  
Vol 44 (12) ◽  
pp. 667-679 ◽  
Author(s):  
Arthur L. Prensky
1935 ◽  
Vol 31 (6) ◽  
pp. 777-787
Author(s):  
D. S. Vorontsov

Not only in the peripheral working organs, irritating substances are formed, which, as we can see, take an active part in their regulation, but also in the central nervous system, in the relationship of its individual elements, such substances apparently play an important role.


PEDIATRICS ◽  
1953 ◽  
Vol 12 (3) ◽  
pp. 337-337

In a compact yet clear manner, this book discusses the uses and limitations of encephalography in the diagnosis, study and treatment of diseases of the central nervous system. Technical details, controversial matter, and interpretative record evaluations are offered in as simplified a manner as is possible, and consistent with reasonable accuracy. In addition to short descriptions of the pertinent historical background, basic neurophysiology involved and general technics, the book also includes chapters on the relationship of the EEG to epilepsy, neurologic and neurosurgical problems, and psychiatric conditions.


2020 ◽  
Vol VII (2) ◽  
pp. 55-59
Author(s):  
S. A. Trushkovskiy

The question of the relationship of the borderline trunk of the sympathetic nerve to the central nervous system is almost completely undeveloped until the present time, and only recently, thanks to the improvement of methods for studying nerve fibers, it became possible for a more accurate further development of this issue.


1905 ◽  
Vol 51 (213) ◽  
pp. 258-270
Author(s):  
John Turner

Workers in the finer structure of the nervous system are suffering from a plethora of observations. New and more searching methods are being discovered every day, and no sooner does he who sets about constructing a scheme of the central nervous system arrive at something which appears to be satisfactory than he has to pull it to pieces and reconstruct it, to fit in further detail which has been brought to light in the meanwhile. Until this vast array of observations has been properly digested, a process which may well take years, we can scarcely hope to obtain a scheme of the relationship of the nerve-cells to one another which will be more than a working hypothesis.


1984 ◽  
Vol 4 (2) ◽  
pp. 93-98 ◽  
Author(s):  
Luigi F. Agnati ◽  
Kjell Fuxe

The hypothesis is introduced that miniaturization of neuronal circuits in the central nervous system and the hierarchical organization of the various levels, where information handling can take place, may be the key to understand the enormous capability of the human brain to store engrams as well as its astonishing capacity to reconstruct and organize engrams and thus to perform highly sophisticated integrations. The concept is also proposed that in order to understand the relationship between the structural and functional plasticity of the central nervous system it is necessary to postulate the existence of memory storage at the network level, at the local circuit level, at the synaptic level, at the membrane level, and finally at the molecular level. Thus, memory organization is similar to the hierarchical organization of the various levels, where information handling takes place in the nervous system. In addition, each higher level plays a role in the reconstruction and organization of the engrams stored at lower levels. Thus, the trace of the functionally stored memory (i.e. its reconstruction and organization at various levels of storage) will depend not only on the chemicophysical changes in the membranes of the local circuits but also on the organization of the local circuits themselves and their associated neuronal networks.


2020 ◽  
Vol 21 (6) ◽  
pp. 2010 ◽  
Author(s):  
Maria Rosaria Rizzo ◽  
Renata Fasano ◽  
Giuseppe Paolisso

Adiponectin (ADPN) is a plasma protein secreted by adipose tissue showing pleiotropic effects with anti-diabetic, anti-atherogenic, and anti-inflammatory properties. Initially, it was thought that the main role was only the metabolism control. Later, ADPN receptors were also found in the central nervous system (CNS). In fact, the receptors AdipoR1 and AdipoR2 are expressed in various areas of the brain, including the hypothalamus, hippocampus, and cortex. While AdipoR1 regulates insulin sensitivity through the activation of the AMP-activated protein kinase (AMPK) pathway, AdipoR2 stimulates the neural plasticity through the activation of the peroxisome proliferator-activated receptor alpha (PPARα) pathway that inhibits inflammation and oxidative stress. Overall, based on its central and peripheral actions, ADPN appears to have neuroprotective effects by reducing inflammatory markers, such as C-reactive protein (PCR), interleukin 6 (IL6), and Tumor Necrosis Factor a (TNFa). Conversely, high levels of inflammatory cascade factors appear to inhibit the production of ADPN, suggesting bidirectional modulation. In addition, ADPN appears to have insulin-sensitizing action. It is known that a reduction in insulin signaling is associated with cognitive impairment. Based on this, it is of great interest to investigate the mechanism of restoration of the insulin signal in the brain as an action of ADPN, because it is useful for testing a possible pharmacological treatment for the improvement of cognitive decline. Anyway, if ADPN regulates neuronal functioning and cognitive performances by the glycemic metabolic system remains poorly explored. Moreover, although the mechanism is still unclear, women compared to men have a doubled risk of developing cognitive decline. Several studies have also supported that during the menopausal transition, the estrogen reduction can adversely affect the brain, in particular, verbal memory and verbal fluency. During the postmenopausal period, in obese and insulin-resistant individuals, ADPN serum levels are significantly reduced. Our recent study has evaluated the relationship between plasma ADPN levels and cognitive performances in menopausal women. Thus, the aim of this review is to summarize both the mechanisms and the effects of ADPN in the central nervous system and the relationship between plasma ADPN levels and cognitive performances, also in menopausal women.


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