mRNA expression of basic fibroblast growth factor from a single intratracheal instillation of papain-induced emphysema in rats

2001 ◽  
Vol 21 (4) ◽  
pp. 297-300 ◽  
Author(s):  
Fu Juan ◽  
Xu Yongjian ◽  
Zhang Zhenxiang
Keyword(s):  
Growth Factor ◽  
Mrna Expression ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Intratracheal Instillation ◽  
Fibroblast Growth

scholarly journals Ovarian Steroids Regulate the Expression of Basic Fibroblast Growth Factor and its mRNA in Fibroblasts Derived from Uterine Endometrium

1997 ◽  
Vol 34 (1) ◽  
pp. 91-96 ◽  
Author(s):  
Jiro Fujimoto ◽  
Masashi Hori ◽  
Satoshi Ichigo ◽  
Teruhiko Tamaya
Keyword(s):  
Growth Factor ◽  
Mrna Expression ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Stromal Cells ◽  
Sex Steroids ◽  
Cell Interaction ◽  
Fibroblast Growth ◽  
Uterine Endometrium

The role of stromal cells in basic fibroblast growth factor (FGF) supply for endometrial neovascularization during the menstrual cycle was investigated. The concentrations of intracellular and secreted FGF, and FGF mRNA expression were determined in fibroblasts derived from uterine endometrium as a substitute for stromal cells. The influence of sex steroids on protein and mRNA expression was investigated. The concentration of FGF and its mRNA expression in the fibroblasts was significantly increased by oestradiol, and these increased concentrations were diminished by progesterone. It is suggested that oestrogen stimulates FGF secretion from the stromal cells, an effect which is inhibited by progesterone. Therefore, endometrial neovascularization might be partially regulated by stromal-derived FGF under the influence of sex steroids, through a paracrine cell-to-cell interaction.

Sign in / Sign up

Export Citation Format

Share Document