Response of biochemical markers of bone turnover to estrogen treatment in post-menopausal women: Evidence against an early anabolic effect on bone formation

2001 ◽  
Vol 24 (6) ◽  
pp. 423-429 ◽  
Author(s):  
C. E. Fiore ◽  
P. Pennisi ◽  
F. G. Tandurella ◽  
R. Amato ◽  
L. Giuliano ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Turnover ◽  
Biochemical Markers ◽  
Estrogen Treatment ◽  
Anabolic Effect ◽  
Menopausal Women ◽  
Markers Of Bone Turnover ◽  
Post Menopausal

scholarly journals Correlates of Selected Biochemical Markers of Bone turnover among Post-Menopausal Women

2018 ◽  
Vol 56 (212) ◽  
pp. 754-758 ◽  
Author(s):  
Bikram Khadka ◽  
Mohan Lal Tiwari ◽  
Ravi Gautam ◽  
Binod Timalsina ◽  
Nandu Prasad Pathak ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Alkaline Phosphatase ◽  
Bone Turnover ◽  
Biochemical Markers ◽  
Inorganic Phosphorus ◽  
Menopausal Women ◽  
Markers Of Bone Turnover ◽  
Post Menopausal ◽  
Year Since Menopause

Introduction: Bone turnover leading to osteoporosis and poor quality of life is common during post-menopausal period. Study of bone turnover markers that contribute to non-invasive assessment of bone-metabolic disorders holds an important of research in low income country like Nepal.  Methods: A hospital-based cross-sectional study conducted during the period of November 2016 to December 2017 among 354 women. Blood samples for calcium, inorganic phosphorus, alkaline phosphatase and vitamin D were collected and analyzed using a validated and calibrated tools. Data were analyzed using Statistical Package for the Social Sciences software version 20. Results: Mean±Standard deviation of age of post-menopausal women was significantly higher compared to pre-menopausal women (post-menopausal women, (57.98±8.08) vs. pre-menopausal, (31.35±5.83), (P<0.001). Selected biochemical markers of bone-turnover such as alkaline phosphatase levels were significantly higher with year since menopause (P<0.001), whereas serum calcium, and vitamin D were decreasing with year since menopause among post-menopausal women. In addition, calcium and vitamin D were significantly negatively correlated with year since menopause (P<0.01) while body mass index, inorganic phosphorus and alkaline phosphatase were significantly positively correlated with year since menopause (P<0.01). Conclusions: Our study revealed that body mass index, inorganic phosphorus and alkaline phosphatase positively correlated with year since menopause while calcium and vitamin D were negatively correlated suggesting for a medical supervision of hormonal changes and periodic dosing of calcium and vitamin D among post-menopausal women to reduce the problem of bone health.

Physical activity increases bone formation and decreases bone resorption as assessed by biochemical markers of bone turnover

1996 ◽  
Vol 6 (S1) ◽  
pp. 250-250
Author(s):  
HW Woitge ◽  
M Müller ◽  
P Bärtsch ◽  
B Friedmann ◽  
MJ Seibel ◽  
...  
Keyword(s):  
Physical Activity ◽  
Bone Resorption ◽  
Bone Formation ◽  
Bone Turnover ◽  
Biochemical Markers ◽  
Markers Of Bone Turnover

Effect of 1-year dietary supplementation with vitaminized olive oil on markers of bone turnover and oxidative stress in healthy post-menopausal women

Endocrine ◽  
2015 ◽  
Vol 50 (2) ◽  
pp. 326-334 ◽  
Author(s):  
Laura Mazzanti ◽  
Maurizio Battino ◽  
Laura Nanetti ◽  
Francesca Raffaelli ◽  
Alessandro Alidori ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Bone Turnover ◽  
Olive Oil ◽  
Dietary Supplementation ◽  
Menopausal Women ◽  
Markers Of Bone Turnover ◽  
Post Menopausal ◽  
And Oxidative Stress

scholarly journals N-MID Osteocalcin (N-MID Oc) and β-Crosslaps (β-CTx) as Biochemical Markers of Bone Turnover in Menopausal Women

2016 ◽  
Vol 5 (1) ◽  
pp. 67-74
Author(s):  
Eli Halimah ◽  
◽  
Wiwik Rositawati ◽  
Irma Pratiwi ◽  
◽  
...  
Keyword(s):  
Bone Turnover ◽  
Biochemical Markers ◽  
Menopausal Women ◽  
Markers Of Bone Turnover

Nomegestrol acetate may enhance the skeletal effects of estradiol on biochemical markers of bone turnover in menopausal women after a 12-week treatment period

Climacteric ◽  
2005 ◽  
Vol 8 (2) ◽  
pp. 136-145 ◽  
Author(s):  
ML Nguyên-Pascal ◽  
JL Thomas ◽  
L Bergougnoux ◽  
P Garnero ◽  
E Drapier-Faure ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Treatment Period ◽  
Biochemical Markers ◽  
Nomegestrol Acetate ◽  
Menopausal Women ◽  
Markers Of Bone Turnover ◽  
Skeletal Effects

scholarly journals Bone markers and osteoporosis

2004 ◽  
Vol 23 (3) ◽  
pp. 221-228 ◽  
Author(s):  
Kaya Emerk
Keyword(s):  
Bone Resorption ◽  
Bone Formation ◽  
Bone Turnover ◽  
Biochemical Markers ◽  
Alcohol Intake ◽  
Bone Markers ◽  
Bone Alkaline Phosphatase ◽  
Low Concentrations ◽  
Trabecular Microstructure ◽  
Markers Of Bone Turnover

Diagnosis of a given disease is often the first step to a successful therapy. The use of biochemical markers of bone turnover in osteoporosis is becoming more important due to their capacity to give early information. Many of the new markers are proteins, peptides, or other large biomolecules, usually present at very low concentrations. Bone is a living, growing tissue that turns over at a rate of about 10% a year. It is lergely made up of collagen, that gives the bone its tensile strength and framework, and calcium phosphate, mineralized complex that hardens the framework. After age 24, bone resorption slowly begins to happen faster than bone formation. Bone loss is most rapid in women in the first few year after menopause but continues into the postmenopausal years. Loss although much slowly, also happens in men. In addition to bone porosity, the bone strength is determined by the trabecular microstructure in wich osteoclastic, and osteoblastic activities play an important role. Osteoporosis develops when bone resorption occurs too rapidly and bone formation fails to keep up. Risk factors for osteoporosis involves age, gender, ethnicity, use of certain drugs, exercise, smoking Vit D deficiency, Ca intake, sex hormones, alcohol intake etc. Mineralization markers are serum osteocalcin, bone alkaline phosphatase, serum prokollagen I extention peptides. Markers for the resorption of bone on the other hand are urine N-telopeptide crosslinks, urine deoxy-piridinoline, urine hydroxyproline, tartarate dependent acid phosphatase and Catepsin K. Biochemical markers of bone turnover should be used with BMD for diagnosis.

scholarly journals Biochemical Markers of Bone Turnover in Rheumatoid Arthritis Patients Treated with Glucocorticoids

2019 ◽  
Vol 70 (2) ◽  
pp. 623-626
Author(s):  
Luana Andreea Macovei ◽  
Alexandra Burlui ◽  
Elena Rezus
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Resorption ◽  
Bone Formation ◽  
Bone Turnover ◽  
Biochemical Markers ◽  
Corticosteroid Treatment ◽  
Control Group ◽  
Bone Resorption Marker ◽  
Bone Formation Marker ◽  
Markers Of Bone Turnover

Osteocalcin and deoxypyridinoline levels were measured in 55 RA patients during and after glucocorticoid therapy with prednisone, methylprednisolone and cortisone. A decrease of 27% of the bone resorption marker deoxypyridinoline (from 10.13 to 7.4) and an increase of 23% of the bone formation marker osteocalcin (from 16.3 to 20.1) were also clinically confirmed by the presence of osteoporosis in 74% of patients receiving corticosteroid treatment as compared with only 31% in the control group.

scholarly journals Quantification of Biochemical Markers of Bone Turnover by Kinetic Measures of Bone Formation and Resorption in Young Healthy Females

1997 ◽  
Vol 12 (10) ◽  
pp. 1714-1720 ◽  
Author(s):  
Connie M. Weaver ◽  
Munro Peacock ◽  
Berdine R. Martin ◽  
George P. McCabe ◽  
Jian Zhao ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Turnover ◽  
Biochemical Markers ◽  
Markers Of Bone Turnover ◽  
Healthy Females
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