Effect of 1-year dietary supplementation with vitaminized olive oil on markers of bone turnover and oxidative stress in healthy post-menopausal women

Endocrine ◽  
2015 ◽  
Vol 50 (2) ◽  
pp. 326-334 ◽  
Author(s):  
Laura Mazzanti ◽  
Maurizio Battino ◽  
Laura Nanetti ◽  
Francesca Raffaelli ◽  
Alessandro Alidori ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Bone Turnover ◽  
Olive Oil ◽  
Dietary Supplementation ◽  
Menopausal Women ◽  
Markers Of Bone Turnover ◽  
Post Menopausal ◽  
And Oxidative Stress

scholarly journals Tamoxifen and oxidative stress: an overlooked connection

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Nermin S. Ahmed ◽  
Marek Samec ◽  
Alena Liskova ◽  
Peter Kubatka ◽  
Luciano Saso
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Gold Standard ◽  
Pharmacological Activities ◽  
Standard Drug ◽  
Menopausal Women ◽  
Wide Range ◽  
Post Menopausal ◽  
Apoptotic Effects ◽  
And Oxidative Stress

AbstractTamoxifen is the gold standard drug for the treatment of breast cancer in pre and post-menopausal women. Its journey from a failing contraceptive to a blockbuster is an example of pharmaceutical innovation challenges. Tamoxifen has a wide range of pharmacological activities; a drug that was initially thought to work via a simple Estrogen receptor (ER) mechanism was proven to mediate its activity through several non-ER mechanisms. Here in we review the previous literature describing ER and non-ER targets of tamoxifen, we highlighted the overlooked connection between tamoxifen, tamoxifen apoptotic effects and oxidative stress.

Prostaglandin F2α metabolite and F2-isoprostane excretion rates in migraine

2001 ◽  
Vol 102 (1) ◽  
pp. 39-43 ◽  
Author(s):  
Johanna HELMERSSON ◽  
Peter MATTSSON ◽  
Samar BASU
Keyword(s):  
Oxidative Stress ◽  
Migraine Attack ◽  
Prostaglandin F2α ◽  
Urine Samples ◽  
Menopausal Women ◽  
The Mean ◽  
Post Menopausal ◽  
Excretion Rates ◽  
And Control ◽  
And Oxidative Stress

The pathophysiology theory of migraine postulates a local, neurogenic inflammation and the possible involvement of oxidative stress. We analysed the levels of 15-oxo-dihydro-prostaglandin F2α (a metabolite of prostaglandin F2α) and 8-iso-prostaglandin F2α (a major isoprostane), which are biomarkers for inflammation and oxidative stress respectively, in urine from 21 patients with migraine, with and without aura. Urine samples from migraine patients were collected during a migraine attack, and control samples were collected from the same subjects on a migraine-free morning. The mean basal levels of 15-oxo-dihydro-prostaglandin F2α and 8-iso-prostaglandin F2α in the morning control urine samples were 0.54±0.11 and 0.31±0.13nmol/mmol of creatinine respectively. The mean levels of 15-oxo-dihydro-prostaglandin F2α and 8-iso-prostaglandin F2α in the urine samples collected during the migraine attack in the 21 patients were 0.53±0.13 and 0.32±0.11nmol/mmol of creatinine respectively. Thus there were no differences in the 15-oxo-dihydro-prostaglandin F2α and 8-iso-prostaglandin F2α excretion rates during the migraine attack compared with on the migraine-free day. However, the basal 8-iso-prostaglandin F2α excretion levels on the migraine-free day were significantly lower in pre-menopausal women (0.24±0.08nmol/mmol of creatinine, n = 11) compared with post-menopausal women (0.39±0.14nmol/mmol of creatinine; n = 7; P = 0.009). In conclusion, in this study we found no support for the involvement of inflammation and oxidative stress in migraine pathophysiology. Our results indicate, however, a lower level of oxidative stress in pre-menopausal compared with post-menopausal women.

scholarly journals Correlates of Selected Biochemical Markers of Bone turnover among Post-Menopausal Women

2018 ◽  
Vol 56 (212) ◽  
pp. 754-758 ◽  
Author(s):  
Bikram Khadka ◽  
Mohan Lal Tiwari ◽  
Ravi Gautam ◽  
Binod Timalsina ◽  
Nandu Prasad Pathak ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Alkaline Phosphatase ◽  
Bone Turnover ◽  
Biochemical Markers ◽  
Inorganic Phosphorus ◽  
Menopausal Women ◽  
Markers Of Bone Turnover ◽  
Post Menopausal ◽  
Year Since Menopause

Introduction: Bone turnover leading to osteoporosis and poor quality of life is common during post-menopausal period. Study of bone turnover markers that contribute to non-invasive assessment of bone-metabolic disorders holds an important of research in low income country like Nepal.  Methods: A hospital-based cross-sectional study conducted during the period of November 2016 to December 2017 among 354 women. Blood samples for calcium, inorganic phosphorus, alkaline phosphatase and vitamin D were collected and analyzed using a validated and calibrated tools. Data were analyzed using Statistical Package for the Social Sciences software version 20. Results: Mean±Standard deviation of age of post-menopausal women was significantly higher compared to pre-menopausal women (post-menopausal women, (57.98±8.08) vs. pre-menopausal, (31.35±5.83), (P<0.001). Selected biochemical markers of bone-turnover such as alkaline phosphatase levels were significantly higher with year since menopause (P<0.001), whereas serum calcium, and vitamin D were decreasing with year since menopause among post-menopausal women. In addition, calcium and vitamin D were significantly negatively correlated with year since menopause (P<0.01) while body mass index, inorganic phosphorus and alkaline phosphatase were significantly positively correlated with year since menopause (P<0.01). Conclusions: Our study revealed that body mass index, inorganic phosphorus and alkaline phosphatase positively correlated with year since menopause while calcium and vitamin D were negatively correlated suggesting for a medical supervision of hormonal changes and periodic dosing of calcium and vitamin D among post-menopausal women to reduce the problem of bone health.

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