Heart disease and vascular risk factors in the cognitively impaired elderly: Implications for Alzheimer’s dementia

2001 ◽  
Vol 13 (3) ◽  
pp. 231-239 ◽  
Author(s):  
M. C. Polidori ◽  
M. Marvardi ◽  
A. Cherubini ◽  
U. Senin ◽  
P. Mecocci
2021 ◽  
Vol 17 (S6) ◽  
Author(s):  
Narges Razavian ◽  
John Dodson ◽  
Leora Horwitz ◽  
Yindalon Aphinyanaphongs ◽  
Thomas Wisniewski ◽  
...  

2012 ◽  
Vol 22 (1) ◽  
pp. 53-58
Author(s):  
Bedile İrem Tiftikcioğlu ◽  
Nilgün Tuncay ◽  
Meltem Korucuk ◽  
Yaşar Zorlu

Author(s):  
RIZALDY TASLIM PINZON ◽  
BULAN MARCHELLIA WIJAYA

Objectives: This research is to measure the prevalence rate of antiplatelet resistance in ischemic stroke patients and measure the vascular risk factors associated with antiplatelet resistance in patients with ischemic stroke. Methods and Subjects: This was a cross-sectional study with the number of respondents in this study amounted to 155 patients who all had ischemic stroke disease at Bethesda Hospital in Yogyakarta Indonesia used stroke registry to complete the data of the risk factors. VerifyNow method is used to measure the responsiveness of antiplatelet therapy. Results: Among the 155 patients with ischemic stroke, 45 were women (29%), 110 were men (71%), and the elderly (age more than 60 years old) in 81 patients. In total 155 patients with ischemic stroke, 106 of them have hypertensive, with diabetes are 19 patients, dyslipidemia is 90 patients, and ischemic heart disease in 13 patients. The prevalence of antiplatelet resistance in risk factors, for age more than 60 years, is 21 patients (25%, RR=1.06, *p=0.96), in diabetes is 7 patients (36%, RR=1.17, **p=0.74), dyslipidemia is 19 patients (21%, RR=0.68, ***p=0.24), and ischemic heart disease is four patients (30%). Among 127 patients, 22% (28 patients) had aspirin resistance, while from 42 patients, 26.2% (11 patients) were resistant to clopidogrel. Conclusion: Antiplatelet resistance is common in ischemic stroke patients. One of five patients treated with antiplatelet showed non-responsiveness. Vascular risk factors do not increase the risk of antiplatelet resistance in ischemic stroke patients.


Kardiologiia ◽  
2018 ◽  
Vol 17 (10) ◽  
pp. 53-58 ◽  
Author(s):  
E. Yu. Andreenko ◽  
◽  
I. S. YAvelov ◽  
M. M. Loukianov ◽  
A. N. Vernohaeva ◽  
...  

1991 ◽  
Vol 90 (2-3) ◽  
pp. 223
Author(s):  
P WINOCOUR ◽  
P DURRINGTON ◽  
D BHATNAGAR ◽  
A MBEWU ◽  
M ISHOLA ◽  
...  

2013 ◽  
Vol 34 (suppl 1) ◽  
pp. P5453-P5453
Author(s):  
V. Bongard ◽  
M. Bodenant ◽  
J. Dallongeville ◽  
D. Arveiler ◽  
F. Kee ◽  
...  

2022 ◽  
pp. 174749302110706
Author(s):  
Raed A Joundi ◽  
Scott B Patten ◽  
Jeanne VA Williams ◽  
Eric E Smith

Background: The incidence of stroke in developed countries is increasing selectively in young individuals, but whether this is secondary to traditional vascular risk factors is unknown. Methods: We used the Canadian Community Health Survey from 2000 to 2016 to create a large population-representative cohort of individuals over the age of 30 and free from prior stroke. All analyses were stratified by age decile. We linked with administrative databases to determine emergency department visits or hospitalizations for acute stroke until December 2017. We calculated time trends in risk factor prevalence (hypertension, diabetes, obesity, and smoking) using meta-regression. We used Cox proportional hazard models to evaluate the association between vascular risk factors and stroke risk, adjusted for demographic, co-morbid, and social variables. We used competing risk regression to account for deaths and calculated population-attributable fractions. In a sensitivity analysis, we excluded those with prior heart disease or cancer. Results: We included 492,400 people in the analysis with 8865 stroke events over a median follow-up time of 8.3 years. Prevalence of hypertension, diabetes, and obesity increased over time while smoking decreased. Associations of diabetes, hypertension, and obesity with stroke risk were progressively stronger at younger age (adjusted hazard ratio for diabetes was 4.47, 95% confidence interval (CI) = 1.95–10.28 at age 30–39, vs 1.21, 95% CI = 0.93–1.57 at age 80+), although the obesity association was attenuated with adjustment. Smoking was associated with higher risk of stroke without a gradient across age deciles, although had the greatest population-attributable fraction at younger age. The hazard ratio for stroke with multiple concurrent risk factors was much higher at younger age (adjusted hazard ratio for 3–4 risk factors was 8.60, 95% CI = 2.97–24.9 at age 30–39 vs 1.61, 95% CI = 0.88–2.97 at age 80+) and results were consistent when accounting for the competing risk of death and excluding those with prior heart disease or cancer. Conclusions: Diabetes and hypertension were associated with progressively elevated relative risk of stroke in younger individuals and prevalence was increasing over time. The association of obesity with stroke was not significant after adjustment for other factors. Smoking had the greatest prevalence and population-attributable fraction for stroke at younger age. Our findings assist in understanding the relationship between vascular risk factors and stroke across the life span and planning public health measures to lower stroke incidence in the young.


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