scholarly journals The classical double copy for M-theory from a Kerr-Schild ansatz for exceptional field theory

2021 ◽  
Vol 2021 (4) ◽  
Author(s):  
David S. Berman ◽  
Kwangeon Kim ◽  
Kanghoon Lee
Keyword(s):  
Field Theory ◽  
State Of The Art ◽  
Single Copy ◽  
Current State ◽  
M Theory ◽  
Double Copy

Abstract We construct the classical double copy formalism for M-theory. This extends the current state of the art by including the three form potential of eleven dimensional supergravity along with the metric. The key for this extension is to construct a Kerr-Schild type Ansatz for exceptional field theory. This Kerr-Schild Ansatz then allows us to find the solutions of charged objects such as the membrane from a set of single copy fields. The exceptional field theory formalism then automatically produces the IIB Kerr-Schild ansatz allowing the construction of the single copy for the fields of IIB supergravity (with manifest SL(2) symmetry).

scholarly journals Metagenomics Strain Resolution on Assembly Graphs

2020 ◽  
Author(s):  
Christopher Quince ◽  
Sergey Nurk ◽  
Sebastien Raguideau ◽  
Robert James ◽  
Orkun S. Soyer ◽  
...  
Keyword(s):  
De Novo ◽  
State Of The Art ◽  
Single Copy ◽  
Community Members ◽  
Bioinformatics Pipeline ◽  
Read Mapping ◽  
Bayesian Algorithm ◽  
Anaerobic Digestor ◽  
Current State ◽  
Core Genes

AbstractWe introduce a novel bioinformatics pipeline, STrain Resolution ON assembly Graphs (STRONG), which identifies strains de novo, when multiple metagenome samples from the same community are available. STRONG performs coassembly, followed by binning into metagenome assembled genomes (MAGs), but uniquely it stores the coassembly graph prior to simplification of variants. This enables the subgraphs for individual single-copy core genes (SCGs) in each MAG to be extracted. It can then thread back reads from the samples to compute per sample coverages for the unitigs in these graphs. These graphs and their unitig coverages are then used in a Bayesian algorithm, BayesPaths, that determines the number of strains present, their sequences or haplotypes on the SCGs and their abundances in each of the samples.Our approach both avoids the ambiguities of read mapping and allows more of the information on co-occurrence of variants in reads to be utilised than if variants were treated independently, whilst at the same time exploiting the correlation of variants across samples that occurs when they are linked in the same strain. We compare STRONG to the current state of the art on synthetic communities and demonstrate that we can recover more strains, more accurately, and with a realistic estimate of uncertainty deriving from the variational Bayesian algorithm employed for the strain resolution. On a real anaerobic digestor time series we obtained strain-resolved SCGs for over 300 MAGs that for abundant community members match those observed from long Nanopore reads.

scholarly journals An analysis of current state of the art software on nanopore metagenomic data

2018 ◽  
Author(s):  
Samantha C Pendleton
Keyword(s):  
Single Molecule ◽  
State Of The Art ◽  
Genetic Material ◽  
Pcr Amplification ◽  
Single Copy ◽  
Metagenomic Data ◽  
Data Set ◽  
Current State ◽  
South Wales ◽  
Long Read

AbstractContextOur insight into DNA is controlled through a process called sequencing. Until recently, it was only possible to sequence DNA into short strings called “reads”. Nanopore is a new sequencing technology to produce significantly longer reads. Using nanopore sequencing, a single molecule of DNA can be sequenced without the need for time consuming PCR amplification (polymerase chain reaction is a technique used in molecular biology to amplify a single copy or a few copies of a segment of DNA across several orders of magnitude).AimsMetagenomics is the study of genetic material recovered from environmental samples. A research team from IBERS (Institute of Biological, Environmental & Rural Sciences) at Aberystwyth University have sampled metagenomes from a coal mine in South Wales using the Nanopore MinION and given initial taxonomic (classification of organisms) summaries of the contents of the microbial community.MethodsUsing various new software aimed for metagenomic data, we are interested to discover how well current bioinformatics software works with the data-set. We will conduct analysis and research into how well these new state of the art software works with this new long read data and try out some recent new developments for such analysis.ResultsMost of the software we used worked very well: we gained understanding of the ACGT count and quality of the data. However some software for bioinformatics don’t seem to work with nanopore data. Furthermore, we can conclude that low quality nanopore data may actually be quite average.

Behavioral Genetics: Concepts for Research and Practice in Language Development and Disorders

1995 ◽  
Vol 38 (5) ◽  
pp. 1126-1142 ◽  
Author(s):  
Jeffrey W. Gilger
Keyword(s):  
Language Development ◽  
Behavioral Genetics ◽  
State Of The Art ◽  
Genetic Research ◽  
Great Promise ◽  
Behavioral Genetic ◽  
Fine Grained ◽  
Future Goals ◽  
Current State ◽  
Research Designs

This paper is an introduction to behavioral genetics for researchers and practioners in language development and disorders. The specific aims are to illustrate some essential concepts and to show how behavioral genetic research can be applied to the language sciences. Past genetic research on language-related traits has tended to focus on simple etiology (i.e., the heritability or familiality of language skills). The current state of the art, however, suggests that great promise lies in addressing more complex questions through behavioral genetic paradigms. In terms of future goals it is suggested that: (a) more behavioral genetic work of all types should be done—including replications and expansions of preliminary studies already in print; (b) work should focus on fine-grained, theory-based phenotypes with research designs that can address complex questions in language development; and (c) work in this area should utilize a variety of samples and methods (e.g., twin and family samples, heritability and segregation analyses, linkage and association tests, etc.).

Schizophrenia Research: Current State of the Art

1976 ◽  
Vol 21 (7) ◽  
pp. 497-498
Author(s):  
STANLEY GRAND
Keyword(s):  
State Of The Art ◽  
Current State

Umbral Calculus

10.37236/24 ◽  
2002 ◽  
Vol 1000 ◽  
Author(s):  
A. Di Bucchianico ◽  
D. Loeb
Keyword(s):  
19Th Century ◽  
Finite Differences ◽  
State Of The Art ◽  
Umbral Calculus ◽  
Current State ◽  
Logical Foundation ◽  
Complete Bibliography ◽  
The 19Th Century ◽  
Mathematical Literature

We survey the mathematical literature on umbral calculus (otherwise known as the calculus of finite differences) from its roots in the 19th century (and earlier) as a set of “magic rules” for lowering and raising indices, through its rebirth in the 1970’s as Rota’s school set it on a firm logical foundation using operator methods, to the current state of the art with numerous generalizations and applications. The survey itself is complemented by a fairly complete bibliography (over 500 references) which we expect to update regularly.

The Receptor-Dependent QSAR Paradigm: An Overview of the Current State of the Art

2009 ◽  
Vol 5 (4) ◽  
pp. 359-366 ◽  
Author(s):  
Osvaldo Santos-Filho ◽  
Anton Hopfinger ◽  
Artem Cherkasov ◽  
Ricardo de Alencastro
Keyword(s):  
State Of The Art ◽  
Current State

scholarly journals Smoothing additive manufactured parts using ns-pulsed laser radiation

2021 ◽  
Author(s):  
Florian Kuisat ◽  
Fernando Lasagni ◽  
Andrés Fabián Lasagni
Keyword(s):  
Surface Roughness ◽  
Mechanical Performance ◽  
State Of The Art ◽  
Pulsed Laser ◽  
Industrial Applications ◽  
Laser Source ◽  
Pulsed Laser Radiation ◽  
Current State ◽  
The Impact

AbstractIt is well known that the surface topography of a part can affect its mechanical performance, which is typical in additive manufacturing. In this context, we report about the surface modification of additive manufactured components made of Titanium 64 (Ti64) and Scalmalloy®, using a pulsed laser, with the aim of reducing their surface roughness. In our experiments, a nanosecond-pulsed infrared laser source with variable pulse durations between 8 and 200 ns was applied. The impact of varying a large number of parameters on the surface quality of the smoothed areas was investigated. The results demonstrated a reduction of surface roughness Sa by more than 80% for Titanium 64 and by 65% for Scalmalloy® samples. This allows to extend the applicability of additive manufactured components beyond the current state of the art and break new ground for the application in various industrial applications such as in aerospace.

scholarly journals In vivo interactome profiling by enzyme‐catalyzed proximity labeling

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yangfan Xu ◽  
Xianqun Fan ◽  
Yang Hu
Keyword(s):  
State Of The Art ◽  
Catalytic Efficiency ◽  
Biological Processes ◽  
Protein Protein Interaction ◽  
Current State ◽  
Protein Interactome ◽  
Potential Applications ◽  
Protein Protein Interaction Networks ◽  
Temporal And Spatial

AbstractEnzyme-catalyzed proximity labeling (PL) combined with mass spectrometry (MS) has emerged as a revolutionary approach to reveal the protein-protein interaction networks, dissect complex biological processes, and characterize the subcellular proteome in a more physiological setting than before. The enzymatic tags are being upgraded to improve temporal and spatial resolution and obtain faster catalytic dynamics and higher catalytic efficiency. In vivo application of PL integrated with other state of the art techniques has recently been adapted in live animals and plants, allowing questions to be addressed that were previously inaccessible. It is timely to summarize the current state of PL-dependent interactome studies and their potential applications. We will focus on in vivo uses of newer versions of PL and highlight critical considerations for successful in vivo PL experiments that will provide novel insights into the protein interactome in the context of human diseases.

Sign in / Sign up

Export Citation Format

Share Document