scholarly journals Universality in asymptotic bounds and its saturation in 2D CFT

2021 ◽  
Vol 2021 (4) ◽  
Author(s):  
Diptarka Das ◽  
Yuya Kusuki ◽  
Sridip Pal
Keyword(s):  
Black Hole Physics ◽  
Conformal Block ◽  
Btz Black Hole ◽  
Asymptotic Results ◽  
Thermal Physics ◽  
Asymptotic Bounds ◽  
Universal Feature ◽  
C 32 ◽  
Heavy State

Abstract We study asymptotics of three point coefficients (light-light-heavy) and two point correlators in heavy states in unitary, compact 2D CFTs. We prove an upper and lower bound on such quantities using numerically assisted Tauberian techniques. We obtain an optimal upper bound on the spectrum of operators appearing with fixed spin from the OPE of two identical scalars. While all the CFTs obey this bound, rational CFTs come close to saturating it. This mimics the scenario of bounds on asymptotic density of states and thereby pronounces an universal feature in asymptotics of 2D CFTs. Next, we clarify the role of smearing in interpreting the asymptotic results pertaining to considerations of eigenstate thermalization in 2D CFTs. In the context of light-light-heavy three point coefficients, we find that the order one number in the bound is sensitive to how close the light operators are from the $$ \frac{c}{32} $$ c 32 threshold. In context of two point correlator in heavy state, we find the presence of an enigmatic regime which separates the AdS3 thermal physics and the BTZ black hole physics. Furthermore, we present some new numerical results on the behaviour of spherical conformal block.

scholarly journals Thermal Physics and Glaucoma II: Preliminary Evidences for a Thermophysical Design of a Possible Visible-Light-Photons Therapy

2021 ◽  
Vol 11 (14) ◽  
pp. 6301
Author(s):  
Giulia Grisolia ◽  
Mariarosa Astori ◽  
Antonio Ponzetto ◽  
Antonio Vercesi ◽  
Umberto Lucia
Keyword(s):  
Quality Of Life ◽  
Thermodynamic Approach ◽  
Equilibrium Thermodynamic ◽  
Pharmacological Treatments ◽  
Light Stimulation ◽  
Cell Behaviour ◽  
Thermal Physics ◽  
Starting Point

Recently, a non-equilibrium thermodynamic approach has been developed in order to model the fundamental role of the membrane electric potential in the cell behaviour. A related new viewpoint is introduced, with a design of a photobiomodulation treatment in order to restore part of the visual field. Here, a first step in experimental evidence of the validity of the thermodynamic approach is developed. This result represents the starting point for future experimental improvements for light stimulation in order to improve the quality of life of the patients. The future possible therapy will be in addition to the pharmacological treatments.

scholarly journals DNA damage responses in ageing

Open Biology ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 190168 ◽  
Author(s):  
Paulo F. L. da Silva ◽  
Björn Schumacher
Keyword(s):  
Dna Damage ◽  
Stress Response ◽  
Cellular Senescence ◽  
Damage Accumulation ◽  
Genome Instability ◽  
Age Related ◽  
Progeroid Syndromes ◽  
Dna Damage Responses ◽  
Universal Feature

Ageing appears to be a nearly universal feature of life, ranging from unicellular microorganisms to humans. Longevity depends on the maintenance of cellular functionality, and an organism's ability to respond to stress has been linked to functional maintenance and longevity. Stress response pathways might indeed become therapeutic targets of therapies aimed at extending the healthy lifespan. Various progeroid syndromes have been linked to genome instability, indicating an important causal role of DNA damage accumulation in the ageing process and the development of age-related pathologies. Recently, non-cell-autonomous mechanisms including the systemic consequences of cellular senescence have been implicated in regulating organismal ageing. We discuss here the role of cellular and systemic mechanisms of ageing and their role in ageing-associated diseases.

scholarly journals Spatial genomics maps the structure, character and evolution of cancer clones

2021 ◽  
Author(s):  
Artem Lomakin ◽  
Jessica Svedlund ◽  
Carina Strell ◽  
Milana Gataric ◽  
Artem Shmatko ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Outcome ◽  
Data Integration ◽  
Cancer Progression ◽  
Lineage Tracing ◽  
Breast Cancer Progression ◽  
Pivotal Role ◽  
Universal Feature

Subclonality is a universal feature of cancers yet how clones grow, are spatially organised, differ phenotypically or influence clinical outcome is unclear. To address this, we developed base specific in situ sequencing (BaSISS). In fixed tissues, transcripts harbouring clone-defining mutations are detected, converted into quantitative clone maps and characterised through multi-layered data integration. Applied to 8 samples from key stages of breast cancer progression BaSISS localised 1.42 million genotype informative transcripts across 4.9cm2 of tissue. Microscopic clonal topographies are shaped by resident tissue architectures. Distinct transcriptional, histological and immunological features distinguish coexistent genetic clones. Spatial lineage tracing temporally orders clone features associated with the emergence of aggressive clinical traits. These results highlight the pivotal role of spatial genomics in deciphering the mechanisms underlying cancer progression.

scholarly journals The role of order and disorder in thermal and material sciences part 1: Heat and society

2002 ◽  
Vol 38 (1-2) ◽  
pp. 1-22 ◽  
Author(s):  
J. Sesták
Keyword(s):  
Open Systems ◽  
Greek Philosophy ◽  
Thermal Physics ◽  
Order And Disorder ◽  
Self Organized ◽  
Material Sciences

The notion of heat is thoroughly analyzed and its historical links are searched particularly with relation to both the Greek philosophy (Milesians, Pythagoreans, atomists, etc.) and in the present day thermal physics. Fluctuation, spontaneity and chaos are discussed. Thermodynamics is reviewed in the relation to both the traditional development and the modern description of disequilibria (open systems). Effect of dissipation is shown often to provide new, self-organized structures. Exploitation of fire and its conscious use as a manufacturing power are analyzed in terms of generalized engines to act in the sense of the information transducers.

Rogers, G. 101 Snow, D. and Bedford, R. 151 Rowe, W. and Schelling, V. 136 Social Work and Criminal Justice 62 Social Work Research Centre (SWRC) safety 197–8; basic measures for 70; 62 designing studies for 62–3; ensuring Song, M. and Parker, D. 169 200–2; in the field 191; interview Speier, M. 149 precautions 65–6; personal Spradley, J. 149 provision for 80–1; and the Stacey, J. 108 researcher 69 Stanley, L. 16, 94, 104; and Wise, S. Said, E. 174 32, 57, 94–5, 107, 143 Santo Domingo festival: commercial Stanton, B. 151 dimension 136; costume and Staples, C. and Mauss, A. 151 greasing 136–7; danger in 133–4; Steier, F. 93 described 134–7; emotional danger at 141–2; equestrian parades 140–1; Temple, B. 100 ethical danger at 142–4; indigenous Thompson, J. 152 culture/European Catholicism in Tilly, C. 151 135–6; levels of participation in Touraine, A. 151 137–40; male/female participation Trejos Ubau, B. 134 in 138–40; meaning of icons in Turner, B.S. 32 134–5; outsider/participant Turner, R. and Killian, L. 151 relationship 133; physical danger at Uildriks, N. and van Mastrigt, H. 28, 137–42; watching/watched roles in 40 142–3 University of Stirling 62 Scarce, R. 18–19, 200 urban plunges 182, 192–3 Scientology movement 22–3, 43 Scott, A. 32 Van Maanen, J. 38–9, 58 Scott, S. 19, 20, 21–2; and Porter, M. 102 Walklate, S. 33 Scottish Office 62 Wallis, R. 17, 22–3, 43 Shaffir, W.B. 100; and Stebbins, R. 149, Walsh, D. 39 152 Warren, C.A.B. 12, 102 Sharrock, W. 58 Wax, M. 199 Shilling, C. 32 Weber, M. 93 Short, J.F. and Wolfgang, M.E. 58 Westmarland, L. 26 Skeggs, B. 108 whiteness: endangered 172–4; ethnic Slack, R. 56 dimension 174, 176; fascist elements Sluka, J.A. 28, 55, 64 176–7; liberal progressive views Smelser, N. 151 178; politically strategic role of Smith, D.J. 107; and Gray, J. 31 174–5; problems concerning 175–6;

2002 ◽  
pp. 221-221
Keyword(s):  
Social Work ◽  
Criminal Justice ◽  
Research Centre ◽  
Santo Domingo ◽  
Female Participation ◽  
Social Work Research ◽  
Strategic Role ◽  
Physical Danger ◽  
C 32

scholarly journals Symmetries of the black hole interior and singularity regularization

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Marc Geiller ◽  
Etera R. Livine ◽  
Francesco Sartini
Keyword(s):  
Black Holes ◽  
Black Hole ◽  
Black Hole Physics ◽  
Proper Time ◽  
White Hole ◽  
Formula Group ◽  
Physical Symmetry ◽  
Black Hole Interior ◽  
Group Quantization

We reveal an \mathfrak{iso}(2,1)𝔦𝔰𝔬(2,1) Poincar'e algebra of conserved charges associated with the dynamics of the interior of black holes. The action of these Noether charges integrates to a symmetry of the gravitational system under the Poincar'e group ISO(2,1)(2,1), which allows to describe the evolution of the geometry inside the black hole in terms of geodesics and horocycles of AdS{}_22. At the Lagrangian level, this symmetry corresponds to M"obius transformations of the proper time together with translations. Remarkably, this is a physical symmetry changing the state of the system, which also naturally forms a subgroup of the much larger \textrm{BMS}_{3}=\textrm{Diff}(S^1)\ltimes\textrm{Vect}(S^1)BMS3=Diff(S1)⋉Vect(S1) group, where S^1S1 is the compactified time axis. It is intriguing to discover this structure for the black hole interior, and this hints at a fundamental role of BMS symmetry for black hole physics. The existence of this symmetry provides a powerful criterion to discriminate between different regularization and quantization schemes. Following loop quantum cosmology, we identify a regularized set of variables and Hamiltonian for the black hole interior, which allows to resolve the singularity in a black-to-white hole transition while preserving the Poincar'e symmetry on phase space. This unravels new aspects of symmetry for black holes, and opens the way towards a rigorous group quantization of the interior.

Sign in / Sign up

Export Citation Format

Share Document