Influenza vaccination and 1-year risk of myocardial infarction, stroke, heart failure, pneumonia, and mortality among intensive care unit survivors aged 65 years or older: a nationwide population-based cohort study

2019 ◽  
Vol 45 (7) ◽  
pp. 957-967 ◽  
Author(s):  
Christian Fynbo Christiansen ◽  
Reimar Wernich Thomsen ◽  
Morten Schmidt ◽  
Lars Pedersen ◽  
Henrik Toft Sørensen
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Claudia Dziegielewski ◽  
Robert Talarico ◽  
Haris Imsirovic ◽  
Danial Qureshi ◽  
Yasmeen Choudhri ◽  
...  

Abstract Background Healthcare expenditure within the intensive care unit (ICU) is costly. A cost reduction strategy may be to target patients accounting for a disproportionate amount of healthcare spending, or high-cost users. This study aims to describe high-cost users in the ICU, including health outcomes and cost patterns. Methods We conducted a population-based retrospective cohort study of patients with ICU admissions in Ontario from 2011 to 2018. Patients with total healthcare costs in the year following ICU admission (including the admission itself) in the upper 10th percentile were defined as high-cost users. We compared characteristics and outcomes including length of stay, mortality, disposition, and costs between groups. Results Among 370,061 patients included, 37,006 were high-cost users. High-cost users were 64.2 years old, 58.3% male, and had more comorbidities (41.2% had ≥3) when likened to non-high cost users (66.1 years old, 57.2% male, 27.9% had ≥3 comorbidities). ICU length of stay was four times greater for high-cost users compared to non-high cost users (22.4 days, 95% confidence interval [CI] 22.0–22.7 days vs. 5.56 days, 95% CI 5.54–5.57 days). High-cost users had lower in-hospital mortality (10.0% vs.14.2%), but increased dispositioning outside of home (77.4% vs. 42.2%) compared to non-high-cost users. Total healthcare costs were five-fold higher for high-cost users ($238,231, 95% CI $237,020–$239,442) compared to non-high-cost users ($45,155, 95% CI $45,046–$45,264). High-cost users accounted for 37.0% of total healthcare costs. Conclusion High-cost users have increased length of stay, lower in-hospital mortality, and higher total healthcare costs when compared to non-high-cost users. Further studies into cost patterns and predictors of high-cost users are necessary to identify methods of decreasing healthcare expenditure.


2007 ◽  
Vol 51 (9) ◽  
pp. 1225-1230 ◽  
Author(s):  
N Obel ◽  
J Schierbeck ◽  
L Pedersen ◽  
M Storgaard ◽  
C Pedersen ◽  
...  

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yu-Feng Huang ◽  
Chao-Shun Lin ◽  
Yih-Giun Cherng ◽  
Chun-Chieh Yeh ◽  
Ray-Jade Chen ◽  
...  

Vaccines ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 716
Author(s):  
Marco Massari ◽  
Stefania Spila-Alegiani ◽  
Massimo Fabiani ◽  
Valeria Belleudi ◽  
Gianluca Trifirò ◽  
...  

To investigate the association of the 2019–2020 influenza vaccine with prognosis of patients positive for SARS-CoV-2A, a large multi-database cohort study was conducted in four Italian regions (i.e., Lazio, Lombardy, Veneto, and Tuscany) and the Reggio Emilia province (Emilia-Romagna). More than 21 million adults were residing in the study area (42% of the population). We included 115,945 COVID-19 cases diagnosed during the first wave of the pandemic (February–May, 2020); 34.6% of these had been vaccinated against influenza. Three outcomes were considered: hospitalization, death, and intensive care unit (ICU) admission/death. The adjusted relative risk (RR) of being hospitalized in the vaccinated group when compared with the non-vaccinated group was 0.87 (95% CI: 0.86–0.88). This reduction in risk was not confirmed for death (RR = 1.04; 95% CI: 1.01–1.06), or for the combined outcome of ICU admission or death. In conclusion, our study, conducted on the vast majority of the population during the first wave of the pandemic in Italy, showed a 13% statistically significant reduction in the risk of hospitalization in some geographical areas and in the younger population. No impact of seasonal influenza vaccination on COVID-19 prognosis in terms of death and death or ICU admission was estimated.


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