Vitamin D supplementation in breastfed infants from Montréal, Canada: 25-hydroxyvitamin D and bone health effects from a follow-up study at 3 years of age

Background: Expert guidelines recommend annual monitoring of 25-hydroxyvitamin D (25-OHD) and maintaining 25-OHD ≥30 ng/ml in patients with dystrophinopathies. Objective: We hypothesized that 25-OHD remains stable and requires less frequent monitoring in patients taking stable maintenance doses of vitamin D. Methods: We performed a retrospective cohort study, using the electronic health record to identify 26 patients with dystrophinopathies with a baseline 25-OHD ≥30 ng/mL and at least one additional 25-OHD measurement. These patients had received a stable dose of vitamin D for ≥3 months prior to their baseline 25-OHD measurement and throughout follow-up. The main outcome measured was the mean duration time the subjects spent with a 25-OHD ≥30 ng/mL. Results: Only 19% of patients dropped their 25-OHD to < 30 ng/ml, with a mean time to drop of 33 months and a median nadir 25-OHD of 28 ng/mL. Conclusions: These results suggest that measurement of 25-OHD every 2–2.5 years may be sufficient in patients with a baseline 25-OHD ≥30 ng/mL and who are on a stable maintenance dose of vitamin D. Other patients may require more frequent assessments.

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Circulating 25-Hydroxyvitamin D Levels in Fully Breastfed Infants on Oral Vitamin D Supplementation

International Journal of Endocrinology ◽

10.1155/2010/235035 ◽

2010 ◽

Vol 2010 ◽

pp. 1-5 ◽

Cited By ~ 22

Author(s):

Carol L. Wagner ◽

Cindy Howard ◽

Thomas C. Hulsey ◽

Ruth A. Lawrence ◽

Sarah N. Taylor ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Supplementation ◽

Vitamin Supplementation ◽

Oral Vitamin ◽

Oil Emulsion ◽

Hydroxyvitamin D ◽

Breastfed Infants ◽

25 Hydroxyvitamin D ◽

The Mean ◽

Nutritional Vitamin

Objective. To examine the effectiveness of oral vitamin (400 IU) supplementation on the nutritional vitamin D status of breastfeeding infants.Design. As part of a larger ongoing vitamin D RCT trial of lactating women, infants of mothers assigned to control received 1 drop of 400 IU vitamin /day starting at one month of age. Infant 25(OH)D levels (mean S.D.) were measured by RIA at visits 1, 4, and 7.Results. The infant mean S.D. 25(OH)D at baseline was 16.0 9.3 ng/mL (range 1.0–40.8; ); 24 (72.7%) had baseline levels <20 ng/mL (consistent with deficiency). The mean levels increased to 43.6 14.1 (range 18.2–69.7) at 4 months and remained relatively unchanged at month 7: 42.5 12.1 ng/mL (range 18.9–67.2). The change in values between 1 and 4 months and 1 and 7 months was statistically significant , and despite a decrease in dose per kilogram, values were not significantly different between months 4 and 7 .Conclusions. Oral vitamin supplementation as an oil emulsion was associated with significant and sustained increases in 25(OH)D from baseline in fully breastfeeding infants through 7 months.

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Vitamin D Supplementation in Sarcoidosis: A Double-Edged Sword

Journal of Health and Allied Sciences NU ◽

10.1055/s-0041-1736280 ◽

2021 ◽

Author(s):

Rishikesh Chandran ◽

Lakshmi Nagendra ◽

Shrikrishna Acharya ◽

Giridhar Belur Hosmane ◽

Vijith Shetty ◽

...

Keyword(s):

Vitamin D ◽

Disease Activity ◽

Bone Health ◽

Calcium Metabolism ◽

Vitamin D Supplementation ◽

Osteoporosis Prevention ◽

Hydroxyvitamin D ◽

Severe Hypercalcemia ◽

25 Hydroxyvitamin D

AbstractSarcoidosis is complicated by disordered vitamin D and calcium metabolism, which has important implications on disease activity and bone health. Although the majority of the patients with sarcoidosis are typically deficient in 25-hydroxyvitamin D, repletion of vitamin D is controversial in light of the hypercalcemia risk. Presently, there are no clear guidelines regarding vitamin D supplementation as a part of osteoporosis prevention in patients with vitamin D deficiency and sarcoidosis. We report a patient with sarcoidosis who presented with severe hypercalcemia following vitamin D supplementation and review the debated role of vitamin D supplementation in vitamin D-deficient sarcoid patients.

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Prenatal vitamin D supplementation and infant vitamin D status in Bangladesh

Public Health Nutrition ◽

10.1017/s1368980015003092 ◽

2015 ◽

Vol 20 (10) ◽

pp. 1865-1873 ◽

Cited By ~ 9

Author(s):

Nandita Perumal ◽

Abdullah Al Mahmud ◽

Abdullah H Baqui ◽

Daniel E Roth

Keyword(s):

Vitamin D ◽

Vitamin D Supplementation ◽

Tropical Region ◽

Maternal Child Health ◽

Vitamin D Status ◽

Third Trimester ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

The Difference

AbstractObjectiveTo determine the effect of prenatal maternal vitamin D supplementation on infant vitamin D status in a tropical region where vitamin D supplementation is not routine.DesignA prospective observational follow-up of a randomized trial.SettingMaternal–child health facility in Dhaka, Bangladesh (23°N).SubjectsInfants born to pregnant women (n 160) randomized to receive 875 µg (35 000 IU) cholecalciferol (vitamin D3) per week (VD) or placebo (PL) during the third trimester were followed from birth until 6 months of age (n 115). Infant serum 25-hydroxyvitamin D concentration (25(OH)D) was measured at <1, 2, 4 and 6 months of age.ResultsMean infant 25(OH)D was higher in the VD v. PL group at <1 month of age (mean (sd): 80 (20) nmol/l v. 22 (18) nmol/l; P<0·001), but the difference was attenuated by 2 months (52 (19) nmol/l v. 40 (23) nmol/l; P=0·05). Groups were similar at 4 months (P=0·40) and 6 months (n 72; P=0·26). In the PL group, mean infant 25(OH)D increased to 78 (95 % CI 67, 88) nmol/l by 6 months of age (n 34). 25(OH)D was higher with infant formula-feeding and higher in summer v. winter.ConclusionsPrenatal third-trimester vitamin D supplementation (875 µg (35 000 IU)/week) significantly ameliorated infant vitamin D status during the neonatal period when the risk of vitamin D deficiency is greatest. Further research is warranted to determine factors that contribute to the rise in 25(OH)D during the first 6 months of life among breast-fed infants in this setting.

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Relationships Between Vitamin D Status and PTH over 5 Years After Roux-en-Y Gastric Bypass: a Longitudinal Cohort Study

Obesity Surgery ◽

10.1007/s11695-020-04582-5 ◽

2020 ◽

Vol 30 (9) ◽

pp. 3426-3434

Author(s):

Stephen Hewitt ◽

Jon Kristinsson ◽

Erlend Tuseth Aasheim ◽

Ingvild Kristine Blom-Høgestøl ◽

Eirik Aaseth ◽

...

Keyword(s):

Vitamin D ◽

Gastric Bypass ◽

Bone Health ◽

Bone Alkaline Phosphatase ◽

Vitamin D Status ◽

Threshold Levels ◽

Hydroxyvitamin D ◽

Vitamin D Levels ◽

25 Hydroxyvitamin D

Abstract Purpose Secondary hyperparathyroidism (SHPT) after obesity surgery may affect bone health. Optimal vitamin D levels have not been established to prevent SHPT postoperatively. We investigated whether SHPT differed across threshold levels of serum 25-hydroxyvitamin D (S-25(OH)D) from 6 months up to 5 years after Roux-en-Y gastric bypass (RYGB). Materials and Methods We included 554 patients at follow-up 5 years postoperatively. Blood samples were analysed for S-25(OH)D, ionized calcium (iCa) and parathyroid hormone (PTH) during follow-up. Results PTH and prevalence of SHPT increased from 6 months to 5 years postoperatively, while S-25(OH)D and iCa decreased (all P < 0.001). PTH and SHPT development are related with S-25(OH)D, and PTH differed between all subgroups of S-25(OH)D. SHPT occurred less frequently across all subgroups of S-25(OH)D ≥ 50 nmol/l during follow-up: odds ratio (OR) 0.44 (95% CI 0.36–0.54) in patients with S-25(OH)D ≥ 50 nmol/l, OR 0.38 (0.30–0.49) with S-25(OH)D ≥ 75 nmol/l and OR 0.19 (0.12–0.31) with S-25(OH) D ≥ 100 nmol/l, all compared with S-25(OH)D < 50 nmol/l. At 5 years, 208/554 patients (38%) had SHPT; SHPT was found in 94/188 patients (50%) with S-25(OH)D < 50 nmol/l, in 69/222 (31%) with S-25(OH)D 50–74 nmol/l, in 40/117 (34%) with S-25(OH)D 75–99 nmol/l and in 5/27 (19%) with S-25(OH)D ≥ 100 nmol/l. An interaction existed between S-25(OH)D and iCa. Bone alkaline phosphatase remained increased with SHPT. Conclusions A significant relationship existed between S-25(OH)D and development of PTH and SHPT. The prevalence of SHPT was lower with threshold levels 25(OH)D ≥ 50 nmol/l and ≥ 75 nmol/l over the 5 years, and lowest with S-25(OH)D ≥ 100 nmol/l.

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Vitamin D supplementation

Practical Neurology ◽

10.1136/practneurol-2017-001720 ◽

2017 ◽

Vol 18 (1) ◽

pp. 35-42 ◽

Cited By ~ 11

Author(s):

Ruth Dobson ◽

Hannah R Cock ◽

Peter Brex ◽

Gavin Giovannoni

Keyword(s):

Multiple Sclerosis ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Bone Health ◽

Vitamin D Supplementation ◽

Hydroxyvitamin D ◽

Increased Risk ◽

25 Hydroxyvitamin D ◽

The Uk

Vitamin D testing and supplementation is of great interest to neurologists and their patients. Recommended nutritional intakes of vitamin D in the UK remain focused on bone health, despite increasing evidence for a role outside this area. Here we discuss how neurologists might approach vitamin D testing and supplementation, focusing on two conditions associated with vitamin D deficiency that have an increased risk of downstream complications resulting from these: multiple sclerosis and epilepsy. We set out a rationale for testing serum 25-hydroxyvitamin D concentrations and discuss our personal practice in terms of supplementation, with evidence where available.

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Vitamin D Knowledge, Attitudes and Practices of Polish Medical Doctors

Nutrients ◽

10.3390/nu13072443 ◽

2021 ◽

Vol 13 (7) ◽

pp. 2443

Author(s):

Wojciech Stefan Zgliczyński ◽

Olga Maria Rostkowska ◽

Beata Sarecka-Hujar

Keyword(s):

Vitamin D ◽

Knowledge Score ◽

Vitamin D Supplementation ◽

Medical Doctors ◽

Self Administration ◽

Hydroxyvitamin D ◽

Attitudes And Practices ◽

Study Results ◽

25 Hydroxyvitamin D ◽

Knowledge Attitudes And Practices

Background Vitamin D deficiency occurs in as much as 90–95% of the Polish population, although this condition is known to cause negative long-term health implications. The role of medical doctors in advising proper supplementation, monitoring and correcting the levels of 25-hydroxyvitamin D in individuals is of great importance and should be used to help mitigate its common deficits. The aim of this study was to evaluate knowledge, attitudes and practices of Polish physicians regarding vitamin D supplementation in order to identify areas for improvement and determinants for the knowledge gaps. Methods The study group comprised 701 medical doctors aged 32.1 ± 5.3 years on average, mostly women (71.61%). An original survey questionnaire was developed for the purpose of the study. Results The mean vitamin D knowledge score was 6.8 ± 2.3 (in a scale 0–13) and was related to gender (p < 0.001), type of specialization (p = 0.032), D3 supplements use (p < 0.001), recommending supplementation to patients (p = 0.005), to relatives and friends (p < 0.001) and to healthy adults (p < 0.001). In terms of self-administration, 14% of respondents take vitamin D all-year-round while 24% only in autumn and winter. 25% of respondents monitor their vitamin D (25-hydroxyvitamin D) serum concentration. Most participants (61%) did not recommend supplementing vitamin D to their patients on a regular basis. Conclusions The study indicates that medical doctors in Poland need to have more training and education on vitamin D supplementation in order to better address the problem of its deficits in the population.

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