Discovery of novel antagonists on β2-adrenoceptor from natural products using a label-free cell phenotypic assay

2018 ◽  
Vol 391 (12) ◽  
pp. 1411-1420 ◽  
Author(s):  
Pengyu Zhang ◽  
Jixia Wang ◽  
Ying Zhao ◽  
Xiuli Zhang ◽  
Lala Qu ◽  
...  
Keyword(s):  
Natural Products ◽  
Free Cell ◽  
Label Free ◽  
Phenotypic Assay

Label-free cell phenotypic study of opioid receptors and discovery of novel mu opioid ligands from natural products

2021 ◽  
Vol 270 ◽  
pp. 113872
Author(s):  
Tao Hou ◽  
Fangfang Xu ◽  
Xingrong Peng ◽  
Han Zhou ◽  
Xiuli Zhang ◽  
...  
Keyword(s):  
Natural Products ◽  
Opioid Receptors ◽  
Free Cell ◽  
Label Free ◽  
Mu Opioid ◽  
Opioid Ligands

scholarly journals Label-free cell phenotypic study of FFA4 and FFA1 and discovery of novel agonists of FFA4 from natural products

RSC Advances ◽  
2019 ◽  
Vol 9 (26) ◽  
pp. 15073-15083 ◽  
Author(s):  
Fangfang Xu ◽  
Han Zhou ◽  
Xiumei Liu ◽  
Xiuli Zhang ◽  
Zhiwei Wang ◽  
...  
Keyword(s):  
Natural Products ◽  
Free Cell ◽  
Label Free ◽  
Pharmacological Studies

Pharmacological studies of the FFA4 and FFA1 and discovery of three novel agonists was conducted using a label-free DMR assay.

Discovery of new targets of phenolic acids in danshen using a label-free cell phenotypic assay

RSC Advances ◽  
2015 ◽  
Vol 5 (33) ◽  
pp. 25768-25776 ◽  
Author(s):  
Jixia Wang ◽  
Tao Hou ◽  
Lai Wei ◽  
Liying Shi ◽  
Jian He ◽  
...  
Keyword(s):  
Phenolic Acids ◽  
Free Cell ◽  
Label Free ◽  
A431 Cells ◽  
Salvianolic Acid ◽  
New Targets ◽  
Phenotypic Assay ◽  
Salvianolic Acid A ◽  
Agonistic Activity ◽  
Ht 29

Pharmacological profiling of 10 known phenolic acids in danshen using a label-free cell phenotypic assay in HT-29 and A431 cells revealed that lithospermic acid, salvianolic acid A, B, C and danshensu all displayed agonistic activity towards GPR35.

Raman spectroscopy-based label-free cell identification using wavelet transform and support vector machine

RSC Advances ◽  
2016 ◽  
Vol 6 (55) ◽  
pp. 50027-50033 ◽  
Author(s):  
S. Bakhtiaridoost ◽  
H. Habibiyan ◽  
S. Muhammadnejad ◽  
M. Haddadi ◽  
H. Ghafoorifard ◽  
...  
Keyword(s):  
Support Vector Machine ◽  
Raman Spectroscopy ◽  
Wavelet Transform ◽  
Raman Spectra ◽  
Free Cell ◽  
Support Vector ◽  
Label Free ◽  
Cell Identification ◽  
Rare Cells

Wavelet transform and SVM applied to Raman spectra makes a powerful and accurate tool for identification of rare cells such as CTCs.

A ‘smart’ aptamer-functionalized continuous label-free cell catch-transport-release system

2021 ◽  
Author(s):  
Bozhen Zhang ◽  
Canran Wang ◽  
Yingjie Du ◽  
Rebecca Paxton ◽  
Ximin He
Keyword(s):  
Biomedical Research ◽  
Cell Sorting ◽  
Free Cell ◽  
Label Free ◽  
Clinical Therapeutics ◽  
Release System ◽  
System P

Label-free cell sorting devices are of great significance for biomedical research and clinical therapeutics. However, current platforms for label-free cell sorting cannot achieve continuity and selectivity simultaneously, resulting in complex...

scholarly journals Pinhole microLED Array as Point Source Illumination for Miniaturized Lensless Cell Monitoring Systems

Proceedings ◽  
2018 ◽  
Vol 2 (13) ◽  
pp. 866 ◽  
Author(s):  
Shinta Mariana ◽  
Gregor Scholz ◽  
Feng Yu ◽  
Agus Budi Dharmawan ◽  
Iqbal Syamsu ◽  
...  
Keyword(s):  
Image Quality ◽  
Light Emitting Diode ◽  
Free Cell ◽  
Monitoring Systems ◽  
Label Free ◽  
Light Emitting ◽  
Non Invasive ◽  
Cell Monitoring ◽  
Blue Spectral Region ◽  
Led Arrays

Pinhole‐shaped light‐emitting diode (LED) arrays with dimension ranging from 100 μm down to 5 μm have been developed as point illumination sources. The proposed microLED arrays, which are based on gallium nitride (GaN) technology and emitting in the blue spectral region (λ = 465 nm), are integrated into a compact lensless holographic microscope for a non‐invasive, label‐free cell sensing and imaging. From the experimental results using single pinhole LEDs having a diameter of 90 μm, the reconstructed images display better resolution and enhanced image quality compared to those captured using a commercial surface‐mount device (SMD)‐based LED.

Sign in / Sign up

Export Citation Format

Share Document