Discovery of new targets of phenolic acids in danshen using a label-free cell phenotypic assay

RSC Advances ◽  
2015 ◽  
Vol 5 (33) ◽  
pp. 25768-25776 ◽  
Author(s):  
Jixia Wang ◽  
Tao Hou ◽  
Lai Wei ◽  
Liying Shi ◽  
Jian He ◽  
...  
Keyword(s):  
Phenolic Acids ◽  
Free Cell ◽  
Label Free ◽  
A431 Cells ◽  
Salvianolic Acid ◽  
New Targets ◽  
Phenotypic Assay ◽  
Salvianolic Acid A ◽  
Agonistic Activity ◽  
Ht 29

Pharmacological profiling of 10 known phenolic acids in danshen using a label-free cell phenotypic assay in HT-29 and A431 cells revealed that lithospermic acid, salvianolic acid A, B, C and danshensu all displayed agonistic activity towards GPR35.

Discovery of novel antagonists on β2-adrenoceptor from natural products using a label-free cell phenotypic assay

2018 ◽  
Vol 391 (12) ◽  
pp. 1411-1420 ◽  
Author(s):  
Pengyu Zhang ◽  
Jixia Wang ◽  
Ying Zhao ◽  
Xiuli Zhang ◽  
Lala Qu ◽  
...  
Keyword(s):  
Natural Products ◽  
Free Cell ◽  
Label Free ◽  
Phenotypic Assay

Label-free cell phenotypic study of opioid receptors and discovery of novel mu opioid ligands from natural products

2021 ◽  
Vol 270 ◽  
pp. 113872
Author(s):  
Tao Hou ◽  
Fangfang Xu ◽  
Xingrong Peng ◽  
Han Zhou ◽  
Xiuli Zhang ◽  
...  
Keyword(s):  
Natural Products ◽  
Opioid Receptors ◽  
Free Cell ◽  
Label Free ◽  
Mu Opioid ◽  
Opioid Ligands

scholarly journals Bioactive Phenolic Compounds from the Roots of Danshen (Salvia miltiorrhiza)

2018 ◽  
Vol 13 (10) ◽  
pp. 1934578X1801301
Author(s):  
Nguyen Huu Tung ◽  
Le Quoc Hung ◽  
Ha Van Oanh ◽  
Duong Thi Ly Huong ◽  
Phuong Thien Thuong ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Methyl Ester ◽  
Ethyl Ester ◽  
Rosmarinic Acid ◽  
Salvia Miltiorrhiza ◽  
Chemical Constituents ◽  
Acid Methyl Ester ◽  
Acid Ethyl Ester ◽  
Salvianolic Acid ◽  
Salvianolic Acid A

Danshen ( Salvia miltiorrhiza Bunge) is one of the most used medicinal plants in the Oriental medicine and has been well studied for application in modern medicine. In our continuing study on chemical constituents of danshen cultivated in Vietnam, using chromatography separation resulted in the isolation of six phenolic compounds including a benzophenone, iriflophenone 2- O- α-L-rhamnopyranoside (1), and five phenolic acids including rosmarinic acid (2), rosmarinic acid methyl ester (3), rosmarinic acid ethyl ester (4), salvianolic acid A methyl ester (5) and salvianolic acid A ethyl ester (6) from the butanol portion of the danshen crude extract. Beside the typically main phenolic acid components, to our knowledge, iriflophenone 2- O- α-L-rhamnopyranoside (1) was first isolated from salvia sp. On biological testing, compound 1 showed strong antiproliferative activity on HL-60 leukemia cells with the IC50 of 8.9 μM; compounds 1 and 3–6 inhibited markedly nitric oxide production in lipopolysaccharide-treated RAW 264.7 cells.

Effect of Salvianolic Acid A, a Depside from Roots ofSalvia miltiorrhiza, on Gastric H+, K+-ATPase

Planta Medica ◽  
1990 ◽  
Vol 56 (04) ◽  
pp. 360-363 ◽  
Author(s):  
Shigeru Murakami ◽  
Haruko Kijima ◽  
Yoshihiko Isobe ◽  
Makoto Muramatsu ◽  
Hironaka Aihara ◽  
...  
Keyword(s):  
Salvianolic Acid ◽  
Salvianolic Acid A

Raman spectroscopy-based label-free cell identification using wavelet transform and support vector machine

RSC Advances ◽  
2016 ◽  
Vol 6 (55) ◽  
pp. 50027-50033 ◽  
Author(s):  
S. Bakhtiaridoost ◽  
H. Habibiyan ◽  
S. Muhammadnejad ◽  
M. Haddadi ◽  
H. Ghafoorifard ◽  
...  
Keyword(s):  
Support Vector Machine ◽  
Raman Spectroscopy ◽  
Wavelet Transform ◽  
Raman Spectra ◽  
Free Cell ◽  
Support Vector ◽  
Label Free ◽  
Cell Identification ◽  
Rare Cells

Wavelet transform and SVM applied to Raman spectra makes a powerful and accurate tool for identification of rare cells such as CTCs.

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