Anxiogenic-like profile of Wistar adult rats based on the pilocarpine model: an animal model for trait anxiety?

2012 ◽  
Vol 227 (2) ◽  
pp. 209-219 ◽  
Author(s):  
Filipe S. Duarte ◽  
Marcelo Duzzioni ◽  
Alexandre A. Hoeller ◽  
Nayana M. Silva ◽  
Andy L. Ern ◽  
...  
Keyword(s):  
Animal Model ◽  
Trait Anxiety ◽  
Adult Rats ◽  
Pilocarpine Model

The rat as an animal model for infant botulism

1980 ◽  
Vol 29 (2) ◽  
pp. 819-821
Author(s):  
L J Moberg ◽  
H Sugiyama
Keyword(s):  
Animal Model ◽  
Botulinum Toxin ◽  
Clostridium Botulinum ◽  
Adult Rats ◽  
Infant Botulism

Susceptibility to intraintestinal Clostridium botulinum colonization of conventional infant and germfree adult rats is comparable to that of mice. C. botulinum-monoassociated rats pass C. botulinum toxin in their milk.

scholarly journals Saffron: A Multitask Neuroprotective Agent for Retinal Degenerative Diseases

Antioxidants ◽  
2019 ◽  
Vol 8 (7) ◽  
pp. 224 ◽  
Author(s):  
Stefano Di Marco ◽  
Veronica Carnicelli ◽  
Nicola Franceschini ◽  
Mattia Di Paolo ◽  
Marco Piccardi ◽  
...  
Keyword(s):  
Animal Model ◽  
Visual Function ◽  
Recovery Period ◽  
Age Related Macular Degeneration ◽  
Added Value ◽  
Chemical Components ◽  
Complex Nature ◽  
Enzyme Activity Assay ◽  
Adult Rats ◽  
Age Related

Both age related macular degeneration (AMD) and light induced retinal damage share the common major role played by oxidative stress in the induction/progression of degenerative events. Light damaged (LD) rats have been widely used as a convenient model to gain insight into the mechanisms of degenerative disease, to enucleate relevant steps and to test neuroprotectants. Among them, saffron has been shown to ameliorate degenerative processes and to regulate many genes and protective pathways. Saffron has been also tested in AMD patients. We extended our analysis to a possible additional effect regulated by saffron and compared in AMD patients a pure antioxidant treatment (Lutein/zeaxanthin) with saffron treatment. Methods: Animal model. Sprague-Dawley (SD) adult rats, raised at 5 lux, were exposed to 1000 lux for 24 h and then either immediately sacrificed or placed back at 5 lux for 7 days recovery period. A group of animals was treated with saffron. We performed in the animal model: (1) SDS-PAGE analysis; (2) Western Blotting (3) Enzyme activity assay (4) Immunolabelling; in AMD patients: a longitudinal open-label study 29 (±5) months in two groups of patients: lutein/zeaxanthin (19) and saffron (23) treated. Visual function was tested every 8 months by ERG recordings in addition to clinical examination. Results: Enzymatic activity of MMP-3 is reduced in LD saffron treated retinas and is comparable to control as it is MMP-3 expression. LD treated retinas do not present “rosettes” and microglia activation and migration is highly reduced. Visual function remains stable in saffron treated AMD patients while deteriorates in the lutein/zeaxanthin group. Conclusion: Our results provide evidence of an additional way of action of saffron treatment confirming the complex nature of neuroprotective activities of its chemical components. Accordingly, long term follow-up in AMD patients reveals an added value of saffron supplementation treatment compared to classical antioxidant protocol.

scholarly journals Long-Term Effects of Maternal Deprivation on the Neuronal Soma Area in the Rat Neocortex

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Milan Aksić ◽  
Nevena V. Radonjić ◽  
Dubravka Aleksić ◽  
Gordana Jevtić ◽  
Branka Marković ◽  
...  
Keyword(s):  
Animal Model ◽  
Morphological Changes ◽  
Maternal Deprivation ◽  
Retrosplenial Cortex ◽  
Control Group ◽  
Long Term Effects ◽  
Adult Rats ◽  
Adult Age ◽  
Neuronal Soma

Early separation of rat pups from their mothers (separatio a matrem) is considered and accepted as an animal model of perinatal stress. Adult rats, separated early postnatally from their mothers, are developing long-lasting changes in the brain and neuroendocrine system, corresponding to the findings observed in schizophrenia and affective disorders. With the aim to investigate the morphological changes in this animal model we exposed 9-day-old (P9) Wistar rats to a 24 h maternal deprivation (MD). At young adult age rats were sacrificed for morphometric analysis and their brains were compared with the control group bred under the same conditions, but without MD. Rats exposed to MD had a 28% smaller cell soma area in the prefrontal cortex (PFCX), 30% in retrosplenial cortex (RSCX), and 15% in motor cortex (MCX) compared to the controls. No difference was observed in the expression of glial fibrillary acidic protein in the neocortex of MD rats compared to the control group. The results of this study demonstrate that stress in early life has a long-term effect on neuronal soma size in cingulate and retrosplenial cortex and is potentially interesting as these structures play an important role in cognition.

scholarly journals A Novel Animal Model of Hippocampal Cognitive Deficits, Slow Neurodegeneration, and Neuroregeneration

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
Simon C. Spanswick ◽  
Hugo Lehmann ◽  
Robert J. Sutherland
Keyword(s):  
Animal Model ◽  
Cell Death ◽  
Cognitive Deficits ◽  
Granule Cells ◽  
Hippocampal Function ◽  
Adult Rats ◽  
Specific Loss ◽  
Cellular Processes ◽  
Pathological Conditions

Long-term adrenalectomy (ADX) results in an extensive and specific loss of dentate gyrus granule cells in the hippocampus of adult rats. This loss of granule cells extends over a period of weeks to months and ultimately results in cognitive deficits revealed in a number of tasks that depend on intact hippocampal function. The gradual nature of ADX-induced cell death and the ensuing deficits in cognition resemble in some important respects a variety of pathological conditions in humans. Here, we characterize behavioural and cellular processes, including adult neurogenesis, in the rat ADX model. We also provide experimental evidence for a neurogenic treatment strategy by which the lost hippocampal cells may be replaced, with the goal of functional recovery in mind.

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