A Central Composite Design in increasing the quercetin content in the aqueous onion waste isolates with antifungal and antioxidant properties

AbstractIn this study, to increase the content of quercetin in the isolates obtained from the white and red onion scales, in accordance with the zero waste philosophy, using water as an environmentally and healthy friendly extractant, a mathematical model was constructed, based on the Central Composite Design. The suitability of the model for the accurate and quick study of complex relationships was demonstrated by obtaining a statistically insignificant difference in the yield predicted by the model and that determined experimentally under optimal extraction conditions, i.e., 44.14 mg/g (33.57 mg/g) and 45.54 mg/g (33.31 mg/g) for white (red) onion scales, respectively. To present the obtained isolates applicability, their biological activity was assessed in terms of antioxidant activity and antifungal activity against various fungi, showing properties that are sufficient to encourage the use of this material, previously treated as worthless waste, for the production of various functional ingredients, including functional food additives. Moreover, they can be also used to produce safe and effective protectants meeting the GRAS criteria.

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Optimisation of Media Components using Central Composite Design for Increased Citric Acid production from Yam Peels using Aspergillus niger

FUOYE Journal of Engineering and Technology ◽

10.46792/fuoyejet.v2i2.124 ◽

2017 ◽

Vol 2 (2) ◽

Author(s):

Andrew N Amenaghawon ◽

Eboseremen Ebewele ◽

Izoduwa Osakue ◽

Richard Obaseki

Keyword(s):

Citric Acid ◽

Aspergillus Niger ◽

Statistical Model ◽

Central Composite Design ◽

Acid Production ◽

Citric Acid Production ◽

Citric Acid Concentration ◽

Manganese Ion ◽

Insignificant Difference ◽

Central Composite

In this study, design of experiment (DOE) for response surface methodology (RSM) was used to analyse and optimise the compositions of the nutrient medium (calcium ion, peptone, ethanol and manganese ion) for citric acid production from yam peels via solid state fermentation (SSF) using Aspergillus niger. A four variable, central composite design (CCD) was used to develop a statistical model for the process while RSM was used to optimise it. The results obtained showed that the model was statistically significant (p<0.0001) and displayed a good fit with the experimental observations (R2 = 0.997). Citric acid production was significant at high levels of ethanol and calcium while the reverse was the case for manganese and peptone. The optimum values of ethanol, manganese, calcium and peptone were 7.0% v/v, 1.0 g/l, 0.1 g/l and 0.1 g/l respectively. Under these conditions, the citric acid concentration was obtained as 66 g/l. Validation of the statistical model showed an insignificant difference between experimental and model predicted results.

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Performance Prediction in a Single-Operator Simulated Surveillance System

Human Factors The Journal of the Human Factors and Ergonomics Society ◽

10.1177/001872087301500405 ◽

1973 ◽

Vol 15 (4) ◽

pp. 337-348 ◽

Cited By ~ 6

Author(s):

Robert G. Mills ◽

Robert C. Williges

Keyword(s):

Central Composite Design ◽

Response Surface ◽

Surveillance System ◽

Automatic Tracking ◽

System Parameters ◽

Operator Performance ◽

Single Operator ◽

Complex Relationships ◽

Performance Results ◽

Central Composite

A semiautomatic radar surveillance system was simulated using a time-compressed, real-time cathode-ray tube display. Subjects were required to detect targets entering the surveillance area, initiate automatic tracking of these targets, and reinitiate lost tracks when automatic tracking failed. A within-subject response surface methodology (RSM) central-composite design was employed which permitted simultaneous investigation of the effects of five system parameters on surveillance operator performance. Response surface fits (second-order polynomials) were obtained and analyses of variance were conducted to describe these effects on two dependent measures of performance. Results support the contention that operator performance may be dependent upon complex relationships among the five system parameters tested. Furthermore, an RSM central-composite design provided an efficient method for obtaining data and quantifying these relationships.

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Development and optimization of solid lipid nanoparticles of amikacin by central composite design

Journal of Liposome Research ◽

10.1080/08982100903103904 ◽

2009 ◽

Vol 00 (00) ◽

pp. 090721051030036-8

Author(s):

Jaleh Varshosaz ◽

Solmaz Ghaffari ◽

Mohammad Reza Khoshayand ◽

Fatemeh Atyabi ◽

Shirzad Azarmi ◽

...

Keyword(s):

Central Composite Design ◽

Solid Lipid Nanoparticles ◽

Lipid Nanoparticles ◽

Solid Lipid ◽

Central Composite

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Central Composite Design for Optimization of Chromium (VI) Removal from Aqueous Solution Using Low Cost Adsorbent

i-manager’s Journal on Future Engineering and Technology ◽

10.26634/jfet.11.1.3654 ◽

2015 ◽

Vol 11 (1) ◽

pp. 1-6

Author(s):

D. Krishna ◽

◽

D.V. Padma ◽

Keyword(s):

Aqueous Solution ◽

Central Composite Design ◽

Low Cost ◽

Chromium Vi ◽

Central Composite

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Selected illustrations of response surface method. Central composite design

10.3403/30242021u ◽

2016 ◽

Keyword(s):

Central Composite Design ◽

Response Surface ◽

Response Surface Method ◽

Surface Method ◽

Central Composite

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Formulation Design and Optimization of Repaglinide Solid Dispersions by Central Composite Design

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2018.11.6.7 ◽

2018 ◽

Vol 11 (6) ◽

pp. 4337-4348

Author(s):

Bhikshapathi D. V. R. N. ◽

Srinivas I

Keyword(s):

Central Composite Design ◽

Dissolution Rate ◽

Solid Dispersion ◽

Solid Dispersions ◽

Solvent Evaporation ◽

Release Mechanism ◽

Solvent Evaporation Method ◽

Onset Of Action ◽

Evaporation Method ◽

Central Composite

Repaglinide is a pharmaceutical drug used for the treatment of type II diabetes mellitus, it is characterized with poor solubility which limits its absorption and dissolution rate and delays onset of action. In the present study, immediate release solid dispersion of repaglinide was formulated by solvent evaporation technique. Repaglinide solid dispersions were prepared using PEG 8000, Pluronic F 127 and Gelucire 44/14 by solvent evaporation method. A 3-factor, 3-level central composite design employed to study the effect of each independent variable on dependent variables. FTIR studies revealed that no drug excipient interaction takes place. From powder X-ray diffraction (p-XRD) and by scanning electron microscopy (SEM) studies it was evident that polymorphic form of repaglinide has been converted into an amorphous form from crystalline within the solid dispersion formulation. The correlation coefficient showed that the release profile followed Higuchi model anomalous behavior and hence release mechanism was indicative of diffusion. The obtained results suggested that developed solid dispersion by solvent evaporation method might be an efficacious approach for enhancing the solubility and dissolution rate of repaglinide.

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