scholarly journals Simultaneous measurement of intra-epidermal electric detection thresholds and evoked potentials for observation of nociceptive processing following sleep deprivation

2022 ◽  
Author(s):  
Boudewijn van den Berg ◽  
Hemme J. Hijma ◽  
Ingrid Koopmans ◽  
Robert J. Doll ◽  
Rob G. J. A. Zuiker ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Evoked Potentials ◽  
Pain Intensity ◽  
Evoked Potential ◽  
Detection Threshold ◽  
Double Pulse ◽  
Activity Measurement ◽  
Detection Thresholds ◽  
Female Population ◽  
Nociceptive Processing

AbstractSleep deprivation has been shown to increase pain intensity and decrease pain thresholds in healthy subjects. In chronic pain patients, sleep impairment often worsens the perceived pain intensity. This increased pain perception is the result of altered nociceptive processing. We recently developed a method to quantify and monitor altered nociceptive processing by simultaneous tracking of psychophysical detection thresholds and recording of evoked cortical potentials during intra-epidermal electric stimulation. In this study, we assessed the sensitivity of nociceptive detection thresholds and evoked potentials to altered nociceptive processing after sleep deprivation in an exploratory study with 24 healthy male and 24 healthy female subjects. In each subject, we tracked nociceptive detection thresholds and recorded central evoked potentials in response to 180 single- and 180 double-pulse intra-epidermal electric stimuli. Results showed that the detection thresholds for single- and double-pulse stimuli and the average central evoked potential for single-pulse stimuli were significantly decreased after sleep deprivation. When analyzed separated by sex, these effects were only significant in the male population. Multivariate analysis showed that the decrease of central evoked potential was associated with a decrease of task-related evoked activity. Measurement repetition led to a decrease of the detection threshold to double-pulse stimuli in the mixed and the female population, but did not significantly affect any other outcome measures. These results suggest that simultaneous tracking of psychophysical detection thresholds and evoked potentials is a useful method to observe altered nociceptive processing after sleep deprivation, but is also sensitive to sex differences and measurement repetition.

scholarly journals A Robot Has a Mind of Its Own Because We Intuitively Share It

2020 ◽  
Vol 10 (18) ◽  
pp. 6531
Author(s):  
Mizuho Sumitani ◽  
Michihiro Osumi ◽  
Hiroaki Abe ◽  
Kenji Azuma ◽  
Rikuhei Tsuchida ◽  
...  
Keyword(s):  
Pain Intensity ◽  
Facial Expressions ◽  
Detection Threshold ◽  
Two Dimensions ◽  
Virtual Agent ◽  
Cold Pain ◽  
Detection Thresholds ◽  
Pain Detection ◽  
Pain Experiences ◽  
The Mind

People perceive the mind in two dimensions: intellectual and affective. Advances in artificial intelligence enable people to perceive the intellectual mind of a robot through their semantic interactions. Conversely, it has been still controversial whether a robot has an affective mind of its own without any intellectual actions or semantic interactions. We investigated pain experiences when observing three different facial expressions of a virtual agent modeling affective minds (i.e., painful, unhappy, and neutral). The cold pain detection threshold of 19 healthy subjects was measured as they watched a black screen, then changes in their cold pain detection thresholds were evaluated as they watched the facial expressions. Subjects were asked to rate the pain intensity from the respective facial expressions. Changes of cold pain detection thresholds were compared and adjusted by the respective pain intensities. Only when watching the painful expression of a virtual agent did, the cold pain detection threshold increase significantly. By directly evaluating intuitive pain responses when observing facial expressions of a virtual agent, we found that we ‘share’ empathic neural responses, which can be intuitively emerge, according to observed pain intensity with a robot (a virtual agent).

scholarly journals Simultaneous tracking of psychophysical detection thresholds and evoked potentials to study nociceptive processing

2020 ◽  
Vol 52 (4) ◽  
pp. 1617-1628 ◽  
Author(s):  
Boudewijn van den Berg ◽  
Robert J. Doll ◽  
Alexander L.H. Mentink ◽  
Pieter S. Siebenga ◽  
Geert J. Groeneveld ◽  
...  
Keyword(s):  
Evoked Potentials ◽  
Detection Thresholds ◽  
Nociceptive Processing

Visual Evoked potential signal processing and analysis for normal and galucomic eyes

2015 ◽  
Vol 8 (2) ◽  
pp. 2106-2121
Author(s):  
Hamed Ibrahem Abdelkader ◽  
Mona Abdelkader ◽  
Mohammed Kabeel ◽  
Malak Alya
Keyword(s):  
Evoked Potentials ◽  
Visual Evoked Potential ◽  
Evoked Potential ◽  
Optic Tract ◽  
Pattern Reversal ◽  
Blue Color ◽  
Check Size ◽  
Retinal Stimulation ◽  
Normal Individuals ◽  
Visual Evoked

Visual evoked potentials (VEPS) are obtained from optic tract by recording the evoked potentials generated by retinal stimulation. The flash VEP (FVEP) is used less frequently than pattern reversal VEP (PRVEP) because; it shows great variation in both latency and amplitude. The present study was undertaken to evaluate the effect of change of wavelength of flash and change of check size on the parameters of visual evoked potential (amplitude and latency) in normal individuals and glaucoma patients. The group of healthy subjects in the age of 20-45 years while the group of glaucoma subjects where  in the age of 25-50 years.  The two groups were exposed to flash VEP with white light and blue color and they also were exposed to checks subtending a visual angles of 15, 30,60 and 120 minutes of arc. The measured data were statistically analyzed and summarized by histograms. The interindividual and intraindividual in latencies and amplitudes for FVEP were assessed using  the coefficient of variation (COV). In conclusion, monochromatic flash VEP was preferred than white as there were minimal inter and intra individual variation of latencies and amplitudes. The most preferred check size in PRVEP was 120' for  the two groups.  

scholarly journals Long-term motor deficit in brain tumour surgery with preserved intra-operative motor-evoked potentials

2021 ◽  
Vol 3 (1) ◽  
Author(s):  
Davide Giampiccolo ◽  
Cristiano Parisi ◽  
Pietro Meneghelli ◽  
Vincenzo Tramontano ◽  
Federica Basaldella ◽  
...  
Keyword(s):  
Evoked Potentials ◽  
Brain Tumour ◽  
Evoked Potential ◽  
Corticospinal Tract ◽  
Motor Evoked Potentials ◽  
Motor Evoked Potential ◽  
Motor Deficit ◽  
Motor Deficits ◽  
Brain Tumour Surgery

Abstract Muscle motor-evoked potentials are commonly monitored during brain tumour surgery in motor areas, as these are assumed to reflect the integrity of descending motor pathways, including the corticospinal tract. However, while the loss of muscle motor-evoked potentials at the end of surgery is associated with long-term motor deficits (muscle motor-evoked potential-related deficits), there is increasing evidence that motor deficit can occur despite no change in muscle motor-evoked potentials (muscle motor-evoked potential-unrelated deficits), particularly after surgery of non-primary regions involved in motor control. In this study, we aimed to investigate the incidence of muscle motor-evoked potential-unrelated deficits and to identify the associated brain regions. We retrospectively reviewed 125 consecutive patients who underwent surgery for peri-Rolandic lesions using intra-operative neurophysiological monitoring. Intraoperative changes in muscle motor-evoked potentials were correlated with motor outcome, assessed by the Medical Research Council scale. We performed voxel–lesion–symptom mapping to identify which resected regions were associated with short- and long-term muscle motor-evoked potential-associated motor deficits. Muscle motor-evoked potentials reductions significantly predicted long-term motor deficits. However, in more than half of the patients who experienced long-term deficits (12/22 patients), no muscle motor-evoked potential reduction was reported during surgery. Lesion analysis showed that muscle motor-evoked potential-related long-term motor deficits were associated with direct or ischaemic damage to the corticospinal tract, whereas muscle motor-evoked potential-unrelated deficits occurred when supplementary motor areas were resected in conjunction with dorsal premotor regions and the anterior cingulate. Our results indicate that long-term motor deficits unrelated to the corticospinal tract can occur more often than currently reported. As these deficits cannot be predicted by muscle motor-evoked potentials, a combination of awake and/or novel asleep techniques other than muscle motor-evoked potentials monitoring should be implemented.

scholarly journals Observation of Nociceptive Processing: Effect of Intra-Epidermal Electric Stimulus Properties on Detection Probability and Evoked Potentials

2021 ◽  
Vol 34 (2) ◽  
pp. 139-153
Author(s):  
Boudewijn van den Berg ◽  
Jan R. Buitenweg
Keyword(s):  
Evoked Potentials ◽  
Detection Probability ◽  
Pulse Interval ◽  
System Behavior ◽  
Stimulus Properties ◽  
Nociceptive System ◽  
Nociceptive Stimulus ◽  
Peripheral Nerve Fiber ◽  
Nociceptive Processing ◽  
Mixed Regression

AbstractMonitoring nociceptive processing is a current challenge due to a lack of objective measures. Recently, we developed a method for simultaneous tracking of psychophysical detection probability and brain evoked potentials in response to intra-epidermal stimulation. An exploratory investigation showed that we could quantify nociceptive system behavior by estimating the effect of stimulus properties on the evoked potential (EP). The goal in this work was to accurately measure nociceptive system behavior using this method in a large group of healthy subjects to identify the locations and latencies of EP components and the effect of single- and double-pulse stimuli with an inter-pulse interval of 10 or 40 ms on these EP components and detection probability. First, we observed the effect of filter settings and channel selection on the EP. Subsequently, we compared statistical models to assess correlation of EP and detection probability with stimulus properties, and quantified the effect of stimulus properties on both outcome measures through linear mixed regression. We observed lateral and central EP components in response to intra-epidermal stimulation. Detection probability and central EP components were positively correlated to the amplitude of each pulse, regardless of the inter-pulse interval, and negatively correlated to the trial number. Both central and lateral EP components also showed strong correlation with detection. These results show that both the observed EP and the detection probability reflect the various steps of processing of a nociceptive stimulus, including peripheral nerve fiber recruitment, central synaptic summation, and habituation to a repeated stimulus.

Cerebral evoked potentials after endorectal mechanical stimulation in humans

1988 ◽  
Vol 254 (4) ◽  
pp. G477-G482 ◽  
Author(s):  
L. Collet ◽  
P. Meunier ◽  
R. Duclaux ◽  
S. Chery-Croze ◽  
P. Falipou
Keyword(s):  
Evoked Potentials ◽  
Mechanical Stimulation ◽  
Evoked Potential ◽  
Rectal Wall ◽  
International System ◽  
Rectal Sensation ◽  
Rectal Balloon ◽  
Female Age ◽  
Cerebral Evoked Potentials ◽  
Stimulation Of

Although numerous clinical studies have proved that impaired rectal sensation is a major factor in fecal continence dysfunctions, objective studies in this field are still lacking. To provide information on normal rectal afferents, a study of cerebral potentials evoked by mechanical stimulation of the rectal wall was carried out in 10 healthy volunteers (5 male, 5 female; age, 33–52 yr). The stimulating device consisted of a rectal balloon rhythmically inflated and deflated by means of an animal breathing ventilator. Recordings were obtained 2 cm behind the vertex (C'z, International system 10–20). The responses were averaged from 300 to 800 sweeps. The average was triggered either on inflation ("on effect") or on deflation ("off effect"). Inflation volume and pressure were adjusted to induce a clear but not painful pulsing sensation. Reproducible responses were recorded by both on and off effects. The evoked potentials were polyphasic with a succession of positive and negative waves (peak latencies between 78 and 310 ms). The shape of the response (morphology, latency, and amplitude) was perfectly reproducible in the same subject. With regard to intrasubject reproducibility, variability was displayed: only the early waves (latency less than 100 ms) were perfectly reproducible; late waves exhibited variable latency and morphology. The present findings are the first demonstration of the possibility of recording an evoked potential on the scalp after a mechanical stimulation of the rectum.

scholarly journals Ejaculatory Pain

2007 ◽  
Vol 107 (2) ◽  
pp. 298-304 ◽  
Author(s):  
Eske K. Aasvang ◽  
Bo Møhl ◽  
Henrik Kehlet
Keyword(s):  
Chronic Pain ◽  
Sexual Dysfunction ◽  
Quantitative Sensory Testing ◽  
Groin Hernia ◽  
Pain Treatment ◽  
Detection Threshold ◽  
Control Group ◽  
Sensory Testing ◽  
Detection Thresholds ◽  
Pain Detection

Background Sexual dysfunction due to ejaculatory and genital pain after groin hernia surgery may occur in approximately 2.5% of patients. However, the specific psychosexological and neurophysiologic characteristics have not been described, thereby precluding assessment of pathogenic mechanisms and treatment strategies. Methods Ten patients with severe pain-related sexual dysfunction and ejaculatory pain were assessed in detail by quantitative sensory testing and interviewed by a psychologist specialized in evaluating sexual functional disorders and were compared with a control group of 20 patients with chronic pain after groin hernia repair but without sexual dysfunction, to identify sensory changes associated with ejaculatory pain. Results Quantitative sensory testing showed significantly higher thermal and mechanical detection thresholds and lowered mechanical pain detection thresholds in both groups compared with the nonpainful side. Pressure pain detection threshold and tolerance were significantly lower in the ejaculatory pain group compared with the control group. 'The maximum pain was specifically located at the external inguinal annulus in all ejaculatory pain patients, but not in controls. The psychosexual interview revealed no major psychosexual disturbances and concluded that the pain was of somatic origin. All patients with ejaculatory pain had experienced major negative life changes and deterioration in their overall quality of life and sexual function as a result of the hernia operation. Conclusions Postherniotomy ejaculatory pain and pain-related sexual dysfunction is a specific chronic pain state that may be caused by pathology involving the vas deferens and/or nerve damage. Therapeutic strategies should therefore include neuropathic pain treatment and/or surgical exploration.

scholarly journals Is Peripheral Motion Detection Affected by Myopia?

2021 ◽  
Vol 15 ◽  
Author(s):  
Junhan Wei ◽  
Deying Kong ◽  
Xi Yu ◽  
Lili Wei ◽  
Yue Xiong ◽  
...  
Keyword(s):  
Visual Field ◽  
Spatial Frequency ◽  
Motion Detection ◽  
High Speed ◽  
Detection Threshold ◽  
High Spatial Frequency ◽  
Spherical Equivalent ◽  
Detection Thresholds ◽  
Significant Difference ◽  
Motion Speed

PurposeThe current study was to investigate whether myopia affected peripheral motion detection and whether the potential effect interacted with spatial frequency, motion speed, or eccentricity.MethodsSeventeen young adults aged 22–26 years participated in the study. They were six low to medium myopes [spherical equivalent refractions −1.0 to −5.0 D (diopter)], five high myopes (<-5.5 D) and six emmetropes (+0.5 to −0.5 D). All myopes were corrected by self-prepared, habitual soft contact lenses. A four-alternative forced-choice task in which the subject was to determine the location of the phase-shifting Gabor from the four quadrants (superior, inferior, nasal, and temporal) of the visual field, was employed. The experiment was blocked by eccentricity (20° and 27°), spatial frequency (0.6, 1.2, 2.4, and 4.0 cycles per degree (c/d) for 20° eccentricity, and 0.6, 1.2, 2.0, and 3.2 c/d for 27° eccentricity), as well as the motion speed [2 and 6 degree per second (d/s)].ResultsMixed-model analysis of variances showed no significant difference in the thresholds of peripheral motion detection between three refractive groups at either 20° (F[2,14] = 0.145, p = 0.866) or 27° (F[2,14] = 0.475, p = 0.632). At 20°, lower motion detection thresholds were associated with higher myopia (p < 0.05) mostly for low spatial frequency and high-speed targets in the nasal and superior quadrants, and for high spatial frequency and high-speed targets in the temporal quadrant in myopic viewers. Whereas at 27°, no significant correlation was found between the spherical equivalent and the peripheral motion detection threshold under all conditions (all p > 0.1). Spatial frequency, speed, and quadrant of the visual field all showed significant effect on the peripheral motion detection threshold.ConclusionThere was no significant difference between the three refractive groups in peripheral motion detection. However, lower motion detection thresholds were associated with higher myopia, mostly for low spatial frequency targets, at 20° in myopic viewers.

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