Bone Mineral Density in Femoral Neck is Positively Correlated to Circulating Insulin-Like Growth Factor (IGF)-I and IGF-Binding Protein (IGFBP)-3 in Swedish Men

2002 ◽  
Vol 70 (1) ◽  
pp. 22-29 ◽  
Author(s):  
P. Gillberg ◽  
H. Olofsson ◽  
H. Mallmin ◽  
W.F. Blum ◽  
S. Ljunghall ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Growth Factor ◽  
Femoral Neck ◽  
Bone Mineral ◽  
Insulin Like Growth Factor ◽  
Mineral Density ◽  
Igf I ◽  
Igf Binding ◽  
Igf Binding Protein ◽  
Igfbp 3

Serum insulin-like growth factor (IGF)-I and IGF binding protein-3 correlate with bone mineral density in 80-year-old males but not in females

1996 ◽  
Vol 6 (S1) ◽  
pp. 99-99 ◽  
Author(s):  
S. Høidrup ◽  
A. Juul ◽  
S. Schifter ◽  
N. E. Skakkebæk ◽  
A. N. Pedersen ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Growth Factor ◽  
Bone Mineral ◽  
Binding Protein ◽  
Serum Insulin ◽  
Insulin Like Growth Factor ◽  
Mineral Density ◽  
Igf I ◽  
Igf Binding ◽  
Igf Binding Protein

Specimen processing time and measurement of total insulin-like growth factor-I (IGF-I), free IGF-I, and IGF binding protein-3 (IGFBP-3)

2006 ◽  
Vol 16 (2) ◽  
pp. 86-92 ◽  
Author(s):  
Tiffany G. Harris ◽  
Howard D. Strickler ◽  
Herbert Yu ◽  
Michael N. Pollak ◽  
E. Scott Monrad ◽  
...  
Keyword(s):  
Growth Factor ◽  
Processing Time ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Igf I ◽  
Specimen Processing ◽  
Igf Binding ◽  
Igf Binding Protein ◽  
Igfbp 3

scholarly journals Genetic Determinants of Circulating Insulin-Like Growth Factor (IGF)-I, IGF Binding Protein (BP)-1, and IGFBP-3 Levels in a Multiethnic Population

2007 ◽  
Vol 92 (9) ◽  
pp. 3660-3666 ◽  
Author(s):  
Iona Cheng ◽  
Katherine DeLellis Henderson ◽  
Christopher A. Haiman ◽  
Laurence N. Kolonel ◽  
Brian E. Henderson ◽  
...  
Keyword(s):  
Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Genetic Determinants ◽  
Igf I ◽  
Igf Binding ◽  
Multiethnic Population ◽  
Igf Binding Protein ◽  
Igfbp 3

scholarly journals Influence of Polymorphisms in Genes Encoding for Insulin-Like Growth Factor (IGF)-I, Insulin, and IGF-Binding Protein (IGFBP)-3 on IGF-I, IGF-II, and IGFBP-3 Levels in Umbilical Cord Plasma

2012 ◽  
Vol 77 (6) ◽  
pp. 341-350 ◽  
Author(s):  
Eva Landmann ◽  
Barbara Kollerits ◽  
Joachim Gerhard Kreuder ◽  
Werner Friedrich Blum ◽  
Florian Kronenberg ◽  
...  
Keyword(s):  
Growth Factor ◽  
Umbilical Cord ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Cord Plasma ◽  
Igf I ◽  
Genes Encoding ◽  
Igf Binding ◽  
Igf Binding Protein ◽  
Igfbp 3

scholarly journals Insulin-Like Growth Factor (IGF)-Binding Protein-3 (IGFBP-3) Binds to Fibronectin (FN): Demonstration of IGF-I/IGFBP-3/FN Ternary Complexes in Human Plasma1

2001 ◽  
Vol 86 (5) ◽  
pp. 2104-2110 ◽  
Author(s):  
Yaoting Gui ◽  
Liam J. Murphy
Keyword(s):  
Growth Factor ◽  
Ternary Complexes ◽  
Insulin Like Growth Factor ◽  
Heparin Binding ◽  
Complementary Dna ◽  
Igf I ◽  
Igf Binding ◽  
Carboxyl Terminal ◽  
Igf Binding Protein ◽  
Igfbp 3

We used a yeast two-hybrid system to identify binding partners for insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3). A partial complementary DNA encoding the carboxyl-terminal of fibronectin (FN), including the cell binding site, the heparin-binding domain, and the fibrin-binding domain, was identified in a screen of a human placental complementary DNA library. The interaction of IGFBP-3 with FN and the 40-kDa heparin-binding carboxyl-terminal fragment of FN was confirmed using Western ligand blotting. Both glycosylated and nonglycosylated IGFBP-3 bound to FN with a Kd of approximately 0.3 nmol/L. IGF-I and IGFBP-1 had no effect on IGFBP-3 binding to FN. Competitive inhibition of IGFBP-3 binding to FN was observed in the presence of IGFBP-5 and heparin. The binding affinity of the immobilized IGFBP-3/FN complex for [125I]IGF-I (Kd = 0.8 nmol/L) was similar to that of IGFBP-3 alone. The presence of IGF-I/IGFBP-3/FN ternary complexes in human plasma was demonstrated by coimmunoprecipitation of IGFBP-3 and [125I]IGF-I with anti-FN monoclonal antibody. These data indicate that FN may have a role in the transportation of IGFBP-3 and IGF-I in the circulation and the sequestration of these proteins in tissues.

Sign in / Sign up

Export Citation Format

Share Document