Matrix metalloproteinase-2 and matrix metalloproteinase-9 serum levels in patients with vertebrobasilar dolichoectasia with and without stroke: case–control study

Latar Belakang: Ulkus kaki diabetik (UKD) adalah salah satu komplikasi dari diabetes melitus (DM) yang insidennya cenderung meningkat. Beberapa penelitian mengindikasikan polimorfisme gen matrix metalloproteinase-9 (MMP-9) pada titik -1562C/T dan +632A/G memiliki peranan penting dalam perkembangan dan patofisiologi ulkus kaki diabetik, yakni sebagai penanda inflamasi. Penelitian ini bertujuan untuk mengetahui hubungan polimorfisme gen MMP-9 dengan penyakit ulkus diabetik pada penderita DM tipe 2. Metode: Evaluasi menggunakan case control study, subjek penelitian adalah semua penderita DM tipe 2 dengan atau tanpa UKD yang memenuhi kriteria inklusi di RSUPN Dr. Cipto Mangunkusumo pada bulan Juli 2016 hingga Desember 2016. Hasil: Terdapat 197 pasien DM tipe 2 (laki-laki 49,2% dan perempuan 50,8%). Faktor yang berpengaruh dan bermakna secara statistik yakni penyakit arteri perifer (p=0,001), nyeri istirahat (p=0,001), neuropati (p=0,001), merokok (p=0,001), hipertensi (p=0,001), klaudikasio (p=0,001), anemia (p=0,001), dan leukositosis (p=0,001). Distribusi polimorfisme alel dari gen -1562C/T pada seluruh populasi, pada alel C = 74,6%, alel T = 25,4%. Distribusi polimorfisme alel dari gen +836A/G, pada alel A = 41,4%, dan alel G = 58,6% pada seluruh populasi. Simpulan: Pada MMP-9 -1562 C>T, genotipe TC secara statistik memiliki perbedaan secara signifikan terhadap insiden dan merupakan faktor pencegah dalam terjadinya UKD (p=0,001).

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Association of Genetic Polymorphisms in Matrix Metalloproteinase-9 and Coronary Artery Disease in the Chinese Han Population: A Case–Control Study

Genetic Testing and Molecular Biomarkers ◽

10.1089/gtmb.2013.0109 ◽

2013 ◽

Vol 17 (9) ◽

pp. 707-712 ◽

Cited By ~ 13

Author(s):

Hai-di Wu ◽

Xiao Bai ◽

Dong-mei Chen ◽

Hong-yan Cao ◽

Ling Qin

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Matrix Metalloproteinase ◽

Case Control Study ◽

Case Control ◽

Chinese Han ◽

Han Population ◽

Artery Disease ◽

Metalloproteinase 9 ◽

Control Study

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Correlation between matrix metalloproteinase-2 polymorphisms and first and recurrent atherosclerotic ischemic stroke events: a case–control study

Journal of International Medical Research ◽

10.1177/03000605211022967 ◽

2021 ◽

Vol 49 (6) ◽

pp. 030006052110229

Author(s):

Ying Li ◽

Qing-rong Ouyang ◽

Juan Li ◽

Xiao-rong Chen ◽

Lin-lin Li ◽

...

Keyword(s):

Ischemic Stroke ◽

Matrix Metalloproteinase ◽

Chinese Population ◽

Case Control Study ◽

Case Control ◽

Matrix Metalloproteinase 2 ◽

Odds Ratios ◽

Control Study

Objective To determine the associations between matrix metalloproteinase-2 (MMP-2, encoded by the MMP2 gene) 1306C/T and 735C/T polymorphisms and first and recurrent ischemic stroke in a Chinese population. Methods Patients with first and recurrent ischemic stroke were included. Serum MMP-2 was measured, and MMP2 1306C/T and 735C/T polymorphisms were detected. The associations between MMP2 1306C/T and 735C/T polymorphisms and first and recurrent ischemic stroke were analyzed. Results Serum MMP-2 in patients with first and recurrent ischemic stroke was significantly higher compared with controls, and patients with recurrent ischemic stroke had higher MMP-2 than those with first ischemic stroke. The frequency of the CC genotype and C allele of MMP2 735C/T was highest in patients with recurrent ischemic stroke, followed by patients with first ischemic stroke, and controls. Conversely, the genotype and allele of MMP2 1306C/T did not significantly differ between groups. The CC genotype of MMP2 735C/T was independently associated with first and recurrent ischemic stroke (odds ratios = 1.45 and 1.64, respectively), as was the C allele of MMP2 735C/T (odds ratios = 1.68 and 1.77, respectively). Conclusions The CC genotype and C allele of MMP2 735C/T were associated with first and recurrent ischemic stroke in a Chinese population.

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