The impact of hepatocyte phase imaging from infancy to young adulthood in patients with a known or suspected liver lesion

Abstract Background Radiomics is expected to improve the management of metastatic colorectal cancer (CRC). We aimed at evaluating the impact of liver lesion contouring as a source of variability on radiomic features (RFs). Methods After Ethics Committee approval, 70 liver metastases in 17 CRC patients were segmented on contrast-enhanced computed tomography scans by two residents and checked by experienced radiologists. RFs from grey level co-occurrence and run length matrices were extracted from three-dimensional (3D) regions of interest (ROIs) and the largest two-dimensional (2D) ROIs. Inter-reader variability was evaluated with Dice coefficient and Hausdorff distance, whilst its impact on RFs was assessed using mean relative change (MRC) and intraclass correlation coefficient (ICC). For the main lesion of each patient, one reader also segmented a circular ROI on the same image used for the 2D ROI. Results The best inter-reader contouring agreement was observed for 2D ROIs according to both Dice coefficient (median 0.85, interquartile range 0.78–0.89) and Hausdorff distance (0.21 mm, 0.14–0.31 mm). Comparing RF values, MRC ranged 0–752% for 2D and 0–1567% for 3D. For 24/32 RFs (75%), MRC was lower for 2D than for 3D. An ICC > 0.90 was observed for more RFs for 2D (53%) than for 3D (34%). Only 2/32 RFs (6%) showed a variability between 2D and circular ROIs higher than inter-reader variability. Conclusions A 2D contouring approach may help mitigate overall inter-reader variability, albeit stable RFs can be extracted from both 3D and 2D segmentations of CRC liver metastases.

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Droplet-Assisted Microfluidic Fabrication and Characterization of Multifunctional Polysaccharide Microgels Formed by Multicomponent Reactions

Polymers ◽

10.3390/polym10101055 ◽

2018 ◽

Vol 10 (10) ◽

pp. 1055 ◽

Cited By ~ 14

Author(s):

Nicolas Hauck ◽

Nalin Seixas ◽

Silvia Centeno ◽

Raimund Schlüßler ◽

Gheorghe Cojoc ◽

...

Keyword(s):

Hyaluronic Acid ◽

Multicomponent Reactions ◽

Building Blocks ◽

Correlation Spectroscopy ◽

Droplet Microfluidics ◽

Phase Imaging ◽

Colloidal Probe ◽

Young’S Moduli ◽

Depth Analysis ◽

The Impact

Polysaccharide-based microgels have broad applications in multi-parametric cell cultures, cell-free biotechnology, and drug delivery. Multicomponent reactions like the Passerini three-component and the Ugi four-component reaction are shown in here to be versatile platforms for fabricating these polysaccharide microgels by droplet microfluidics with a narrow size distribution. While conventional microgel formation requires pre-modification of hydrogel building blocks to introduce certain functionality, in multicomponent reactions one building block can be simply exchanged by another to introduce and extend functionality in a library-like fashion. Beyond synthesizing a range of polysaccharide-based microgels utilizing hyaluronic acid, alginate and chitosan, exemplary in-depth analysis of hyaluronic acid-based Ugi four-component gels is conducted by colloidal probe atomic force microscopy, confocal Brillouin microscopy, quantitative phase imaging, and fluorescence correlation spectroscopy to elucidate the capability of microfluidic multicomponent reactions for forming defined polysaccharide microgel networks. Particularly, the impact of crosslinker amount and length is studied. A higher network density leads to higher Young’s moduli accompanied by smaller pore sizes with lower diffusion coefficients of tracer molecules in the highly homogeneous network, and vice versa. Moreover, tailored building blocks allow for crosslinking the microgels and incorporating functional groups at the same time as demonstrated for biotin-functionalized, chitosan-based microgels formed by Ugi four-component reaction. To these microgels, streptavidin-labeled enzymes are easily conjugated as shown for horseradish peroxidase (HRP), which retains its activity inside the microgels.

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Gendered pathways to young adult symptomatology

International Journal of Behavioral Development ◽

10.1177/0165025416646485 ◽

2016 ◽

Vol 41 (1) ◽

pp. 52-63 ◽

Cited By ~ 4

Author(s):

Inge Seiffge-Krenke ◽

Malte Persike

Keyword(s):

Young Adults ◽

Transition To Adulthood ◽

Young Adulthood ◽

Perceived Support ◽

Internalizing Symptomatology ◽

Relationship Stress ◽

A Prospective Study ◽

The Impact ◽

Gender Specific ◽

Gendered Pathways

The transition to adulthood is a critical juncture in the course of psychopathology. This study examined the ways in which earlier capacity to deal with relationship stress during adolescence contributed to an adaptive outcome in emerging adulthood. In a prospective study of 145 individuals, relationship stress, individual coping capacities, and perceived support from fathers, mothers, and peers were analyzed, when the participants were 13 and 17 years old. The effects of these earlier capacities to deal with relationship stress on health outcomes were examined in young adulthood (age 23). Gendered pathways to young adults’ symptomatology emerged. Females experiencing earlier relationship stress, but also support by mothers, fathers, and friends, showed less symptomatology at age 23. In addition, females’ withdrawal coping mediated the impact of stressful encounters on later internalizing symptomatology. In contrast, earlier coping with relationship stress was not found to be predictive for males. Earlier support from parents or friends was associated with later externalizing symptomatology in young men. Reasons for the gender-specific pathways to symptomatology are discussed.

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Inter-observer agreement on the assessment of relative liver lesion signal intensity on hepatobiliary phase imaging with gadoxetate (Gd-EOB-DTPA)

Abdominal Radiology ◽

10.1007/s00261-015-0609-3 ◽

2015 ◽

Vol 41 (1) ◽

pp. 50-55 ◽

Cited By ~ 1

Author(s):

Sharon Ngu ◽

Lizza Lebron-Zapata ◽

Christy Pomeranz ◽

Seth Katz ◽

Scott Gerst ◽

...

Keyword(s):

Signal Intensity ◽

Liver Lesion ◽

Observer Agreement ◽

Hepatobiliary Phase ◽

Phase Imaging

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Psychosocial impairment in offspring of depressed parents

Psychological Medicine ◽

10.1017/s0033291705005350 ◽

2005 ◽

Vol 35 (10) ◽

pp. 1493-1503 ◽

Cited By ~ 64

Author(s):

PETER M. LEWINSOHN ◽

THOMAS M. OLINO ◽

DANIEL N. KLEIN

Keyword(s):

Social Competence ◽

Young Adulthood ◽

Psychosocial Functioning ◽

Adolescent Depression ◽

Subsequent Development ◽

Physical Symptoms ◽

Paternal Depression ◽

Diagnostic Interviews ◽

The Impact ◽

Depressed Parents

Background. Offspring of depressed parents experience impairment in a number of domains of functioning. Few studies have examined the impact of both maternal and paternal depression and co-morbid psychopathology on offspring functioning.Method. Oregon Adolescent Depression Project participants were administered diagnostic interviews and completed measures of psychosocial functioning during adolescence (mean=16·6, S.D.=1·19) and again during young adulthood (mean=24·5, S.D.=0·51). Diagnostic interviews were also conducted with the mothers and fathers of the target individual.Results. After controlling for relevant demographic characteristics, parental co-morbid psychopathology, and offspring psychopathology, maternal depression was associated with higher levels of physical symptoms (β=0·14, S.E.=0·07) during adolescence, and higher levels of minor stressors (β=2·52, S.E.=1·07) and a greater risk for using mental health services (OR 1·86, 95% CI 1·14–3·03) in young adulthood. Paternal depression was associated with offspring experiencing more major stressors (β=0·27, S.E.=0·07), having lower perceived social competence (β=−0·17, S.E.=0·08), and being more likely to attempt suicide (OR 2·65, 95% CI 1·19–5·92) during adolescence, as well as lower perceived social competence (β=−1·21, S.E.=0·49) in young adulthood.Conclusions. Offspring of depressed parents demonstrate impairment in a variety of domains, even after controlling for the effects of their own psychopathology. Further research on the mechanisms that lead to these impairments, as well as the role of these impairments in the subsequent development of psychopathology, is warranted.

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Abstract 13246: The Impact of Body-Mass Index Trajectories During Early Adulthood on Cardiac Mechanics in Middle Age: The CARDIA Study

Circulation ◽

10.1161/circ.130.suppl_2.13246 ◽

2014 ◽

Vol 130 (suppl_2) ◽

Author(s):

Sadiya S Khan ◽

Sanjiv J Shah ◽

Kiang J Liu ◽

Cora E Lewis ◽

Christina Shay ◽

...

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Young Adulthood ◽

Cardiac Dysfunction ◽

Middle Age ◽

Cardiac Mechanics ◽

Left Ventricular ◽

Left Ventricular Ejection ◽

The Impact ◽

Baseline Bmi

Introduction: Obesity is a risk factor for left ventricular dysfunction and incident heart failure. We hypothesized that baseline body mass index (BMI) and trajectories in weight change through young adulthood are associated with abnormal cardiac mechanics in middle age. Methods: We examined 2,735 participants from the Coronary Artery Risk Development in Young Adults (CARDIA) study. BMI was calculated at exam years 0, 2, 5, 7, 10, 15, 20, 25. 2D echo was performed with speckle-tracking analysis. Left ventricular ejection fraction (LVEF) and global longitudinal, circumferential, and radial strain (GLS, GCS, GRS, respectively) were measured at y25. Group-based modeling with latent class analysis (PROC TRAJ) was used to identify trajectories in relative changes in BMI (% change in BMI from baseline at each exam). Linear regression examined associations between baseline BMI and trajectory of BMI change and absolute GLS, GCS, and GRS at y25 adjusting for demographics, risk factors, and echo parameters. Results: Mean age at baseline was 25±4 years. Baseline BMI at y0 was significantly associated with mean GLS at y25 (p=0.01), but not GRS or GCS. We identified 4 distinct trajectories of relative BMI change: stable weight (36% of sample), mild increase (40%), moderate increase (18%), and major increase (6%) in weight (Figure). At y25, there was no difference in LVEF across the 4 BMI trajectory groups (P=NS). After adjustment for clinical variables and baseline BMI, absolute GLS was lower in groups with BMI increases (overall P<0.001). GRS and GCS were not significantly different between the groups. Conclusion: In conclusion, baseline BMI and increases in BMI during young adulthood are significantly associated with the presence of subclinical cardiac dysfunction in middle age despite normal EF. This novel characterization of BMI trajectories across young adulthood may assist in improving understanding of the impact of weight gain and obesity on cardiac dysfunction.

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