scholarly journals Modeling long-term tumor growth and kill after combinations of radiation and radiosensitizing agents

2019 ◽  
Vol 83 (6) ◽  
pp. 1159-1173 ◽  
Author(s):  
Tim Cardilin ◽  
Joachim Almquist ◽  
Mats Jirstrand ◽  
Astrid Zimmermann ◽  
Floriane Lignet ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Radiosensitizing Agents

Long-Term Survival of a Patient with Hepatocellular Carcinoma under Treatment with Viscum album – Case Report

2021 ◽  
pp. 237-243
Author(s):  
Ana Catarina Viana Valle ◽  
Aloísio Cunha de Carvalho
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Growth ◽  
Liver Neoplasm ◽  
Viscum Album ◽  
Health Condition ◽  
Continuous Treatment ◽  
Term Survival ◽  
History Of ◽  
Application Frequency

Hepatocellular carcinoma (HCC) is the most common liver neoplasm in dogs and can be treated by the Viscum album therapy in a curative or palliative way. The objective is to report a hepatocellular carcinoma case in a dog treated by homeopathic therapy, extending to Palliative Care, with a 24-month survival. A 12-year-old Schnauzer male with a history of a liver nodule was treated by intravenous and subcutaneous applications of V. album in different dynamization and combinations, chromotherapy, and oral homeopathic medicines. The tumor growth was controlled, and the health condition of the patient was stable while the medication was given as prescribed. However, as application frequency was reduced, tumor growth increased, and health deterioration was verified. Nevertheless and contrary to expectations, the patient had a 24-month survival. Therefore, these findings point to the potential of V. album on enhancing the quality of life, controlling tumor growth, and prolonging survival on patients with HCC. Patients under continuous treatment would benefit better of these properties.

scholarly journals NIMG-66. LONG-TERM FOLLOW-UP OF NEUROFIBROMATOSIS TYPE 1 PATIENTS USING WHOLE-BODY MRI DEMONSTRATES DYNAMIC CHANGES IN INTERNAL NEUROFIBROMA SIZE

2019 ◽  
Vol 21 (Supplement_6) ◽  
pp. vi176-vi176
Author(s):  
Ina Ly ◽  
Raquel Thalheimer ◽  
Wenli Cai ◽  
Miriam Bredella ◽  
Vanessa Merker ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Neurofibromatosis Type 1 ◽  
Neurofibromatosis Type ◽  
Whole Body ◽  
Childhood And Adolescence ◽  
Entire Study ◽  
Whole Body Mri

Abstract BACKGROUND Neurofibromas affect 40–50% of neurofibromatosis type 1 (NF1) patients and can cause significant morbidity and mortality. They grow more rapidly during childhood and adolescence but studies in adults are limited by their retrospective nature and follow-up time < 3 years. The long-term natural history of neurofibromas remains unknown. No guidelines exist on the need and frequency of surveillance imaging for patients. Whole-body MRI (WBMRI) can detect whole-body tumor burden, including internal neurofibromas. METHODS 17 adult NF1 patients who underwent WBMRI between 2007–2010 (Scan 1) underwent repeat WBMRI between 2018–2019 (Scan 2). Internal neurofibromas were segmented on short tau inversion recovery (STIR) sequences and tumor volume was calculated using a computerized volumetry and three-dimensional segmentation software. Circumscribed tumors were defined as discrete; invasive tumors or those involving multiple nerves were defined as plexiform. Tumor growth and shrinkage were defined as volume change ≥ 20% over the entire study period. RESULTS Median patient age was 43 years during Scan 1 and 53 years during Scan 2. Median time between Scan 1 and 2 was 9 years. A total of 140 neurofibromas were assessed. 24% of tumors grew by a median 63% (6.8% per year). 54% of tumors spontaneously decreased in volume by a median 60% (7% per year) without treatment. On a per-patient basis, 18% of patients had overall tumor growth and 41% overall tumor shrinkage. 8 new tumors developed in 7 patients. 16 tumors resolved entirely without medical or surgical intervention. Growth behavior did not correlate with discrete or plexiform morphology. CONCLUSION A subset of internal neurofibromas in adult NF1 patients grow significantly over a long-term period, suggesting that continued monitoring of these patients may be warranted. Surprisingly, more than half of neurofibromas shrink spontaneously without intervention. Continued patient enrollment and correlation of imaging findings with functional outcomes are underway.

scholarly journals Immunization associated with primary tumor growth leads to rejection of commonly used syngeneic tumors upon tumor rechallenge

2020 ◽  
Vol 8 (2) ◽  
pp. e000532
Author(s):  
Bruno Alicke ◽  
Klara Totpal ◽  
Jill M Schartner ◽  
Amy M Berkley ◽  
Sophie M Lehar ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Tumor Immunity ◽  
Primary Tumor ◽  
Checkpoint Inhibitors ◽  
Response To Therapy ◽  
Primary Tumors ◽  
Tumor Bed ◽  
Recent Success ◽  
Treatment Naïve

The recent success of multiple immunomodulating drugs in oncology highlights the potential of relieving immunosuppression by directly engaging the immune system in the tumor bed to target cancer cells. Durable responses to immune checkpoint inhibitors experienced by some patients may be indicative of the formation of a T cell memory response. This has prompted the search for preclinical evidence of therapy-induced long-term immunity as part of the evaluation of novel therapeutics. A common preclinical method used to document long-term immunity is the use of tumor rechallenge experiments in which tumor growth is assessed in mice that have previously rejected tumors in response to therapy. Failure of rechallenge engraftment, typically alongside successful engraftment of the same tumor in naive animals as a control, is often presented as evidence of therapy-induced tumor immunity. Here, we present evidence that formation of tumor immunity often develops independent of therapy. We observed elevated rates of rechallenge rejection following surgical resection of primary tumors for four of five commonly used models and that such postexcision immunity could be adoptively transferred to treatment-naïve mice. We also show that tumor-specific cytolytic T cells are induced on primary tumor challenge independent of therapeutic intervention. Taken together these data call into question the utility of tumor rechallenge studies and the use of naïve animals as controls to demonstrate therapy-induced formation of long-term tumor immunity.

scholarly journals Long-term in vivo microscopy of CAR T cell dynamics during eradication of CNS lymphoma in mice

2019 ◽  
Vol 116 (48) ◽  
pp. 24275-24284 ◽  
Author(s):  
Matthias Mulazzani ◽  
Simon P. Fräßle ◽  
Iven von Mücke-Heim ◽  
Sigrid Langer ◽  
Xiaolan Zhou ◽  
...  
Keyword(s):  
T Cells ◽  
Tumor Growth ◽  
B Cell ◽  
B Cell Lymphoma ◽  
Therapeutic Effects ◽  
Term Survival ◽  
Car T Cells ◽  
Car T

T cells expressing anti-CD19 chimeric antigen receptors (CARs) demonstrate impressive efficacy in the treatment of systemic B cell malignancies, including B cell lymphoma. However, their effect on primary central nervous system lymphoma (PCNSL) is unknown. Additionally, the detailed cellular dynamics of CAR T cells during their antitumor reaction remain unclear, including their intratumoral infiltration depth, mobility, and persistence. Studying these processes in detail requires repeated intravital imaging of precisely defined tumor regions during weeks of tumor growth and regression. Here, we have combined a model of PCNSL with in vivo intracerebral 2-photon microscopy. Thereby, we were able to visualize intracranial PCNSL growth and therapeutic effects of CAR T cells longitudinally in the same animal over several weeks. Intravenous (i.v.) injection resulted in poor tumor infiltration of anti-CD19 CAR T cells and could not sufficiently control tumor growth. After intracerebral injection, however, anti-CD19 CAR T cells invaded deeply into the solid tumor, reduced tumor growth, and induced regression of PCNSL, which was associated with long-term survival. Intracerebral anti-CD19 CAR T cells entered the circulation and infiltrated distant, nondraining lymph nodes more efficiently than mock CAR T cells. After complete regression of tumors, anti-CD19 CAR T cells remained detectable intracranially and intravascularly for up to 159 d. Collectively, these results demonstrate the great potential of anti-CD19 CAR T cells for the treatment of PCNSL.

Long-term interferon-α treatment suppresses tumor growth but promotes metastasis capacity in hepatocellular carcinoma

2010 ◽  
Vol 136 (12) ◽  
pp. 1891-1900 ◽  
Author(s):  
Peng-Yuan Zhuang ◽  
Ju-Bo Zhang ◽  
Wei Zhang ◽  
Xiao-Dong Zhu ◽  
Ying Liang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Growth ◽  
Interferon Α

Pt(II) Complexes of a Combretastatin A-4 Analogous Chalcone: Effects of Conjugation on Cytotoxicity, Tumor Specificity, and Long-Term Tumor Growth Suppression

2009 ◽  
Vol 52 (2) ◽  
pp. 241-246 ◽  
Author(s):  
Rainer Schobert ◽  
Bernhard Biersack ◽  
Andrea Dietrich ◽  
Sebastian Knauer ◽  
Miroslava Zoldakova ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Growth Suppression ◽  
Tumor Specificity ◽  
Tumor Growth Suppression

scholarly journals Long-Term Treatment with Aqueous Garlic and/or Tomato Suspensions Decreases Ehrlich Ascites Tumors

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Jenifer Bom ◽  
Patrícia Gunutzmann ◽  
Elizabeth C. Pérez Hurtado ◽  
Jussara M. R. Maragno-Correa ◽  
Silvia Regina Kleeb ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Term Treatment ◽  
Therapeutic Effects ◽  
Short Term ◽  
Volume Number ◽  
Aqueous Suspensions ◽  
Ehrlich Ascites ◽  
Long Term Treatment ◽  
Ascites Tumors

We evaluated the preventive and therapeutic effects of aqueous suspensions of garlic, tomato, and garlic + tomato in the development of experimental Ehrlich tumors in mice. The aqueous suspensions (2%) were administered over a short term for 30 days before tumor inoculation and 12 days afterward, and suspensions at 6% were administered for 180 days before inoculation and for 12 days afterward. The volume, number, and characteristics of the tumor cells and AgNOR counts were determined to compare the different treatments. Aqueous 6% suspensions of garlic, tomato, and garlic + tomato given over the long term significantly reduced tumor growth but when given over the short term, they did not alter tumor growth.

scholarly journals Rescue of cognitive function following fractionated brain irradiation in a novel preclinical glioma model

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Xi Feng ◽  
Sharon Liu ◽  
David Chen ◽  
Susanna Rosi ◽  
Nalin Gupta
Keyword(s):  
Tumor Growth ◽  
Cognitive Deficits ◽  
Memory Deficits ◽  
Cognitive Outcomes ◽  
Whole Brain Irradiation ◽  
Clinical Model ◽  
Brain Irradiation ◽  
Reliable Assessment ◽  
Radiation Induced

More than half of long-term brain tumor survivors develop irreversible cognitive decline that severely affect their quality of life. However, there is no pre-clinical model that allows long-term assessment of cognition, and there is no treatment which ameliorates cognitive deficits in patients. Here, we report a novel glioma mouse model that offers manageable tumor growth and reliable assessment of cognitive functions in a post-treatment manner. Using this model, we found that fractionated whole-brain irradiation (fWBI), but not tumor growth, results in memory deficits. Transient inhibition of CSF-1R during fWBI prolongs survival of glioma-bearing mice and fully prevents fWBI-induced memory deficits. This result suggests that CSF-1R inhibition during radiotherapy can be explored as an approach to improve both survival and cognitive outcomes in patients who will receive fWBI. Taken together, the current study provides a proof of concept of a powerful tool to study radiation-induced cognitive deficits in glioma-bearing animals.

scholarly journals Some experimental data on the etiology of uterine fibroids

2021 ◽  
Vol 43 (2) ◽  
pp. 77-78
Author(s):  
M. S. Todortseva
Keyword(s):  
Experimental Data ◽  
Nervous System ◽  
Tumor Growth ◽  
Guinea Pigs ◽  
Morphological Changes ◽  
Uterine Fibroids ◽  
Nervous Apparatus ◽  
Term Administration

Taking into account the great interest in identifying the role of the nervous system in the processes of tumor growth and the insufficient study of morphological changes in the nervous apparatus of neoplasms, in our clinic (Head - Prof. AM Foy), since 1955, work has been carried out to study the effect of prolonged hyperestrogenism on the nervous apparatus of the uterus during the development of experimental fibroids in it. Experiments with long-term administration of estrogenic hormones were carried out on 120 non-castrated female guinea pigs weighing from 150.0 to 250.0, which were divided into 4 groups.

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