scholarly journals A historical perspective on the role of sensory nerves in neurogenic inflammation

2018 ◽  
Vol 40 (3) ◽  
pp. 229-236 ◽  
Author(s):  
João Sousa-Valente ◽  
Susan D. Brain
Keyword(s):  
Historical Perspective ◽  
Neurogenic Inflammation ◽  
Sensory Nerves

Involvement of neurogenic inflammation in antigen-induced bronchoconstriction in guinea pigs

1993 ◽  
Vol 265 (5) ◽  
pp. L507-L511 ◽  
Author(s):  
C. Bertrand ◽  
P. Geppetti ◽  
P. D. Graf ◽  
A. Foresi ◽  
J. A. Nadel
Keyword(s):  
Guinea Pigs ◽  
Neurogenic Inflammation ◽  
Neutral Endopeptidase ◽  
Receptor Activation ◽  
Sensory Nerves ◽  
Pulmonary Resistance ◽  
Receptor Antagonists ◽  
Tachykinin Receptor ◽  
Nk2 Receptor

The role of tachykinins released from sensory nerves in bronchoconstriction induced by antigen was studied in sensitized guinea pigs anesthetized with pentobarbital sodium and pretreated with atropine. The combination of NK2 (SR-48968) and NK1 (CP-96,345) tachykinin-receptor antagonists abolished the increase in total pulmonary resistance (RL) evoked by intravenous capsaicin but did not affect the response evoked by intravenous histamine. A small dose of aerosolized ovalbumin (OVA, 0.1%) produced a small increase in RL that was further increased and markedly prolonged by the neutral endopeptidase (NEP) inhibitor phosphoramidon; this bronchoconstrictor effect of OVA was markedly reduced by the NK2-receptor antagonist and was abolished by the combination of the NK1 and NK2-receptor antagonists together. When a larger dose of OVA (0.5%) was used, a maximal bronchoconstrictor response was obtained. Phosphoramidon did not potentiate this response significantly. The combination of NK1- and NK2-receptor antagonists blunted the response at 5 min only slightly but markedly attenuated the later (10–20 min) response. These results show that tachykinins released from sensory nerves play a significant role in antigen-induced bronchoconstriction in guinea pigs. This effect is exaggerated when the normal modulation of neuropeptides by NEP is inhibited and is mediated predominantly by NK2-receptor activation, with a smaller contribution by NK1 receptors.

scholarly journals Neurogenic Inflammation in the Context of Endometriosis—What Do We Know?

2021 ◽  
Vol 22 (23) ◽  
pp. 13102
Author(s):  
Renata Voltolini Velho ◽  
Eliane Taube ◽  
Jalid Sehouli ◽  
Sylvia Mechsner
Keyword(s):  
Immune Cells ◽  
Neurotrophic Factors ◽  
Peripheral Nerves ◽  
Neurogenic Inflammation ◽  
Treatment Options ◽  
Uterine Cavity ◽  
Sensory Nerves ◽  
Tailored Treatment ◽  
Growth Phenotype

Endometriosis (EM) is an estrogen-dependent disease characterized by the presence of epithelial, stromal, and smooth muscle cells outside the uterine cavity. It is a chronic and debilitating condition affecting ~10% of women. EM is characterized by infertility and pain, such as dysmenorrhea, chronic pelvic pain, dyspareunia, dysuria, and dyschezia. Although EM was first described in 1860, its aetiology and pathogenesis remain uncertain. Recent evidence demonstrates that the peripheral nervous system plays an important role in the pathophysiology of this disease. Sensory nerves, which surround and innervate endometriotic lesions, not only drive the chronic and debilitating pain associated with EM but also contribute to a growth phenotype by secreting neurotrophic factors and interacting with surrounding immune cells. Here we review the role that peripheral nerves play in driving and maintaining endometriotic lesions. A better understanding of the role of this system, as well as its interactions with immune cells, will unearth novel disease-relevant pathways and targets, providing new therapeutics and better-tailored treatment options.

National Liberalisms in Historical Perspective

2018 ◽  
Author(s):  
Mark I. Vail
Keyword(s):  
Economic Model ◽  
Historical Perspective ◽  
Source Material ◽  
Historical Source ◽  
Market Making ◽  
Role Of The State ◽  
The Face ◽  
Political Economic ◽  
Analytical Frameworks

This chapter analyzes the development of French, German, and Italian liberalism from the nineteenth century to the 1980s, giving particular attention to each tradition’s conceptions of the role of the state and its relationship to groups and individual citizens. Using a broad range of historical source material and the works of influential political philosophers, it outlines the analytical frameworks central to French “statist liberalism,” German “corporate liberalism,” and Italian “clientelist liberalism.” It shows how these evolving traditions shaped the structure of each country’s postwar political-economic model and the policy priorities developed during the postwar boom through the early 1970s and provides conceptual touchstones for the direction and character of these traditions’ evolution in the face of the neoliberal challenge since the 1990s. The chapter demonstrates that each tradition accepted elements of a more liberal economic order while rejecting neoliberalism’s messianic market-making agenda and its abstract and disembedded political-economic vision.

Pearls From Bones: Relics, Chortens, Tertons and the Signs of Saintly Death in Tibet

Numen ◽  
1994 ◽  
Vol 41 (3) ◽  
pp. 273-324 ◽  
Author(s):  
Dan Martin
Keyword(s):  
Historical Perspective ◽  
Religious Studies ◽  
Religious Culture ◽  
Tibetan Buddhist ◽  
Devotional Practice ◽  
Cultural Pattern ◽  
Other Substances ◽  
Critical Links ◽  
Point Of Departure

AbstractAlthough there has been much work, in recent years, on the sacrum of Christianity, and some important studies have appeared on Buddhist relic cults and related facets of Buddhism, so far very little has been written on Tibetan Buddhist relics. This paper, while offering some material for a historical perspective, mainly seeks to find a larger cultural pattern for understanding the interrelationships of a complex of factors active in Tibetan religious culture. Beginning with problems of relic-related terms and classifications, we then suggest a new assessment of the role of the Terton ('treasure revealer'). Then we discuss 'miracles' in Tibet, and the intersection of categories of 'signs of saintly death' and relics. Much of the remaining pages are devoted to those items that fall within both categories, specifically the 'pearls' that emerge miraculously from saintly remains and images that appear in bodily or other substances connected with cremations. After looking at a number of testimonials on these miraculous relics, we examine the possibility that these items might be 'deceitfully manufactured', looking at a few Tibetan polemical writings which raise this possibility. In the conclusion, we suggest that there are some critical links between three spheres of Tibetan religiosity: 1. sacrum which are not relics, 2. relics, and 3. signs of sainthood. Finally, we recommend an approach to religious studies that takes its point of departure in actual practices, and particularly the objects associated with popular devotional practice.

Greek National Identity and the Greek Education System in the Age of Austerity

2021 ◽  
pp. 1-16
Author(s):  
Maria Chalari ◽  
Thomas Georgas
Keyword(s):  
European Union ◽  
National Identity ◽  
Economic Crisis ◽  
Education System ◽  
Historical Perspective ◽  
Social Attitudes ◽  
The European Union ◽  
Humanitarian Crisis ◽  
Current Climate

This paper critically reviews discourses of Greek national identity and the role of the Greek education system first in a historical perspective and then in the current climate of economic crisis in Greece. It also discusses the reason why teachers and schools are key to tackling growing discriminatory social attitudes. The preceding nationalistic discourse and the historical forms of nationhood and education in Greece might help us unravel the difficulties Greek national identity faces in the current era of economic and humanitarian crisis and uncertainty with regard to the European Union project, its evolution, its struggles, the nature of its challenges and tensions, and the empowerment of its ethnocentric and racist sentiment.

Reflections on the Status and Direction of Psychology: An External Historical Perspective

2013 ◽  
Vol 44 (2) ◽  
pp. 244-261 ◽  
Author(s):  
Amedeo Giorgi
Keyword(s):  
Historical Perspective ◽  
Phenomenological Approach ◽  
Natural Sciences ◽  
Gestalt Theory ◽  
The Everyday ◽  
The Status ◽  
History Of ◽  
A Minor ◽  
Aron Gurwitsch

Abstract Whenever one reads internal histories of psychology what is covered is the establishment of a lab by Wundt in 1879 as the initiating act and then the breakaway movements of the 20th Century are discussed: Behaviorism, Gestalt Theory, Psychoanalysis, and most recently the Cognitive revival. However, Aron Gurwitsch described a perspective noted by Cassirer and first developed by Malebranche, which dates the founding of psychology at the same time as that of physics in the 17th Century. This external perspective shows the dependency of psychology upon the concepts, methods and procedures of physics and the natural sciences in general up until the present time. Gurwitsch argues that this approach has blocked the growth of psychology and has assured its status as a minor science. He argued that the everyday Lifeworld achievements of subjectivity are the true subject matter of psychology and that a phenomenological approach to subjectivity could give psychology the authenticity it has been forever seeking but never finding as a naturalistic science. Some clarifying thoughts concerning this phenomenologically grounded psychology are offered, especially the role of desire. The assumption of an external perspective toward the history of psychology fostered the insights about psychology’s scientific role.

Social and Familial Childrearing: An Examination of Daycare and the Modern Family

1983 ◽  
Vol 165 (4) ◽  
pp. 375-397
Author(s):  
Carol S. Klass
Keyword(s):  
Historical Perspective ◽  
National Policy ◽  
American Family ◽  
Policy And Practice ◽  
High Quality ◽  
Self Identity ◽  
The Family ◽  
Modern Family ◽  
Changing Patterns

American families' need for out-of-home childcare increases at an accelerated rate each year; yet our society lacks a policy for—and even a national commitment to—high-quality daycare. Such a national policy needs to be formulated within an examination of the tensions between social and familial childrearing. This essay explores these contextual issues from a historical perspective. The essay discusses: first, changes in the family as they relate to changes in the economy and polity; second, the role of the family as the basis for the young child's self-identity and internalization of society's values and practices; and third, the potential implications of changing patterns of the structure and functioning of the American family. Finally, the essay examines historical and current daycare policy and practice in relation to the family and the broader social structure.

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