The association of haemoglobin A1C levels with the clinical and CT characteristics of Klebsiella pneumoniae liver abscesses in patients with diabetes mellitus

2014 ◽  
Vol 24 (5) ◽  
pp. 980-989 ◽  
Author(s):  
Hong-Hau Wang ◽  
Shih-Hung Tsai ◽  
Chih-Yung Yu ◽  
Hsian-He Hsu ◽  
Chang-Hsien Liu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Klebsiella Pneumoniae ◽  
Haemoglobin A1c ◽  
Liver Abscesses ◽  
Patients With Diabetes

Influence of diabetes mellitus on deep neck infection

2006 ◽  
Vol 120 (8) ◽  
pp. 650-654 ◽  
Author(s):  
H-T Lin ◽  
C-S S Tsai ◽  
Y-L Chen ◽  
J-G Liang
Keyword(s):  
Diabetes Mellitus ◽  
Klebsiella Pneumoniae ◽  
Haemoglobin Level ◽  
Complication Rate ◽  
Glycosylated Haemoglobin ◽  
Haemoglobin A1c ◽  
Deep Neck Infection ◽  
Glycosylated Haemoglobin Level ◽  
Neck Infection ◽  
Patients With Diabetes

Objective: To investigate the influence of hyperglycaemia on deep neck infection (DNI) and the differences between the diabetic and non-diabetic form of DNI.Study design and setting: Retrospective review of 131 patients with DNI treated between 1993 and 2002 at Shin Kong Memorial Hospital, Taipei, Taiwan.Results: Deep neck infection was significantly more prevalent in patients with diabetes mellitus (DM) over 60 years of age than in non-DM subjects of a similar age (p = 0.004). In the DM group, Klebsiella pneumoniae was the most common aerobic pathogen and tended to involve more than two anatomical spaces (p < 0.0001). Seventeen out of 18 patients (94.4 per cent) displayed an elevated (≥7 per cent) glycosylated haemoglobin level. The DM group had a significantly higher complication rate, longer hospital stay and tracheotomy rate than the non-DM group.Conclusions: Diabetic DNI differs from non-diabetic DNI in several aspects and is associated with a higher morbidity. A greater than normal haemoglobin A1c level was commonly observed.

scholarly journals Case of Pyogenic Liver Abscesses Caused by Klebsiella Pneumoniae

2018 ◽  
Vol 2 (2) ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Escherichia Coli ◽  
Klebsiella Pneumoniae ◽  
Liver Abscess ◽  
Anaerobic Bacteria ◽  
Pyogenic Liver Abscess ◽  
Hepatobiliary Disease ◽  
Liver Abscesses ◽  
Patients With Diabetes ◽  
Aerobic And Anaerobic

Liver abscess is a serious intraabdominal infection can be due to result of bacteria, fungi, or parasites infection. Until the end of the last century, pyogenic liver abscesses were predominantly caused by mixed aerobic and anaerobic bacteria, the most frequent isolate being Escherichia coli [1]. Klebsiella pneumoniae (K.pneumoniae) is a known cause of pyogenic liver abscess (PLA) in the absence of hepatobiliary disease. In settings of hepatic infection, it has also been known to cause disseminated infections including meningitis and endopthalmitis. Patients with diabetes mellitus and the preexisting hepatobiliary disease are particularly susceptible to infection as well as those from Southeast Asia [2]. We present a case of Klebsiella liver abscess with bacteremia.

scholarly journals Lack of association between peroxisome proliferator-activated receptor-gamma-2 gene variants and the occurrence of coronary heart disease in patients with diabetes mellitus

2002 ◽  
pp. 545-551 ◽  
Author(s):  
M Bluher ◽  
T Klemm ◽  
T Gerike ◽  
H Krankenberg ◽  
G Schuler ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Multiple Logistic Regression Analysis ◽  
Peroxisome Proliferator ◽  
Haemoglobin A1c ◽  
Peroxisome Proliferator Activated Receptor ◽  
Patients With Diabetes ◽  
Reduced Risk

OBJECTIVE: Recent evidence indicates that peroxisome proliferator-activated receptor-gamma (PPARgamma) is expressed at high levels in foam cells of atherosclerotic lesions, that PPARgamma agonists may directly modulate vessel wall function and that mutations in the PPARgamma-2 gene are associated with a reduced risk of coronary artery disease. METHODS: We investigated whether known variants in the PPARgamma-2 gene are associated with the occurrence of coronary heart disease (CHD) in 365 patients with type 2 diabetes, prospectively characterised for the presence or absence of CHD. The Pro115Gln, Pro12Ala, Pro467Leu, Val290Met mutations and two polymorphisms C478T and C161T of the PPARgamma-2 gene were examined using PCR, denaturing gradient gel electrophoresis and direct sequencing. RESULTS: The distribution of the Pro12Ala, Ala12Ala, C161T and T161T variants was not significantly different between patients with and without CHD, independent of the gender. The Pro12Ala (P=0.011) and the Ala12Ala (P=0.006) variant were associated with a higher body mass index (BMI) compared with the Pro12Pro genotype. A multiple logistic regression analysis introducing the typical risk factors for CHD (age, sex, hypertension, smoking, BMI >26 kg/m2, elevated low density lipoprotein cholesterol and haemoglobin A1c >7%) identified age >60, male gender, hypertension and a higher BMI, but not the PPARgamma-2 variants, as significant risk factors for CHD in our study groups. CONCLUSION: The PPARgamma-2 genotype was not associated with an increased or reduced risk of the occurrence of CHD and can therefore not be regarded as an independent risk factor for CHD in patients with diabetes mellitus.

Haemoglobin A1c Goal Attainment in Relation to Dose in Patients with Diabetes Mellitus Taking Metformin

2008 ◽  
Vol 28 (8) ◽  
pp. 487-493
Author(s):  
Fernie J A Penning-van Beest ◽  
Bruce H R Wolffenbuttel ◽  
Ron M C Herings
Keyword(s):  
Diabetes Mellitus ◽  
Goal Attainment ◽  
Haemoglobin A1c ◽  
Patients With Diabetes

scholarly journals Assessing efficacy of diabetes school using diabetes knowledge scale in Turkey

2019 ◽  
Vol 8 (1) ◽  
pp. 280
Author(s):  
Bengur Taskiran ◽  
Guven Baris Cansu
Keyword(s):  
Diabetes Mellitus ◽  
Diabetes Management ◽  
Diabetes Education ◽  
Education Programme ◽  
Haemoglobin A1c ◽  
Diabetes Knowledge ◽  
Poor Knowledge ◽  
Knowledge Questionnaire ◽  
Number Of Patients ◽  
Patients With Diabetes

Background: Diabetes education, as an essential component of diabetes management, improves various aspects of diabetes mellitus including lowering Haemoglobin A1c. There is a number of surveys evaluating diabetes knowledge.Methods: The purpose of this study to measure diabetes knowledge of patients with diabetes mellitus after a structured group education programme named as diabetes school. This study is an observational study and the design is a cohort study. The study took place in 2017-2018. The duration of follow-up is 4 weeks. Fifty-four patients aged over 18 with a previous diagnosis of diabetes mellitus, who attended to the diabetes school education programme, were included to the study. Twenty-three patients participated in the true-false version of the revised Michigan diabetes knowledge questionnaire before and after the programme.Results: Twenty female and 3 male patients were aged 60.43±9.97 years. The scores improved significantly after the education programme (7.61±4.59 vs 12.39±3.35, p<0.0001). The number of patients correctly identifying more than half of the statements showed a steep increase after the programme (n=6, 26.0% vs n=17, 73.9%). Before education programme 13 had poor knowledge, 9 had moderate, and 1 had good knowledge. After completion 6 had poor knowledge, 11 had moderate, and 5 had good knowledge.Conclusions: Diabetes school is effective in improving diabetes knowledge in patients with diabetes mellitus. Revised Michigan Diabetes Knowledge Questionnaire can be used to evaluated diabetes knowledge. It may aid to detect the subgroup of patients who are lack knowledge of various aspects of diabetes mellitus.

Two novel haemoglobin variants that affect haemoglobin A1c measurement by ion-exchange chromatography

2015 ◽  
Vol 53 (9) ◽  
Author(s):  
Michael Bots ◽  
An K. Stroobants ◽  
Barend Delzenne ◽  
Maarten R. Soeters ◽  
Johan E. de Vries ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Ion Exchange ◽  
Dna Sequencing ◽  
Ion Exchange Chromatography ◽  
Exchange Chromatography ◽  
Heterozygous Mutation ◽  
Haemoglobin A1c ◽  
Patients With Diabetes

AbstractHaemoglobin (Hb) variants are well-known factors interfering with accurate HbAGlycated forms of novel Hb variants were recognised in the blood of two patients with diabetes mellitus screened by HbAA fraction of 15% of abnormal Hb was observed in a 37-year-old female. DNA sequencing revealed a heterozygous mutation in the αClose examination of HbA

scholarly journals Benefits of the addition of continuous or flash glucose monitoring versus standard practice using self-monitored blood glucose and haemoglobin A1c in the primary care of diabetes mellitus: a systematic review protocol

BMJ Open ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. e050027
Author(s):  
Alexander Kieu ◽  
Romona Devi Govender ◽  
Linda Östlundh ◽  
Jeffrey King
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Primary Care ◽  
Blood Glucose ◽  
Glycaemic Control ◽  
Glucose Monitoring ◽  
Physician Satisfaction ◽  
Haemoglobin A1c ◽  
Flash Glucose Monitoring ◽  
Patients With Diabetes

IntroductionStudies demonstrate that optimal glycaemic control reduces morbidity from diabetes mellitus but remains elusive in a significant portion of patients. Although research shows that continuous glucose monitoring (CGM) and flash glucose monitoring (FGM) improves glycaemic control in selected subsets of patients with diabetes in specialty practices, we found no systematic reviews evaluating the use of CGM/FGM in primary care, where the majority of patients with diabetes are cared for.This systematic review aims to answer the questions: ‘compared with usual care of self-monitoring blood glucose and haemoglobin A1c (HbA1c), does the addition of CGM/FGM use in the primary care of patients with diabetes improve glycaemic control, decrease rates of hypoglycaemia, and improve patient and physician satisfaction?’ and if so, ‘what subgroups of primary care patients with diabetes are most likely to benefit?’.Methods and analysisAligning with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols guidelines, a search will be conducted in PubMed, EMBASE, Scopus, CINAHL, Cochrane Central Register of Controlled Trials and Web of Science. We will include studies investigating CGM/FGM use and reporting the primary outcome measure of HbA1c and secondary outcome measures of hypoglycaemia, time in range, time below range, time above range and patient/staff satisfaction. We will examine which patient populations appear to benefit from CGM/FGM. Three independent researchers will use the Covidence systematic review software for blinded screening and study selection. The National Heart, Lung, and Blood Institute quality assessment tool and Grading of Recommendations Assessment, Development and Evaluation will be used to assess the risk of bias and quality of evidence.Ethics and disseminationThe systematic review methodology does not require ethics approval due to the nature of the study design. Study findings will be publicly available to a wide readership across disciplines and will be published in a peer-reviewed journal.PROSPERO registration numberCRD42021229416.

Haemoglobin A1c analysis in the management of patients with diabetes: from chaos to harmony: Table 1

2008 ◽  
Vol 61 (9) ◽  
pp. 983-987 ◽  
Author(s):  
A H Berg ◽  
D B Sacks
Keyword(s):  
Diabetes Mellitus ◽  
Microvascular Complications ◽  
Blood Glucose Control ◽  
Detection Methods ◽  
Haemoglobin A1c ◽  
Patients With Diabetes ◽  
Blood Haemoglobin ◽  
Diabetic Microvascular Complications ◽  
Based Medicine

Effective management of patients with diabetes mellitus requires accurate assessments of blood glucose control. The best characterised marker of long term glycaemic control is whole blood haemoglobin A1c (HbA1c). Published clinical trials have identified quantitative and direct relationships between the HbA1c concentration and risks of diabetic microvascular complications. However, in order to practice evidence-based medicine, assays used to measure patient samples should ideally produce values comparable to the assays used in these trials. Numerous assays using chromatographic and immunological detection methods are used around the world. This paper briefly reviews the scientific evolution of HbA1c and its analysis, discusses the reasons why HbA1c assay standardisation is a challenge, describes the approaches that have been adopted to harmonise HbA1c assays, and addresses the current initiatives to standardise HbA1c globally. These efforts have established HbA1c as an essential component in the management of patients with diabetes mellitus and are likely to lead to the use of HbA1c in the screening/diagnosis of diabetes.

scholarly journals Associations of grip strength with retinal and choroidal thickness in patients with type 2 diabetes mellitus without retinopathy: a cross-sectional study

BMJ Open ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. e036782
Author(s):  
Zihan Qiu ◽  
Wei Wang ◽  
Yan Tan ◽  
Miao He ◽  
Langhua Wang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Grip Strength ◽  
Choroidal Thickness ◽  
Chinese Patients ◽  
Haemoglobin A1c ◽  
Cross Sectional ◽  
Patients With Diabetes

ObjectiveTo evaluate the associations of grip strength with retinal or choroidal thickness in patients with type 2 diabetes mellitus without retinopathy.DesignObservational study-cross-sectional design.Setting and participantsThis study included the Chinese patients with type 2 diabetes without retinopathy registered in the community health system in Guangzhou, China.MeasuresThe grip strength in both hands were measured by using a dynamometer. The retinal and choroidal thickness in macular region stratified by Early Treatment Diabetic Retinopathy Study (ETDRS) sectors were measured by a swept-source optical coherence tomography.ResultsA total of 1029 patients were included. Both retinal thickness and choroidal thickness decreased with the lower quartile of grip strength. Regression analyses indicated that the average retinal and choroidal thickness increased by 0.14 µm (95% CI: 0.03 to 0.25 µm, p=0.011) and 0.57 µm (95% CI: 0.03 to 1.11 µm, p=0.037), respectively, for each additional kilogram of grip strength following adjustment for age and sex. Further adjustments were made for axial length, haemoglobin A1c, length of time the patient had diabetes, insulin usage, height, weight and systolic and diastolic blood pressure, which resulted in an average retinal and choroidal thickness increase of 0.13 µm (95% CI: 0.02 to 0.24 µm, p=0.024) and 0.65 µm (95% CI: 0.13 to 1.16 µm, p=0.013), respectively, for each additional kilogram of grip strength. Consistent results were obtained in the analyses in ETDRS 9 sectors.ConclusionLower hand grip strength was found to be significantly associated with thinner retinal and choroidal layers in patients with diabetes. Grip strength may provide a useful and easily administered indicator of retinal status in patients with diabetes.

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