Clinical significance of definite muscle layer in TUR specimen for evaluating progression rate in T1G3 bladder cancer: multicenter retrospective study by the Sapporo Medical University Urologic Oncology Consortium (SUOC)

The Authors report the results of a retrospective study concerning the use of mitomycin C in the prophylactic treatment of superficial bladder cancer after trans-urethral resection. The series includes 113 patients; minimum follow-up: 6 months, maximum 54, mean 17.7 months. Recurrence and progression rate was evaluated at 6, 12, 24, and 36 months. The cumulative recurrence and progression rate was 16.8% and 6.1% respectively. Patients with pTa neoplasms didn't develop progressions. G2 and G3 carcinoma recurrence and progression rate was higher than with G1 tumours. Multifocal neoplasms showed a higher trend recurrence compared to solitary tumours. The number of recurrences in the patient group with primitive neoplasms was not significantly different from that of patients with recurrent carcinoma.

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Preoperative hypoxemia in patients with type A acute aortic dissection: a retrospective study on incidence, related factors and clinical significance

Journal of Thoracic Disease ◽

10.21037/jtd.2019.11.68 ◽

2019 ◽

Vol 11 (12) ◽

pp. 5390-5397

Author(s):

Zijian Guo ◽

Yanwei Yang ◽

Mingming Zhao ◽

Bo Zhang ◽

Jiakai Lu ◽

...

Keyword(s):

Retrospective Study ◽

Aortic Dissection ◽

Clinical Significance ◽

Acute Aortic Dissection ◽

Type A ◽

Related Factors

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Analysis of clinical characteristics of severe pertussis in infants and children: a retrospective study

BMC Pediatrics ◽

10.1186/s12887-021-02507-4 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Caiying Wang ◽

Huimin Zhang ◽

Yanlan Zhang ◽

Lin Xu ◽

Min Miao ◽

...

Keyword(s):

Retrospective Study ◽

Clinical Characteristics ◽

Severe Disease ◽

Severe Pneumonia ◽

Infants And Children ◽

Critically Ill Children ◽

Young Infants ◽

Incidence And Mortality ◽

Increasing Trend ◽

Medical University

Abstract Background The incidence of pertussis shows an increasing trend in recent years, but some clinicians often lack sufficient understanding of the clinical characteristics and risk factors for severe pertussis, and more effective measures should be taken to reduce the incidence and mortality of pertussis in young infants Methods A retrospective study was conducted, and 184 infants and children with pertussis who had been hospitalized in the Department of Pediatrics of Beijing Ditan Hospital affiliated with Capital Medical University from January 2016 to December 2017 were included. Clinical data of the patients were collected and the clinical characteristics were statistically analyzed Results Among the 184 patients, 41.85% were infants < 3 months of age, and 65.22% of the total patients were not vaccinated against pertussis. There were 22 critically ill children, among whom 4 died, and compared with mild cases, they had a higher proportion of children younger than 3 months of age and infants not vaccinated against pertussis (63.64% vs. 38.89% and 100% vs. 60.49%, respectively); a higher proportion of children with severe pneumonia (100% vs. 0%); higher leukocyte count(× 109/L , 35.80 ± 20.53 vs 19.41 ± 8.59); and a higher proportion of children with severe hyperleukocytosis (18.18% vs. 0%, respectively) (P<0.05) Conclusions 1. Infants aged <3 months not vaccinated for pertussis appear more likely to become infected and have more severe disease. 2. Severe pneumonia and hyperleukocytosis are the main mechanisms underlying severe pertussis.

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Classification of non-acute bronchial asthma according to allergy and eosinophil characteristics: a retrospective study

Allergy Asthma & Clinical Immunology ◽

10.1186/s13223-021-00546-1 ◽

2021 ◽

Vol 17 (1) ◽

Author(s):

Yi Jiang ◽

Ruoli An ◽

Li Cheng ◽

Qianru Yue ◽

Hanwei Zhang ◽

...

Keyword(s):

Retrospective Study ◽

Lung Function ◽

Allergic Asthma ◽

Asthma Management ◽

Effective Management ◽

Sputum Cytology ◽

Eosinophilic Asthma ◽

Asthma Patients ◽

Medical University

Abstract Background Investigating the endotypes of the different asthma phenotypes would help disease monitoring, prognosis determination, and improving asthma management standardization. This study aimed to classify asthma into four endotypes according to the allergic and eosinophilic characteristics and explore the phenotypes (clinical characteristics, pulmonary functions, and fractional expired nitric oxide (FeNO)) of each endotype. Methods This retrospective study included non-acute asthma patients treated at the First Hospital of Shanxi Medical University (05/2016–01/2018). The patients were classified into the eosinophilic allergic, eosinophilic non-allergic, non-eosinophilic allergic, and non-eosinophilic non-allergic asthma endotypes. Serum sIgE, lung function, FeNO, and induced sputum cytology were tested and compared among groups. Results Of the 171 included patients, 22 had eosinophilic allergic asthma, 17 had eosinophilic non-allergic asthma, 66 had non-eosinophilic allergic asthma, and 66 had non-eosinophilic non-allergic asthma. Lung function measurements (FEV1%, FEF25%, FEF50%, FEF75%, and FEF25–75%) showed that airway dysfunction was worse in eosinophilic non-allergic asthma than in the other three endotypes (all P < 0.001). In allergic asthma patients, eosinophilic asthma had worse airway dysfunction than non-eosinophilic asthma (all P < 0.05). Similar results were found in non-allergic asthma (all P < 0.01). The FeNO levels in eosinophilic allergic asthma were higher than in eosinophilic non-allergic and non-eosinophilic non-allergic asthma (both P = 0.001). Conclusions FeNO can objectively reflect eosinophilic airway inflammation in asthma. Endotypic classification of asthma patients regarding the allergic and eosinophilic characteristics is conducive to the effective management of patients with asthma.

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