Original manuscript by Wu et al.: The relationship between glucose homeostasis status and prostate size in aging Chinese males with benign prostatic hyperplasia

2021 ◽  
Author(s):  
Yuan-Ping Xu ◽  
Peng Zhang
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Glucose Homeostasis ◽  
Prostatic Hyperplasia ◽  
Original Manuscript ◽  
Prostate Size ◽  
The Relationship

scholarly journals The relationship between glucose homeostasis status and prostate size in aging Chinese males with benign prostatic hyperplasia

2020 ◽  
Vol 38 (11) ◽  
pp. 2923-2931
Author(s):  
Y. Wu ◽  
Y. Ding ◽  
Q. F. Cao ◽  
S. B. Qian ◽  
C. Wang ◽  
...  
Keyword(s):  
Growth Rate ◽  
Benign Prostatic Hyperplasia ◽  
Glucose Homeostasis ◽  
Transrectal Ultrasound ◽  
Transitional Zone ◽  
Prostatic Hyperplasia ◽  
Significant Difference ◽  
Prostate Size ◽  
Prostate Growth ◽  
The Relationship

Abstract Purpose Increasing evidence shows that many metabolic factors are involved in the progression of benign prostatic hyperplasia (BPH). We aimed to assess the relationship between the status of glucose homeostasis and prostate size in aging Chinese males undergoing transurethral resection of the prostate (TURP) for BPH. Methods A total of 1006 medical records of BPH patients undergoing TURP were reviewed. Prostate size was measured by transrectal ultrasound. Annual total prostate (TP) and transitional zone (TZ) growth rates were calculated. According to the American Diabetes Association criteria, the patients were categorized as normoglycemic, prediabetic, or diabetic. Levels of glucose homeostasis and other variables were considered independent variables in an effort to evaluate any potential correlations using non-adjusted and multivariate-adjusted regression models. Results A total of 659 individuals were included in the study. BPH patients < 70 years old and ≥ 70 years old in the normoglycemic group had a stable prostate growth rate. The change in prostate size in those younger than 70 years, however, was faster in the prediabetic and diabetic group. Further analysis revealed that abnormal glucose homeostasis was positively correlated with prostate size. In those younger than 70 years, compared with the normal glucose group, the adjusted odds ratio (OR) for TP and TZ enlargement in the prediabetic group was 2.27 (95%CI 1.29–4.00) and 3.19 (95%CI 1.78–5.72), respectively, and the adjusted ORs were 4.74 (95%CI 2.18–10.30) and 6.16 (95%CI 2.70–14.06), respectively, for men with diabetes. However there was no significant difference among men aged ≥ 70 years. Conclusions Among patients undergoing TURP, the prostate volume and growth rate were affected by different status of glucose homeostasis. Hyperglycemia may play an important role in prostate growth.

scholarly journals The Relationship between Eicosanoid Levels and Serum Levels of Metabolic and Hormonal Parameters Depending on the Presence of Metabolic Syndrome in Patients with Benign Prostatic Hyperplasia

2019 ◽  
Vol 16 (6) ◽  
pp. 1006
Author(s):  
Katarzyna Grzesiak ◽  
Aleksandra Rył ◽  
Ewa Stachowska ◽  
Marcin Słojewski ◽  
Iwona Rotter ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Benign Prostatic Hyperplasia ◽  
Free Testosterone ◽  
Serum Levels ◽  
Prostatic Hyperplasia ◽  
Lipid Mediators ◽  
Total Testosterone ◽  
Blood Samples ◽  
Mediators Of Inflammation ◽  
The Relationship

Background: The purpose of our investigation was to analyze the relationship between the serum levels of inflammatory mediators (HETE, HODE) and the levels of selected metabolic and hormonal parameters in patients with benign prostatic hyperplasia (BPH) with regard to concomitant metabolic syndrome (MetS). Methods: The study involved 151 men with BPH. Blood samples were taken for laboratory analysis of the serum levels of metabolic and hormonal parameters. Gas chromatography was performed using an Agilent Technologies 7890A GC System. Results: We found that waist circumference was the only parameter related to the levels of fatty acids, namely: 13(S)-HODE, 9(S)-HODE, 15(S)-HETE, 12(S)-HETE, and 5-HETE. In the patients with BPH and MetS, triglycerides correlated with 9(S)-HODE, 15(S)-HETE, 12(S)-HETE, and 5-HETE, which was not observed in the patients without MetS. Similarly, total cholesterol correlated with 9(S)-HODE, and 15(S)-HETE in the patients with BPH and MetS, but not in those without MetS. In the group of BPH patients with MetS, total testosterone positively correlated with 13(S)-HODE, and free testosterone with 9(S)-HODE. Conclusions: Based on this study, it can be concluded that lipid mediators of inflammation can influence the levels of biochemical and hormonal parameters, depending on the presence of MetS in BPH patients.

Over expression of PI3K-AkT reduces apoptosis and increases prostate size in benign prostatic hyperplasia

2018 ◽  
pp. 1-7 ◽  
Author(s):  
Karli Sreenivasulu ◽  
Hanumanthappa Nandeesha ◽  
Lalgudi Narayanan Dorairajan ◽  
Rajesh Nachiappa Ganesh
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Prostatic Hyperplasia ◽  
Over Expression ◽  
Prostate Size
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