The effect of high-fat–high-fructose diet on skeletal muscle mitochondrial energetics in adult rats

2014 ◽  
Vol 54 (2) ◽  
pp. 183-192 ◽  
Author(s):  
Raffaella Crescenzo ◽  
Francesca Bianco ◽  
Paola Coppola ◽  
Arianna Mazzoli ◽  
Luisa Cigliano ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
High Fat ◽  
Adult Rats ◽  
High Fructose Diet ◽  
High Fructose

scholarly journals Estrogen and voluntary exercise attenuate cardiometabolic syndrome and hepatic steatosis in ovariectomized rats fed a high-fat high-fructose diet

2019 ◽  
Vol 316 (5) ◽  
pp. E908-E921 ◽  
Author(s):  
Jariya Buniam ◽  
Natsasi Chukijrungroat ◽  
Tanaporn Khamphaya ◽  
Jittima Weerachayaphorn ◽  
Vitoon Saengsirisuwan
Keyword(s):  
Skeletal Muscle ◽  
Fatty Acid ◽  
Glucose Transport ◽  
Ldl Cholesterol ◽  
Density Lipoprotein ◽  
High Fat ◽  
High Fructose Diet ◽  
High Fructose ◽  
Hepatic Fat ◽  
Muscle Glucose Transport

The prevalence of cardiometabolic syndrome (CMS) is increased in women after menopause. While hormone replacement therapy has been prescribed to relieve several components of CMS in postmenopausal women, some aspects of cardiometabolic dysfunction cannot be completely restored. The present study examined the effectiveness of estrogen replacement alone and in combination with exercise by voluntary wheel running (VWR) for alleviating the risks of CMS, insulin-mediated skeletal muscle glucose transport, and hepatic fat accumulation in ovariectomized Sprague-Dawley rats fed a high-fat high-fructose diet (OHFFD). We compared a sham-operated group with OHFFD rats that were subdivided into a sedentary, estradiol replacement (E2), and E2 plus VWR for 12 wk. E2 prevented the development of insulin resistance in skeletal muscle glucose transport and decreased hepatic fat accumulation in OHFFD rats. Furthermore, E2 treatment decreased visceral fat mass and low-density lipoprotein (LDL)-cholesterol in OHFFD rats, while VWR further decreased LDL-cholesterol and increased the ratio of high-density lipoprotein-cholesterol to total cholesterol to a greater extent. Although E2 treatment alone did not reduce serum triglyceride levels in OHFFD rats, the combined intervention of E2 and VWR lowered serum triglycerides in E2-treated OHFFD rats. The addition of VWR to E2-treated OHFFD rats led to AMPK activation and upregulation of peroxisome proliferator-activated receptor-γ (PPARγ) coactivator-1α and PPARδ in skeletal muscle along with increased fatty acid oxidation and suppressed fatty acid synthesis in the liver. Collectively, our findings indicate that, to achieve greater health benefits, physical exercise is required for E2-treated individuals under ovarian hormone deprivation with high-energy consumption.

scholarly journals Differential effects of a High‐Fructose diet or a High‐Fat/High‐Sucrose diet on the mitochondrial ROS production and respiration in rat liver and skeletal muscle

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Karine Couturier ◽  
Marie Le Guen ◽  
Charles Coudray ◽  
Christine Feillet-Coudray ◽  
Chantal Wrutniak-Cabello ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Rat Liver ◽  
Ros Production ◽  
High Fat ◽  
High Fructose Diet ◽  
Mitochondrial Ros ◽  
High Fructose ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
High Sucrose

Effect of Administration of Carnitine, Resveratrol, and Aromatic Amino Acids with High-Fat-High-Fructose Diet on Gene Expression in Liver of Rats: Full Transcriptome Analysis

2021 ◽  
Vol 57 (10) ◽  
pp. 1149-1163
Author(s):  
N. V. Trusov ◽  
S. A. Apryatin ◽  
V. A. Shipelin ◽  
A. A. Shumakova ◽  
I. V. Gmoshinski ◽  
...  
Keyword(s):  
Gene Expression ◽  
Amino Acids ◽  
Transcriptome Analysis ◽  
Aromatic Amino Acids ◽  
High Fat ◽  
High Fructose Diet ◽  
High Fructose

Kombuchas from green and black teas reduce oxidative stress, liver steatosis and inflammation, and improve glucose metabolism in Wistar rats fed a high-fat high-fructose diet

2021 ◽  
Author(s):  
Rodrigo Cardoso ◽  
Luiza Dias Moreira ◽  
Mirian Costa ◽  
Renata Celi Lopes Toledo ◽  
Mariana Grancieri ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Metabolism ◽  
Glucose Metabolism ◽  
Wistar Rats ◽  
Liver Steatosis ◽  
Black Tea ◽  
High Fat ◽  
High Fructose Diet ◽  
High Fructose ◽  
Green And Black Tea

The aim of this study was to evaluate the effect of green and black tea kombuchas consumption on adiposity, lipid metabolism, liver steatosis, oxidative stress, and inflammation in Wistar rats...

Ezetimibe prevents hepatic steatosis induced by a high-fat but not a high-fructose diet

2013 ◽  
Vol 305 (2) ◽  
pp. E293-E304 ◽  
Author(s):  
Masateru Ushio ◽  
Yoshihiko Nishio ◽  
Osamu Sekine ◽  
Yoshio Nagai ◽  
Yasuhiro Maeno ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Liver Disease ◽  
Hepatic Steatosis ◽  
High Fat Diet ◽  
Fatty Acid Synthase ◽  
Binding Protein ◽  
High Fat ◽  
High Fructose Diet ◽  
High Fructose ◽  
Element Binding Protein

Nonalcoholic fatty liver disease is the most frequent liver disease. Ezetimibe, an inhibitor of intestinal cholesterol absorption, has been reported to ameliorate hepatic steatosis in human and animal models. To explore how ezetimibe reduces hepatic steatosis, we investigated the effects of ezetimibe on the expression of lipogenic enzymes and intestinal lipid metabolism in mice fed a high-fat or a high-fructose diet. CBA/JN mice were fed a high-fat diet or a high-fructose diet for 8 wk with or without ezetimibe. High-fat diet induced hepatic steatosis accompanied by hyperinsulinemia. Treatment with ezetimibe reduced hepatic steatosis, insulin levels, and glucose production from pyruvate in mice fed the high-fat diet, suggesting a reduction of insulin resistance in the liver. In the intestinal analysis, ezetimibe reduced the expression of fatty acid transfer protein-4 and apoB-48 in mice fed the high-fat diet. However, treatment with ezetimibe did not prevent hepatic steatosis, hyperinsulinemia, and intestinal apoB-48 expression in mice fed the high-fructose diet. Ezetimibe decreased liver X receptor-α binding to the sterol regulatory element-binding protein-1c promoter but not expression of carbohydrate response element-binding protein and fatty acid synthase in mice fed the high-fructose diet, suggesting that ezetimibe did not reduce hepatic lipogenesis induced by the high-fructose diet. Elevation of hepatic and intestinal lipogenesis in mice fed a high-fructose diet may partly explain the differences in the effect of ezetimibe.

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