The effects of low-intensity pulsed ultrasound and pulsed electromagnetic fields bone growth stimulation in acute fractures: a systematic review and meta-analysis of randomized controlled trials

2014 ◽  
Vol 134 (8) ◽  
pp. 1093-1106 ◽  
Author(s):  
P. F. W. Hannemann ◽  
E. H. H. Mommers ◽  
J. P. M. Schots ◽  
P. R. G. Brink ◽  
M. Poeze
Keyword(s):  
Bone Growth ◽  
Meta Analysis ◽  
Growth Stimulation ◽  
Controlled Trials ◽  
Pulsed Electromagnetic Fields ◽  
Pulsed Ultrasound ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity ◽  
Randomized Controlled ◽  
Pulsed Electromagnetic

scholarly journals Bone Growth Stimulators for Treatment of Adults with Bone Disease or Injury

2021 ◽  
Vol 1 (10) ◽  
Author(s):  
Khai Tran ◽  
Jennifer Horton
Keyword(s):  
Electrical Stimulation ◽  
Bone Growth ◽  
Mouth Opening ◽  
Cost Effective ◽  
Growth Stimulation ◽  
Fusion Rate ◽  
Pulsed Ultrasound ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity ◽  
Assessment Outcomes

Electrical stimulation and low intensity pulsed ultrasound technologies for bone healing may have some beneficial effects on radiographic assessment outcomes (e.g., spinal fusion rate, radiographic nonunion rates, number of days to radiographic healing) and clinical assessment outcomes (e.g., mouth opening, wrist and shoulder mobility, exteroceptive sensation, and wound healing), but may not improve outcomes that are important to patients (e.g., functional recovery). Pain may be reduced by electrical bone growth stimulation devices, but not by low intensity pulsed ultrasound. No adverse events (AEs) related to the low intensity pulsed ultrasound device were reported. It is unknown if there are AEs related to electrical stimulation devices (no evidence found). Low intensity pulsed ultrasound for treatment of fresh tibial fractures was not cost-effective compared with placebo from either a payer perspective or societal perspective within the Canadian context. It is unknown if electrical bone growth stimulator devices are cost-effective (no evidence found).

Low-Intensity Pulsed Ultrasound Therapy: A Nonsurgical Treatment Modality for Mandible Fracture Nonunion?

2021 ◽  
Author(s):  
Adam R. Abel ◽  
Gwendolyn S. Reeve
Keyword(s):  
Treatment Modality ◽  
Controlled Trials ◽  
Ultrasound Therapy ◽  
Pulsed Ultrasound ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity ◽  
Mandible Fracture ◽  
Randomized Controlled ◽  
Fracture Nonunion ◽  
Fracture Nonunions

AbstractStandard treatment of mandibular nonunion includes debridement and application of maxillomandibular or rigid internal fixation techniques, with adjunctive bone grafting when necessary. Frequently described in the orthopaedic literature, low-intensity pulsed ultrasound therapy (LIPUS) is a noninvasive treatment modality used to accelerate healing of fresh fractures and established nonunions. The purpose of this study was to conduct a systematic review to determine the extent of LIPUS study in the treatment of mandibular nonunions to identify whether LIPUS represents an effective nonsurgical alternative or adjunct for nonunion management. A literature review was conducted to investigate published reports on the utilization of LIPUS in treating mandible fracture nonunions. The search yielded two randomized controlled trials demonstrating favorable healing parameters in fresh human mandible fractures treated with LIPUS, two randomized controlled trials demonstrating osteogenic differentiation in human mandibular fracture cellular components, and one study reporting improved healing at rabbit mandibular osteotomy sites. No articles published reports studying LIPUS in facial fracture nonunion were identified. This report reviews published literature on mandibular nonunions, and the evidence of LIPUS use in long bone nonunions. There are no known studies presenting LIPUS treatment of mandible fracture nonunions. However, on the basis of published orthopaedic data, LIPUS therapy could be considered as an adjunct or alternative to traditional surgical management of select mandible fracture nonunions.

scholarly journals Meta-analysis of randomized controlled trials that assess the efficacy of low-intensity shockwave therapy for the treatment of erectile dysfunction

2019 ◽  
Vol 11 ◽  
pp. 175628721983836 ◽  
Author(s):  
Jeffrey D. Campbell ◽  
Bruce J. Trock ◽  
Adam R. Oppenheim ◽  
Ifeanyichukwu Anusionwu ◽  
Ronak A. Gor ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Treatment Group ◽  
Sham Group ◽  
Meta Analysis ◽  
Group Versus ◽  
Post Treatment ◽  
Controlled Trials ◽  
Low Intensity ◽  
Randomized Controlled ◽  
The Mean

Background: The aim of this study was to perform a meta-analysis of randomized controlled trials (RCTs) that evaluate the efficacy of low-intensity extracorporeal shock wave therapy (LiESWT) for the treatment of erectile dysfunction (ED). Materials and methods: A comprehensive search of PubMed, Medline, and Cochrane databases was performed from November 2005 to July 2018. RCTs evaluating efficacy of LiESWT in the treatment of ED were selected. The primary outcomes were the mean difference between treatment and sham patients in the International Index of Erectile Function-Erectile Function (IIEF-EF) domain score 1 month after treatment, and the mean change in IIEF-EF from baseline to 1 month post-treatment. The secondary analysis considered the percentage of men whose erectile hardness score (EHS) changed from <2 at baseline to >3 after treatment. All analyses used a random effects method to pool study-specific results. Results: A total of seven RCTs provided data for 607 patients. The mean IIEF-EF 1 month post-treatment ranged from 12.8 to 22.0 in the treatment group versus 8.17–16.43 in the sham group. The mean difference between the treatment and sham groups at the 1 month follow up was a statistically significant increase in IIEF-EF of 4.23 ( p = 0.012). Overall, five of the seven trials provided data on the proportion of patients with baseline EHS <2 who improved to EHS >3 at 1 month post-treatment. The proportions ranged from 3.5 to 90% in the treatment group versus 0–9% in the sham group and the pooled relative risk of EHS improvement for the treated versus sham group was 6.63 ( p = 0.0095). No significant adverse events were reported. Conclusions: This is the first meta-analysis that evaluates RCTs exploring LiESWT as a treatment modality strictly for ED. This therapeutic strategy appears to be well tolerated with short-term benefits. However further studies exploring specific treatment regimens and long-term outcomes are needed.

scholarly journals Effects of low intensity pulsed ultrasound to reduce the effusion volumes and pain with knee osteoarthritis: a randomized controlled trial

2018 ◽  
Vol 5 (1) ◽  
pp. 77
Author(s):  
P. Shanmuga Raju ◽  
Chokkarapu Ramu ◽  
N. S. Harshavardhan ◽  
K. Rajender ◽  
G. Sachin
Keyword(s):  
Randomized Controlled Trial ◽  
Knee Osteoarthritis ◽  
Controlled Trial ◽  
Control Group ◽  
Ultrasound Therapy ◽  
Pulsed Ultrasound ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity ◽  
Randomized Controlled ◽  
And Control

<p class="abstract"><strong>Background:</strong> The study aim was to determine the effect of low intensity pulsed ultrasound therapy to reduce the effusion volumes and pain in patients with Knee OA.</p><p class="abstract"><strong>Methods:</strong> This study design was randomized controlled trial. Total 50 patients diagnosed with Knee osteoarthritis were randomly assigned to two groups. Group I was using treatment of low intensity pulsed ultrasound therapy and group II was administered TENS with home exercise respectively. Treatments were 6 days per week and duration of 2 week. The amount of effusion volume will be measured via ultrasonograpy in knee.<strong></strong></p><p class="abstract"><strong>Results:</strong> The<strong> </strong>maximum number of cases are lying in age group &gt;60 years which is 28% and 40% in cases and control group respectively and age distribution in both the group is statistically not significant. The mean age of patients in cases and control group is 57.08±7.40 years and 58.04±9.93 years respectively.</p><p class="abstract"><strong>Conclusions:</strong> Low intensity pulsed ultrasound therapy significantly reduced the effusion volumes and pain in patients with knee osteoarthritis.</p>

scholarly journals Low-Intensity Pulsed Ultrasound for Nonoperative Treatment of Scaphoid Nonunions: A Meta-Analysis

Hand ◽  
2017 ◽  
Vol 13 (3) ◽  
pp. 275-280 ◽  
Author(s):  
Edward W. Seger ◽  
Julio J. Jauregui ◽  
Steven A. Horton ◽  
Gerardo Davalos ◽  
Erika Kuehn ◽  
...  
Keyword(s):  
Surgical Intervention ◽  
Meta Analysis ◽  
Relevant Literature ◽  
Nonoperative Treatment ◽  
Scaphoid Nonunion ◽  
Pulsed Ultrasound ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity ◽  
Scaphoid Fractures ◽  
Fracture Nonunion

Background: Scaphoid fractures progress to nonunion rates of up to 15% when non-displaced, and are even more frequent when the fracture is displaced. Standard treatment in these cases is surgery; however, individuals unable to undergo this operation, or for those who wish to try more conservative measures, there may be benefit from nonoperative options. Of these, low-intensity pulsed ultrasound (LIPUS) has been shown to improve fracture nonunion healing. The purpose of this study was to perform a comprehensive meta-analysis of relevant literature to determine success of the use of LIPUS for treatment of scaphoid nonunion. Methods: Utilizing PubMed, Embase, and Ovid databases, we performed a literature search using key terms for scaphoid nonunions. A total of 686 studies met initial search criteria. Studies reporting fewer than 5 cases, those not published in English, those not related to LIPUS nonoperative scaphoid nonunion treatment, and those without sufficient data were excluded. Five studies met these criteria, and statistical analysis was performed to determine overall union rates. Results: The use of LIPUS on 166 nonunions reported a mean healing index of 78.6%. The average time to union following LIPUS treatment was 4.2 months. Conclusions: While surgical intervention is still the standard, our results show that LIPUS may serve as a nonoperative alternative to scaphoid nonunion in certain cases. The results are encouraging in which these challenging fracture a nonunions can heal without further surgical intervention in the majority of patients.

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