Nuclear receptor corepressor (NCoR) is a positive prognosticator for cervical cancer

Abstract Purpose Enzymes with epigenetic functions play an essential part in development of cancer. However, the significance of epigenetic changes in cervical carcinoma as a prognostic factor has not been fully investigated. Nuclear receptor corepressor (NCoR) presents itself as a potentially important element for epigenetic modification and as a potential prognostic aspect in cervical cancer. Methods By immunohistochemical staining of 250 tumor samples, the expression strength of NCoR was measured and evaluated by immunoreactive score (IRS) in the nucleus and cytoplasm. Results A low expression of NCoR in our patients was a disadvantage in overall survival. Expression of NCoR was negatively correlated with viral oncoprotein E6, acetylated histone H3 acetyl K9 and FIGO status, and positively correlated to p53. Conclusions Our study has identified epigenetic modification of tumor cells thus seems to be of relevance in cervical cancer as well for diagnosis, as a marker or as a potential therapeutic target in patients with advanced cervical carcinoma.

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Concurrent chemoradiation in treatment of carcinoma cervix

Nepal Journal of Obstetrics and Gynaecology ◽

10.3126/njog.v2i1.1467 ◽

1970 ◽

Vol 2 (1) ◽

pp. 4-8

Author(s):

Meeta Singh ◽

Rajshree Jha ◽

Josie Baral ◽

Suniti Rawal

Keyword(s):

Cervical Cancer ◽

Radiation Therapy ◽

Cervical Carcinoma ◽

Locally Advanced ◽

Concurrent Chemoradiation ◽

Advanced Cervical Cancer ◽

European Organization ◽

Locally Advanced Cervical Cancer ◽

Advanced Cervical Carcinoma ◽

To Come

Aim: to compare if concurrent chemoradiation is better than radiotherapy given alone in the treatment of women with locally advanced cervical cancer from published literature Method: Study Design: Randomized control trials of > than 2, 403 women participants who underwent treatment for advanced cervical carcinoma mainly in two huge center i.e. from National Cancer Institute (NCI), USA and European Organization for Research and Treatment of Cancer (EORTC) were reviewed regarding the treatment they received at the center: concurrent chemoradiation/ radiation therapy alone. The results were analyzed to come to conclusion. Result demonstrated a 30-50% improvement in survival when cisplatin-based chemotherapy in NCI or 5 fluorouracil and cisplatin based chemotherapy was used in EORTC was administered with concurrent radiation therapy (chemoradiation) Conclusions: The addition of chemotherapy (cisplatin) in NCI and (cisplatin and fluorouracil) in the EORTC for the treatment of locally advanced cervical cancer with the concurrent chemoradition have elicited better survival than those treated with radiotherapy alone dittoed by several other trials which can be anticipated to benefit Nepalese women with locally advanced cervical carcinoma. Key-words: Cancer cervix, chemoradiation, radiotherapy doi:10.3126/njog.v2i1.1467 N. J. Obstet. Gynaecol Vol. 2, No. 1, p. 4 - 8 May -June 2007

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Prevalence of Para-Aortic Lymphadenopathy in Locally Advanced Cervical Cancer using Computed Tomography: A Retrospective Study

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2020/44649.14122 ◽

2020 ◽

Author(s):

Garba Haruna Yunusa ◽

Usman Malami Aliyu

Keyword(s):

Cervical Cancer ◽

Retrospective Study ◽

Cell Carcinoma ◽

Cervical Carcinoma ◽

Clinical Stage ◽

Univariate Analysis ◽

Locally Advanced ◽

Figo Stage ◽

University Teaching ◽

Advanced Cervical Carcinoma

Introduction: Determination of status of Para-Aortic Lymph Node (PALN) in patients with cervical cancer is one of the most important factors guiding the treatment. It is essential in determining individualised therapy and prognosis. Aim: To assess the prevalence of para-aortic lymphadenopathy among patients with advanced cervical carcinoma referred for radiotherapy. Materials and Methods: A retrospective study of patients referred to Radiotherapy and Oncology Department of Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria was carried out. Patient demographics, history of co-morbid conditions, histology, stage at diagnosis, and Computed Tomographic (CT) scan findings of enlarged PALN greater or equal to 10 mm in short axis diameter were retrieved. Data was analysed using IBM SPSS statistics version 23. Results: A total of 220 patients, age range 27-84 years with mean age 49.95±11.96 years were studied. The histological diagnosis were squamous cell carcinoma in 182 (87.2%), adenocarcinoma in 22 (10%), clear cell carcinoma in 9 (4.1%) while 7 (3.2%) patients had other histological variants. Co-morbities found were chronic cervicitis and HIV in 27 (12.3%) and 19 (8.6%) of the patients, respectively. CT prevalence of PALN was 23 (10.5%). The prevalence of PALN according to International Federation of Gynaecology and Obstetrics (FIGO) stage were 4.3%, 17.4%, 34.8%, 30.4% and 13.0% in stages IIB, IIIA, IIIB, IVA and IVB, respectively. Clinical stage determined based on physical examination and imaging findings, was shown to be related to PALN by univariate analysis (χ2=29.162, p=0.0001). Conclusion: This study found a 10.5% prevalence of para-aortic lymphadenopathy and a significant relationship between clinical stage and PALN. This should be taken into consideration during treatment planning for patients with advanced cervical carcinoma.

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Multimodality Therapy for Locally Advanced Cervical Carcinoma: State of the Art and Future Directions

Journal of Clinical Oncology ◽

10.1200/jco.2007.10.8324 ◽

2007 ◽

Vol 25 (20) ◽

pp. 2952-2965 ◽

Cited By ~ 137

Author(s):

Bradley J. Monk ◽

Krishnansu S. Tewari ◽

Wui-Jin Koh

Keyword(s):

Cervical Cancer ◽

Cervical Carcinoma ◽

State Of The Art ◽

Locally Advanced ◽

Multimodality Therapy ◽

Advanced Cervical Cancer ◽

Future Directions ◽

Risk Of Death ◽

Locally Advanced Cervical Cancer ◽

Advanced Cervical Carcinoma

Globally, cervical cancer is the second most common cause of cancer-related mortality among women causing approximately 234,000 deaths annually among developing countries and killing 40,000 in developed nations. Most of these deaths occur in women with bulky or locally advanced cervical cancer, International Federation of Gynecology and Obstetrics (FIGO) stages IIB through IVA, when lesions are not amenable to high cure rates with surgery or radiation (RT). The standard prescription for RT used to treat locally advanced cervical cancer has been dictated by common practice and patterns of care studies. In contrast, the addition of concomitant chemotherapy to RT has been studied in a number of randomized prospective trials, which are discussed in detail. When added to RT, cisplatin reduces the relative risk of death from cervical carcinoma by approximately 50% by decreasing local/pelvic failure and distant metastases. In 1999, weekly intravenous cisplatin at 40 mg/m2 for 6 weeks in combination with RT was established as a new standard for the treatment of locally advanced cervical carcinoma. More recently, this recommendation has been expanded to include women with FIGO stage IB2 lesions as well as those with bulky stage IIA cancers. This monograph reviews the state of the art in treating locally advanced cervical cancer with combined chemotherapy and RT and discusses clinical and pathologic prognostic factors that impact cure. Quality of life during and after multimodality therapy is considered as well as ongoing clinical trials and future directions.

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IMPACT OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) AND HYPOXIA – INDUCTIBLE FACTOR-1ALPHA (HIF-1) EXPRESSION ON RESPONSE TO RADIO-CHEMOTHERAPY IN PATIENTS WITH LOCALLY ADVANCED CERVICAL CARCINOMA.

10.26226/morressier.597eedbdd462b80296ca0abb ◽

2017 ◽

Author(s):

Madani Julia

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Cervical Carcinoma ◽

Locally Advanced ◽

Vascular Endothelial ◽

Advanced Cervical Carcinoma ◽

Endothelial Growth Factor ◽

Radio Chemotherapy

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Faculty Opinions recommendation of Novel role of nuclear receptor Rev-erbα in hepatic stellate cell activation: potential therapeutic target for liver injury.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718266522.793492233 ◽

2014 ◽

Author(s):

Gianfranco Alpini ◽

Anastasia Renzi

Keyword(s):

Liver Injury ◽

Nuclear Receptor ◽

Hepatic Stellate Cell ◽

Therapeutic Target ◽

Cell Activation ◽

Stellate Cell ◽

Potential Therapeutic Target ◽

Hepatic Stellate Cell Activation ◽

Activation Potential

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BRD4 downregulation inhibits the viability of cervical cancer cells without affecting viral oncoprotein expression

Current Research in Virological Science ◽

10.1016/j.crviro.2021.100010 ◽

2021 ◽

pp. 100010

Author(s):

Veronica Canarte ◽

Karl Munger

Keyword(s):

Cervical Cancer ◽

Cancer Cells ◽

Viral Oncoprotein ◽

Cervical Cancer Cells

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HPV and Other Microbiota; Who’s Good and Who’s Bad: Effects of the Microbial Environment on the Development of Cervical Cancer—A Non-Systematic Review

Cells ◽

10.3390/cells10030714 ◽

2021 ◽

Vol 10 (3) ◽

pp. 714

Author(s):

Matthias Läsche ◽

Horst Urban ◽

Julia Gallwas ◽

Carsten Gründker

Keyword(s):

Systematic Review ◽

Cervical Cancer ◽

High Risk ◽

Cervical Carcinoma ◽

Hpv Infection ◽

Human Papillomaviruses ◽

Inflammatory Reactions ◽

Metabolic Signalling ◽

Microbial Environment ◽

High Risk Hpv

Cervical cancer is responsible for around 5% of all human cancers worldwide. It develops almost exclusively from an unsolved, persistent infection of the squamocolumnar transformation zone between the endo- and ecto-cervix with various high-risk (HR) human papillomaviruses (HPVs). The decisive turning point on the way to persistent HPV infection and malignant transformation is an immune system weakened by pathobionts and oxidative stress and an injury to the cervical mucosa, often caused by sexual activities. Through these injury and healing processes, HPV viruses, hijacking activated keratinocytes, move into the basal layers of the cervical epithelium and then continue their development towards the distal prickle cell layer (Stratum spinosum). The microbial microenvironment of the cervical tissue determines the tissue homeostasis and the integrity of the protective mucous layer through the maintenance of a healthy immune and metabolic signalling. Pathological microorganisms and the resulting dysbiosis disturb this signalling. Thus, pathological inflammatory reactions occur, which manifest the HPV infection. About 90% of all women contract an HPV infection in the course of their lives. In about 10% of cases, the virus persists and cervical intra-epithelial neoplasia (CIN) develops. Approximately 1% of women with a high-risk HPV infection incur a cervical carcinoma after 10 to 20 years. In this non-systematic review article, we summarise how the sexually and microbial mediated pathogenesis of the cervix proceeds through aberrant immune and metabolism signalling via CIN to cervical carcinoma. We show how both the virus and the cancer benefit from the same changes in the immune and metabolic environment.

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