Oral HPV prevalence in women positive for cervical HPV infection and their sexual partners: a German screening study

A high-risk population, formed by 79 consecutive male attendees of our sexually transmissible infections clinic, and who did not have any overt signs of human papillomavirus (HPV) infection, were examined. Oral HPV prevalence (37%) was much higher than previously reported. Periurethral HPV-DNA was found in 49% of the patients and anal HPV-DNA was found in 43% of the patients. Considering the high prevalence of oral HPV obtained in the current study, it is important to further investigate the burden of oral HPV, not only in men who have sex with men, but also in heterosexual men and in women.

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HPV Infection in a Cohort of HIV-Positive Men and Women: Prevalence of Oncogenic Genotypes and Predictors of Mucosal Damage at Genital and Oral Sites

Journal of Sexually Transmitted Diseases ◽

10.1155/2013/915169 ◽

2013 ◽

Vol 2013 ◽

pp. 1-8

Author(s):

Giulia Marchetti ◽

Laura Comi ◽

Teresa Bini ◽

Marco Rovati ◽

Francesca Bai ◽

...

Keyword(s):

Mucosal Damage ◽

Hpv Infection ◽

Cross Sectional Study ◽

Hiv Positive ◽

Low Grade ◽

Abnormal Cytology ◽

Cross Sectional ◽

Squamous Cells ◽

Hpv Prevalence ◽

Oral Hpv

The aim of this study was to assess the prevalence of HPV infection and determinants of abnormal cytology in HIV-positive patients. In a cross-sectional study, patients of both sexes, asymptomatic for HPV, underwent anorectal (men)/cervical (women) and oral swabs. Cytology and HPV-PCR detection/genotyping (high- and low-risk genotypes, HR-LR/HPV) were performed. A total of 20% of the 277 enrolled patients showed oral HPV, with no atypical cytology; in men, anal HPV prevalence was 81% with 64% HR genotypes. In women, cervical HPV prevalence was 58% with 37% HR-HPV. The most frequent genotypes were HPV-16 and HPV-18; 37% of men and 20% of women harbored multiple genotypes. Also, 47% of men showed anal squamous intraepithelial lesions (SILs); 6% had high- and 35% low-grade SILs (HSILs/LSILs); 5% had atypical squamous cells of undetermined significance (ASC-US). HR-HPV was independently associated with anal-SIL in men (P=0.039). Moreover, 37% of women showed cervical SIL: 14 ASC-US, 15 LSILs, 4 HSILs, and 1 in situ cancer. The presence of both LR and HR-HPV in women was independently associated with SIL (P=0.003 and P=0.0001). HR-HPV and atypical cytology were frequently identified in our cohort. HPV screening should be mandatory in HIV-infected subjects, and vaccine programs for HPV-negative patients should be implemented.

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Differences in Factors Associated With High- and Low-Risk Oral Human Papillomavirus Genotypes in Men

The Journal of Infectious Diseases ◽

10.1093/infdis/jiaa693 ◽

2020 ◽

Author(s):

Deepti Bettampadi ◽

Brittney Dickey ◽

Martha Abrahamsen ◽

Bradley Sirak ◽

Maria Luiza Baggio ◽

...

Keyword(s):

Human Papillomavirus ◽

High Risk ◽

Sexual Behaviors ◽

Hpv Infection ◽

Low Risk ◽

Factors Associated ◽

Hpv Prevalence ◽

Oral Hpv ◽

Multivariable Models ◽

High Risk Hpv

Abstract Background Human papillomavirus (HPV) causes oral warts and oropharyngeal cancer (OPC). Human papillomavirus-attributable OPC incidence among men is significantly increasing worldwide, yet few studies have reported oral HPV across multiple countries or examined factors associated with low- and high-risk HPV separately. Methods Oral gargles from 3095 men in the multinational HPV Infection in Men (HIM) Study were HPV genotyped. Multivariable models assessed factors independently associated with high-risk and low-risk HPV prevalence. Results The prevalence of high-risk and low-risk HPV was 6.0% and 2.8%, respectively. Greater number of sexual partners was only associated with high-risk HPV (1.88; 95% confidence interval [CI], 1.22–2.90) prevalence. In multivariable models, residing in Mexico (1.66; 95% CI, 1.15–2.40) and smoking (1.66; 95% CI, 1.13–2.44) were significantly associated with high-risk HPV, and history of consistent gum bleeding (2.16; 95% CI, 1.35–3.45) was significantly associated with low-risk HPV. Gender of the sexual partner did not alter the results for either high- or low-risk HPV endpoints. Conclusions Different factors were independently associated with high- and low-risk oral HPV. Oral sexual behaviors were associated with high-risk HPV, and oral health was associated with low-risk HPV. High-risk HPV prevalence differed by country of residence, highlighting the need for additional studies in multiple countries.

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Prevalence of oral HPV infection in cervical HPV positive women and their sexual partners

Archives of Gynecology and Obstetrics ◽

10.1007/s00404-019-05135-7 ◽

2019 ◽

Vol 299 (6) ◽

pp. 1659-1665 ◽

Cited By ~ 4

Author(s):

T. K. Eggersmann ◽

K. Sharaf ◽

P. Baumeister ◽

C. Thaler ◽

C. J. Dannecker ◽

...

Keyword(s):

Hpv Infection ◽

Sexual Partners ◽

Oral Hpv

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1100National prevalence of oral HPV infection in vaccinated and unvaccinated young adults in Brazil

International Journal of Epidemiology ◽

10.1093/ije/dyab168.707 ◽

2021 ◽

Vol 50 (Supplement_1) ◽

Author(s):

Natália Luiza Kops ◽

Juliana Comerlato ◽

Isabel Bandeira ◽

Marina Bessel ◽

Ana Goretti Kalume Maranhão ◽

...

Keyword(s):

Hpv Vaccination ◽

Hpv Infection ◽

Quadrivalent Vaccine ◽

Sampling Weights ◽

Cross Sectional ◽

Hpv Prevalence ◽

Significant Difference ◽

Oral Hpv ◽

Hpv Types ◽

Putative Precursor

Abstract Background Prophylactic HPV vaccination has been recommended for the prevention of cancers caused by HPV infection. Nevertheless, may be reduce the oral HPV prevalence, the putative precursor to oral squamous cell carcinoma. This study aimed to report the prevalence of oral HPV among vaccinated and unvaccinated women and men aged 16 to 25 years who use the public health system. Methods POP-Brazil study is a cross-sectional, multicentric survey. Participants were recruited from 119 public primary care units distributed throughout all 27 capitals of Brazil. Trained health professionals applied a face-to-face interview. Oral sample was collected through mouthwash and gargle cycles. HPV genotyping was performed in a central lab using the Roche PCR-based Linear Array genotyping test. Sampling weights by sex and age were applied to the data. Results Oral HPV samples were collected from 5,684 participants; 613 (8.93%) vaccinated against HPV, in which 86.57% were women. Among women, the overall HPV prevalence was significantly lower in those vaccinated [0.43% (95% CI, 0.03-0.83)] than unvaccinated [1.65% (95% CI, 0.97– 2.33] (p < 0.01). Among men, no significant difference was found. All vaccinated individuals were negative to the HPV types present in the quadrivalent vaccine (6, 11, 16, and 18). Conclusion Vaccinated individuals had a lower prevalence of overall oral HPV besides the null infection by 6, 11, 16, and 18 HPV types showing another benefit of this cancer prevention measure. Due to the low prevalence of oral HPV, type specific analysis demand higher number of positive participants.

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Factors associated with persistence and clearance of high-risk oral HPV among participants in the HPV Infection in Men (HIM) study

Clinical Infectious Diseases ◽

10.1093/cid/ciaa1701 ◽

2020 ◽

Author(s):

Deepti Bettampadi ◽

Bradley A Sirak ◽

Martha E Abrahamsen ◽

Richard R Reich ◽

Luisa L Villa ◽

...

Keyword(s):

High Risk ◽

Hpv Infection ◽

Sexual Partners ◽

Factors Associated ◽

Kaplan Meier ◽

Lifetime Number ◽

Number Of Sexual Partners ◽

Hpv Clearance ◽

Oral Hpv ◽

High Risk Hpv

Abstract Background HPV attributable oropharyngeal cancer (HPV-OPC) incidence is increasing in many high-income countries among men. Factors associated with oral HPV persistence, the precursor of HPV-OPC, is unknown. Data from the HPV Infection in Men (HIM) study which followed participants >7 years were utilized to examine rates of persistence and associated factors. Methods Oral gargle samples from 3095 HIM study participants were HPV genotyped using SPF10 PCR-DEIA-LiPA25 assay. Oral HPV persistence for individual and grouped high-risk HPV types among 184 men positive for any high-risk HPV at their oral baseline visit was assessed at 6-month intervals. Factors associated with grouped high-risk HPV and HPV16 persistence were examined using logistic regression. Kaplan-Meier curves were constructed to examine median time to HPV clearance overall, and by selected risk factors. Results Among the 7 HPV vaccine types, HPV33 had the longest median duration (7.6 months) followed by HPV16 and HPV45 (6.4 months). 10-30% of oral high-risk HPV infections persisted >24 months. Six months persistence of oral high-risk HPV infections was positively associated with age and gingivitis and negatively associated with lifetime number of sexual partners, while twelve months persistence was only inversely associated with lifetime number of sexual partners. Oral HPV16 persistence was positively associated with baseline HPV16 L1 antibody status. Conclusions 18% of HPV16 infections persisted beyond 24 months potentially conferring higher risk of HPV-OPC among these men. Older age appears to be an important and consistently reported factor associated with oral high-risk HPV persistence. More studies among healthy men are required to understand the progression of oral HPV infection to HPV-OPC.

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Incidence and clearance of oral and cervicogenital HPV infection: longitudinal analysis of the MHOC cohort study

BMJ Open ◽

10.1136/bmjopen-2021-056502 ◽

2022 ◽

Vol 12 (1) ◽

pp. e056502

Author(s):

Andrew F Brouwer ◽

Lora P Campredon ◽

Heather M Walline ◽

Brittany M Marinelli ◽

Christine M Goudsmit ◽

...

Keyword(s):

Hpv Vaccination ◽

Hpv Infection ◽

Sexual Partners ◽

Infection Prevalence ◽

College Age ◽

Adult Participants ◽

Ann Arbor ◽

Oral Hpv ◽

The Mean ◽

Mean Time

ObjectivesThe Michigan HPV and Oropharyngeal Cancer study aimed to evaluate patterns of oral and cervicogenital human papillomavirus (HPV) infection prevalence, incidence, and clearance as well as their relationship to sexual behaviours.DesignCohortSettingGeneral public in and around Ann Arbor, Michigan.Participants394 college-age and older-adult participants of both sexes provided oral samples, and 325 completed at least 2 visits. 130 who provided a cervicogenital samples, and 127 completed at least 2 visits.OutcomesIncidence and clearance rates as well as HRs for oral and cervicogenital HPV.ResultsOral HPV infections were transient, with only 16% of genotypes persisting to the next visit. The mean time to clearance of a genotype was 46 days (95% CI 37 to 58). In contrast, cervicogenital infections were more persistent, with 56% of genotypes persisting to the next visit. The mean time to clearance of a genotype was 87 days (95% CI 74 to 102). HPV vaccination was associated with reduced incidence of cervicogenital HPV infection (HR 0.63; 95% CI 0.47 to 0.83) but not oral HPV infection. Incidence of oral HPV infection was associated with 2+ recent deep kissing partners (HR 2.00; 95% CI 1.13 to 3.56). Incidence of both oral (HR: 1.70; 95% CI 1.08 to 2.68) and cervicogenital (HR 2.46; 95% CI 1.69 to 3.59) was associated with 2+ recent sexual partners.ConclusionsDetection of oral HPV was highly transient, but incidence was associated with recent deep kissing and sexual partners. Detection of cervicogenital HPV was more persistent, and incidence was positively associated with recent sexual partners and negatively associated with HPV vaccination.

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Oral HPV prevalence assessment by Linear Array vs. SPF10 PCR-DEIA-LiPA25 system in the HPV Infection in Men (HIM) study

Papillomavirus Research ◽

10.1016/j.pvr.2020.100199 ◽

2020 ◽

Vol 9 ◽

pp. 100199

Author(s):

Deepti Bettampadi ◽

Bradley A. Sirak ◽

William J. Fulp ◽

Martha Abrahamsen ◽

Luisa L. Villa ◽

...

Keyword(s):

Linear Array ◽

Hpv Infection ◽

Hpv Prevalence ◽

Oral Hpv

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Prevalence and determinants of oral and cervicogenital HPV infection: baseline analysis of the MHOC cohort study

10.1101/2022.01.15.22269344 ◽

2022 ◽

Author(s):

Andrew Brouwer ◽

Lora P Campredon ◽

Heather M Walline ◽

Brittany M Marinelli ◽

Christine M Goudsmit ◽

...

Keyword(s):

Older Adult ◽

Sexual Behaviors ◽

Hpv Infection ◽

Infection Prevalence ◽

Full Cohort ◽

College Age ◽

Hpv Prevalence ◽

Adult Participants ◽

Ann Arbor ◽

Oral Hpv

We determined baseline oral and cervicogenital human papillomavirus (HPV) prevalence and determinants of infection in the Michigan HPV and Oropharyngeal Cancer (MHOC) study. We enrolled 394 college-age and older-adult participants of both sexes in Ann Arbor, Michigan and the surrounding area. All participants provided an oral sample at baseline, and 130 females provided a cervicogenital sample. Samples were tested for 18 HPV genotypes using polymerase chain reaction (PCR) MassArray. Participants filled out sociodemographic and behavioral questionnaires. Prevalence ratios for HPV oral or cervicogenital prevalence by predictor variables were estimated in univariable log-binomial models. Analysis was conducted 2018-20. In the full cohort, baseline oral HPV prevalence was 10.0% for any detected genotype (among the 338 valid oral tests at baseline) and 6.5% for high-risk types, and cervicogenital prevalence was 20.0% and 10.8%, respectively (among the 130 first valid cervicogenital tests). Oral HPV prevalence did not vary by sex, with 10.5% of women and 9.0% of men having an infection. We found a high prevalence of oral and cervicogenital HPV infection among those reporting no recent sexual partners compared to those with a single recent sexual partner, but prevalence increased with the number of recent partners for most sexual behaviors. We observed an ecological fallacy masking the direction of impact of vaccination on HPV prevalence in the full cohort compared to the college-aged and older-adult populations considered separately. Substance use was not significantly associated with oral or cervicogenital HPV infection. Many studies report substantially higher oral HPV infection prevalence in men than in women. That difference may not be uniform across populations in the US.

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