HPV prevalence among healthy Italian male sexual partners of women with cervical HPV infection

Human papillomavirus (HPV) infection in males is associated with various cancers, including cervical cancer in women and penile and bladder cancers in men. However, there is limited research on the prevalence and prevention of male HPV infection. Moreover, a rapid test that can prevent the increase in HPV infection is needed. In this study, the prevalence of sexually transmitted pathogen (STP) and HPV infection was analyzed using real-time polymerase chain reaction assay in random urine samples collected from asymptomatic male sexual partners of women with sexually transmitted diseases. Among 130 men, 65 (50.0%) had STP and 12 (9.23%) had HPV infection. There was no association between STP and HPV infection. Among 12 cases of HPV infection, three were HPV-16 single infections, six were multiple infections, including HPV-16, and three of other high-risk HPV infections. Our results suggest the need for STP testing, including HPV testing, in sexual partners of high-risk women with sexually transmitted diseases, even in men without clinical symptoms (asymptomatic). Further research should be conducted by diversifying urine samples. We report the most convenient method for HPV detection, and it is expected to be widely applied to prevent sexually transmitted diseases in men and women.

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Importance of lifetime sexual history on the prevalence of genital human papillomavirus among unvaccinated adults in NHANES: implications for adult HPV vaccination

Clinical Infectious Diseases ◽

10.1093/cid/ciaa1050 ◽

2020 ◽

Author(s):

Anne F Rositch ◽

Eshan U Patel ◽

Molly R Petersen ◽

Thomas C Quinn ◽

Patti E Gravitt ◽

...

Keyword(s):

Decision Making ◽

Sexual Partner ◽

Hpv Vaccination ◽

Hpv Infection ◽

Sexual Partners ◽

Sexual History ◽

Age Group ◽

The Past ◽

Hpv Prevalence ◽

Vaccine Type

Abstract Background Although the FDA recently approved the HPV vaccine for individuals aged 27-45 years old, the CDC did not change their guidelines for routine HPV vaccination. Since recommendations for adult vaccination emphasize shared clinical decision-making based on risk of new infections, we examined the relationship between HPV prevalence and sexual behavior. Methods This study was conducted among 5,093 HPV-unvaccinated, sexually experienced adults aged 18-59 years in the National Health and Nutrition Examination Survey (2013-2016). For each sex and age group, adjusted prevalences of 9-valent vaccine-specific, high-risk, and any-HPV infection were estimated by number of lifetime sexual partners (LTSP) using logistic regression. An analysis restricted to persons who did not have a new sexual partner in the past year (i.e., removing those at highest risk of newly acquired HPV) was also conducted. Results In each age group, genital HPV prevalence was higher among persons with >5 LTSP compared with 1-5 LTSP in both males and females. There were only slight reductions in HPV prevalence after removing participants who reported a new sexual partner in the past year. For example, among females aged 27-45 years with >5 LTSP, the adjusted prevalence of 9-valent vaccine-type HPV infection was 13.4% (95% CI 9.9-17.0) in the full group compared to 12.1% (95% CI 8.8-15.4) among those with no new sexual partners. Conclusions Prevalent HPV infection was primarily reflective of cumulative exposures over time (higher LTSP). New exposures had limited impact, emphasizing the need to consider sexual history in the decision-making process for adult HPV vaccination.

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Association of serum 25-hydroxyvitamin D with prevalence, incidence, and clearance of vaginal HPV infection in young women

The Journal of Infectious Diseases ◽

10.1093/infdis/jiaa758 ◽

2020 ◽

Author(s):

Mariam El-Zein ◽

Farzin Khosrow-Khavar ◽

Ann N Burchell ◽

Pierre-Paul Tellier ◽

Shaun Eintracht ◽

...

Keyword(s):

Vitamin D ◽

Proportional Hazards ◽

Hpv Infection ◽

Cox Proportional Hazards ◽

Baseline Serum ◽

Hpv Dna ◽

Hydroxyvitamin D ◽

Hpv Prevalence ◽

Vitamin D Levels ◽

25 Hydroxyvitamin D

Abstract Background We assessed the association between serum 25-hydroxyvitamin D levels and genital human papillomavirus (HPV) prevalence, incidence, and clearance among female participants of the HITCH cohort study. Methods We genotyped HPV DNA in vaginal samples and quantified baseline serum 25-hydroxyvitamin D levels using Roche’s Linear Array and Total vitamin D assay, respectively. We used logistic and Cox proportional hazards models to respectively estimate adjusted odds ratios (OR) and hazards ratios (HR) with 95% confidence intervals (CI). Results There was no association between vitamin D levels (every 10ng/mL increase) at baseline and HPV prevalence (OR=0.88, CI:0.73-1.03) or incidence (HR=0.88, CI:0.73-1.06), but we observed a modest negative association with HPV clearance (HR=0.76, CI:0.60-0.96). Vitamin D levels <30ng/mL, compared to ≥30ng/mL, were not associated with HPV prevalence (OR=0.98, CI:0.57-1.69) or incidence (HR=0.87, CI:0.50-1.43), but were associated with a marginally significant increased clearance (OR=2.14, CI:0.99-4.64). We observed consistent results with restricted cubic spline modelling of vitamin D levels and clinically defined categories. HPV type-specific analyses accounting for multiple HPV infections per participant showed no association between vitamin D levels and all study outcomes. Conclusion This study provided no evidence of an association between low vitamin D levels and increased HPV prevalence, acquisition, or clearance.

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Prevalence and genotype distribution of human papillomavirus in Czech non-vaccinated heterosexual couples

Virology Journal ◽

10.1186/s12985-021-01551-x ◽

2021 ◽

Vol 18 (1) ◽

Author(s):

Hana Jaworek ◽

Vladimira Koudelakova ◽

Ivana Oborna ◽

Blazena Zborilova ◽

Jana Brezinova ◽

...

Keyword(s):

Human Papillomavirus ◽

Hpv Infection ◽

Sexual Partners ◽

Fisher Exact Test ◽

Genotype Distribution ◽

Heterosexual Couples ◽

Anatomic Site ◽

Hpv Dna ◽

Hpv Test ◽

Penile Swabs

Abstract Background Data about the genotype-specific human papillomavirus (HPV) prevalence in the Czech Republic is limited. We aimed to evaluate the prevalence and concordance of genotype-specific HPV infection detected in semen samples, penile swabs and cervical swabs from non-vaccinated heterosexual couples without HPV-associated disease. Methods Semen samples and penile swabs were collected from male partners and cervical swabs were collected from female partners of heterosexual couples treated for infertility (n = 195). Presence of HPV DNA in semen samples and cervical swabs was analyzed using the cobas® HPV Test and PapilloCheck®. Only the PapilloCheck® test was used to detect HPV in penile swabs. The genotype-specific prevalence and concordance of HPV infection not targeted by vaccine were evaluated using Fisher exact test. Results Both partners were infected with any HPV type in 13.8% (27/195) of couples and, of these couples, 55.6% (15/27) harbored at least one mutual genotype. High-risk HPV (hrHPV) genotypes were detected in 12.3% (24/195) of semen samples, 31.3% (61/195) of penile swabs, and 19.5% (38/195) of cervical swabs (P < 0.001). The most prevalent hrHPV genotype were HPV53 (2.56%; 5/195) in semen samples, HPV16 (6.67%, 13/195) in penile swabs and HPV39 (3.59%, 7/195) in cervical swabs. Low-risk (lrHPV) genotypes were detected in 5.13% (10/195) of semen samples, 15.9% (31/195) of penile swabs, and 4.10% (8/195) of cervical swabs (P < 0.001). Male sexual partners of HPV-positive women were more likely to be infected with at least one of the same HPV types than female sexual partners of HPV-positive men (34.9% vs. 17.9%, P = 0.055). Conclusions This study showed that the detection of HPV infection differ by anatomic site and gender. Regardless the anatomic site, high prevalence of HPV genital infection was found in both Czech men and women.

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Anaerobic Vaginosis: Study of Male Sexual Partners

International Journal of STD & AIDS ◽

10.1177/095646249100200204 ◽

1991 ◽

Vol 2 (2) ◽

pp. 102-104 ◽

Cited By ~ 7

Author(s):

J T Arumainayagam ◽

Y de Silva ◽

M Shahmanesh

Keyword(s):

Sexual Partners ◽

Male Sexual Partners

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Men who have sex with men in China have relatively low numbers of sexual partners

Infectious Disease Reports ◽

10.4081/idr.2011.e10 ◽

2011 ◽

Vol 3 (1) ◽

pp. 10 ◽

Cited By ~ 4

Author(s):

Lei Zhang ◽

Eric Pui Fung Chow ◽

David P. Wilson

Keyword(s):

Median Number ◽

Sexual Partners ◽

Hiv Prevalence ◽

Comprehensive Review ◽

The Past ◽

Male Sexual Partners ◽

Sex With Men ◽

Over Time

HIV prevalence is increasing rapidly among men who have sex with men (MSM) in China and potentially associated with the number of male sexual partners that each man has on average. This study estimates the distribution of the number of male sexual partners among Chinese MSM through a comprehensive review of English and Chinese published literature. The overall median number of male sexual partners of Chinese MSM in the past 6 months China was estimated to be 1.5 (95% CI, 1.1-1.9) and 3.8 (95% CI 1.5-6.9) sexual partners in the past 6-month and 12-month periods respectively. An estimated 31% of sexual partners of MSM in China are regular partners, 54% are casual partners, and 16% are commercial partners. The reported numbers of sexual partners has not changed over time during the past decade. The numbers of male sexual partners reported by Chinese MSM is consistently lower than other settings and may not be sufficient to explain the recent rapid increase in HIV prevalence.

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Prevalence of human papillomavirus by geographical regions, sexual orientation and HIV status in China: a systematic review and meta-analysis

Sexually Transmitted Infections ◽

10.1136/sextrans-2017-053412 ◽

2018 ◽

Vol 94 (6) ◽

pp. 434-442 ◽

Cited By ~ 13

Author(s):

Xiaomeng Ma ◽

Qian Wang ◽

Jason J Ong ◽

Christopher K Fairley ◽

Shu Su ◽

...

Keyword(s):

Systematic Review ◽

Cervical Cancer ◽

Human Papillomavirus ◽

Meta Analysis ◽

Hpv Vaccination ◽

Hpv Infection ◽

Central China ◽

Hiv Positive ◽

Heterosexual Men ◽

Hpv Prevalence

ObjectiveHuman papillomavirus (HPV) infection causes multiple cancers in both women and men. In China, both HPV vaccination and cervical cancer screening coverages are low. We aim to investigate the temporal and geographical trends of HPV DNA prevalence in heterosexual men, women, men who have sex with men (MSM) and people living with HIV (PLHIV) in China.MethodsWe conducted a systematic review, collecting publications in PubMed, Web of Science, China National Knowledge Infrastructure (CNKI) and Wanfang Data from January 2000 to May 2017. A total of 247 studies were selected for this meta-analysis to estimate pooled HPV prevalence, incidence of cervical cancer and risk of infection for subgroups. Meta-regression was applied to identify contributing factors to prevalence heterogeneities.ResultsThe national HPV prevalence was 15.6% (95% CI (14.4% to 16.9%)) in women with normal cervical cytology, and Central China had the highest prevalence (20.5% (15.2% to 25.8%)). HPV prevalence in heterosexual men (14.5% (11.3% to 17.7%)) was comparable with that of women (OR=1.09 (0.98 to 1.17)), but HPV prevalence in MSM (59.9% (52.2% to 67.6%)) was significantly higher than that in heterosexual men (OR=8.81 (8.01 to 9.69)). HIV-positive women (45.0% (38.4% to 51.6%)) and HIV-positive MSM (87.5% (82.3% to 90.9%)) had 4.67 (3.61 to 6.03) and 6.46 (5.20 to 8.02) times higher risk of HPV infection than their HIV negative counterparts.ConclusionHPV infection is prevalent in China, particularly in Central China, in comparison with the global level and neighbouring countries. Targeted HPV vaccination for women, MSM and PLHIV and scale-up of cervical screening for women are priorities in curbing the HPV epidemic in China.

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