Prevalence and determinants of oral and cervicogenital HPV infection: baseline analysis of the MHOC cohort study

We determined baseline oral and cervicogenital human papillomavirus (HPV) prevalence and determinants of infection in the Michigan HPV and Oropharyngeal Cancer (MHOC) study. We enrolled 394 college-age and older-adult participants of both sexes in Ann Arbor, Michigan and the surrounding area. All participants provided an oral sample at baseline, and 130 females provided a cervicogenital sample. Samples were tested for 18 HPV genotypes using polymerase chain reaction (PCR) MassArray. Participants filled out sociodemographic and behavioral questionnaires. Prevalence ratios for HPV oral or cervicogenital prevalence by predictor variables were estimated in univariable log-binomial models. Analysis was conducted 2018-20. In the full cohort, baseline oral HPV prevalence was 10.0% for any detected genotype (among the 338 valid oral tests at baseline) and 6.5% for high-risk types, and cervicogenital prevalence was 20.0% and 10.8%, respectively (among the 130 first valid cervicogenital tests). Oral HPV prevalence did not vary by sex, with 10.5% of women and 9.0% of men having an infection. We found a high prevalence of oral and cervicogenital HPV infection among those reporting no recent sexual partners compared to those with a single recent sexual partner, but prevalence increased with the number of recent partners for most sexual behaviors. We observed an ecological fallacy masking the direction of impact of vaccination on HPV prevalence in the full cohort compared to the college-aged and older-adult populations considered separately. Substance use was not significantly associated with oral or cervicogenital HPV infection. Many studies report substantially higher oral HPV infection prevalence in men than in women. That difference may not be uniform across populations in the US.

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Incidence and clearance of oral and cervicogenital HPV infection: longitudinal analysis of the MHOC cohort study

BMJ Open ◽

10.1136/bmjopen-2021-056502 ◽

2022 ◽

Vol 12 (1) ◽

pp. e056502

Author(s):

Andrew F Brouwer ◽

Lora P Campredon ◽

Heather M Walline ◽

Brittany M Marinelli ◽

Christine M Goudsmit ◽

...

Keyword(s):

Hpv Vaccination ◽

Hpv Infection ◽

Sexual Partners ◽

Infection Prevalence ◽

College Age ◽

Adult Participants ◽

Ann Arbor ◽

Oral Hpv ◽

The Mean ◽

Mean Time

ObjectivesThe Michigan HPV and Oropharyngeal Cancer study aimed to evaluate patterns of oral and cervicogenital human papillomavirus (HPV) infection prevalence, incidence, and clearance as well as their relationship to sexual behaviours.DesignCohortSettingGeneral public in and around Ann Arbor, Michigan.Participants394 college-age and older-adult participants of both sexes provided oral samples, and 325 completed at least 2 visits. 130 who provided a cervicogenital samples, and 127 completed at least 2 visits.OutcomesIncidence and clearance rates as well as HRs for oral and cervicogenital HPV.ResultsOral HPV infections were transient, with only 16% of genotypes persisting to the next visit. The mean time to clearance of a genotype was 46 days (95% CI 37 to 58). In contrast, cervicogenital infections were more persistent, with 56% of genotypes persisting to the next visit. The mean time to clearance of a genotype was 87 days (95% CI 74 to 102). HPV vaccination was associated with reduced incidence of cervicogenital HPV infection (HR 0.63; 95% CI 0.47 to 0.83) but not oral HPV infection. Incidence of oral HPV infection was associated with 2+ recent deep kissing partners (HR 2.00; 95% CI 1.13 to 3.56). Incidence of both oral (HR: 1.70; 95% CI 1.08 to 2.68) and cervicogenital (HR 2.46; 95% CI 1.69 to 3.59) was associated with 2+ recent sexual partners.ConclusionsDetection of oral HPV was highly transient, but incidence was associated with recent deep kissing and sexual partners. Detection of cervicogenital HPV was more persistent, and incidence was positively associated with recent sexual partners and negatively associated with HPV vaccination.

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Differences in Factors Associated With High- and Low-Risk Oral Human Papillomavirus Genotypes in Men

The Journal of Infectious Diseases ◽

10.1093/infdis/jiaa693 ◽

2020 ◽

Author(s):

Deepti Bettampadi ◽

Brittney Dickey ◽

Martha Abrahamsen ◽

Bradley Sirak ◽

Maria Luiza Baggio ◽

...

Keyword(s):

Human Papillomavirus ◽

High Risk ◽

Sexual Behaviors ◽

Hpv Infection ◽

Low Risk ◽

Factors Associated ◽

Hpv Prevalence ◽

Oral Hpv ◽

Multivariable Models ◽

High Risk Hpv

Abstract Background Human papillomavirus (HPV) causes oral warts and oropharyngeal cancer (OPC). Human papillomavirus-attributable OPC incidence among men is significantly increasing worldwide, yet few studies have reported oral HPV across multiple countries or examined factors associated with low- and high-risk HPV separately. Methods Oral gargles from 3095 men in the multinational HPV Infection in Men (HIM) Study were HPV genotyped. Multivariable models assessed factors independently associated with high-risk and low-risk HPV prevalence. Results The prevalence of high-risk and low-risk HPV was 6.0% and 2.8%, respectively. Greater number of sexual partners was only associated with high-risk HPV (1.88; 95% confidence interval [CI], 1.22–2.90) prevalence. In multivariable models, residing in Mexico (1.66; 95% CI, 1.15–2.40) and smoking (1.66; 95% CI, 1.13–2.44) were significantly associated with high-risk HPV, and history of consistent gum bleeding (2.16; 95% CI, 1.35–3.45) was significantly associated with low-risk HPV. Gender of the sexual partner did not alter the results for either high- or low-risk HPV endpoints. Conclusions Different factors were independently associated with high- and low-risk oral HPV. Oral sexual behaviors were associated with high-risk HPV, and oral health was associated with low-risk HPV. High-risk HPV prevalence differed by country of residence, highlighting the need for additional studies in multiple countries.

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Prevalence of oral human papillomavirus in men attending an Italian sexual health clinic

Sexual Health ◽

10.1071/sh16155 ◽

2016 ◽

Vol 13 (6) ◽

pp. 597 ◽

Cited By ~ 4

Author(s):

Francesco Drago ◽

Astrid Herzum ◽

Giulia Ciccarese ◽

Roberto Bandelloni

Keyword(s):

Human Papillomavirus ◽

Hpv Infection ◽

Health Clinic ◽

High Risk Population ◽

Hpv Dna ◽

Hpv Prevalence ◽

Sexually Transmissible Infections ◽

High Prevalence ◽

Oral Hpv ◽

Sex With Men

A high-risk population, formed by 79 consecutive male attendees of our sexually transmissible infections clinic, and who did not have any overt signs of human papillomavirus (HPV) infection, were examined. Oral HPV prevalence (37%) was much higher than previously reported. Periurethral HPV-DNA was found in 49% of the patients and anal HPV-DNA was found in 43% of the patients. Considering the high prevalence of oral HPV obtained in the current study, it is important to further investigate the burden of oral HPV, not only in men who have sex with men, but also in heterosexual men and in women.

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HPV Infection in a Cohort of HIV-Positive Men and Women: Prevalence of Oncogenic Genotypes and Predictors of Mucosal Damage at Genital and Oral Sites

Journal of Sexually Transmitted Diseases ◽

10.1155/2013/915169 ◽

2013 ◽

Vol 2013 ◽

pp. 1-8

Author(s):

Giulia Marchetti ◽

Laura Comi ◽

Teresa Bini ◽

Marco Rovati ◽

Francesca Bai ◽

...

Keyword(s):

Mucosal Damage ◽

Hpv Infection ◽

Cross Sectional Study ◽

Hiv Positive ◽

Low Grade ◽

Abnormal Cytology ◽

Cross Sectional ◽

Squamous Cells ◽

Hpv Prevalence ◽

Oral Hpv

The aim of this study was to assess the prevalence of HPV infection and determinants of abnormal cytology in HIV-positive patients. In a cross-sectional study, patients of both sexes, asymptomatic for HPV, underwent anorectal (men)/cervical (women) and oral swabs. Cytology and HPV-PCR detection/genotyping (high- and low-risk genotypes, HR-LR/HPV) were performed. A total of 20% of the 277 enrolled patients showed oral HPV, with no atypical cytology; in men, anal HPV prevalence was 81% with 64% HR genotypes. In women, cervical HPV prevalence was 58% with 37% HR-HPV. The most frequent genotypes were HPV-16 and HPV-18; 37% of men and 20% of women harbored multiple genotypes. Also, 47% of men showed anal squamous intraepithelial lesions (SILs); 6% had high- and 35% low-grade SILs (HSILs/LSILs); 5% had atypical squamous cells of undetermined significance (ASC-US). HR-HPV was independently associated with anal-SIL in men (P=0.039). Moreover, 37% of women showed cervical SIL: 14 ASC-US, 15 LSILs, 4 HSILs, and 1 in situ cancer. The presence of both LR and HR-HPV in women was independently associated with SIL (P=0.003 and P=0.0001). HR-HPV and atypical cytology were frequently identified in our cohort. HPV screening should be mandatory in HIV-infected subjects, and vaccine programs for HPV-negative patients should be implemented.

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Prevalence and distribution of human papillomavirus genotypes among women in northern Henan Province of China

10.21203/rs.3.rs-889505/v1 ◽

2021 ◽

Author(s):

Xiangpeng Wang ◽

Yuan Song ◽

Xiaofei Wei ◽

Guanyu Wang ◽

Ruili Sun ◽

...

Keyword(s):

Human Papillomavirus ◽

Age Groups ◽

Hpv Infection ◽

Cervical Cancer Prevention ◽

Henan Province ◽

Infection Prevalence ◽

Genotype Distribution ◽

Hpv Dna ◽

Hpv Prevalence ◽

Specific Hybridization

Abstract Background Human papillomavirus (HPV) infection can cause cervical and other cancers including cancer of vulva, vagina, penis, anus, or oropharynx. However, data concerning the prevalence and genotype distribution of HPV among women are limited in northern Henan Province of China. This study aimed to make an investigation on the current prevalence and genotype distribution of HPV among women and provided comprehensive data to guide HPV-based cervical cancer prevention in northern Henan Province. Methods A total of 15616 women aged 16 to 81 years who attended the department of gynecology of Xinxiang central hospital between January 2018 and December 2019 were enrolled in this study. HPV DNA was detected by PCR method followed by HPV type-specific hybridization. The overall prevalence, age-specific prevalence and genotype distribution of HPV were investigated. Results The overall HPV prevalence was 19.7% among women in northern Henan Province. Single, double and multiple HPV infections accounted for 13.7%, 4.3% and 1.8% of the total cases, respectively. HPV prevalence was 41.8% among women aged 16 to 19 years, 21.1% among women aged 20 to 29 years, 18.1% among women aged 30 to 39 years, 17.7% among women aged 40 to 49 years, 20.8% among women aged 50 to 59 years, 22.9% among women more than 60 years. HPV infection rates differed significantly across different age groups. Most infections were caused by high-risk HPV (HR-HPV) and single genotype HPV infection was the most common pattern. The most common HR-HPV genotype was HPV16, followed by HPV52, HPV58, HPV53 and HPV39. The most common low-risk HPV (LR-HPV) genotype was HPV6, followed by HPV61, HPV81, HPV54 and HPV11. Conclusions HPV infection is common among women in northern Henan Province. The highest infection prevalence was found in women less than 20 years old. The 9-valent HPV vaccine for routine vaccination is strongly recommended in northern Henan Province.

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Impact of prophylactic human papillomavirus (HPV) vaccination on oral HPV infections among young adults in the U.S.

Journal of Clinical Oncology ◽

10.1200/jco.2017.35.15_suppl.6003 ◽

2017 ◽

Vol 35 (15_suppl) ◽

pp. 6003-6003 ◽

Cited By ~ 9

Author(s):

Maura L. Gillison ◽

Tatevik Broutian ◽

Barry Graubard ◽

Robert Pickard ◽

Zhen-Yue Tong ◽

...

Keyword(s):

Young Adults ◽

Hpv Vaccine ◽

Hpv Vaccination ◽

Vaccine Dose ◽

Population Level ◽

Hpv Infection ◽

Vaccine Uptake ◽

Infection Prevalence ◽

The Us ◽

Oral Hpv

6003 Background: The incidence of HPV-positive oropharyngeal cancers has risen in recent decades among US men. The potential impact of HPV vaccines on oral HPV infections has yet to be evaluated in efficacy-trials or surveillance studies. Methods: To evaluate the impact of prophylactic HPV vaccination on oral HPV infections in the US population, we conducted a cross-sectional study among men and women aged 18-33 years (n = 2,627) in the National Health and Nutrition Examination Survey, 2011-2014. We examined the effect of self-reported receipt of ≥1 vaccine dose on oral HPV infection (vaccine-types 16/18/6/11) prevalence among vaccinated vs. unvaccinated individuals. Additional outcomes included percent reduction in infection-prevalence among vaccinated individuals and population-level effectiveness of vaccination. Analyses accounted for the complex sampling design. Comparisons between vaccinated and unvaccinated individuals were conducted using binary logistic regression, with adjustment for age, gender, and race. Statistical significance was assessed using a quasi-score test. Results: During 2011-2014, 18.3% of the US population aged 18-33 years reported receipt of ≥1 HPV vaccine-dose prior to age 26 (29.2% in women and 6.9% in men; P< 0.001). The prevalence (population-weighted) of oral HPV16/18/6/11 infections was significantly reduced in vaccinated vs. unvaccinated individuals (0.11% vs. 1.61%; P= 0.008), corresponding to an estimated 88.2% (95%CI = 5.7%-98.5%) reduction in prevalence. Notably, oral HPV16/18/6/11 prevalence was significantly reduced in vaccinated vs. unvaccinated men (0.0% vs. 2.13%; P= 0.007). In contrast, prevalence for 33 non-vaccine HPV types was similar (3.98% vs. 4.74%; P= 0.24). Accounting for HPV vaccine-uptake, the population-level effectiveness of HPV vaccination on the burden of oral HPV16/18/6/11 infections was 17.0% overall, 25.0% in women and 6.9% in men. Conclusions: HPV vaccination substantially reduced vaccine-type oral HPV infection prevalence among young adults (ages 18-33 years) in the US population during 2011-2014. However, due to low vaccine uptake, population-level effectiveness was modest overall and particularly low in men.

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Oral HPV prevalence in women positive for cervical HPV infection and their sexual partners: a German screening study

European Archives of Oto-Rhino-Laryngology ◽

10.1007/s00405-016-3953-1 ◽

2016 ◽

Vol 273 (7) ◽

pp. 1933-1942 ◽

Cited By ~ 7

Author(s):

Ralf B. Uken ◽

Oliver Brummer ◽

Carolin von Schubert-Bayer ◽

Thomas Brodegger ◽

Ingo U. Teudt

Keyword(s):

Hpv Infection ◽

Sexual Partners ◽

Hpv Prevalence ◽

Screening Study ◽

Oral Hpv

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1100National prevalence of oral HPV infection in vaccinated and unvaccinated young adults in Brazil

International Journal of Epidemiology ◽

10.1093/ije/dyab168.707 ◽

2021 ◽

Vol 50 (Supplement_1) ◽

Author(s):

Natália Luiza Kops ◽

Juliana Comerlato ◽

Isabel Bandeira ◽

Marina Bessel ◽

Ana Goretti Kalume Maranhão ◽

...

Keyword(s):

Hpv Vaccination ◽

Hpv Infection ◽

Quadrivalent Vaccine ◽

Sampling Weights ◽

Cross Sectional ◽

Hpv Prevalence ◽

Significant Difference ◽

Oral Hpv ◽

Hpv Types ◽

Putative Precursor

Abstract Background Prophylactic HPV vaccination has been recommended for the prevention of cancers caused by HPV infection. Nevertheless, may be reduce the oral HPV prevalence, the putative precursor to oral squamous cell carcinoma. This study aimed to report the prevalence of oral HPV among vaccinated and unvaccinated women and men aged 16 to 25 years who use the public health system. Methods POP-Brazil study is a cross-sectional, multicentric survey. Participants were recruited from 119 public primary care units distributed throughout all 27 capitals of Brazil. Trained health professionals applied a face-to-face interview. Oral sample was collected through mouthwash and gargle cycles. HPV genotyping was performed in a central lab using the Roche PCR-based Linear Array genotyping test. Sampling weights by sex and age were applied to the data. Results Oral HPV samples were collected from 5,684 participants; 613 (8.93%) vaccinated against HPV, in which 86.57% were women. Among women, the overall HPV prevalence was significantly lower in those vaccinated [0.43% (95% CI, 0.03-0.83)] than unvaccinated [1.65% (95% CI, 0.97– 2.33] (p < 0.01). Among men, no significant difference was found. All vaccinated individuals were negative to the HPV types present in the quadrivalent vaccine (6, 11, 16, and 18). Conclusion Vaccinated individuals had a lower prevalence of overall oral HPV besides the null infection by 6, 11, 16, and 18 HPV types showing another benefit of this cancer prevention measure. Due to the low prevalence of oral HPV, type specific analysis demand higher number of positive participants.

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HPV prevalence and genotype distribution among women from Hengyang district of Hunan province, China

10.21203/rs.3.rs-22870/v1 ◽

2020 ◽

Author(s):

Shuang-yang Tang ◽

S Ding ◽

L Yu ◽

SY Shen ◽

YP Wan ◽

...

Keyword(s):

Cervical Cancer ◽

Infection Rate ◽

Hpv Infection ◽

Hospitalized Patients ◽

Hunan Province ◽

Infection Prevalence ◽

Genotype Distribution ◽

Infection Rates ◽

Hpv Prevalence ◽

Geographical Regions

Abstract Background Human papillomavirus (HPV) infection can cause a variety of epithelial lesions, including even various malignant cancers, such as cervical cancer, vulvar cancer and etc. Most cervical cancers were closely associated with HPV infections. Therefore, understanding the ecological diversity of HPV prevalence and genotype distribution among various populations in different geographical regions was essential for optimizing HPV vaccination and maximizing vaccination effects. Aim This study was designed to investigate HPV infection prevalence and genotype distribution among women from Hengyang district of Hunan province in China.Methods A total of 12053 patient data from the three-level hospitals in Hengyang city between July 2016 and July 2017 were retrospectively analyzed. The HPV positive was identified by Polymerase chain reaction (PCR). The HPV PCR-Flow fluorescence assay was used for HPV genotyping. The Chi-square test was performed to compare the differences among HPV infection rates or HR-HPV ratio-in-positives.Results In this study, the HPV prevalence was 10.16% overall, and the multiple-type infection rate was 1.83%. The HR-HPV infection rate was 8.52%. The top six HPV genotypes were as follows in a descending order: HPV16, HPV58, HPV52, HPV39, HPV51, and HPV53. The patients who were above 60 years and below 21 years old were the most and second HPV prevalent group, respectively, the corresponding HR-HPV infection rates were the most and the third, respectively. The infection rates of HPV and HR-HPV among outpatients were lower than those among hospitalized-patients, respectively. Among the hospitalized-patients, the infection rates of HPV and HR-HPV among 50~60 years group were both the most, following by those among above 60 years group. The HR-HPV ratio-in-positive among HPV-positive patients with histopathologic examination was higher than that among those patients without. Among 52 HPV-positive patients with cervical squamous carcinoma, the ratio-in-positive of HPV16 was 61.54%.Conclusions This study demonstrated that the HPV prevalence varied with the age among women from Hengyang district of Hunan province in China and showed their HPV genotype distribution that HPV16, HPV58, HPV52, HPV39, HPV51 and HPV53 infection were more popular in this region, which could provide the experimental basis for Chinese public health measures on cervical cancer prevention.

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