Head and neck cutaneous leishmania: clinical characteristics, microscopic features and molecular analysis in a cohort of 168 cases

Objectives: To study clinical characteristics and treatment outcome of epistaxis in head and neck trauma. Methods: A prospective descriptive study of 71 cases of epistaxis managed at Hue Center Hospital and Hue Univesity Hospital from April 2015 to June 2016. Results: Most of bleeding times were at night (59.2%). Unilateral bleeding was seen in almost 72.9% cases. Anterior nasal bleeding was noted in majority of the patients (70.4%), anterior and posterior nasal was 18.3%, posterior nasal was 11.3%. There were three stage: mild (77.5%), moderate (15.5%), severe (7%). Anterior nasal packing (70.4%) were the most common methods, Posterior nasal packing were 25.4%, Local cauterization were 1.4%, Constriction of the blood vessels were 1.4%, Embolization procedure were 1.4%. Complication rate was 8.4% include: fever (5%), pressure necrosis (1.7%), scars (1.7%). The rate of good recovery after treatment was 91.7%, partial recovery was 8.3%. The overall mean of hospital stay was 6,33 ± 5,61 days (range 1 to 36 days). Key words: Epistaxis

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Molecular Tumor Subtypes of HPV-Positive Head and Neck Cancers: Biological Characteristics and Implications for Clinical Outcomes

Cancers ◽

10.3390/cancers13112721 ◽

2021 ◽

Vol 13 (11) ◽

pp. 2721

Author(s):

Tingting Qin ◽

Shiting Li ◽

Leanne E. Henry ◽

Siyu Liu ◽

Maureen A. Sartor

Keyword(s):

Head And Neck ◽

Stromal Cells ◽

Clinical Characteristics ◽

Molecular Subtypes ◽

Squamous Cell Carcinomas ◽

Head And Neck Cancers ◽

Molecular Signatures ◽

Tumor Subtypes ◽

Mesenchymal Differentiation ◽

High Incidence

Until recently, research on the molecular signatures of Human papillomavirus (HPV)-associated head and neck cancers mainly focused on their differences with respect to HPV-negative head and neck squamous cell carcinomas (HNSCCs). However, given the continuing high incidence level of HPV-related HNSCC, the time is ripe to characterize the heterogeneity that exists within these cancers. Here, we review research thus far on HPV-positive HNSCC molecular subtypes, and their relationship with clinical characteristics and HPV integration into the host genome. Different omics data including host transcriptomics and epigenomics, as well as HPV characteristics, can provide complementary viewpoints. Keratinization, mesenchymal differentiation, immune signatures, stromal cells and oxidoreductive processes all play important roles.

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Head and Neck Rhabdomyosarcoma Harboring TFCP2 Fusions and ALK overexpression: A Clinicopathologic and Molecular Analysis of 11 cases

Histopathology ◽

10.1111/his.14323 ◽

2020 ◽

Author(s):

Bin Xu ◽

Albert JH Suurmeijer ◽

Narasimhan P Agaram ◽

Lei Zhang ◽

Cristina R. Antonescu

Keyword(s):

Head And Neck ◽

Molecular Analysis

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Ocular Dirofilariasis Case in Thailand Confirmed by Molecular Analysis to Be Caused by Dirofilaria immitis

American Journal of Tropical Medicine and Hygiene ◽

10.4269/ajtmh.21-0764 ◽

2021 ◽

Author(s):

Yuwadee Somsap ◽

Patcharaporn Boonroumkaew ◽

Attawit Somsap ◽

Rutchanee Rodpai ◽

Lakkhana Sadaow ◽

...

Keyword(s):

Molecular Analysis ◽

Male Patient ◽

Molecular Identification ◽

Causative Agent ◽

Clinical Characteristics ◽

Dirofilaria Immitis ◽

Anterior Part ◽

Zoonotic Disease ◽

Tissue Growth ◽

Cuticular Surface

A rare ocular dirofilariasis case along with the clinical characteristics, treatment, and outcome is reported. A whitish roundworm (10.6 cm long and 0.5 mm width) emerged from the pterygium, a triangular tissue growth on the cornea of the eye, of a male patient. The worm had a rounded anterior part, mouth without lips, smooth cuticular surface, and short rounded posterior tail with spicules: these features suggested that it was a male Dirofilaria sp. Molecular identification confirmed that the worm belonged to Dirofilaria immitis. This is the first molecular confirmation that D. immitis is a causative agent of ocular dirofilariasis in Thailand: dirofilariasis is a newly emerging zoonotic disease. Physicians should be alert to zoonotic filarial worms and knowledgeable about treatment of this disease.

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Two Cases of Sinonasal Non-Intestinal-Type Adenocarcinoma with Squamoid Morules Expressing Nuclear β-Catenin and CDX2: A Curious Morphologic Finding Supported by Molecular Analysis

Case Reports in Pathology ◽

10.1155/2018/8741017 ◽

2018 ◽

Vol 2018 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Tatiana M. Villatoro ◽

Stacey K. Mardekian

Keyword(s):

Head And Neck ◽

Molecular Analysis ◽

Underlying Mechanism ◽

Intestinal Type ◽

Low Grade ◽

Gene Encoding ◽

Aberrant Expression ◽

Nuclear Expression ◽

Intestinal Type Adenocarcinoma

Sinonasal non-intestinal-type adenocarcinoma (non-ITAC) is a rare, morphologically diverse neoplasm of the head and neck. Squamoid morular metaplasia has recently been reported as an occasional finding in non-ITAC. Interestingly, these squamoid morules often show aberrant expression of CDX2 as well as nuclear expression of β-catenin, similar to other tumors that show this type of metaplasia, but the underlying mechanism responsible for this finding is not completely understood. We present two cases of low-grade non-ITAC with squamoid morules coexpressing CDX2 and nuclear β-catenin by immunohistochemistry, both of which were found to harbor a mutation in CTNNB1, the gene encoding β-catenin. This finding provides support that an alteration in the β-catenin pathway, including mutations in the β-catenin gene itself, is responsible for this recently described morphologic phenomenon in non-ITAC.

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