Joint impact of seven risk factors on incident dementia in elderly Japanese: the Ohsaki Cohort 2006 Study

2019 ◽  
Vol 266 (5) ◽  
pp. 1222-1229 ◽  
Author(s):  
Yumika Kotaki ◽  
Yasutake Tomata ◽  
Fumiya Tanji ◽  
Shu Zhang ◽  
Yumi Sugawara ◽  
...  
Keyword(s):  
Risk Factors ◽  
Incident Dementia ◽  
Elderly Japanese

scholarly journals Relation of Serum Total Cholesterol and Other Risk Factors to Risk of Coronary Events in Middle-Aged and Elderly Japanese Men With Hypercholesterolemia

2004 ◽  
Vol 68 (5) ◽  
pp. 405-409 ◽  
Author(s):  
Mikio Iwashita ◽  
Yasuyuki Matsushita ◽  
Jun Sasaki ◽  
Kikuo Arakawa ◽  
Suminori Kono ◽  
...  
Keyword(s):  
Risk Factors ◽  
Total Cholesterol ◽  
Serum Total Cholesterol ◽  
Middle Aged ◽  
Japanese Men ◽  
Coronary Events ◽  
Elderly Japanese

Impact of time spent walking on incident dementia in elderly Japanese

2018 ◽  
Vol 34 (1) ◽  
pp. 204-209 ◽  
Author(s):  
Yasutake Tomata ◽  
Shu Zhang ◽  
Yumi Sugawara ◽  
Ichiro Tsuji
Keyword(s):  
Incident Dementia ◽  
Elderly Japanese

scholarly journals Preventing dementia

2005 ◽  
Vol 11 (3) ◽  
pp. 176-183 ◽  
Author(s):  
Nitin Purandare ◽  
Clive Ballard ◽  
Alistair Burns
Keyword(s):  
Risk Factors ◽  
Randomised Controlled Trials ◽  
Primary Outcome ◽  
Secondary Outcome ◽  
Controlled Trials ◽  
Multiple Risk Factors ◽  
Incident Dementia ◽  
Treatment Of Hypertension ◽  
Intervention Trials ◽  
Randomised Controlled

Epidemiological evidence has identified key strategies that may be used in the prevention of both Alzheimer's disease and vascular dementia. These strategies may be loosely divided into three areas: treatment of vascular risk factors, neuroprotection and increasing neuronal reserves. Evidence from randomised controlled trials already exists for treatment of hypertension but results for statins have been disappointing. Most of the intervention trials currently in progress focus on one or two risk factors and include cognition or dementia only as a secondary outcome. The potential of intervention strategies awaits confirmation by randomised controlled trials that target multiple risk factors in at-risk people with mild cognitive impairment, with incident dementia as the primary outcome.

scholarly journals Previous and Incident Dementia as Risk Factors for Mortality in Stroke Patients

Stroke ◽  
2002 ◽  
Vol 33 (8) ◽  
pp. 1993-1998 ◽  
Author(s):  
Raquel Barba ◽  
Maria-del-Mar Morin ◽  
Carlos Cemillán ◽  
Carlos Delgado ◽  
Julio Domingo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Stroke Patients ◽  
Incident Dementia

Cardiovascular and biochemical risk factors for incident dementia in the Hypertension in the Very Elderly Trial

2009 ◽  
Vol 27 (10) ◽  
pp. 2055-2062 ◽  
Author(s):  
Ruth Peters ◽  
Ruth Poulter ◽  
Nigel Beckett ◽  
Françoise Forette ◽  
Robert Fagard ◽  
...  
Keyword(s):  
Risk Factors ◽  
Very Elderly ◽  
Incident Dementia

scholarly journals Citrus consumption and incident dementia in elderly Japanese: the Ohsaki Cohort 2006 Study

2017 ◽  
Vol 117 (8) ◽  
pp. 1174-1180 ◽  
Author(s):  
Shu Zhang ◽  
Yasutake Tomata ◽  
Kemmyo Sugiyama ◽  
Yumi Sugawara ◽  
Ichiro Tsuji
Keyword(s):  
Cox Model ◽  
Baseline Survey ◽  
Inverse Association ◽  
Term Care ◽  
Hazard Ratios ◽  
Incident Dementia ◽  
Biological Studies ◽  
Long Term Care Insurance ◽  
Elderly Japanese

AbstractAlthough some experimental biological studies have indicated that citrus may have preventive effects against cognitive impairment, no cohort study has yet examined the relationship between citrus consumption and incident dementia. In a baseline survey, we collected data on daily citrus intake (categorised as ≤2, 3–4 times/week or almost every day) and consumption of other foods using a FFQ, and used a self-reported questionnaire to collect data on other covariates. Data on incident dementia were retrieved from the Japanese Long-term Care Insurance database. A multivariate-adjusted Cox model was used to estimate the hazard ratios (HR) and 95 % CI for incident dementia according to citrus consumption. Among 13 373 participants, the 5·7-year incidence of dementia was 8·6 %. In comparison with participants who consumed citrus ≤2 times/week, the multivariate-adjusted HR for incident dementia among those did so 3–4 times/week and almost every day was 0·92 (95 % CI 0·80, 1·07) and 0·86 (95 % CI 0·73, 1·01), respectively (Ptrend=0·065). The inverse association persisted after excluding participants whose dementia events had occurred in the first 2 years of follow-up. The multivariate HR was 1·00 (reference) for ≤2 times/week, 0·82 (95 % CI 0·69, 0·98) for 3–4 times/week and 0·77 (95 % CI 0·64, 0·93) for almost every day (Ptrend=0·006). The present findings suggest that frequent citrus consumption was associated with a lower risk of incident dementia, even after adjustment for possible confounding factors.

scholarly journals Daytime Sleepiness and Sleep Inadequacy as Risk Factors for Dementia

2015 ◽  
Vol 5 (2) ◽  
pp. 286-295 ◽  
Author(s):  
Angeliki Tsapanou ◽  
Yian Gu ◽  
Jennifer Manly ◽  
Nicole Schupf ◽  
Ming-Xin Tang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Daytime Sleepiness ◽  
Cox Regression ◽  
Sleep Problems ◽  
Community Dwelling ◽  
Medical Outcomes ◽  
Cox Regression Analysis ◽  
Incident Dementia ◽  
Increased Risk ◽  
Sleep Adequacy

Background/Aims: To examine the association between self-reported sleep problems and incidence of dementia in community-dwelling elderly people. Methods: 1,041 nondemented participants over 65 years old were examined longitudinally. Sleep problems were estimated using the RAND Medical Outcomes Study Sleep Scale examining sleep disturbance, snoring, sleep short of breath or with a headache, sleep adequacy, and sleep somnolence. Cox regression analysis was used to examine the association between sleep problems and risk for incident dementia. Age, gender, education, ethnicity, APOE-ε4, stroke, heart disease, hypertension, diabetes, and depression were included as covariates. Results: Over 3 years of follow-up, 966 (92.8%) participants remained nondemented, while 78 (7.2%) developed dementia. In unadjusted models, sleep inadequacy (‘Get the amount of sleep you need') at the initial visit was associated with increased risk of incident dementia (HR = 1.20; 95% CI 1.02-1.42; p = 0.027). Adjusting for all the covariates, increased risk of incident dementia was still associated with sleep inadequacy (HR = 1.20; 95% CI 1.01-1.42; p = 0.040), as well as with increased daytime sleepiness (‘Have trouble staying awake during the day') (HR = 1.24; 95% CI 1.00-1.54; p = 0.047). Conclusion: Our results suggest that sleep inadequacy and increased daytime sleepiness are risk factors for dementia in older adults, independent of demographic and clinical factors.

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