scholarly journals Multimodal treatment options for bilobar colorectal liver metastases

2010 ◽  
Vol 395 (6) ◽  
pp. 633-641 ◽  
Author(s):  
Kia Homayounfar ◽  
Torsten Liersch ◽  
Martin Niessner ◽  
Johannes Meller ◽  
Thomas Lorf ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Multimodal Treatment ◽  
Colorectal Liver Metastases ◽  
Treatment Options

scholarly journals Trends in multimodal treatment and long-term outcomes of patients with resected colorectal liver metastases in a Brazilian Cancer Center

HPB ◽  
2016 ◽  
Vol 18 ◽  
pp. e193-e194
Author(s):  
M.C. Marques ◽  
A.L. Diniz ◽  
H.S.C. Ribeiro ◽  
W.L. Costa ◽  
A.L. Godoy ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Multimodal Treatment ◽  
Colorectal Liver Metastases ◽  
Cancer Center ◽  
Long Term Outcomes

scholarly journals FIRST BRAZILIAN CONSENSUS ON MULTIMODAL TREATMENT OF COLORECTAL LIVER METASTASES. MODULE 1: PRE-TREATMENT EVALUATION

2015 ◽  
Vol 28 (4) ◽  
pp. 222-230 ◽  
Author(s):  
Felipe José Fernandez COIMBRA ◽  
Heber Salvador de Castro RIBEIRO ◽  
Márcio Carmona MARQUES ◽  
Paulo HERMAN ◽  
Rubens CHOJNIAK ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Multimodal Treatment ◽  
Colorectal Liver Metastases ◽  
Epidemiological Data ◽  
Treatment Modalities ◽  
Established Method ◽  
Curative Intent ◽  
Pre Treatment ◽  
Definition Of

Background : Liver metastases of colorectal cancer are frequent and potentially fatal event in the evolution of patients with these tumors. Aim : In this module, was contextualized the clinical situations and parameterized epidemiological data and results of the various treatment modalities established. Method: Was realized deep discussion on detecting and staging metastatic colorectal cancer, as well as employment of imaging methods in the evaluation of response to instituted systemic therapy. Results : The next step was based on the definition of which patients would have their metastases considered resectable and how to expand the amount of patients elegible for modalities with curative intent. Conclusion : Were presented clinical, pathological and molecular prognostic factors, validated to be taken into account in clinical practice.

scholarly journals High hepatic expression of PDK4 improves survival upon multimodal treatment of colorectal liver metastases

2019 ◽  
Vol 120 (7) ◽  
pp. 675-688 ◽  
Author(s):  
Moritz J. Strowitzki ◽  
Praveen Radhakrishnan ◽  
Sandra Pavicevic ◽  
Jana Scheer ◽  
Gwendolyn Kimmer ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Multimodal Treatment ◽  
Colorectal Liver Metastases ◽  
Hepatic Expression

scholarly journals I BRAZILIAN CONSENSUS FOR MULTIMODAL TREATMENT OF COLORECTAL LIVER METASTASES

2015 ◽  
Vol 28 (4) ◽  
pp. 221-221 ◽  
Author(s):  
Felipe José Fernandez COIMBRA ◽  
Heber Salvador de Castro RIBEIRO ◽  
Orlando Jorge Martins TORRES
Keyword(s):  
Liver Metastases ◽  
Multimodal Treatment ◽  
Colorectal Liver Metastases

scholarly journals BRAZILIAN CONSENSUS FOR MULTIMODAL TREATMENT OF COLORECTAL LIVER METASTASES. MODULE 3: CONTROVERSIES AND UNRESECTABLE METASTASES

2016 ◽  
Vol 29 (3) ◽  
pp. 173-179 ◽  
Author(s):  
Orlando Jorge Martins TORRES ◽  
Márcio Carmona MARQUES ◽  
Fabio Nasser SANTOS ◽  
Igor Correia de FARIAS ◽  
Anelisa Kruschewsky COUTINHO ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Resection ◽  
Liver Metastases ◽  
Multimodal Treatment ◽  
Colorectal Liver Metastases ◽  
Hepatic Disease ◽  
First Line ◽  
Unresectable Disease ◽  
Unresectable Metastases ◽  
Line Chemotherapy

ABSTRACT In the last module of this consensus, controversial topics were discussed. Management of the disease after progression during first line chemotherapy was the first discussion. Next, the benefits of liver resection in the presence of extra-hepatic disease were debated, as soon as, the best sequence of treatment. Conversion chemotherapy in the presence of unresectable liver disease was also discussed in this module. Lastly, the approach to the unresectable disease was also discussed, focusing in the best chemotherapy regimens and hole of chemo-embolization.

LiverMetSurvey: Analysis of clinicopathologic factors associated with the efficacy of preoperative chemotherapy in 2,122 patients with colorectal liver metastases

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 3521-3521 ◽  
Author(s):  
R. Adam ◽  
T. Aloia ◽  
J. Figueras ◽  
L. Capussotti ◽  
G. Poston ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Preoperative Chemotherapy ◽  
Primary Tumor ◽  
Colorectal Liver Metastases ◽  
Systemic Chemotherapy ◽  
Treatment Options ◽  
Treatment Strategies ◽  
Multimodality Treatment ◽  
Primary Tumor Site ◽  
Number Of Patients

3521 Background: LiverMetSurvey is an international, internet-based registry designed to assess the efficacy of multimodality treatment options for colorectal liver metastases (CLM) by analyzing outcomes following hepatic resection (HR) in a large number of patients. Methods: Data were analyzed for the 2,122 patients entered into LiverMetSurvey by six hepatobiliary centers from inception to August 2004 (HR: 1974 to 2004; 1,306 men: 816 women; mean age: 61 years). The distributions of potential prognostic factors including age, sex, primary tumor site, timing of metastasis diagnosis, tumor number, diameter of the largest metastasis, bilaterality, and treatment with chemotherapy were compared to survivals using univariate and multivariate statistics. Results: Metastases originated in the colon in 69% of patients and were synchronous (diagnosed within 3 mo of primary tumor treatment) in 49% of patients. 34% of patients had ≥ 3 metastases and tumors were distributed bilaterally in 43% of cases. The mean size of the largest metastasis was 41.8 mm. 55% of patients were treated with preoperative systemic chemotherapy. Following resection, 60-day mortality was 1.2% and median, 5-year, and 10-year overall survivals (OS) were 46 mo, 42%, and 26%, respectively. Variables independently associated with poor prognosis included number of metastases > 3 (p<0.0001), bilateral metastases (p=0.0002), and size of the largest metastasis > 5 cm (p=0.03). Preoperative chemotherapy (PC) did not appear to benefit patients with solitary CLM (5-yr OS: PC 45% vs. no PC 58%), but was associated with improved survival in patients with > 5 metastases (5-yr OS: PC 22% vs. no PC 12%). Conclusions: Assessment of outcomes for the first 2,122 registrants to LiverMetSurvey not only confirms the prognostic importance of intrahepatic tumor burden, but also indicates that the ability of preoperative systemic chemotherapy to improve survivals is limited to patients with multiple (> 5) metastases. In addition, this analysis demonstrates the potential for LiverMetSurvey, which is now prospectively enrolling patients from over 40 centers, to determine the therapeutic value of current and future treatment strategies. No significant financial relationships to disclose.

Surgical Management of Liver Metastases From Colorectal Cancer

2016 ◽  
Vol 12 (1) ◽  
pp. 33-39 ◽  
Author(s):  
Mashaal Dhir ◽  
Aaron R. Sasson
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Factors ◽  
Liver Metastases ◽  
Surgical Resection ◽  
Surgical Management ◽  
Colorectal Liver Metastases ◽  
Multidisciplinary Approach ◽  
Treatment Options ◽  
Optimal Timing ◽  
Medical Oncologists

Surgical resection remains one of the major curative treatment options available to patients with colorectal liver metastases. Surgery and chemotherapy form the backbone of the treatment in patients with colorectal liver metastases. With more effective chemotherapy regimens being available, the optimal timing and sequencing of treatments are important. A multidisciplinary approach with the involvement of medical oncologists and surgical oncologists from the beginning is crucial. Identification of the clinical and molecular prognostic factors may help personalize the treatment approaches for these patients. This article provides an overview of the surgical management of colorectal liver metastases.

scholarly journals Treatment Options in Colorectal Liver Metastases: Hepatic Arterial Infusion

2017 ◽  
Vol 33 (1) ◽  
pp. 47-53 ◽  
Author(s):  
Alice Zervoudakis ◽  
Taryn Boucher ◽  
Nancy E. Kemeny
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Treatment Options ◽  
Hepatic Arterial Infusion ◽  
Arterial Infusion

scholarly journals Reszekábilis colorectalis eredetű májáttét esetén javasolt-e a preoperatív szisztémás kezelés? Onkosebészeti nézőpont

2018 ◽  
Vol 159 (21) ◽  
pp. 823-830
Author(s):  
Kristóf Dede ◽  
Zsuzsa Póti ◽  
Attila Bursics
Keyword(s):  
Chronic Disease ◽  
Liver Metastasis ◽  
Liver Metastases ◽  
Preoperative Chemotherapy ◽  
Colorectal Liver Metastases ◽  
Hot Spot ◽  
Treatment Options ◽  
Current Evidence ◽  
Collective Decisions ◽  
Complex Therapy

Abstract: Surgical resection is still the only curative treatment for colorectal liver metastases, but this is one part of a complex therapy. Nowadays a patient with colorectal liver metastasis is not treated only by a surgeon or by an oncologist or even only by an invasive radiologist. Collective decisions, complement treatments give the only chance to treat these patients for longer time. Patients with colorectal liver metastases could be regarded as patients with chronic disease. Specially interesting are the various treatment options of resectable colorectal liver metastases. The efficiency and necessity of preoperative chemotherapy are still a hot spot in the treatment of resectable liver metastases. In this study, we try to summarize the international and local experiences and the current evidence of the use of preoperative chemotherapy in the treatment of colorectal liver metastases. Orv Hetil. 2018; 159(21): 823–830.

scholarly journals CONTRAST-ENHANCED ULTRASOUND IMAGING OF COLORECTAL LIVER METASTASES

2017 ◽  
pp. 32-36
Author(s):  
L. A. Mitina ◽  
S. O. Stepanov ◽  
D. V. Sidorov ◽  
O. V. Guts ◽  
L. O. Petrov ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Imaging Techniques ◽  
Treatment Options ◽  
Tumor Resection ◽  
Contrast Enhanced Ultrasound ◽  
Term Survival ◽  
Contrast Enhanced ◽  
Aggressive Surgical Approach

At present, aggressive surgical approach in combination with perioperative chemotherapy allows to extend indications for surgical intervention in patients with metastatic colorectal cancer, since only a radical liver resection provides better long-term survival. Contrast enhancement imaging techniques are important before considering treatment options to identify patients with resectable and potentially resectableliver metastases. Our study evaluated the qualitative and quantitative parameters of thedynamic enhancement pattern of liver metastases. This review will be analyzed the results of liver contrast-enhanced ultrasound studies in 104 patients with secondary colorectal liver metastases before primary tumor resection, as well as the monitoring of systemic chemotherapy and post-ablation follow-up to access treatment respond.

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