scholarly journals High hepatic expression of PDK4 improves survival upon multimodal treatment of colorectal liver metastases

2019 ◽  
Vol 120 (7) ◽  
pp. 675-688 ◽  
Author(s):  
Moritz J. Strowitzki ◽  
Praveen Radhakrishnan ◽  
Sandra Pavicevic ◽  
Jana Scheer ◽  
Gwendolyn Kimmer ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Multimodal Treatment ◽  
Colorectal Liver Metastases ◽  
Hepatic Expression

scholarly journals Trends in multimodal treatment and long-term outcomes of patients with resected colorectal liver metastases in a Brazilian Cancer Center

HPB ◽  
2016 ◽  
Vol 18 ◽  
pp. e193-e194
Author(s):  
M.C. Marques ◽  
A.L. Diniz ◽  
H.S.C. Ribeiro ◽  
W.L. Costa ◽  
A.L. Godoy ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Multimodal Treatment ◽  
Colorectal Liver Metastases ◽  
Cancer Center ◽  
Long Term Outcomes

scholarly journals FIRST BRAZILIAN CONSENSUS ON MULTIMODAL TREATMENT OF COLORECTAL LIVER METASTASES. MODULE 1: PRE-TREATMENT EVALUATION

2015 ◽  
Vol 28 (4) ◽  
pp. 222-230 ◽  
Author(s):  
Felipe José Fernandez COIMBRA ◽  
Heber Salvador de Castro RIBEIRO ◽  
Márcio Carmona MARQUES ◽  
Paulo HERMAN ◽  
Rubens CHOJNIAK ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Multimodal Treatment ◽  
Colorectal Liver Metastases ◽  
Epidemiological Data ◽  
Treatment Modalities ◽  
Established Method ◽  
Curative Intent ◽  
Pre Treatment ◽  
Definition Of

Background : Liver metastases of colorectal cancer are frequent and potentially fatal event in the evolution of patients with these tumors. Aim : In this module, was contextualized the clinical situations and parameterized epidemiological data and results of the various treatment modalities established. Method: Was realized deep discussion on detecting and staging metastatic colorectal cancer, as well as employment of imaging methods in the evaluation of response to instituted systemic therapy. Results : The next step was based on the definition of which patients would have their metastases considered resectable and how to expand the amount of patients elegible for modalities with curative intent. Conclusion : Were presented clinical, pathological and molecular prognostic factors, validated to be taken into account in clinical practice.

scholarly journals Multimodal treatment options for bilobar colorectal liver metastases

2010 ◽  
Vol 395 (6) ◽  
pp. 633-641 ◽  
Author(s):  
Kia Homayounfar ◽  
Torsten Liersch ◽  
Martin Niessner ◽  
Johannes Meller ◽  
Thomas Lorf ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Multimodal Treatment ◽  
Colorectal Liver Metastases ◽  
Treatment Options

scholarly journals I BRAZILIAN CONSENSUS FOR MULTIMODAL TREATMENT OF COLORECTAL LIVER METASTASES

2015 ◽  
Vol 28 (4) ◽  
pp. 221-221 ◽  
Author(s):  
Felipe José Fernandez COIMBRA ◽  
Heber Salvador de Castro RIBEIRO ◽  
Orlando Jorge Martins TORRES
Keyword(s):  
Liver Metastases ◽  
Multimodal Treatment ◽  
Colorectal Liver Metastases

scholarly journals BRAZILIAN CONSENSUS FOR MULTIMODAL TREATMENT OF COLORECTAL LIVER METASTASES. MODULE 3: CONTROVERSIES AND UNRESECTABLE METASTASES

2016 ◽  
Vol 29 (3) ◽  
pp. 173-179 ◽  
Author(s):  
Orlando Jorge Martins TORRES ◽  
Márcio Carmona MARQUES ◽  
Fabio Nasser SANTOS ◽  
Igor Correia de FARIAS ◽  
Anelisa Kruschewsky COUTINHO ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Resection ◽  
Liver Metastases ◽  
Multimodal Treatment ◽  
Colorectal Liver Metastases ◽  
Hepatic Disease ◽  
First Line ◽  
Unresectable Disease ◽  
Unresectable Metastases ◽  
Line Chemotherapy

ABSTRACT In the last module of this consensus, controversial topics were discussed. Management of the disease after progression during first line chemotherapy was the first discussion. Next, the benefits of liver resection in the presence of extra-hepatic disease were debated, as soon as, the best sequence of treatment. Conversion chemotherapy in the presence of unresectable liver disease was also discussed in this module. Lastly, the approach to the unresectable disease was also discussed, focusing in the best chemotherapy regimens and hole of chemo-embolization.

scholarly journals I BRAZILIAN CONSENSUS ON MULTIMODAL TREATMENT OF COLORECTAL LIVER METASTASES. MODULE 2: APPROACH TO RESECTABLE METASTASES

2016 ◽  
Vol 29 (1) ◽  
pp. 9-13 ◽  
Author(s):  
Héber Salvador de Castro RIBEIRO ◽  
Orlando Jorge Martins TORRES ◽  
Márcio Carmona MARQUES ◽  
Paulo HERMAN ◽  
Antonio Nocchi KALIL ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Clinical Practice ◽  
Liver Metastases ◽  
Treatment Response ◽  
Multimodal Treatment ◽  
Colorectal Liver Metastases ◽  
Preoperative Treatment ◽  
Metachronous Metastases

Background : Liver metastases of colorectal cancer are frequent and potentially fatal event in the evolution of patients. Aim : In the second module of this consensus, management of resectable liver metastases was discussed. Method : Concept of synchronous and metachronous metastases was determined, and both scenarius were discussed separately according its prognostic and therapeutic peculiarities. Results : Special attention was given to the missing metastases due to systemic preoperative treatment response, with emphasis in strategies to avoid its reccurrence and how to manage disappeared lesions. Conclusion : Were presented validated ressectional strategies, to be taken into account in clinical practice.

scholarly journals Multimodal treatment strategies for colorectal liver metastases

2021 ◽  
Author(s):  
Dominique L Birrer ◽  
Christoph Tschuor ◽  
Caecilia Reiner ◽  
Ralph Fritsch ◽  
Thomas Pfammatter ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Multimodal Treatment ◽  
Colorectal Liver Metastases ◽  
Treatment Strategies

Colorectal Liver Metastases - Does the Number of Lesions Determine the Sensibility of Resection?

Swiss Surgery ◽  
2000 ◽  
Vol 6 (1) ◽  
pp. 6-10
Author(s):  
Knoefel ◽  
Brunken ◽  
Neumann ◽  
Gundlach ◽  
Rogiers ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Rank Test ◽  
Log Rank Test ◽  
Kaplan Meier ◽  
Chirurgische Entfernung

Die komplette chirurgische Entfernung von Lebermetastasen bietet Patienten nach kolorektalem Karzinom die einzige kurative Chance. Es gibt jedoch eine, anscheinend unbegrenzte, Anzahl an Parametern, die die Prognose dieser Patienten bestimmen und damit den Sinn dieser Therapie vorhersagen können. Zu den am häufigsten diskutierten und am einfachsten zu bestimmenden Parametern gehört die Anzahl der Metastasen. Ziel dieser Studie war es daher die Wertigkeit dieses Parameters in der Literatur zu reflektieren und unsere eigenen Patientendaten zu evaluieren. Insgesamt konnte von 302 Patienten ein komplettes Follow-up erhoben werden. Die gebildeten Patientengruppen wurden mit Hilfe einer Kaplan Meier Analyse und konsekutivem log rank Test untersucht. Die Literatur wurde bis Dezember 1998 revidiert. Die Anzahl der Metastasen bestätigte sich als ein prognostisches Kriterium. Lagen drei oder mehr Metastasen vor, so war nicht nur die Wahrscheinlichkeit einer R0 Resektion deutlich geringer (17.8% versus 67.2%) sondern auch das Überleben der Patienten nach einer R0 Resektion tendenziell unwahrscheinlicher. Das 5-Jahres Überleben betrug bei > 2 Metastasen 9% bei > 2 Metastasen 36%. Das 10-Jahres Überleben beträgt bislang bei > 2 Metastasen 0% bei > 2 Metastasen 18% (p < 0.07). Die Anzahl der Metastasen spielt in der Prognose der Patienten mit kolorektalen Lebermetastasen eine Rolle. Selbst bei mehr als vier Metastasen ist jedoch gelegentlich eine R0 Resektion möglich. In diesen Fällen kann der Patient auch langfristig von einer Operation profitieren. Das wichtigere Kriterium einer onkologisch sinnvollen Resektabilität ist die Frage ob technisch und funktionell eine R0 Resektion durchführbar ist. Ist das der Fall, so sollte auch einem Patienten mit mehreren Metastasen die einzige kurative Chance einer Resektion nicht vorenthalten bleiben.

Sign in / Sign up

Export Citation Format

Share Document