Today, helminthous invasions in horses are one of the important problems for veterinary specialists, since the action of helminths significantly affects the general condition of horses, allergic and toxic manifestations of diseases are observed, external qualities are worsened, performance, endurance, natural resistance are reduced, which leads to the emergence of diseases of various etiologies. We set the goal – to study the helminthofauna of horses in the Tyumen region. For the study of horse helminthoses, an animal survey was conducted in the period 2017–2020. As a result of the data obtained, it was found that horses have a mixed helminthose invasion consisting of nematodes of the Oxyuridae family (Oxyuris equi) during the parasitization of which, in horses, it was revealed – the rumpleness of the hair-covering of the dock, the formation of bald patches and the release of white plaque from the anal orifice, with Ascaridae (Parascaris equorum) there were seizures of cough and nasal secretions, as well as horses had reduced appetite and increased fatigue, with Strongyloididae (Strongyloides westeri) – foals had a delay in molting and an increase in abdominal volume, the Strongylata suborder caused digestive disorder with colic attacks. To prevent the spread of helminthous invasions, it is necessary to carry out the main integrated system for control helminthosis, which includes veterinary, sanitary and therapeutic and preventive events.