EFFICIENCY OF ANTIPARASITIC DRUG IVERPRADAG IN THE TREATMENT OF PARASITOSES OF HORSES

2018 ◽  
Vol 1 (1) ◽  
pp. 110-113
Author(s):  
D. I. Ruban ◽  
◽  
I. G. Glamazdin ◽  
D. I. Udavliev ◽  
M. D. Mamedberdyeva ◽  
...  
Keyword(s):  
Body Weight ◽  
High Efficiency ◽  
Active Principle ◽  
Parascaris Equorum ◽  
High Effectiveness ◽  
Antiparasitic Drug ◽  
Anoplocephala Perfoliata ◽  
Prevention And Treatment ◽  
Setaria Equina ◽  
Strongyloides Westeri

The article provides information about the new preparation Iverpradag, developed by the firm "Gudratli lukman" (Turkmenistan), which is being tested in Russian Federation and Turkmenistan, intended for the prevention and treatment of parasitosis in horses. The active principle of the developed preparation is widely known and very effective ivermectin and praziquantel (in complex). Studies conducted in Russia and Turkmenistan showed high effectiveness of the drug against nematodes including Delafondia vulgaris, Alfortia edentatus, Dictyocaulus arnfieldi, Parascaris equorum, Strongylus equinus, Strongyloides westeri, Setaria equina, and cestode, including Anoplocephala magna, Anoplocephala perfoliata and Paranoplocephala mamillana, as well as against gastric larvae (Gastrophilus spp.) parasitizing in horses. The conducted studies showed high efficiency of the drug Iverpradag in the form of paste when applied at the rate of 1 dose (0,9 ml) per 100 kg of body weight.

scholarly journals Monitoring of anthelmintic resistance in small strongyles in the Czech Republic in the years 2006–2009

2013 ◽  
Vol 82 (3) ◽  
pp. 243-248
Author(s):  
Štěpán Bodeček ◽  
Eva Vavrouchová
Keyword(s):  
Czech Republic ◽  
Anthelmintic Resistance ◽  
Drug Resistant ◽  
The Czech Republic ◽  
Parascaris Equorum ◽  
Reduction Test ◽  
Anoplocephala Perfoliata ◽  
Faecal Egg Count ◽  
Pre Treatment ◽  
Strongyloides Westeri

The aim of the field study performed in 2006 was to investigate the occurrence and distribution of intestinal helminths in horses based on pre-treatment faecal egg counts. In total, 948 horses bred on 37 farms were tested. Thirty six (97.2%) farms tested were positive for cyathostomins; horses in 9 (24.3%), 6 (16.2%) and 1 (2.7%) different herds tested were positive for Parascaris equorum, Anoplocephala perfoliata and Strongyloides westeri, respectively. In 21 herds, 344 horses with values exceeding 100 eggs per gram were included in the trial for the presence of drug resistant cyathostomins by a faecal egg count reduction test. Horses were treated orally with recommended doses of fenbendazole and ivermectin. Resistance to fenbendazole was detected on 20 farms (95.24%) with values of faecal egg count reduction test ranging from 0 to 90%. Ivermectin remained effective in all tested herds with the value of faecal egg count reduction test 96–100%. In autumn 2008, 178 horses on 10 farms were examined. Of these, only seven horses tested were negative for cyathostomins. One farm was tested positively for Anoplocephala perfoliata, and one for Parascaris equorum. In spring 2009, six farms were examined, four of which were the same farms as in 2006. We found a decreased number of eggs per gram in all horses, but an increase in benzimidazole resistance, which was found in 5 farms out of 6 (faecal egg count reduction test 15.2–84.6%). This is the first wide survey in horses from the Czech Republic. Based on this study, we can conclude that benzimidazole resistant cyathostomins in horses are widespread but ivermectin is still fully effective.

scholarly journals Endoparasites of horses from the Formiga city, located in center-west region of the state of Minas Gerais, Brazil

2014 ◽  
Vol 23 (4) ◽  
pp. 534-538 ◽  
Author(s):  
Weslen Fabricio Pires Teixeira ◽  
Gustavo Felippelli ◽  
Breno Cayeiro Cruz ◽  
Willian Giquelin Maciel ◽  
Flávia Carolina Fávero ◽  
...  
Keyword(s):  
Minas Gerais ◽  
The State ◽  
Parascaris Equorum ◽  
West Region ◽  
Anoplocephala Perfoliata ◽  
Strongylus Vulgaris ◽  
High Incidence ◽  
Habronema Muscae ◽  
Strongyloides Westeri

With the aim of studying the endoparasite fauna of horses from the Formiga city, located in center-west region of the state of Minas Gerais, 25 animals that were naturally infected with helminths were evaluated. By means of parasitological necropsies, different endoparasites were found. The subfamily Cyathostominae presented the highest incidence, followed by Trichostrongylus axei, Oxyuris equi, Triodontophorus serratus, Strongyloides westeri, Strongylus edentatus, Habronema muscae, Parascaris equorum, Probstmayria vivipara, Strongylus vulgaris, Gasterophilus nasalis, Anoplocephala magna and Anoplocephala perfoliata. In the present study, if the species Probstmayria vivipara was not considered in the prevalence, the frequency of Cyathostominae was equivalent to 94.85%. The results obtained in this study allowed us to detect and identify different species of helminths in horses, and confirmed the high incidence of nematodes belonging to the subfamily Cyathostominae in the center-west region of Minas Gerais.

scholarly journals Frecuencia de parásitos gastrointestinales en burros criollos (Equus africanus asinus) en el departamento de Córdoba, Colombia

2016 ◽  
Vol 8 (2) ◽  
pp. 159 ◽  
Author(s):  
Yonairo Herrera B. ◽  
Jheremmys Vergara A. ◽  
Carlos Ensuncho H. ◽  
Luis Causil V.
Keyword(s):  
Parascaris Equorum ◽  
Anoplocephala Perfoliata ◽  
Eimeria Spp ◽  
Strongyloides Westeri

El presente estudio fue diseñado con el objetivo de determinar la frecuencia de parásitos gastrointestinales en burros criollos (Equus africanus asinus) del departamento de Córdoba, Colombia. El tipo de estudio fue descriptivo transversal. El estudio se llevó a cabo en 47 predios entre los meses de agosto y noviembre de 2015. Se recolectaron muestras coprológicas y se empleó la técnica de flotación, examinándose 144 muestras, De las 144 muestras examinadas 136 (94,44%) resultaron positivas al menos para algún género de parásito. Las frecuencias encontradas fueron de Trichostrongylus spp. 91,67%, Strongylus spp. 68.06%, Strongyloides westeri 66,67%, Parascaris equorum 9,72%, Anoplocephala perfoliata 5,56% y Eimeria spp. 2,78%. Se pudo concluir que existe una elevada presencia de nematodos en comparación con los cestodos y protozoarios, encontrados en los asnos del departamento de Córdoba, Colombia.

scholarly journals Transmission of some species of internal parasites in horse foals born in 2013 in the same pasture on a farm in Central Kentucky

2015 ◽  
Vol 52 (3) ◽  
pp. 211-218 ◽  
Author(s):  
S. C. Tolliver ◽  
E. T. Lyons ◽  
M. K. Nielsen ◽  
J. L. Bellaw
Keyword(s):  
Large Intestine ◽  
Parascaris Equorum ◽  
Anoplocephala Perfoliata ◽  
Strongylus Vulgaris ◽  
Artificial Digestion ◽  
Internal Parasites ◽  
Over 40 Years ◽  
Strongyloides Westeri

Abstract The present research is a continuation of studies conducted periodically over 40 years on transmission of natural infections of internal parasites in the same horse herd on pasture (Field 10) on a farm in Central Kentucky. It included 12 mixed light horse foals born in 2013 and euthanatized between July, 2013 and April, 2014 for collection of internal parasites. Parasites found: Gasterophilus intestinalis, Strongyloides westeri, Parascaris equorum, Anoplocephala perfoliata, small strongyles (cyathostomes), Strongylus vulgaris, Strongylus edentatus and Thelazia lacrymalis. Prevalence generally was related to age of the foals. Overall prevalence and number of specimens were lower than in earlier studies except for P. equorum. There were 15 species (much fewer than previously) of small strongyles found and recorded by location in the large intestines. All stages of small strongyles encysted in the mucosa of the large intestine were recovered by artificial digestion and in significantly lower numbers in older foals

scholarly journals Parasitological survey of Polish primitive horses (Equus caballus gmelini Ant.): influence of age, sex and management strategies on the parasite community

2016 ◽  
Vol 53 (3) ◽  
pp. 233-242 ◽  
Author(s):  
K. Slivinska ◽  
V. Kharchenko ◽  
Z. Wróblewski ◽  
J. Gawor ◽  
T. Kuzmina
Keyword(s):  
Management Strategies ◽  
Age Groups ◽  
Nematode Species ◽  
Parasite Community ◽  
Gastrointestinal Parasites ◽  
Parascaris Equorum ◽  
Anoplocephala Perfoliata ◽  
Young Horses ◽  
Free Ranging ◽  
Strongyloides Westeri

Summary An extensive analysis of the relationship between age, sex, and different types of management strategies relative to the gastrointestinal parasite community of Polish primitive horses was performed on 124 horses maintained in nine farms from four regions of Poland. The horses (96 females and 28 males) were housed in three types of management strategies: stabled (ST), free-ranging (FR) and semi-free (SF). These horses also were divided into three age groups: <3 years, 3 – 10 years and >10 years old. The gastrointestinal parasites were collected following deworming of all horses with anthelmintics containing the macrocyclic lactones and praziquantel. Totally, 66,192 parasite specimens were collected and identified. The analysis of dependence of horse infection with intestinal nematodes using sex, age and management strategies demonstrated that females had significantly heavier infections of strongylids. Young horses (<3 years old) had higher infections of Parascaris equorum and Strongyloides westeri. Free ranging horses were more infected with strongylids, Oxyuris equi and Gasterophilus intestinalis. Thirty-five nematode species, one cestode and one species of the botfly larvae of Gasterophilus were found. Diagnostic deworming examination revealed presence of Parascaris equorum in 27.4 %, Oxyuris equi in 38.7 %, Habronema muscae in 16.9 %, Anoplocephala perfoliata in 42.7 % and Gasterophilus intestinalis in 46.8% in the Polish primitive horses examined. Strongyloides westeri presence was confirmed only by fecal samples examination; threadworms were not observed in these horses after deworming. In the strongylid community, 31 species (6 of subfamily Strongylinae and 25 of Cyathostominae) were found. Significant differences in prevalence of separate strongylid species, or their proportions in the communities were not observed between females and males, or between age groups (p > 0.05). The highest species diversity (n=30 or 31) was observed in the FR horses, the lowest (n=15) – in ST horses. The FR horses had higher prevalence and proportion of large strongyles in the community, in comparison to SF or ST horses (p < 0.05).

Inspector Quadro - the complex of preparation for the treatment of ectoand endoparasitoses in cats and dogs

2018 ◽  
Vol 12 (2) ◽  
pp. 75-84
Author(s):  
M.V. Arisov ◽  
I.P. Belykh ◽  
V.V. Artemov
Keyword(s):  
Body Weight ◽  
Clinical Picture ◽  
High Efficiency ◽  
The Body ◽  
Negative Effects ◽  
Laboratory Methods ◽  
Diagnosis Of Infection

The purpose of the research: the study of the efficacy of the preparations for veterinary use "Inspector Quadro C" and "Inspector Quadro K" against ecto- and endoparasitoses of dogs and cats. Materials and methods. Studies were conducted on spontaneously infected dogs and cats of different sexes, age, weight and breed. The diagnosis of infection with ectoparasites was made based on the clinical picture and laboratory methods of investigation (microscopy of scrapings taken from ectoparasitized skin areas, examination of the coat for fleas, lice, worms, ixodids). Infection with helminths was established by detecting eggs of helminths in faeces of animals by the method of Füleleborn and mature segments of cestodes. Preparations were applied to the animals by drip application on dry undamaged skin in places inaccessible to licking in a dose of 0.1-0.4 ml per 1 kg of body weight. The results were statistically processed. Results and discussion. "Inspector Quadro S" and "Inspector Quadro K" showed 100% efficacy at sarcoptosis in dogs, notoedrosis in cats, otodectosis in dogs and cats, ixodidoses and entomoses. "Inspector Quadro C" showed a high efficiency (92.3%) at demodecosis in dogs. However, single mites were found in one dog. 100% efficacy of "Inspector Quadro C" and "Inspector Quadro K" has been established against intestinal nematodes and cestodes in dogs and cats. Negative effects of drugs on the body of animals have not been revealed.

TOTAL POLYPHENOL CONTENT, FREE RADICAL SCAVENGING, ALPHA-GLUCOSIDASE INHIBITION CAPACITY, THE EFFICACY IN CONTROLLING BLOOD GLUCOSE OF DIABETIC RATS OF THE MIXTURE VOS EXTRACTED FROM THE LEAVES OF CLEISTOCALYX OPERCULATUS, PSIDIUM GUAJAVA AND NELUMBO NUCIFERA

2013 ◽  
pp. 50-55
Author(s):  
Tuyet Mai Truong ◽  
Thi Lam Nguyen ◽  
Lan Anh Pham ◽  
Hoang Kien Truong
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Radical Scavenging ◽  
Psidium Guajava ◽  
Free Radical Scavenging ◽  
Diabetic Mice ◽  
Cleistocalyx Operculatus ◽  
Prevention And Treatment ◽  
Treatment Of Diabetes ◽  
Alpha Glucosidase

Objective: Plant polyphenols have antioxidant capacity and alpha-glucosidase inhibition to supporting for prevention and treatment of diabetes. Materials and Method: Present study was conducted to determine the content of total polyphenols, free radical scavenging and alpha-glucosidase inhibition of the VOS mixture that extracted from leaves (Voi leaves - Cleistocalyx operculatus (V), Oi leaves - Psidium guajava (O), Sen leaves - Nelumbo nucifera (S)). Results: The efficacy of blood glucose controlling in diabetic mice was investigated. After 8 weeks of administration with 200 mg VOS/kg body weight and 400 mg VOS/kg body weight, VOS diabetic mice had significantly reduced blood glucose level as compared to control diabetic mice. VOS diabetic mice with 400 mg dosage are lower in blood glucose levels than that of the diabetic mice with 200 mg. Also, the significant reducing in HbA1c was observed in VOS diabetic mice as compared with control diabetic mice. Conclusion: VOS-product extracted from Cleistocalyx operculatus leaves, guava leaves, lotus leaves might be considered as a safe product and to be a potential product in the supporting of prevention and treatment of diabetes.

scholarly journals Application of enzyme engineering in pharmacy

2020 ◽  
Vol 9 (2) ◽  
Author(s):  
Qiaole Li ◽  
Yanhong Li ◽  
Haoran Niu
Keyword(s):  
High Efficiency ◽  
Development Trend ◽  
Enzyme Engineering ◽  
Reaction Conditions ◽  
Important Method ◽  
Reaction Specificity ◽  
Prevention And Treatment ◽  
Modern Biotechnology ◽  
Catalytic Functions ◽  
The Development Trend

Enzyme engineering is an important part of modern biotechnology. Due to its high reaction specificity, high efficiency, mild reaction conditions, and low pollution, it is also an important method widely used in the pharmaceutical field. The application of enzymes in medicine is diverse, such as: diagnosis, prevention and treatment of diseases with enzymes, manufacture of various drugs with enzymes, etc., mainly through manual operations, to obtain enzymes required by the pharmaceutical industry, and through various means Enzymes perform their catalytic functions. This article mainly introduces the application of enzyme engineering in the pharmaceutical field, and also prospects the development trend of enzyme engineering in the pharmaceutical field.

scholarly journals Prevalence and Intensity of Gastrointestinal Parasites in Donkeys in Selected Abattoirs in Kenya

Scientifica ◽  
2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Nancy Mulwa ◽  
Samuel Githigia ◽  
Davis Karanja ◽  
Cecilia Mbae ◽  
Eberhard Zeyhle ◽  
...  
Keyword(s):  
Body Condition ◽  
Gastrointestinal Parasites ◽  
Morphological Identification ◽  
Helminth Parasites ◽  
Parascaris Equorum ◽  
Helminth Infections ◽  
Strongylus Vulgaris ◽  
Faecal Samples ◽  
Pregnancy Status ◽  
Setaria Equina

The aim of this study was to determine the prevalence and intensity of gastrointestinal parasites in donkeys slaughtered in Kinamba, Mogotio, and Lodwar slaughterhouses and their association with several host factors. A survey was done between July and September 2017 in three slaughterhouses. Faecal samples were collected per rectum from all the study donkeys for faecal egg counts (EPG) and morphological identification of the eggs. At slaughter, the gastrointestinal tracts were opened and examined visually, and all helminth parasites collected were subjected to morphological identification. Prevalence and intensity were calculated based on the helminth identified and EPG. A total of 282 donkeys were sampled. A majority of the donkeys (89%) were in poor body condition. Ten helminth parasite species were identified in 85.5% donkeys. They were Strongylus vulgaris (52.8%), Parascaris equorum (20.2%), Strongylus edentatus (12.1%), Anaplocephala perfoliata (10.3%), Setaria equina (3.5%) Anaplocephala magna (2.5%), Cylicocyclus auriculatus (2.1%), Cyathostomum species (1.8%), Strongylus equinus (0.4%), and Triodontophorus serratus (0.4%). A significant percentage (55.3%) had no eggs in their feces, 39% had low infection, 5% had medium, and only 0.7% were heavily infected. Prevalence rates via use of the EPG showed Strongyles (44.7%), Parascaris equorum (5.3%), Oxyuris equi (11%), Triodontophorus tenuicolis (0.7%), Habronema species (0.7%), and cestodes eggs (0.4%). No significant differences were observed between fecal Strongylus egg count and age, sex, and pregnancy status. However, donkeys with poor body condition shed more Strongylus eggs in feces. Helminth infections are prevalent in donkeys in Kenya; however, this is not reflected in coprological analyses. These helminth parasites may contribute to poor body condition, ill health, and poor productivity of donkeys.

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