scholarly journals Preventing tuberculosis in paediatric kidney transplant recipients: is there a role for BCG immunisation pre-transplantation in low tuberculosis incidence countries?

2020 ◽  
Author(s):  
Alasdair Bamford ◽  
Garth Dixon ◽  
Nigel Klein ◽  
Stephen D. Marks ◽  
Nicole Ritz ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Transplant ◽  
Primary Infection ◽  
Latent Infection ◽  
Bacillus Calmette Guerin ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
National Immunisation ◽  
Testing Strategies

AbstractThe risk of tuberculosis (TB) disease is increased in children with chronic kidney disease (CKD), even higher in stage 5 CKD/kidney failure and especially high after kidney transplantation due to immunosuppression. TB disease may follow recent primary infection, or result from reactivation of latent infection. Reactivation is more common in adults, while progression following primary infection makes up a greater proportion of disease in children. Recommendations for preventing TB disease in some low TB incidence countries have previously included offering Bacillus Calmette-Guérin (BCG) vaccine to all children listed for kidney transplant if they had not received this as part of previous national immunisation programmes. Based on the available evidence, we recommend modifying this practice, focusing instead on awareness of risk factors for TB exposure, infection and disease and the use of appropriate testing strategies to identify and treat TB infection and disease.

scholarly journals Probable Donor-Derived Human Adenovirus Type 34 Infection in 2 Kidney Transplant Recipients From the Same Donor

2018 ◽  
Vol 6 (3) ◽  
Author(s):  
Matthew A Pettengill ◽  
Tara M Babu ◽  
Paritosh Prasad ◽  
Sally Chuang ◽  
Michael G Drage ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Primary Infection ◽  
Latent Infection ◽  
Tubulointerstitial Nephritis ◽  
Hemorrhagic Cystitis ◽  
Organ Donor ◽  
Human Adenovirus ◽  
Adenovirus Type ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

Abstract Human adenovirus type 34 (HAdV-34) infection is a recognized cause of transplant-associated hemorrhagic cystitis and, in rare cases, tubulointerstitial nephritis. The source of such infections is often difficult to assess, that is, whether acquired as a primary infection, exposure to a pathogen in the transplanted organ, or reactivation of an endogenous latent infection. We present here 2 cases of likely transplant-acquired HAdV-34 infection from the same organ donor, manifesting as tubulointerstitial nephritis in 1.

scholarly journals Chronic kidney disease progression in kidney transplant recipients: A focus on traditional risk factors

Nephrology ◽  
2019 ◽  
Vol 24 (2) ◽  
pp. 141-147 ◽  
Author(s):  
Moisés Carminatti ◽  
Hélio Tedesco-Silva ◽  
Natália Maria Silva Fernandes ◽  
Helady Sanders-Pinheiro
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Disease Progression ◽  
Kidney Transplant ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Chronic Kidney Disease Progression ◽  
Kidney Disease Progression ◽  
Traditional Risk Factors

scholarly journals 1389. Risk Factors and Clinical Outcomes of Tuberculosis Among Kidney Transplant Recipients in High Endemic Country: A Case–Control Study

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S505-S505
Author(s):  
Saranya Thitisuriyarax ◽  
Kamonwan Jutivorakool ◽  
Suwasin Udomkarnjananun ◽  
Natavudh Townamchai ◽  
Gompol Suwanpimolkul ◽  
...  
Keyword(s):  
Risk Factors ◽  
Kidney Transplant ◽  
Allograft Rejection ◽  
Case Control Study ◽  
Latent Infection ◽  
Case Control ◽  
Transplant Recipients ◽  
Endemic Country ◽  
Kidney Transplant Recipients ◽  
Control Study

Abstract Background Tuberculosis (TB) is considered as a challenging issue in solid-organ transplant recipients because of high morbidity and mortality. Active TB after transplant can occur from reactivation of latent infection or newly acquired from community. Understanding risk factors and clinical information of TB may provide an appropriate prevention and treatment strategies in this specific patient population; however, most of data were from non-endemic countries. Methods A single-center, matched case–control study was conducted in our institute. Cases were defined as newly diagnosed proven or probable active TB in patients who underwent kidney transplant between April 1992 and October 2018. For each case, 5 controls were matched by age and sex. Risk factor associated with TB was determined using univariate and multivariate conditional logistic regression. Results Between study period, kidney transplant was performed in 787 patients. None of the recipients was screened or treated for latent tuberculosis. Twenty-seven patients (3.43%) were diagnosed with active TB including 20 proven and 7 probable cases. The overall incidence of TB in our population was 315 cases per 100,000 patients per year. Allograft rejection was significantly associated with active TB (P < 0.001). The median onset of infection was 17 months (IQR, 4–59 months) after transplantation and 3.4 months (IQR, 2.7–16.3 months) after episode of allograft rejection. Majority of patients (96.3%) were cured after complete treatment; however, those with TB remained having significant unfavorable outcomes including higher all-cause mortality and graft loss. Conclusion Incidence of TB in kidney transplant recipients is higher than normal population. Increasing risk of active TB after allograft rejection is probably due to mycobacterial reactivation following high-dose immunosuppression. Since TB is associated with poor post-transplant outcomes, screening, and treatment of latent infection may be beneficial even in endemic country. Disclosures All authors: No reported disclosures.

Risk Factors for Late-Onset Cytomegalovirus Infection or Disease in Kidney Transplant Recipients

2014 ◽  
Vol 97 (5) ◽  
pp. 569-575 ◽  
Author(s):  
Alainna J. Jamal ◽  
Shahid Husain ◽  
Yanhong Li ◽  
Olusegun Famure ◽  
S. Joseph Kim
Keyword(s):  
Risk Factors ◽  
Kidney Transplant ◽  
Cytomegalovirus Infection ◽  
Late Onset ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

Assessment risk factors and different lines of treatment of anemia in kidney transplant recipients

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Mohamed Elsaftawy ◽  
Medhat Mahmoud ◽  
Yaser Elhendy ◽  
Ahmed Akl
Keyword(s):  
Risk Factors ◽  
Kidney Transplant ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

Risk factors for colonization and infection by resistant microorganisms in kidney transplant recipients

2021 ◽  
Vol 74 (suppl 6) ◽  
Author(s):  
Monica Taminato ◽  
Richarlisson Borges de Morais ◽  
Dayana Souza Fram ◽  
Rogério Rodrigues Floriano Pereira ◽  
Cibele Grothe Esmanhoto ◽  
...  
Keyword(s):  
Risk Factors ◽  
Length Of Stay ◽  
Kidney Transplant ◽  
Multidrug Resistant ◽  
Morbidity And Mortality ◽  
Epidemiological Surveillance ◽  
Resistant Bacteria ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Tract Infections

ABSTRACT Objectives: to assess the prevalence of colonization and infection by multidrug-resistant bacteria in patients undergoing kidney transplantation and identify the rate of infection, morbidity and mortality and associated risk factors. Methods: a prospective cohort of 200 randomly included kidney transplant recipients. Epidemiological surveillance of the studied microorganisms was carried out in the first 24 hours and 7 days after transplantation. Results: ninety (45%) patients were considered colonized. Female sex, hypertension and diabetes (p<0.005), dialysis time (p<0.004), length of stay after transplantation, delayed renal function, and length of stay were identified as risk factors. The microorganisms were isolated from surgical site, bloodstream and urinary tract infections. Conclusions: colonization by resistant microorganisms in kidney transplant patients was frequent and risk factors associated with infection were identified. The results should guide the care team in order to minimize morbidity and mortality related to infectious causes in this population.

Prevalence and risk factors for tertiary hyperparathyroidism in kidney transplant recipients

Surgery ◽  
2021 ◽  
Author(s):  
Whitney Sutton ◽  
Xiaomeng Chen ◽  
Palak Patel ◽  
Shkala Karzai ◽  
Jason D. Prescott ◽  
...  
Keyword(s):  
Risk Factors ◽  
Kidney Transplant ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Tertiary Hyperparathyroidism
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