scholarly journals Strong correlation between prevalence of severe vitamin D deficiency and population mortality rate from COVID-19 in Europe

2021 ◽  
Author(s):  
Isaac Z. Pugach ◽  
Sofya Pugach
Keyword(s):  
Vitamin D ◽  
Mortality Rate ◽  
Vitamin D Deficiency ◽  
Strong Correlation ◽  
Severe Vitamin ◽  
Population Mortality

scholarly journals Delta-Procalcitonin and Vitamin D Can Predict Mortality of Internal Medicine Patients with Microbiological Identified Sepsis

Medicina ◽  
2021 ◽  
Vol 57 (4) ◽  
pp. 331
Author(s):  
Alberto Tosoni ◽  
Anthony Cossari ◽  
Mattia Paratore ◽  
Michele Impagnatiello ◽  
Giovanna Passaro ◽  
...  
Keyword(s):  
Internal Medicine ◽  
Vitamin D ◽  
Mortality Rate ◽  
Prospective Study ◽  
Vitamin D Deficiency ◽  
Severe Vitamin ◽  
Prognostic Accuracy ◽  
Vitamin D Levels ◽  
Internal Medicine Wards ◽  
Previous Prospective Study

Background: The management of septic patients hospitalized in Internal Medicine wards represents a challenge due to their complexity and heterogeneity, and a high mortality rate. Among the available prognostic tools, procalcitonin (PCT) is considered a marker of bacterial infection. Furthermore, an association between vitamin D deficiency and poor sepsis-related outcomes has been described. Objectives: To evaluate the prognostic accuracy of two consecutive PCT determinations (Delta-PCT) and of vitamin D levels in predicting mortality in a population of patients with microbiological identified sepsis admitted to Internal Medicine wards. Methods: This is a sub-analysis of a previous prospective study. A total of 80 patients had at least two available consecutive PCT determinations, while 63 had also vitamin D. Delta-PCT was defined as a reduction of PCT > 50% after 48 h, >75% after 72 h, and >85% after 96 h. Mortality rate at 28- and 90-days were considered as main outcome. Results: Mortality rate was 18.7% at 28-days and 30.0% at 90-days. Baseline PCT levels did not differ between survived and deceased patients (28-days: p = 0.525; 90-days: p = 0.088). A significantly higher proportion of survived patients showed Delta-PCT (28-days: p = 0.002; 90-days: p < 0.001). Delta-PCT was associated with a lower 28-days (p = 0.007; OR = 0.12, 95%CI 0.02–0.46) and 90-days mortality (p = 0.001; OR = 0.17, 95%CI 0.06–0.48). A significantly higher proportion of deceased patients showed severe vitamin D deficiency (28-days: p = 0.047; 90-days: p = 0.049). Severe vitamin D deficiency was associated with a higher 28-days (p = 0.058; OR = 3.95, 95%CI 1.04–19.43) and 90-days mortality (p = 0.054; OR = 2.94, 95%CI 1.00–9.23). Conclusions: Delta-PCT and vitamin D represent two useful tests for predicting prognosis of septic patients admitted to Internal Medicine wards.

scholarly journals Strong Correlation Between Prevalence of Severe Vitamin D Deficiency and Population Mortality Rate from COVID-19 in Europe

2020 ◽  
Author(s):  
Isaac Z. Pugach ◽  
Sofya Pugach
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Strong Correlation ◽  
Death Rate ◽  
Pearson Correlation ◽  
Published Data ◽  
Data Set ◽  
Severe Vitamin ◽  
Vitamin D Levels ◽  
Wide Range

AbstractBackgroundSARS-CoV-2 virus causes a very wide range of COVID-19 disease severity in humans: from completely asymptomatic to fatal, and the reasons behind it are often not understood. There is some data that Vitamin D may have protective effect, so authors decided to analyze European country-wide data to determine if Vitamin D levels are associated with COVID-19 population death rate.MethodsTo retrieve the Vitamin D levels data, authors analyzed the Vitamin D European population data compiled by 2019 ECTS Statement on Vitamin D Status published in the European Journal of Endocrinology. For the data set to used for analysis, only recently published data, that included general adult population of both genders ages 40-65 or wider, and must have included the prevalence of Vitamin D deficiency.ResultsThere were 10 countries data sets that fit the criteria and were analyzed. Severe Vitamin D deficiency was defined as 25(OH)D less than 25 nmol/L (10 ng/dL). Pearson correlation analysis between death rate per million from COVID-19 and prevalence of severe Vitamin D deficiency shows a strong correlation with r = 0.76, p = 0.01, indicating significant correlation. Correlation remained significant, even after adjusting for age structure of the population. Additionally, over time, correlation strengthened, and r coefficient asymptoticaly increased.ConclusionsAuthors recommend universal screening for Vitamin D deficiency, and further investigation of Vitamin D supplementation in randomized control studies, which may lead to possible treatment or prevention of COVID-19.

scholarly journals Vitamin D and Cardiovascular Disease: An Updated Narrative Review

2021 ◽  
Vol 22 (6) ◽  
pp. 2896
Author(s):  
Armin Zittermann ◽  
Christian Trummer ◽  
Verena Theiler-Schwetz ◽  
Elisabeth Lerchbaum ◽  
Winfried März ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Vitamin D ◽  
High Risk ◽  
General Population ◽  
Vitamin D Deficiency ◽  
Specific Gene ◽  
Vitamin D Status ◽  
Cvd Risk ◽  
Severe Vitamin ◽  
Increased Risk

During the last two decades, the potential impact of vitamin D on the risk of cardiovascular disease (CVD) has been rigorously studied. Data regarding the effect of vitamin D on CVD risk are puzzling: observational data indicate an inverse nonlinear association between vitamin D status and CVD events, with the highest CVD risk at severe vitamin D deficiency; however, preclinical data and randomized controlled trials (RCTs) show several beneficial effects of vitamin D on the surrogate parameters of vascular and cardiac function. By contrast, Mendelian randomization studies and large RCTs in the general population and in patients with chronic kidney disease, a high-risk group for CVD events, largely report no significant beneficial effect of vitamin D treatment on CVD events. In patients with rickets and osteomalacia, cardiovascular complications are infrequently reported, except for an increased risk of heart failure. In conclusion, there is no strong evidence for beneficial vitamin D effects on CVD risk, either in the general population or in high-risk groups. Whether some subgroups such as individuals with severe vitamin D deficiency or a combination of low vitamin D status with specific gene variants and/or certain nutrition/lifestyle factors would benefit from vitamin D (metabolite) administration, remains to be studied.

Association between vitamin D deficiency and prostate cancer: Prospective case-control study

2021 ◽  
pp. 205141582199360
Author(s):  
Ghanshyam Kumawat ◽  
Vijay Chaudhary ◽  
Anurag Garg ◽  
Nishkarsh Mehta ◽  
Gagan Talwar ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Case Control Study ◽  
Serum Vitamin ◽  
P Value ◽  
Serum Vitamin D ◽  
Severe Vitamin ◽  
Vitamin D Levels ◽  
Control Study

Objective: We aimed to find out the association of low serum vitamin D levels with the incidence of prostate cancer through a prospective case-control study. Material and methods: This study was carried out in the tertiary care hospital (India). All newly diagnosed patients of prostate cancer and age-matched controls were included. Serum vitamin D levels were measured in all of them. Vitamin D status (ng/mL) was classified as severe deficiency <10, moderate deficiency 10–<30, normal 30–100, and toxicity >100. Normality of the data was tested by the Kolmogorov–Smirnov test, statistical analysis was done with Statistical Package for the Social Sciences version 26.0, p-value of <0.05 was considered significant. Results: In our study, 320 cases and 320 controls were included. The mean vitamin D levels in cases and controls were 15.71 ± 6.5 (ng/mL) and 17.63 ± 4.54 (ng/mL), respectively, ( p-Value <0.01). Patients with severe vitamin D deficiency (73.58%) had a Gleason score ⩾8 on biopsy and 79.24% of them had a serum prostate specific antigen (PSA) level >20 ng/mL. Conclusion: We had concluded that there was no significant association between vitamin D deficiency and increased risk of prostate cancer, although patients with higher-grade prostate cancer and with higher PSA level had severe vitamin D deficiency. Level of evidence: Not applicable for this multicentre audit.

Severe vitamin D deficiency among pregnant women and their newborns in Turkey

2014 ◽  
Vol 28 (5) ◽  
pp. 548-551 ◽  
Author(s):  
Mesut Parlak ◽  
Salih Kalay ◽  
Zuhal Kalay ◽  
Ahmet Kirecci ◽  
Ozgur Guney ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Severe Vitamin

Efavirenz is associated with severe vitamin D deficiency and increased alkaline phosphatase

AIDS ◽  
2010 ◽  
Vol 24 (12) ◽  
pp. 1923-1928 ◽  
Author(s):  
Tanya Welz ◽  
Kate Childs ◽  
Fowzia Ibrahim ◽  
Mary Poulton ◽  
Chris B Taylor ◽  
...  
Keyword(s):  
Vitamin D ◽  
Alkaline Phosphatase ◽  
Vitamin D Deficiency ◽  
Severe Vitamin

SEVERE VITAMIN D DEFICIENCY IS ASSOCIATED WITH ADVANCED-STAGE DEMENTIA IN GERIATRIC INPATIENTS

2011 ◽  
Vol 59 (1) ◽  
pp. 169-171 ◽  
Author(s):  
Cédric Annweiler ◽  
Bruno Fantino ◽  
Didier Le Gall ◽  
Anne-Marie Schott ◽  
Gilles Berrut ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Advanced Stage ◽  
Severe Vitamin ◽  
Geriatric Inpatients

Severe vitamin D deficiency in patients with Kawasaki disease: a potential role in the risk to develop heart vascular abnormalities?

2015 ◽  
Vol 35 (7) ◽  
pp. 1865-1872 ◽  
Author(s):  
Stefano Stagi ◽  
Donato Rigante ◽  
Gemma Lepri ◽  
Marco Matucci Cerinic ◽  
Fernanda Falcini
Keyword(s):  
Vitamin D ◽  
Kawasaki Disease ◽  
Vitamin D Deficiency ◽  
Potential Role ◽  
Vascular Abnormalities ◽  
Severe Vitamin
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