Preoperative severe vitamin D deficiency is a significant independent risk factor for poorer functional outcome and quality of life 6 months after surgery for fragility hip fractures

Background: Vitamin D has several roles, namely physiological function of calcium and bone metabolism, cell growth and differentiation, immune and cardiovascular function. Vitamin D deficiency can cause the risk of cancer. Head and neck cancer is one of the cancers that occur due to vitamin D deficiency in the body. This literature review was to asses and evaluate the impact and benefits of vitamin D supplementation for head and neck cancer.Discussion: A study found an association between vitamin D supplementation and a low risk of recurrence in conditions of high total vitamin D levels. Another study found a significant increase in quality of life (QOL). The primary mechanism of vitamin D action is mediated through binding of either 1,25(OH)2D3 (active form) or 25(OH)D (less active form) to the VDR, which is a member of the nuclear receptor superfamily of steroid and thyroid hormones with gene-regulatory and consequent anti-proliferative properties.Conclusions: Vitamin D supplementation provides a role in improving the condition of patients with head and neck cancer. Both in terms of suppressing recurrence and in terms of increasing quality of life

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Analysis of risk factors for vitamin D deficiency by results of the first stage of Russian non-interventional register study

Medical Council ◽

10.21518/2079-701x-2021-7-109-118 ◽

2021 ◽

pp. 109-118

Author(s):

L. A. Suplotova ◽

V. A. Avdeeva ◽

L. Y. Rozhinskaya ◽

E. A. Pigarova ◽

E. A. Troshina

Keyword(s):

Quality Of Life ◽

Risk Factors ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Russian Federation ◽

Direct Sunlight ◽

Cross Sectional ◽

Wide Range ◽

Smoking Duration

Introduction. In Russian Federation, there are no comprehensive studies assessing the quality of life and risk factors for vitamin D deficiency and insufficiency, taking into account its status in different geographic latitudes.Aim. To assess the quality of life and risk factors for vitamin D deficiency and insufficiency among the population living in the regions of the Russian Federation located at latitudes from 45 ° to 70 °.Materials and methods. The first stage of the Russian multicenter non-interventional registry study using the “cross-sectional” method was carried out from March 2020 to May 2020.Results and discussion. According to the results of the correlation analysis, qualitative and quantitative factors were identified, presumably being risk factors for vitamin D deficiency and deficiency. Qualitative risk factors include: education; alcohol consumption; being in direct sunlight for more than 30 minutes a day; visit to the solarium; using sunscreen; drinking coffee; taking medications (not vitamin-mineral complexes). Quantitative factors include: visits to specialists (total per year); smoking (duration, years); exercise for more than 30 minutes a day, once a week; being in direct sunlight for more than 30 minutes a day.Conclusion. A wide range of risk factors for vitamin D deficiency dictates the need for their further study to clarify the category of persons who are shown targeted biochemical screening with subsequent drug correction.

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Effect of vitamin D supplementation on asthma control in patients with vitamin D deficiency: the ACVID randomised clinical trial

Thorax ◽

10.1136/thoraxjnl-2019-213936 ◽

2020 ◽

pp. thoraxjnl-2019-213936

Author(s):

Rubén Andújar-Espinosa ◽

Lourdes Salinero-González ◽

Fátima Illán-Gómez ◽

Manuel Castilla-Martínez ◽

Chunshao Hu-Yang ◽

...

Keyword(s):

Quality Of Life ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Asthma Control ◽

Intervention Group ◽

Vitamin D Supplementation ◽

Control Group ◽

Asthmatic Patients ◽

Secondary Endpoints

BackgroundThe relationship between asthma and vitamin D deficiency has been known for some time. However, interventional studies conducted in this regard have shown conflicting results.ObjectiveTo evaluate the efficacy of vitamin D supplementation in asthmatic patients in improving the degree of control of asthma.MethodsRandomised, triple-blind, placebo-controlled, parallel-group study in adult asthmatic patients with serum 25-hydroxyvitamin-D3 <30 ng/mL. The intervention group received oral supplementation with 16 000 IU of calcifediol per week, and the control group had placebo added to their usual asthma treatment. The study period was 6 months. The primary endpoint was the degree of asthma control as determined by the asthma control test (ACT). Secondary endpoints included quality of life measured using the mini Asthma Quality of Life Questionnaire, the number of asthma attacks, oral corticosteroid cycles, the dose of inhaled corticosteroids, number of emergency visits, unscheduled consultations with the primary care physician and hospitalisations for asthma.ResultsOne hundred and twelve patients were randomised (mean age 55 years, with 87 (78%) being women). Of the 112 patients, 106 (95%) completed the trial. Half the patients (56) were assigned to the intervention group and the other half to the control group. A statistically significant clinical improvement was observed in the intervention group (+3.09) compared with the control group (−0.57) (difference 3.66 (95% CI 0.89 to 5.43); p<0.001) as measured using ACT scores. Among the secondary endpoints, a significant improvement in the quality of life was found in the intervention group (5.34), compared with the control group (4.64) (difference 0.7 (95% CI 0.15 to 1.25); p=0.01).ConclusionAmong adults with asthma and vitamin D deficiency, supplementation with weekly oral calcifediol compared with placebo improved asthma control over 6 months. Further research is needed to assess long-term efficacy and safety.Trial registration numberNCT02805907.

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Vitamin D Deficiency Is an Independent Risk Factor for Urinary Tract Infections After Renal Transplants

Medicine ◽

10.1097/md.0000000000000594 ◽

2015 ◽

Vol 94 (9) ◽

pp. e594 ◽

Cited By ~ 17

Author(s):

Young Eun Kwon ◽

Hyunwook Kim ◽

Hyung Jung Oh ◽

Jung Tak Park ◽

Seung Hyeok Han ◽

...

Keyword(s):

Vitamin D ◽

Risk Factor ◽

Urinary Tract ◽

Vitamin D Deficiency ◽

Urinary Tract Infections ◽

Independent Risk Factor ◽

Renal Transplants ◽

Tract Infections

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Vitamin D deficiency, self-reported physical activity and health-related quality of life: the Comprehensive Dialysis Study

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfr098 ◽

2011 ◽

Vol 26 (11) ◽

pp. 3683-3688 ◽

Cited By ~ 40

Author(s):

Shuchi Anand ◽

George A. Kaysen ◽

Glenn M. Chertow ◽

Kirsten L. Johansen ◽

Barbara Grimes ◽

...

Keyword(s):

Quality Of Life ◽

Physical Activity ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Health Related Quality ◽

Related Quality ◽

Health Related

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Relationship between anemia, hypoalbuminemia, vitamin D deficiency and quality of life in advanced non-small cell lung carcinoma patients at tertiary hospital in Bali

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20214126 ◽

2021 ◽

Vol 8 (11) ◽

pp. 1644

Author(s):

I. B. P. Ekaruna ◽

Ketut Suryana ◽

Jasminarti D. K. ◽

N. W. Candrawati ◽

N. L. P. Eka Arisanti ◽

...

Keyword(s):

Quality Of Life ◽

Vitamin D ◽

Multivariate Analysis ◽

Vitamin D Deficiency ◽

Small Cell ◽

Advanced Lung Cancer ◽

Advanced Stage ◽

Cell Lung Carcinoma ◽

Nsclc Patients

Background: The main purpose of treatment in patients with advanced lung cancer is more emphasizing on prolonging survival and improving the patient's quality of life (QOL). Micronutrient deficiency has an impact on the patient's QOL. The purpose of this study was to analyse the relationship between biochemical parameters of nutrient deficiency with QOL in patients with advanced non-small cell carcinoma (NSCLC) at Sanglah hospital.Methods: A cross sectional study was conducted in Sanglah general hospital on March-June 2021. Hemoglobin, albumin, and 2.5 (OH) D levels were obtained from patient's serum. The participant’s QOL was measured with EQ-5D-3L questionnaire. Bivariate analysis using chi-square test or Fisher's exact test, and multivariate analysis using logistic regression.Results: A total of 80 participants were included in this study, and 55% had poor QOL. Seventy percent participants had anemia, 36.3% had hypoalbuminemia, and 26.3% had vitamin D deficiency. The QOL of patients with advanced stage NSCLC was significantly associated with hypoalbuminemia (p=0.000) and vitamin D deficiency (p=0.044). Multivariate analysis showed that the most influential factor on the QOL of patients with advanced stage NSCLC was hypoalbuminemia (AOR 9.158; 95% CI 2.150-30.001; p=0.003).Conclusions: Hypoalbuminemia and vitamin D deficiency were significantly related with QOL of advance NSCLC patients. No relationship was found between anemia and the QOL of advance NSCLC patients. Hypoalbuminemia was the most influential factors related to the QOL of advance NSCLC patients.

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The effectiveness of vitamin D supplementation in functional outcome and quality of life (QoL) of lumbar spinal stenosis (LSS) requiring surgery

Journal of Orthopaedic Surgery and Research ◽

10.1186/s13018-020-01629-2 ◽

2020 ◽

Vol 15 (1) ◽

Author(s):

Sangbong Ko ◽

Seungbum Chae ◽

Wonkee Choi ◽

Jaibum Kwon ◽

Je-Yong Choi

Keyword(s):

Quality Of Life ◽

Vitamin D ◽

Functional Outcome ◽

Spinal Stenosis ◽

Lumbar Spinal Stenosis ◽

Vitamin D Supplementation ◽

Lumbar Spinal

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Effects of Vitamin D Supplementation on Nonspecific Musculoskeletal Pain, Quality of Life, Self-Related Health and Sexual Satisfaction: A Randomized Control Trial

Current Topics in Nutraceutical Research ◽

10.37290/ctnr2641-452x.17:17-22 ◽

2018 ◽

Vol 17 (1) ◽

pp. 17-22

Author(s):

Mottaghi Peyman ◽

Miraghajani Maryam ◽

Hajianfar Hossein ◽

Abadi Rayehe Shekl

Keyword(s):

Quality Of Life ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Sexual Satisfaction ◽

Intervention Group ◽

Vitamin D Supplementation ◽

Unknown Etiology ◽

Self Rated Health ◽

Pain Scores

Non-specific musculoskeletal pains (CNMP) are common problem with unknown etiology which has become a major concern because of their negative impact on health. The aim of the present study was to investigate the effect of vitamin D supplementation on pain scores, quality of life, self-rated health and sexual satisfaction among CNMP patients with vitamin D deficiency. In this clinical trial study, sixty-six patients (18–50 years in both sex) with CNMP and vitamin D deficiency were randomly assigned to consume 50000 IU vitamin D, once every week for 8 weeks in the intervention group or placebo in the control condition. Clinical examination, pain scores, quality of life (QoL), self-rated health and sexual satisfaction were measured at the beginning and at the end of study. Patients in the vitamin D group had a significant pain relief after 8 weeks compared to the placebo group (p = 0.04 vs. p = 0.42). Also, they had increased QoL scores and sexual satisfaction compared with placebo (p < 0.0001 and p = 0.01, respectively). We observed a significant effect on improvement of quality of life, sexual satisfaction and pain in patients with CNMP after administration of therapeutic doses of vitamin D. Such findings could be considered to implement informative interventional programs to control CNMP complications and develop practical policies to improve the diet quality among CNMP patients. Further studies are needed to determine whether vitamin D supplementation lead to significant modifications in CNMP complications with consideration of confounding factors in different population.

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Severe vitamin D deficiency is a risk factor for renal hyperfiltration

American Journal of Clinical Nutrition ◽

10.1093/ajcn/nqy194 ◽

2018 ◽

Vol 108 (6) ◽

pp. 1342-1351 ◽

Cited By ~ 2

Author(s):

Jong Hyun Jhee ◽

Ki Heon Nam ◽

Seong Yeong An ◽

Min-Uk Cha ◽

Misol Lee ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Vitamin D ◽

Risk Factor ◽

Glomerular Filtration Rate ◽

Vitamin D Deficiency ◽

Filtration Rate ◽

Estimated Glomerular Filtration Rate ◽

Hydroxyvitamin D ◽

Severe Vitamin ◽

25 Hydroxyvitamin D

ABSTRACT Background Vitamin D deficiency is associated with renal progression in chronic kidney disease. Moreover, improvement of clinical outcomes after vitamin D supplementation has been reported in the diabetic and chronic kidney disease population. Objective We investigated the association between renal hyperfiltration (RHF) and vitamin D status in a relatively healthy population. Design Data were retrieved from the Korean NHANES, a nationwide population-based cross-sectional study from 2008 to 2015. Overall, 33,210 subjects with normal renal function were included in the final analysis. Severe vitamin D deficiency was defined as serum 25-hydroxyvitamin D concentration <10 ng/mL. RHF was defined as estimated glomerular filtration rate with residual in the >95th percentile after adjustment for age, sex, height, weight, and history of hypertension or diabetes. Results The mean ± SD age of subjects was 48.1 ± 15.9 y, and the number of women was 18,779 (56.5%). Estimated glomerular filtration rate was negatively associated with serum 25-hydroxyvitamin D concentrations in multivariable linear regression analysis (β: −0.02; 95% CI: −0.02, −0.01; P < 0.001). Furthermore, 1637 (4.9%) subjects were categorized into the RHF group, and the prevalence of RHF was significantly higher in the severe vitamin D deficiency group than in the sufficiency group (5.8% compared with 5.0%, P < 0.001). In a multivariable logistic regression model, severe vitamin D deficiency was a significant risk factor for RHF (OR: 2.41; 95% CI, 1.72, 3.43; P < 0.001). Conclusions Severe vitamin D deficiency is significantly associated with increasing prevalence of RHF in a relatively healthy adult population.

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