Factors associated with the desire to undergo post-mastectomy breast reconstruction in a Mexican breast cancer center

2020 ◽  
Author(s):  
Paulina Bajonero-Canonico ◽  
Ana S. Ferrigno ◽  
Jorge A. Saldaña-Rodriguez ◽  
David E. Hinojosa-Gonzalez ◽  
Cristel G. de la O-Maldonado ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Reconstruction ◽  
Cancer Center ◽  
Factors Associated

Sociodemographic factors associated with cancer treatment completion among women with breast cancer at Butaro Cancer Center of Excellence (BCCOE) in Rwanda.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e19220-e19220
Author(s):  
Abirami Natarajan ◽  
Niclas Rudolfson ◽  
Daniel O'Neil ◽  
Lauren Schleimer ◽  
Jean Marie Vianney Dusengimana ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Social Support ◽  
Hormonal Therapy ◽  
Advanced Disease ◽  
Locally Advanced ◽  
Treatment Completion ◽  
Sociodemographic Factors ◽  
Cancer Center ◽  
Factors Associated ◽  
Complete Treatment

e19220 Background: Many barriers exist to delivering comprehensive breast cancer care in low-income countries. We examined sociodemographic factors associated with treatment completion among women receiving care for breast cancer at Butaro Cancer Center of Excellence (BCCOE), Rwanda’s first public cancer facility. Methods: We retrospectively measured treatment completion rates in women with early and locally advanced breast cancer diagnosed at BCCOE between July 1, 2012 and December 31, 2016. We defined treatment completion as receipt of surgery, 4 cycles of chemotherapy, and initiation of hormonal therapy for estrogen receptor positive (ER+) breast cancer. We used logistic regression to examine associations between socio-demographic and clinical factors and treatment completion. Travel time was estimated using a geographic information systems model using the WHO tool AccessMod 5.0. Results: Of 212 eligible women, 138 (65%) had surgery and 141 (66%) received 4 cycles of chemotherapy. Among 139 women with ER+ cancer, 59% initiated hormonal therapy. Overall 56% received all indicated treatment including surgery, chemotherapy, and hormonal therapy (if ER positive); 44% did not complete indicated treatment. Women who lived closer to the hospital ( <50 minutes travel time) were more likely than other women to complete treatment (OR 4.2; 95% CI 1.1-15.1). Women with early-stage disease were also more likely than women with locally advanced disease to complete treatment (OR 2.2, 95% CI 1.1-4.4). Among 100 women with available information about ubudehe (Rwandan social categorization used as a proxy for socioeconomic status), rates of treatment completion were higher for women who were eligible for social support (ie: transportation support or insurance subsidy) than women who were not (74% v. 63%), although this difference was not statistically significant (p= 0.51). Conclusions: Significant barriers exist for breast cancer patients receiving treatment in this low resource setting; nevertheless, over half of the patients completed therapy. Interventions are needed to facilitate care for women with long travel times and locally advanced disease to reduce disparities in outcomes for this population of patients. Further research is needed to determine the role of social support in treatment completion.

scholarly journals Korean Translation and Psychometric Evaluation of Korean Version EORTC QLQ-BRECON23

2020 ◽  
Vol 17 (24) ◽  
pp. 9163
Author(s):  
Soo-Kyung Bok ◽  
Youngshin Song ◽  
Ancho Lim ◽  
Hyunsuk Choi ◽  
Hyunkyung Shin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Construct Validity ◽  
Breast Reconstruction ◽  
Cancer Center ◽  
European Organization ◽  
Korean Version ◽  
Reconstruction Methods ◽  
Group Validity

The purpose of this study was to evaluate the psychometric properties of the Korean version of the European Organization for Research and Treatment of Cancer Quality of Life-QLQ-BRECON23 in women diagnosed and treated for breast cancer undergoing all types of breast reconstruction. Methods: A total of 148 Korean women who underwent breast reconstruction were recruited from the breast cancer center to participate in the study. After performing forward and backward translation of the original English version of the questionnaire into Korean, its validity (construct, known-group validity, concurrent) and reliability were assessed. A structural equation model (SEM) was used to assess construct validity. Results: The mean age of the patients was 52 years, and 89.8% underwent implant-based reconstruction. Construct validity using confirmatory factor analysis showed a good fit, and the effect size was small-to-medium regarding known-group validity. Concurrent validity was confirmed by the significant correlation between the QLQ-BRECON23 and the QLQ-BR23. The reliability of the QLQ-BRECON23 symptom and function scales ranged from 0.61 to 0.87. Conclusion: The Korean QLQ-BRECON23 can be applied to assess quality of life and its related factors, and also to internationally compare the level of quality of life in breast cancer patients undergoing breast reconstruction.

Therapy-Related Myeloid Neoplasms in Breast Cancer Patients: A Single-Institution Report of 150 Cases

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 962-962
Author(s):  
Katarina Sevcikova ◽  
Zuo Zhuang ◽  
Guillermo Garcia-Manero ◽  
Ricardo Alvarez ◽  
Hagop M. Kantarjian ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Conflicts Of Interest ◽  
Myeloproliferative Neoplasms ◽  
Subsequent Development ◽  
Cancer Center ◽  
Cell Transplant ◽  
Her2 Positive ◽  
Factors Associated ◽  
Myeloid Neoplasms

Abstract Introduction: Patients who receive chemotherapy and/or radiation therapy for breast cancer (BCA) are at risk for developing therapy-related myeloid neoplasms (t-MN). In fact, BCA is one of the most common malignant solid tumors among patients with t-MN. Nonetheless, the association between t-MN features and the demographic, biologic, and therapeutic characteristics of patients with BCA remain poorly characterized. The aim of this study was to assess the factors associated with t-MN in BCA patients and determine the features and outcomes of t-MN in this patient group. Methods: We conducted a retrospective analysis of BCA patients who developed t-MN seen at The University of Texas M.D. Anderson Cancer Center between January 1997 and April 2013. As defined in the current WHO classification, t-MN includes therapy-related acute myeloid leukemia (t-AML), myelodysplastic syndrome (t-MDS), and myelodysplastic/myeloproliferative neoplasms (t-MDS/MPN). The study inclusion criteria included receipt of neoadjuvant or adjuvant chemotherapy and/or radiation therapy for BCA with subsequent development of t-MN. Results: All patients (n=150) were women with a median age of 57 years (range, 26-79 years) at the time of BCA diagnosis (64 at time of t-MN; range, 29-84 years). At presentation with BCA, stage ranged from 0 to 3. In addition to surgery, 93 (62%) patients were treated with combination chemotherapy and radiation therapy, 30 (20%) with radiation therapy alone, and 27 (18%) with chemotherapy alone. The median interval between BCA and t-MN was 57 months (range, 8-374 months); 54 months and 57 months respectively for patients who received chemotherapy alone or radiation therapy alone. At the time of t-MN diagnosis, 90 (60%) patients had t-AML, 56 (37%) t-MDS, and 4 (3%) t-MDS/MPN. Among patients with t-MDS and t-MDS/MPN, 26 (22%) developed t-AML after a median of 13.9 months (range, 2.3-69.6 months). Notably, development of t-MN among patients with BCA was associated with a body-mass index <25 (p=0.030) and with HER2-positive BCA (14/55; p=0.037). Among all patients with t-MN, those with MLL gene (11q23) rearrangement had a worse overall survival (OS) (p=0.017) while those with favorable recurrent chromosomal translocations (PML/RARA; CBFB-MYH11; RUNX1/RUNX1T1) had a better OS (p=0.001). Patients who received allogeneic stem-cell transplant (SCT) for t-MN had a better OS calculated from the onset of t-MN compared to those who did not (p=0.018). By multivariate analysis, factors associated independently with OS calculated from the time of BCA diagnosis included age at BCA diagnosis (p<0.001), BMI category (p=0.016), chemotherapy for BCA (p=0.027), anti-HER2 therapy (p=0.003), and growth factor administration (p=0.023). Notable factors associated independently with OS calculated from the time of t-MN diagnosis included MLL rearrangement (p=0.014), favorable recurrent balanced translocations (p=0.006), and SCT (p=0.010). Conclusions: Patients with BCA who have a BMI <25 and are HER2-positive appear to be at a higher risk for t-MN. In addition, the OS of BCA patients in our study group appears to be associated with BMI and anti-HER2 therapy. Disclosures No relevant conflicts of interest to declare.

Factors Associated With Breast Cancer Clinical Trials Participation and Enrollment at a Large Academic Medical Center

2004 ◽  
Vol 22 (11) ◽  
pp. 2046-2052 ◽  
Author(s):  
Michael S. Simon ◽  
Wei Du ◽  
Lawrence Flaherty ◽  
Philip A. Philip ◽  
Patricia Lorusso ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Trials ◽  
Medical Center ◽  
Performance Status ◽  
Academic Medical Center ◽  
Comprehensive Cancer Center ◽  
Cancer Center ◽  
Poor Performance Status ◽  
Cancer Clinical Trials ◽  
Factors Associated

Purpose The practice patterns of medical oncologists at a large National Cancer Institute Comprehensive Cancer Center in Detroit, MI were evaluated to better understand factors associated with accrual to breast cancer clinical trials. Patients and Methods From 1996 to 1997, physicians completed surveys on 319 of 344 newly evaluated female breast cancer patients. The 19-item survey included clinical data, whether patients were offered clinical trial (CT) participation and enrollment, and when applicable, reasons why they were not. Multivariate analyses using logistic regression were performed to evaluate predictors of an offer and enrollment. Results The patients were 57% white, 32% black, and 11% other/unknown race. One hundred six (33%) were offered participation and 36 (34%) were enrolled. In multivariate analysis, CTs were less likely offered to older women (mean age, 52 years for those offered v 57 years for those not offered; P = .0005) and black women (21% of blacks offered v 42% of whites; P = .0009). Women with stage 1 disease, poor performance status, and those who were previously diagnosed were also less likely to be offered trials. None of these factors were significant predictors of enrollment. Women were not offered trials because of ineligibility (57%), lack of available trials (41%), and noncompliance (2%). Reasons for failed enrollment included patient refusal (88%) and failed eligibility (12%). Conclusion It is important for cooperative groups to design studies that will accommodate a broader spectrum of patients. Further work is needed to assess ways to improve communication about breast cancer CT participation to all eligible women.

scholarly journals Goldilocks Principle: Preference for Change in Breast Size in Breast Cancer Reconstruction Patients

2021 ◽  
Vol 12 ◽  
Author(s):  
Krista M. Nicklaus ◽  
Thao Bui ◽  
Mary Catherine Bordes ◽  
Jun Liu ◽  
Deepti Chopra ◽  
...  
Keyword(s):  
Breast Reconstruction ◽  
Multinomial Logistic Regression ◽  
The United States ◽  
Preliminary Evidence ◽  
Cancer Center ◽  
Breast Size ◽  
Size Change ◽  
Logistic Regression Models ◽  
Factors Associated ◽  
The Mean

Patients’ preferences regarding changing or maintaining their breast size after mastectomy and reconstruction are important but understudied determinants of post-surgical satisfaction and quality of life. The goal of this study was to identify factors associated with preferences for changing or maintaining breast size for women undergoing breast reconstruction at The University of Texas MD Anderson Cancer Center in the United States from 2011 to 2014. The average age of participants was 45.7 ± 9.1 years. At baseline, mean average breast volumes were 755.7 ± 328.4 mL for all women (n = 48), 492.3 mL ± 209.3 for 13 women who preferred to be “bigger than now,” 799.2 mL ± 320.9 for 25 women who preferred to remain “about the same,” and 989.3 mL ± 253.1 for 10 women who preferred “smaller than now.” Among the 23 women who preferred to change their breast size, 19 desired to shift toward the mean. Women with the smallest and largest 20% of baseline breast size were more likely to desire a change toward the mean (p = 0.006). Multinomial logistic regression models found average breast volume and satisfaction with breast size to be the most important factors associated with preferences for changing or maintaining breast size for women undergoing breast reconstruction. This study provides preliminary evidence for a “Goldilocks principle” in women’s preferences for breast size change in the context of breast reconstruction, and identifies hypotheses for future studies of the associations among preference for change in breast size, preference achievement, and post-reconstruction body image.

Early-stage breast cancer (BC) patients: Factors associated with aromatase inhibitor-induced musculoskeletal symptoms.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 525-525
Author(s):  
Simran Arora Elder ◽  
Yamin Sun ◽  
Seungyoun Jung ◽  
Candace Bavette Mainor ◽  
Shruti Murali ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Aromatase Inhibitor ◽  
Early Stage ◽  
Musculoskeletal Symptoms ◽  
Comprehensive Cancer Center ◽  
Cancer Center ◽  
Tumor Characteristics ◽  
Factors Associated ◽  
The Mean

525 Background: Hormone receptor positive (HR+) breast cancer comprises the largest subgroup of breast cancer. Aromatase Inhibitors (AI) are a key treatment for HR+ BC patients (pts) and reduce mortality. Aromatase Inhibitor-Associated Musculoskeletal Symptoms (AIMSS), defined as myalgias, arthralgias, or joint stiffness, occur in up to 50% of pts leading to low adherence to and often discontinuation of therapy. Little is known of the mechanism of AIMSS or its predisposing risk factors. This study aims to identify risk factors associated with AIMSS development in BC patients on AI therapy. Methods: We conducted a medical record review of pts with non-metastatic HR+ BC on adjuvant AI therapy between January 2009 and June 2017 at the University of Maryland Comprehensive Cancer Center. This study included 194 ptswho were free of arthralgia prior to AI therapy. We analyzed pts’ demographics, lifestyle factors, reproductive history, tumor characteristics, medications, cancer treatment, co-morbidities, AI type, onset and severity of AIMSS. Severe AIMSS was defined as requiring change in AI therapy or discontinuation. Multivariable-adjusted logistic regression was used to identify risk factors for severe AIMSS. Results: The mean age of participants was 61. The mean BMI at diagnosis was 30 kg/m2. 41% of pts were White, 40% were Black, 7% other and 12% unknown. Most (79%) did not have a history of tamoxifen and 16% were on GnRH agonists. Most (71%) used letrozole as initial AI therapy; 18% anastrozole; and 11% exemestane. 56% experienced AIMSS while on AI therapy and 20% required change or hold of AI therapy. 4% permanently discontinued AI due to AIMSS severity. BMI at diagnosis was significantly positively associated with risk of AIMSS. Multivariate odds ratio (95% confidence intervals) comparing the highest to lowest tertile of body mass index (BMI) at diagnosis was 4.01 (1.07-10.90; Ptrend: 0.05). There were no significant associations with race, smoking, reproductive factors, type of AI therapy, tamoxifen use prior to AI therapy, medication use, experience of other cancer treatments, and tumor characteristics. Conclusions: 56% of BC pts on adjuvant AI therapy experienced AIMSS. 24% of these changed, held or discontinued AI regimen due to severe AIMSS. Higher BMI at diagnosis was associated with a higher risk of AIMSS. Our results confirm clinical significance of AIMSS among BC pts on AI therapy and suggest BMI as a modifiable factor for AIMSS. A larger study is warranted to replicate our findings and seek other possible risk factors for AIMSS.

scholarly journals Factors Associated With Local Recurrence After Skin-Sparing Mastectomy and Immediate Breast Reconstruction for Invasive Breast Cancer

2002 ◽  
Vol 235 (6) ◽  
pp. 814-819 ◽  
Author(s):  
Heriberto Medina-Franco ◽  
Luis O. Vasconez ◽  
R. Jobe Fix ◽  
Martin J. Heslin ◽  
Samuel W. Beenken ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Local Recurrence ◽  
Breast Reconstruction ◽  
Invasive Breast Cancer ◽  
Immediate Breast Reconstruction ◽  
Factors Associated

Abstract P6-11-15: Information gaps and perceived barriers to achieve breast reconstruction among patients with mastectomy in a public breast cancer center in Mexico

2020 ◽  
Author(s):  
Paulina Bajonero-Canonico ◽  
Melina Miaja-Avila ◽  
José Moral de la Rubia ◽  
Jorge A Saldaña-Rodríguez ◽  
David E Hinojosa-González ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Reconstruction ◽  
Perceived Barriers ◽  
Cancer Center ◽  
Information Gaps

Effect of chemotherapy and psychosocial distress parameters on perceived cognitive disturbances in Asian breast cancer patients.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 9041-9041
Author(s):  
Yin Ting Cheung ◽  
Maung Shwe Ham Guo ◽  
Wai Keung Chui ◽  
Rebecca Alexandra Dent ◽  
Yoon Sim Yap ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Psychosocial Factors ◽  
Hormonal Therapy ◽  
Psychosocial Distress ◽  
Cancer Center ◽  
Breast Cancer Patients ◽  
Cognitive Changes ◽  
Factors Associated ◽  
Cognitive Disturbances

9041 Background: A qualitative study has revealed that Asian breast cancer patients attributed their post-chemotherapy cognitive disturbances to psychosocial distress. To validate this claim, we aim to examine perceived cognitive disturbances, anxiety and quality of life (QoL) in Asian breast cancer patients and to identify clinical and psychosocial factors associated with perceived cognitive disturbances. Methods: A prospective, observational study was held at the largest cancer center in Singapore. Chemotherapy (CT) and non-chemotherapy (non-CT) receiving breast cancer patients completed self- reported questionnaires to assess the following domains: patients’ perceived impact of chemotherapy on cognitive disturbances (FACT-Cog), health-related QoL (EORTC QLQ-C30) and anxiety (Beck Anxiety Inventory). Multiple regression was conducted to delineate factors associated with perceived cognitive impairment. Results: A total of 166 (1:1 CT/non-CT) patients were recruited (age: 54.1±10.2 years; 78.9% Chinese; 53.6% post-menopausal). Most of the CT patients received anthracycline-based chemotherapy (93.1%) and anti-hormonal therapy (69.4%). Comparing to non-CT patients, CT patients experienced more fatigue (QLQ-C30 fatigue scores: 22.2 vs 33.3 points; p=0.005), more significant anxiety (8.6% vs 21.9%; p=0.002), and more cognitive disturbances (FACT-Cog scores: 110 vs 124 points; p<0.0001). Regression model identified chemotherapy, anti-hormonal therapy, emotional functioning and global health status to be strongly associated with cognitive disturbances in Asian breast cancer patients. The interacting effect between anxiety and fatigue, comparing to fatigue alone, was more associated with cognitive disturbances (β=-0.212; p=0.032 vs β=-0.07; p=0.25, respectively). Conclusions: This is the first study to demonstrate that Asian breast cancer patients experiencing both fatigue and anxiety are more predisposed to cognitive disturbances. Post-chemotherapy cognitive changes are observed in our patients, and our results suggest that psychosocial factors are impactful to identify cancer patients who are more susceptible to cognitive disturbances.

Short-term outcomes of immediate breast reconstruction using implant or tissue expander after mastectomy in breast cancer patients.

2012 ◽  
Vol 30 (27_suppl) ◽  
pp. 176-176
Author(s):  
Haekyung Lee ◽  
Se Won Kim ◽  
Tae Ho Kang ◽  
Chan Seok Yoon ◽  
Seung Sang Ko ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Reconstruction ◽  
Tissue Expander ◽  
Immediate Breast Reconstruction ◽  
Cosmetic Result ◽  
Cancer Center ◽  
Patient’S Satisfaction ◽  
Areolar Complex ◽  
Operational Result

176 Background: Mastectomy is a life-saving management but can cause significant adverse reactions. So, breast reconstruction is a concern in recovery after mastectomy. We report our experience with immediate breast reconstruction using implant or tissue expander, which confirmed the oncologic safety and high patients’ satisfaction. Methods: This study is a retrospective review of all patients who underwent reconstruction with implant or tissue expander immediately after mastectomy. Seventy-seven patients underwent breast reconstruction at a general hospital breast cancer center from January of 2008 to December of 2010 and 14 patients were excluded because of follow-up loss. Therefore 63 patients were included. To access patient’s satisfaction, questionnaire was sent to all patients. Results: Mean age of the patients is 44.1 years. ( range: 29-64) After median follow-up periods of 22.4 months, there was 1 case of locoregional recurrence, 1 case of distant metastasis and overall breast cancer specific survival was 100%. Overall major complication rate was 11.1% (7 patients), such as nipple areolar complex (NAC) necrosis and implant removal. Among 10 patients who had NAC necrosis, 6 patients improved after observation, and 4 patients performed NAC excision. Three patients were removed their implant due to severe infection, leakage or dissatisfaction. There were 32 cases of total mastectomy, 12 cases of skin sparing mastectomy (SSM), 19 cases of NAC sparing mastectomy (NSM). According to the result of questionnaire, 84.1% was satisfied with generalized operational result, 77.8% with cosmetic result. Among 19 patients who had performed NSM, 89.5% was satisfied with general result, 84.2% with cosmetic result. Conclusions: Immediate breast reconstruction using implant after mastectomy is technically feasible and oncologically safe as well as relatively good patient’s satisfaction. But we need more long-term experience.

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