Effect of high-intensity interval training on patient-reported outcomes and physical function in women with breast cancer receiving anthracycline-based chemotherapy

2021 ◽  
Author(s):  
Kyuwan Lee ◽  
Mary K. Norris ◽  
Ellice Wang ◽  
Christina M. Dieli-Conwright
Keyword(s):  
Breast Cancer ◽  
Physical Function ◽  
High Intensity ◽  
Patient Reported Outcomes ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
Patient Reported ◽  
High Intensity Interval

scholarly journals High Intensity Interval Training Increases Natural Killer Cell Number and Function in Obese Breast Cancer-challenged Mice and Obese Women

2017 ◽  
Vol 22 (4) ◽  
pp. 260-266 ◽  
Author(s):  
Nicole G. Barra ◽  
Isabella Y. Fan ◽  
Jenna B. Gillen ◽  
Marianne Chew ◽  
Katarina Marcinko ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Natural Killer Cell ◽  
High Intensity ◽  
Killer Cell ◽  
Interval Training ◽  
Cell Number ◽  
Obese Women ◽  
High Intensity Interval Training ◽  
High Intensity Interval ◽  
And Function

scholarly journals Interactive effect of 6 weeks of High-intensity interval training and quercetin supplementation on expression of some tumor angiogenesis markers in female mice with breast cancer

2021 ◽  
Vol 43 (1) ◽  
pp. 142-151
Author(s):  
Zohreh Jalali ◽  
Fereshteh Shahidi ◽  
abbas ali Gaeini ◽  
Shaban Alizadeh ◽  
Alireza Ramezani
Keyword(s):  
Breast Cancer ◽  
Tumor Angiogenesis ◽  
High Intensity ◽  
Breast Cancer Cells ◽  
Tumor Tissue ◽  
Statistical Tests ◽  
Interactive Effect ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
High Intensity Interval

Background: About angiogenesis, metastasis of breast cancer and exercise, Many studies have been done in recent decades to better understand of regulatory mechanisms. The purpose of this study was to investigate the Interactive effect of high-intensity interval training (HIIT) and quercetin supplementation (Q) on the expression of key angiogenic factors in tumor tissue of mouse with breast cancer. Methods: Twenty-four female Balb/C mouse were injected with estrogen receptor-dependent breast cancer cells MC4L2 and then divided into three groups of tumor (T), tumor + of high-intensity interval training (TH) and tumor + high-intensity interval training + quercetin (THQ). The TH and THQ groups ran the treadmill 3 days a week for 6 weeks and each session 1 hour. The THQ group received 110 mg / kg quercetin solution for 6 weeks, 3 days a week with training. After completion of the work, the mouse were sacrificed and their tumor tissue removed and frozen in liquid nitrogen And stored at -70 ° C. Expression of TIE-2 and VEGF-A genes was measured by REAL TIME-PCR. ΔCt, ΔΔCt, and Fold change were calculated with the relevant statistical tests at the significant level (P <0.05) by GENEX software. Results: The results showed that THQ interaction significantly decreased the expression of TIE-2 and VEGF-A genes in TH and THQ groups compared to T group. In addition, quercetin in THQ group significantly decreased TIE-2 and VEGF-A gene expression compared to TH group. Conclusion: interaction of HIIT and Q supplementation are probably effective in inhibiting tumor angiogenesis.

scholarly journals High intensity exercise during breast cancer chemotherapy - effects on long-term myocardial damage and physical capacity - data from the OptiTrain RCT

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Josefin Ansund ◽  
Sara Mijwel ◽  
Kate A. Bolam ◽  
Renske Altena ◽  
Yvonne Wengström ◽  
...  
Keyword(s):  
Breast Cancer ◽  
High Intensity ◽  
Troponin T ◽  
Interval Training ◽  
High Intensity Exercise ◽  
Moderate Intensity ◽  
High Intensity Interval Training ◽  
Post Intervention ◽  
High Intensity Interval

Abstract Background Adjuvant systemic breast cancer treatment improves disease specific outcomes, but also presents with cardiac toxicity. In this post-hoc exploratory analysis of the OptiTrain trial, the effects of exercise on cardiotoxicity were monitored by assessing fitness and biomarkers over the intervention and into survivorship. Methods; Women starting chemotherapy were randomized to 16-weeks of resistance and high-intensity interval training (RT-HIIT), moderate-intensity aerobic and high-intensity interval training (AT–HIIT), or usual care (UC). Outcome measures included plasma troponin-T (cTnT), Nt-pro-BNP and peak oxygen uptake (VO2peak), assessed at baseline, post-intervention, and at 1- and 2-years. Results For this per-protocol analysis, 88 women met criteria for inclusion. Plasma cTnT increased in all groups post-intervention. At the 1-year follow-up, Nt-pro-BNP was lower in the exercise groups compared to UC. At 2-years there was a drop in VO2peak for patients with high cTnT and Nt-pro-BNP. Fewer patients in the RT-HIIT group fulfilled biomarker risk criteria compared to UC (OR 0.200; 95% CI = 0.055–0.734). Conclusions In this cohort, high-intensity exercise was associated with lower levels of NT-proBNP 1-year post-baseline, but not with cTnT directly after treatment completion. This may, together with the preserved VO2peak in patients with low levels of biomarkers, indicate a long-term cardioprotective effect of exercise. Trial registration Clinicaltrials.govNCT02522260, Registered 13th of august 2015 – Retrospectively Registered Graphical abstract

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