scholarly journals High Intensity Interval Training Increases Natural Killer Cell Number and Function in Obese Breast Cancer-challenged Mice and Obese Women

2017 ◽  
Vol 22 (4) ◽  
pp. 260-266 ◽  
Author(s):  
Nicole G. Barra ◽  
Isabella Y. Fan ◽  
Jenna B. Gillen ◽  
Marianne Chew ◽  
Katarina Marcinko ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Natural Killer Cell ◽  
High Intensity ◽  
Killer Cell ◽  
Interval Training ◽  
Cell Number ◽  
Obese Women ◽  
High Intensity Interval Training ◽  
High Intensity Interval ◽  
And Function

High-intensity interval training acutely alters plasma adipokine levels in young overweight/obese women

2017 ◽  
Vol 124 (2) ◽  
pp. 149-155 ◽  
Author(s):  
Selma Arzu Vardar ◽  
Aziz Karaca ◽  
Sibel Güldiken ◽  
Orkide Palabıyık ◽  
Necdet Süt ◽  
...  
Keyword(s):  
High Intensity ◽  
Interval Training ◽  
Obese Women ◽  
High Intensity Interval Training ◽  
High Intensity Interval

scholarly journals High-intensity Interval Training Improves Inflammatory Mediators in Obese Women: Based on the Study of the UCP2 Ala55Val Gene

2021 ◽  
Vol 9 (A) ◽  
pp. 871-875
Author(s):  
Susiana Candrawati ◽  
Emy Huriyati ◽  
Zaenal Muttaqien Sofro ◽  
Lantip Rujito ◽  
Aulia Nury Faza ◽  
...  
Keyword(s):  
Body Weight ◽  
Inflammatory Mediators ◽  
High Intensity ◽  
Interval Training ◽  
T Test ◽  
Wilcoxon Test ◽  
Obese Women ◽  
High Intensity Interval Training ◽  
Before And After ◽  
High Intensity Interval

Background: Increased inflammatory mediators in obesity are associated with metabolic syndrome. Exercise is an effective effort to reduce the incidence of obesity. The High-Intensity Interval Training (HIIT) program is an exercise which include combination of high-intensity exercise and rest periods. The decrease in body fat levels due to physical training will further affect inflammatory mediators such as IL6 and TNFα. Besides training factor, genetic also play a role on obesity. One of the genes that influence obesity is the UCP2 Ala55Val gene. Objectives: This research aims to see the effect of HIIT on the levels of inflammatory mediators in obese patients based on the study of the Ala55Val UCP2 gene. Methods: This study was a Quasi-Experimental Pre and Post Design Without Control Group. Thirty obese women (BMI≥25 kg/m2) were given High-Intensity Interval Training (HIIT) as an intervention by comparing the data before and after the intervention. The training intervention was conducted for 12 weeks, consisting of two weeks of adaptation and ten weeks of HIIT intervention. The body weight, BMI and inflammatory mediators (TNFα and IL 6) before and after the intervention were analyzed using the Dependent T-Test and Wilcoxon Test as a nonparametric test. Independent T-Test and Mann Whitney test used to determine the effect of the UCP2 Ala55Val gene on changes in body weight, BMI and the inflammatory mediator. The test results were considered significantly different if p<0.05. Results: Bivariate analysis using Dependent T-Test showed that HIIT significantly improved Body Weight, BMI and IL6 with p=0.0001. Wilcoxon Test showed that HIIT significantly improved TNFα with p=0.0001. Independent T-Test showed no difference in body weight (p=0.719), BMI (p=0.663) and TNFα (p=0.264) improvement in the two genotypes of the UCP2 Ala55Val gene. Mann Whitney Test showed no difference in IL6 (p=0.288) improvement in the two genotypes of the UCP2 Ala55Val gene. Conclusion: The research concluded that the 12-week HIIT interventions improved inflammatory mediators by reducing IL6 and TNFα in obese women. There was no effect of genetic variation on the response to training intervention.

Effects of High-Intensity Interval Training Under Normobaric Hypoxia on Cardiometabolic Risk Markers in Overweight/Obese Women

2018 ◽  
Vol 19 (4) ◽  
pp. 356-366 ◽  
Author(s):  
Alba Camacho-Cardenosa ◽  
Marta Camacho-Cardenosa ◽  
Javier Brazo-Sayavera ◽  
Martin Burtscher ◽  
Rafael Timón ◽  
...  
Keyword(s):  
High Intensity ◽  
Cardiometabolic Risk ◽  
Interval Training ◽  
Normobaric Hypoxia ◽  
Risk Markers ◽  
Obese Women ◽  
High Intensity Interval Training ◽  
High Intensity Interval ◽  
Cardiometabolic Risk Markers

scholarly journals Comparison of Two High-Intensity Interval Training Modalities on Cardiometabolic Health in Overweight/Obese Women

2019 ◽  
Vol 51 (Supplement) ◽  
pp. 448-449
Author(s):  
Ozgur Alan ◽  
Emily W. Flanagan ◽  
Lafayette T. Watson ◽  
Andrew N.L. Buskard ◽  
Demet Tekin ◽  
...  
Keyword(s):  
High Intensity ◽  
Interval Training ◽  
Cardiometabolic Health ◽  
Obese Women ◽  
High Intensity Interval Training ◽  
High Intensity Interval ◽  
Training Modalities

scholarly journals Interactive effect of 6 weeks of High-intensity interval training and quercetin supplementation on expression of some tumor angiogenesis markers in female mice with breast cancer

2021 ◽  
Vol 43 (1) ◽  
pp. 142-151
Author(s):  
Zohreh Jalali ◽  
Fereshteh Shahidi ◽  
abbas ali Gaeini ◽  
Shaban Alizadeh ◽  
Alireza Ramezani
Keyword(s):  
Breast Cancer ◽  
Tumor Angiogenesis ◽  
High Intensity ◽  
Breast Cancer Cells ◽  
Tumor Tissue ◽  
Statistical Tests ◽  
Interactive Effect ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
High Intensity Interval

Background: About angiogenesis, metastasis of breast cancer and exercise, Many studies have been done in recent decades to better understand of regulatory mechanisms. The purpose of this study was to investigate the Interactive effect of high-intensity interval training (HIIT) and quercetin supplementation (Q) on the expression of key angiogenic factors in tumor tissue of mouse with breast cancer. Methods: Twenty-four female Balb/C mouse were injected with estrogen receptor-dependent breast cancer cells MC4L2 and then divided into three groups of tumor (T), tumor + of high-intensity interval training (TH) and tumor + high-intensity interval training + quercetin (THQ). The TH and THQ groups ran the treadmill 3 days a week for 6 weeks and each session 1 hour. The THQ group received 110 mg / kg quercetin solution for 6 weeks, 3 days a week with training. After completion of the work, the mouse were sacrificed and their tumor tissue removed and frozen in liquid nitrogen And stored at -70 ° C. Expression of TIE-2 and VEGF-A genes was measured by REAL TIME-PCR. ΔCt, ΔΔCt, and Fold change were calculated with the relevant statistical tests at the significant level (P <0.05) by GENEX software. Results: The results showed that THQ interaction significantly decreased the expression of TIE-2 and VEGF-A genes in TH and THQ groups compared to T group. In addition, quercetin in THQ group significantly decreased TIE-2 and VEGF-A gene expression compared to TH group. Conclusion: interaction of HIIT and Q supplementation are probably effective in inhibiting tumor angiogenesis.

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