Correlation of BDNF blood levels with interoceptive awareness and maturity fears in anorexia and bulimia nervosa patients

2010 ◽  
Vol 117 (4) ◽  
pp. 505-512 ◽  
Author(s):  
J. M. Mercader ◽  
F. Fernández-Aranda ◽  
Mònica Gratacòs ◽  
Zaida Aguera ◽  
Laura Forcano ◽  
...  
2008 ◽  
Vol 93 (11) ◽  
pp. 4418-4421 ◽  
Author(s):  
Palmiero Monteleone ◽  
Cristina Serritella ◽  
Vassilis Martiadis ◽  
Pasquale Scognamiglio ◽  
Mario Maj

Introduction: Peptides of the gut-brain axis have a pivotal role in the regulation of energy homeostasis. Obestatin, a sibling of ghrelin derived from preproghrelin, is thought to oppose ghrelin effects on food intake. Because changes in ghrelin levels have been associated with anorexia nervosa (AN) and bulimia nervosa (BN), the investigation of obestatin production may further contribute to understanding the role of peripheral peptides in patients with eating disorders. Methods: In the present study, we measured circulating blood levels of obestatin and ghrelin and assessed their relationships with anthropometric and clinical measures in 20 AN patients, 21 BN patients, and 20 appropriate healthy controls. Results: Compared with healthy women, patients with BN showed no significant differences in plasma obestatin and ghrelin concentrations and in the ghrelin/obestatin ratio, whereas underweight AN patients displayed significantly increased circulating levels of both obestatin (P < 0.009) and ghrelin (P < 0.002) and an increased ghrelin/obestatin ratio (P < 0.04). Moreover, in AN women, positive correlations emerged between the ghrelin/obestatin ratio and current body weight and body mass index. Conclusions: Underweight AN patients are characterized by increased concentrations of ghrelin and obestatin and a higher ghrelin to obestatin ratio. No changes in circulating ghrelin or obestatin as well as in ghrelin to obestatin ratio seem to occur in acutely ill patients with BN. Although those changes likely reflect the physiological state of symptomatic AN individuals, they may also contribute to the pathophysiology of the disorder.


2005 ◽  
Vol 30 (6) ◽  
pp. 1216-1221 ◽  
Author(s):  
Palmiero Monteleone ◽  
Isabelle Matias ◽  
Vassilis Martiadis ◽  
Luciano De Petrocellis ◽  
Mario Maj ◽  
...  

2008 ◽  
Vol 103 (1) ◽  
pp. 231-242
Author(s):  
Erica B. Fäldt Ciccolo

Elements of family dynamics have been shown to be related to onset, course, as well as prognosis of anorexia nervosa and bulimia nervosa. The goal was to explore the experience of family relations in a group of patients with eating disorders using a projective family test. The Patient group (anorexia = 21, bulimia=16), as well as a healthy Control group, were given a projective family test, the Eating Disorder Inventory-2, as well as Karolinska Scales of Personality. The Patient group expressed more discord within the family picture than the Control group, such as cold and loveless relationships and not feeling validated. The group of patients reporting the most family discord did not show more eating disorder pathology or general psychopathology. They did, however, have higher scores on the Eating Disorder Inventory—2 subscale Maturity Fears, as well as higher values on the Karolinska Scales of Personality subscale Socialization. These results are interpreted within the background of methodological challenges in this area of research.


1996 ◽  
Vol 168 (5) ◽  
pp. 636-640 ◽  
Author(s):  
Abdullah S. Al-Subaie ◽  
Elijah Bamgboye ◽  
Sulaiman Al-Shammari ◽  
Khalid N. Al-Sabhan ◽  
Sulaiman Nasser Al-Shehri ◽  
...  

BackgroundWe aimed to validate the Eating Disorders Inventory (EDI) in Arabic.MethodsSubjects were chosen randomly from female school students. Only healthy Saudi students were included. They were asked to fill the EDI and undergo a semi-structured interview by a psychiatrist who was unaware of the EDI scores. Of 146 students approached 12 did not meet our criteria and were excluded; 16 other students were excluded for incomplete responses.ResultsThe difference between the two diagnostic methods in the proportion of caseness was statistically significant (P < 0.0001). The scores on Perfectionism, Maturity Fears and Interoceptive Awareness were significantly higher in the Saudi students compared with Canadians (P < 0.05).ConclusionsThe EDI-DT subscale has a sensitivity of 100% and a specificity of 85%. Despite its low positive predictive value of 5%, it may be useful for screening large non-clinical groups for eating disorders.


2004 ◽  
Vol 37 (4) ◽  
pp. 168-174 ◽  
Author(s):  
Secondo Fassino ◽  
Andrea Pierò ◽  
Carla Gramaglia ◽  
Giovanni Abbate-Daga

2007 ◽  
Vol 177 (4S) ◽  
pp. 311-312
Author(s):  
Heman Carrion ◽  
Jorge R. Caso ◽  
Gerard D. Henry ◽  
J. Christopher Webster ◽  
Rafael E. Carrion

2003 ◽  
Vol 2 (1) ◽  
pp. 79
Author(s):  
P PAVLIDIS ◽  
J PARISSIS ◽  
S ANTONOPOULOS ◽  
D POLLATOS ◽  
P KIRIAZOPOULOS ◽  
...  

2011 ◽  
Vol 81 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Rahime Bedir Findik ◽  
Nurcihan Karakurt Hascelik ◽  
Kadir Okhan Akin ◽  
Ayse Nurcan Unluer ◽  
Jale Karakaya

Background: Striae gravidarum, a clinical condition commonly seen in pregnant women, produces serious cosmetic problems and may lead to psychological problems. Aim: The present study investigated whether there was any relation between the presence of striae in primigravid pregnant women and blood vitamin C levels, and factors thought to contribute to the formation of striae such as family history, weight gained during pregnancy, smoking status, abdominal and thigh circumference, and age. Methods: Overall, 69 primigravid women attending routine antenatal follow-up and, using prophylactic iron and vitamin preparations, underwent investigation. All were pregnant 36 or more weeks. Scoring was based on striae examination and whether striae were present. The relation between the presence of striae, vitamin C blood levels, and other factors was investigated. Results and Conclusions: Multiple logistic regression analysis showed a significant relation between the presence of striae and blood vitamin C levels (p = 0.046) and between the presence of striae and family history (p = 0.023). No significant relation was found between the presence of striae and age, weight gained during pregnancy, abdominal and thigh circumference, or smoking status. It was concluded that further, more comprehensive studies on the issue are required.


Author(s):  
Katharina Bühren ◽  
Kristian Holtkamp ◽  
Beate Herpertz-Dahlmann ◽  
Kerstin Konrad

Zusammenfassung: Anorexia und Bulimia nervosa sind häufige psychiatrische Erkrankungen des Kindes- und Jugendalters, die insbesondere Mädchen betreffen. Im Akutzustand der Starvation treten bei Essstörungen eine Vielzahl von hormonellen, neuropsychologischen und hirnmorphologischen Veränderungen auf, von denen einige nur teilweise reversibel sind. Komorbide psychiatrische Erkrankungen verkomplizieren das Krankheitsbild und erschweren adäquate therapeutische Interventionen. Der folgende Artikel setzt sich ausführlich mit den neuropsychologischen Defiziten bei Essstörungen, möglichen Einflussfaktoren auf die kognitive Leistungsfähigkeit und daraus resultierenden Implikationen für den klinischen Alltag auseinander.


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