Implementation of ISO Guide 34: Accreditation for reference material production

2003 ◽  
Vol 8 (9) ◽  
pp. 424-427 ◽  
Author(s):  
Steven Westwood ◽  
Bernard King ◽  
Bruce Noble
Keyword(s):  
Reference Material ◽  
Material Production ◽  
Iso Guide 34

scholarly journals Cooperation in publicly funded reference material production

2018 ◽  
Vol 23 (6) ◽  
pp. 371-377 ◽  
Author(s):  
Håkan Emteborg ◽  
Doris Florian ◽  
Steven Choquette ◽  
Stephen L. R. Ellison ◽  
Maria Fernandes-Whaley ◽  
...  
Keyword(s):  
Reference Material ◽  
Publicly Funded ◽  
Material Production

scholarly journals DEVELOPMENT OF REFERENCE MATERIAL OF HOLMIUM OXIDE FOR SPECTROMETERS WAVELENGTH CALIBRATION: FEASIBILITY STUDIES

2018 ◽  
Vol 15 (29) ◽  
pp. 243-250
Author(s):  
D. E. GONÇALVES ◽  
J. F. S. GOMES ◽  
A. P. D. ALVARENGA ◽  
T. de O. ARAUJO ◽  
P. P. BORGES
Keyword(s):  
Quality Assurance ◽  
Reference Material ◽  
Wavelength Range ◽  
Certified Reference Material ◽  
Metrological Traceability ◽  
Feasibility Studies ◽  
Wavelength Calibration ◽  
Material Production ◽  
Important Requirement

The use of certified reference material (CRM) in chemical analyzes is an important requirement in quality assurance systems, since it allows the metrological traceability of results, thus achieving valid and comparable results. This work describes the development and production of holmium oxide reference material that, after certification, will be used in the calibration of the wavelength range of UV-Vis spectrometers and also the necessary feasibility studies to establish the measurement parameters to be used in the next steps of the material production and certification.

Multi-Center Calibration of the Second Reference Material for Thromboplastin, Rabbit, Plain, Coded CRM 149R

1991 ◽  
Vol 65 (03) ◽  
pp. 263-267 ◽  
Author(s):  
A M H P van den Besselaar ◽  
R M Bertina
Keyword(s):  
Reference Material ◽  
Standard Error ◽  
Standard Errors ◽  
Sensitivity Index ◽  
Long Term Stability ◽  
Significant Bias ◽  
The Mean ◽  
The Relationship ◽  
International Sensitivity Index

SummaryIn a collaborative trial of eleven laboratories which was performed mainly within the framework of the European Community Bureau of Reference (BCR), a second reference material for thromboplastin, rabbit, plain, was calibrated against its predecessor RBT/79. This second reference material (coded CRM 149R) has a mean International Sensitivity Index (ISI) of 1.343 with a standard error of the mean of 0.035. The standard error of the ISI was determined by combination of the standard errors of the ISI of RBT/79 and the slope of the calibration line in this trial.The BCR reference material for thromboplastin, human, plain (coded BCT/099) was also included in this trial for assessment of the long-term stability of the relationship with RBT/79. The results indicated that this relationship has not changed over a period of 8 years. The interlaboratory variation of the slope of the relationship between CRM 149R and RBT/79 was significantly lower than the variation of the slope of the relationship between BCT/099 and RBT/79. In addition to the manual technique, a semi-automatic coagulometer according to Schnitger & Gross was used to determine prothrombin times with CRM 149R. The mean ISI of CRM 149R was not affected by replacement of the manual technique by this particular coagulometer.Two lyophilized plasmas were included in this trial. The mean slope of relationship between RBT/79 and CRM 149R based on the two lyophilized plasmas was the same as the corresponding slope based on fresh plasmas. Tlowever, the mean slope of relationship between RBT/79 and BCT/099 based on the two lyophilized plasmas was 4.9% higher than the mean slope based on fresh plasmas. Thus, the use of these lyophilized plasmas induced a small but significant bias in the slope of relationship between these thromboplastins of different species.

Effect of Concentration of Trisodium Citrate Anticoagulant on Calculation of the International Normalised Ratio and the International Sensitivity Index of Thromboplastin

1994 ◽  
Vol 72 (01) ◽  
pp. 084-088 ◽  
Author(s):  
E M Duncan ◽  
C R Casey ◽  
B M Duncan ◽  
J V Lloyd
Keyword(s):  
Reference Material ◽  
Oral Anticoagulants ◽  
Reference Method ◽  
Trisodium Citrate ◽  
Sensitivity Index ◽  
Blood Samples ◽  
Orthogonal Regression ◽  
Significant Difference ◽  
International Normalised Ratio ◽  
International Sensitivity Index

SummaryThe aim of this study was to determine whether the concentration of trisodium citrate used to anticoagulate blood has an effect on the INR of the sample and the ISI of the thromboplastin. Five thromboplastins including and Australian reference material were used to measure the prothrombin time of normal and patient samples collected into two concentrations of trisodium citrate - 109 mM and 129 mM. There was no effect of citrate concentration on the INRs determined with the reference material. However for the other four thromboplastins there was a significant difference between INRs for the two citrate groups. The prothrombin times of the samples collected into 129 mM were longer than those collected into 109 mM. This difference was only slight in normal plasma but more marked in patients receiving oral anticoagulants, causing the INRs for patient plasmas collected into 129 mM citrate to be higher then the corresponding samples collected into 109 mM citrate.From orthogonal regression of log prothrombin times by the reference method against each thromboplastin, we found that the ISI for each thromboplastin was approximately 10% lower when determined with samples collected into 129 mM citrate than with samples collected into 109 mM. These results suggest that the concentration of trisodium citrate used for collection of blood samples can affect the calculation of the INR and the calibration of the ISI of thromboplastin. This was found both for commercial thromboplastins prepared by tissue extraction and for a recombinant tissue factor.

Sign in / Sign up

Export Citation Format

Share Document